Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice

Neuroscience

Volumn 169, Issue 3, 2010, Pages 1007-1016

  Klein, A B ^a   Santini, M A ^a   Aznar, S ^a   Knudsen, G M ^a   Rios, M ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT1A; 5 HT2A; 5 HT2C; BDNF; Behavior; Serotonin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 4-IODO-2,5-DIMETHOXYPHENYLISOPROPYLAMINE; AMPHETAMINE DERIVATIVE; PROTEIN C FOS; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; SEROTONIN TRANSPORTER;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN REGION; CELL ACTIVATION; CONTROLLED STUDY; FRONTAL CORTEX; HEAD TWITCH; HIPPOCAMPUS; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; AUTORADIOGRAPHY; BINDING SITE; FRONTAL LOBE; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RADIOASSAY;

AMPHETAMINES; ANIMALS; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; BINDING SITES; BRAIN-DERIVED NEUROTROPHIC FACTOR; FRONTAL LOBE; HIPPOCAMPUS; MICE; MICE, KNOCKOUT; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN RECEPTOR AGONISTS;

EID: 77955267304     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.05.054     Document Type: Article

References (26)

1. Akimova E., Lanzenberger R., Kasper S. The serotonin-1A receptor in anxiety disorders. Biol Psychiatry 2009, 66:627-635.
2. Chan J.P., Unger T.J., Byrnes J., Rios M. Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. Neuroscience 2006, 142:49-58.
3. Cornea-Hebert V., Riad M., Wu C., Singh S.K., Descarries L. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. J Comp Neurol 1999, 409:187-209.
4. Darmani N.A. Cannabinoids of diverse structure inhibit two DOI-induced 5-HT(2A) receptor-mediated behaviors in mice. Pharmacol Biochem Behav 2001, 68:311-317.
5. Dave K.D., Fernando G.S., Quinn J.L., Harvey J.A., Aloyo V.J. Serotonin 5-HT2A receptors in the CA1 field of the hippocampus mediate head movements in the rabbit. Psychopharmacology (Berl) 2004, 176:287-295.
6. Deltheil T., Guiard B.P., Cerdan J., David D.J., Tanaka K.F., Reperant C., Guilloux J.P., Coudore F., Hen R., Gardier A.M. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology 2008, 55:1006-1014.
7. Feng J., Cai X., Zhao J., Yan Z. Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J Neurosci 2001, 21:6502-6511.
8. Gonzalez-Maeso J., Weisstaub N.V., Zhou M., Chan P., Ivic L., Ang R., Lira A., Bradley-Moore M., Ge Y., Zhou Q., Sealfon S.C., Gingrich J.A. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron 2007, 53:439-452.
9. Gray J.A., Roth B.L. Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Res Bull 2001, 56:441-451.
10. Heisler L.K., Zhou L., Bajwa P., Hsu J., Tecott L.H. Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav 2007, 6:491-496.
11. Hensler J.G., Advani T., Monteggia L.M. Regulation of serotonin-1A receptor function in inducible brain-derived neurotrophic factor knockout mice after administration of corticosterone. Biol Psychiatry 2007, 62:521-529.
12. Kernie S.G., Liebl D.J., Parada L.F. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000, 19:1290-1300.
13. Kozisek M.E., Middlemas D., Bylund D.B. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacol Ther 2008, 117:30-51.
14. Leysen J.E. 5-HT2 receptors. Curr Drug Targets CNS Neurol Disord 2004, 3:11-26.
15. Lyons W.E., Mamounas L.A., Ricaurte G.A., Coppola V., Reid S.W., Bora S.H., Wihler C., Koliatsos V.E., Tessarollo L. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 1999, 96:15239-15244.
16. Naughton M., Mulrooney J.B., Leonard B.E. A review of the role of serotonin receptors in psychiatric disorders. Hum Psychopharmacol 2000, 15:397-415.
17. Riad M., Watkins K.C., Doucet E., Hamon M., Descarries L. Agonist-induced internalization of serotonin-1a receptors in the dorsal raphe nucleus (autoreceptors) but not hippocampus (heteroreceptors). J Neurosci 2001, 21:8378-8386.
18. Rios M., Fan G., Fekete C., Kelly J., Bates B., Kuehn R., Lechan R.M., Jaenisch R. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 2001, 15:1748-1757.
19. Rios M., Lambe E.K., Liu R., Teillon S., Liu J., Akbarian S., Roffler-Tarlov S., Jaenisch R., Aghajanian G.K. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. J Neurobiol 2006, 66:408-420.
20. Savitz J., Lucki I., Drevets W.C. 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 2009, 88:17-31.
21. Thomsen C., Helboe L. Regional pattern of binding and c-Fos induction by (R)-and (S)-citalopram in rat brain. Neuroreport 2003, 14:2411-2414.
22. Trajkovska V., Santini M.A., Marcussen A.B., Thomsen M.S., Hansen H.H., Mikkelsen J.D., Arneberg L., Kokaia M., Knudsen G.M., Aznar S. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochem Int 2009, 55:697-702.
23. Unger T.J., Calderon G.A., Bradley L.C., Sena-Esteves M., Rios M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 2007, 27:14265-14274.
24. Weisstaub N.V., Zhou M., Lira A., Lambe E., Gonzalez-Maeso J., Hornung J.P., Sibille E., Underwood M., Itohara S., Dauer W.T., Ansorge M.S., Morelli E., Mann J.J., Toth M., Aghajanian G., Sealfon S.C., Hen R., Gingrich J.A. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 2006, 313:536-540.
25. Willins D.L., Meltzer H.Y. Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. J Pharmacol Exp Ther 1997, 282:699-706.
26. Yuen E.Y., Jiang Q., Chen P., Feng J., Yan Z. Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-d-aspartate receptor channels in pyramidal neurons of prefrontal cortex. J Biol Chem 2008, 283:17194-17204.