Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: This effect persists after repeated citalopram treatment

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 475-482

  Gundlah, C ^a   Hjorth, S ^b   Auerbach, S B ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

( ) penbutolol; 5 HT; 5 HT autoreceptor; 5 Hydroxytryptamine (serotonin); Antidepressant; Citalopram; Frontal cortex; Hippocampus; Microdialysis; SSRI; WAY100635

Indexed keywords

AUTORECEPTOR; CITALOPRAM; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PENBUTOLOL; SEROTONIN; SEROTONIN 1 ANTAGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1B ANTAGONIST; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG POTENTIATION; FRONTAL CORTEX; HIPPOCAMPUS; HISTOLOGY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; AUTORECEPTORS; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITALOPRAM; EXTRACELLULAR SPACE; HIPPOCAMPUS; MALE; MICRODIALYSIS; PENBUTOLOL; PIPERAZINES; PROSENCEPHALON; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 0030904124     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00052-X     Document Type: Article

References (42)

1. Adell A. and Artigas F. (1991) Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. Naunyn-Schmiedeberg's Archives of Pharmacology 343: 237-244.
2. Aghajanian, G. K., Sprouse, J. S. and Rasmussen, K. (1987) Physiology of midbrain serotonin systems. In: Psychopharmacology: The Third Generation of Progress. (Metzler H. Y., Ed.), pp. 141-149. Raven Press, NY.
3. 1A receptor gene. Journal of Biology and Chemistry 265: 5825-5832.
4. 1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn-Schmiedeberg's Archives of Pharmacology 352: 157-165.
5. 1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. Naunyn-Schmiedeberg's Archives of Pharmacology 353: 630-640.
6. 1A antagonists. Trends in Neuroscience 19: 378-383.
7. Auerbach S. B. and Hjorth S. (1995) Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology 352: 597-606.
8. Bel N. and Artigas F. (1993) Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei. Synapse 15: 243-245.
9. Blier P., Montigny C. de and Chaput Y. (1987) Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. Journal of Clinical Psychopharmacology 7: 24S-35S.
10. Bosker F. J., Klompmakers A. A. and Westenberg H. G. (1995a) Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 34: 501-508.
11. 1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology 117: 358-363.
12. Chaput Y., Blier P. and Montigny C. de (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. Journal of Neuroscience 6: 2796-2801.
13. Chaput Y., de Montigny C. and Blier P. (1991) Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology 5: 219-229.
14. 1A receptor antagonist. Behaviour and Brain Research 73: 337-353.
15. 1A receptor antagonist WAY-100635. European Journal of Pharmacology 281: 81-88.
16. Fuller R. W. (1994) Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Science 55: 163-167.
17. 1A autoreceptors. Anxiety 3: 149-152.
18. 1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. British Journal of Pharmacology 115: 1064-1070.
19. 1A receptor regulation: effects of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 4: 131-144.
20. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. Journal of Neurochemistry 60: 776-779.
21. 1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis. Neuropharmacology 33: 331-334.
22. 1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. Journal of Pharmacology and Experimental Therapeutics 265: 707-712.
23. 1A autoreceptors and α1-adrenoceptors in the inhibition of 5-HT release. (I) Bmy7378 and prazosin. Neuropharmacology 34: 615-620.
24. 1A receptors or β-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-HT in vivo, European Journal of Pharmacology 316: 43-47.
25. 1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology, in press.
26. 1A receptors in rat brain. European Journal of Pharmacology 271: 515-523.
27. Invernizzi R., Belli S. and Samanin R. (1992) Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Research 584: 322-324.
28. 1A receptors. European Journal of Pharmacology 260: 243-246.
29. 1A receptors in the effects of acute and chronic fluoxetine on extracellular serotonin in the frontal cortex. Pharmacology and Biochemistry of Behaviour 54: 143-147.
30. 1A receptors in rats treated chronically with a novel antidepressant, cericlamine. Journal of Pharmacology and Experimental Therapeutics 268: 1432-1443.
31. 1A autoreceptors by chronic administration of 8-OH-DPAT. Neuropharmacology 31: 1073-1076.
32. Kreiss D. S. and Lucki I. (1995) Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. Journal of Pharmacology and Experimental Therapeutics 274: 866-876.
33. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's Archives of Pharmacology 352: 141-148.
34. 1A agonists. Molecular Pharmacology 37: 231-237.
35. 1A antagonists WAY100135 and WAY100635, on guinea pig behavior and dorsal raphe 5-HT neuronal firing. British Journal of Pharmacology 117: 750-756.
36. Paxinos, G. and Watson, C. (1982). The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
37. 1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of Neurochemistry 58: 1338-1340.
38. Rutter J. J., Gundlah C. and Auerbach S. B. (1994) Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neuroscience Letters 171: 183-186.
39. Rutter J. J., Gundlah C. and Auerbach S. B. (1995) Systemic uptake inhibition decreases serotonin release via somatodendritic autoreceptor activation. Synapse 20: 225-233.
40. 1 receptor. European Journal of Pharmacology 157: 173-181.
41. Tork I. (1990) Anatomy of the serotonergic system. Annals of the New York Academy of Science 600: 9-35.
42. 1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochemistry International 7: 1061-1072.