메뉴 건너뛰기




Volumn 310, Issue 1-2, 2011, Pages 107-111

Synuclein deposition and non-motor symptoms in Parkinson disease

Author keywords

Synuclein pathology; Brainstem; Non motor features; Parkinson disease

Indexed keywords

ALPHA SYNUCLEIN; SYNUCLEIN;

EID: 80054089850     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2011.04.012     Document Type: Article
Times cited : (90)

References (99)
  • 1
    • 64349083816 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
    • K.R. Chaudhuri, and A.H. Schapira Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment Lancet Neurol 8 2009 464 474
    • (2009) Lancet Neurol , vol.8 , pp. 464-474
    • Chaudhuri, K.R.1    Schapira, A.H.2
  • 2
  • 4
    • 84885982317 scopus 로고    scopus 로고
    • Nonmotor aspects of Parkinson's disease
    • A.H.V. Schapira, A.E.T. Lang, S. Fahn, Saunders-Elsevier Philadelphia
    • E. Tolosa, J. Santamaria, C. Gaig, and Y. Compta Nonmotor aspects of Parkinson's disease A.H.V. Schapira, A.E.T. Lang, S. Fahn, Movement disorders 4 2010 Saunders-Elsevier Philadelphia 229 251
    • (2010) Movement Disorders 4 , pp. 229-251
    • Tolosa, E.1    Santamaria, J.2    Gaig, C.3    Compta, Y.4
  • 5
    • 41049106214 scopus 로고    scopus 로고
    • Non-motor symptoms in Parkinson's disease
    • DOI 10.1111/j.1468-1331.2008.02056.x
    • W. Poewe Non-motor symptoms in Parkinson's disease Eur J Neurol 15 Suppl 1 2008 14 20 (Pubitemid 351421304)
    • (2008) European Journal of Neurology , vol.15 , Issue.SUPPL. 1 , pp. 14-20
    • Poewe, W.1
  • 6
    • 78349236177 scopus 로고    scopus 로고
    • What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?
    • D.A. Gallagher, A.J. Lees, and A. Schrag What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? Mov Disord 25 2010 2493 2500
    • (2010) Mov Disord , vol.25 , pp. 2493-2500
    • Gallagher, D.A.1    Lees, A.J.2    Schrag, A.3
  • 7
    • 74149088543 scopus 로고    scopus 로고
    • Parkinson's disease: Before the motor symptoms and beyond
    • A.D. Korczyn, and T. Gurevich Parkinson's disease: before the motor symptoms and beyond J Neurol Sci 289 2010 2 6
    • (2010) J Neurol Sci , vol.289 , pp. 2-6
    • Korczyn, A.D.1    Gurevich, T.2
  • 8
    • 74249113945 scopus 로고    scopus 로고
    • The pathophysiological basis of sensory disturbances in Parkinson's disease
    • C. Juri, M. Rodriguez-Oroz, and J.A. Obeso The pathophysiological basis of sensory disturbances in Parkinson's disease J Neurol Sci 289 2010 60 65
    • (2010) J Neurol Sci , vol.289 , pp. 60-65
    • Juri, C.1    Rodriguez-Oroz, M.2    Obeso, J.A.3
  • 9
    • 77958558412 scopus 로고    scopus 로고
    • Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    • T. Lebouvier, M. Neunlist, S. Bruley des Varannes, E. Coron, A. Drouard, and J.M. N'Guyen Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms PLoS One 5 2010 e12728
    • (2010) PLoS One , vol.5 , pp. 12728
    • Lebouvier, T.1    Neunlist, M.2    Bruley Des Varannes, S.3    Coron, E.4    Drouard, A.5    N'Guyen, J.M.6
  • 10
    • 72149101615 scopus 로고    scopus 로고
    • Initial clinical manifestations of Parkinson's disease: Features and pathophysiological mechanisms
    • M.C. Rodriguez-Oroz, M. Jahanshahi, P. Krack, I. Litvan, R. Macias, and E. Bezard Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms Lancet Neurol 8 2009 1128 1139
    • (2009) Lancet Neurol , vol.8 , pp. 1128-1139
