Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in gaucher cells

Journal of the American Chemical Society

Volumn 133, Issue 14, 2011, Pages 5474-5484

  Trapero, Ana ^a   Alfonso, Ignacio ^a   Butters, Terry D ^b   Llebaria, Amadeu ^a  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL SUBSTITUENT; BICYCLIC COMPOUNDS; CARBON ATOMS; CELLULAR PROPERTIES; DIASTEREOMERIC; ENZYME DEFICIENCIES; GAUCHER DISEASE; GLUCOCEREBROSIDASE; GUANIDINE DERIVATIVE; HUMAN FIBROBLAST; HYDROXYL GROUPS; ISOLATED ENZYMES; NANOMOLAR; NANOMOLAR CONCENTRATION; POTENT INHIBITOR; RING FUSION; SELECTIVE INHIBITION; SUBSTITUTION PATTERNS; WILD TYPES;

CELL CULTURE; ENZYMES; GLUCOSE; SELF ASSEMBLY;

ENZYME ACTIVITY;

CHAPERONE; GLUCOSYLCERAMIDASE; GLYCOSIDASE INHIBITOR; GUANIDINE DERIVATIVE; HYDROXYL GROUP; IMIGLUCERASE; UREA DERIVATIVE;

ALKYLATION; ARTICLE; COMPETITIVE INHIBITION; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME DEFICIENCY; FIBROBLAST; GAUCHER DISEASE; HUMAN; HUMAN CELL; HYDROXYLATION; IC 50; INCUBATION TIME; MUTATION; PROTEIN TARGETING; SUBSTITUTION REACTION; SYNTHESIS; WILD TYPE;

BICYCLO COMPOUNDS; CELL LINE; ENZYME INHIBITORS; ENZYME STABILITY; FIBROBLASTS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; GUANIDINE; HUMANS; HYDROXYLATION; MUTATION; PROTEIN DENATURATION; TEMPERATURE; UREA;

EID: 79953679283     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja111480z     Document Type: Article

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