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2O (5 equiv) in THF was added DIAD (20 equiv), and the resulting mixture was stirred at 20 °C (30 min). The heterogenous mixture was cooled to 0 °C, and a solution of the hydroxy acid 12b in THF was added by syringe pump (2 h). The resulting mixture was allowed to stir for an additional 60 min after the addition was completed. The solvents were removed under reduced pressure, and the mixture was purified by flash chromatography to give 13 (62% yield).
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