    • Rodriguez-Oroz, M.C.1    Jahanshahi, M.2    Krack, P.3    Litvan, I.4    MacIas, R.5    Bezard, E.6
  • 12
    • 79955112282 scopus 로고    scopus 로고
    • A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials
    • A.E. Lang A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials Mov Disord 26 2011 775 783
    • (2011) Mov Disord , vol.26 , pp. 775-783
    • Lang, A.E.1
  • 13
    • 77957232523 scopus 로고    scopus 로고
    • The challenge of non-motor symptoms in Parkinson's disease
    • K.R. Chaudhuri, and P. Odin The challenge of non-motor symptoms in Parkinson's disease Prog Brain Res 184 2010 325 341
    • (2010) Prog Brain Res , vol.184 , pp. 325-341
    • Chaudhuri, K.R.1    Odin, P.2
  • 16
    • 77957264418 scopus 로고    scopus 로고
    • The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia
    • W.J. Schulz-Schaeffer The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia Acta Neuropathol 120 2010 131 143
    • (2010) Acta Neuropathol , vol.120 , pp. 131-143
    • Schulz-Schaeffer, W.J.1
  • 18
    • 0033538002 scopus 로고    scopus 로고
    • Extensive axonal Lewy neurites in Parkinson's disease: A novel pathological feature revealed by α-synuclein immunocytochemistry
    • DOI 10.1016/S0304-3940(99)00208-6, PII S0304394099002086
    • H. Braak, D. Sandmann-Keil, W. Gai, and E. Braak Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry Neurosci Lett 265 1999 67 69 (Pubitemid 29210200)
    • (1999) Neuroscience Letters , vol.265 , Issue.1 , pp. 67-69
    • Braak, H.1    Sandmann-Keil, D.2    Gai, W.3    Braak, E.4
  • 19
    • 68749116710 scopus 로고    scopus 로고
    • A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders
    • K.A. Jellinger A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders Biochim Biophys Acta 1792 2009 730 740
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 730-740
    • Jellinger, K.A.1
  • 20
    • 79956196722 scopus 로고    scopus 로고
    • Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: Preclinical Parkinson disease
    • 10.1007/s00702-010-0482-8
    • I. Ferrer, A. Martinez, R. Blanco, E. Dalfo, and M. Carmona Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease J Neural Transm 2010 10.1007/s00702-010-0482-8
    • (2010) J Neural Transm
    • Ferrer, I.1    Martinez, A.2    Blanco, R.3    Dalfo, E.4    Carmona, M.5
  • 22
    • 53149130592 scopus 로고    scopus 로고
    • Nigral burden of alpha-synuclein correlates with striatal dopamine deficit
    • G.G. Kovacs, I.J. Milenkovic, M. Preusser, and H. Budka Nigral burden of alpha-synuclein correlates with striatal dopamine deficit Mov Disord 23 2008 1608 1612
    • (2008) Mov Disord , vol.23 , pp. 1608-1612
    • Kovacs, G.G.1    Milenkovic, I.J.2    Preusser, M.3    Budka, H.4
  • 23
    • 77953021942 scopus 로고    scopus 로고
    • Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    • T.G. Beach, C.H. Adler, L.I. Sue, L. Vedders, L. Lue, and C.L. White Iii Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders Acta Neuropathol 119 2010 689 702
    • (2010) Acta Neuropathol , vol.119 , pp. 689-702
    • Beach, T.G.1    Adler, C.H.2    Sue, L.I.3    Vedders, L.4    Lue, L.5    White Iii, C.L.6
  • 24
    • 77953033188 scopus 로고    scopus 로고
    • Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain
    • K. Wakabayashi, F. Mori, K. Tanji, S. Orimo, and H. Takahashi Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain Acta Neuropathol 120 2010 1 12
    • (2010) Acta Neuropathol , vol.120 , pp. 1-12
    • Wakabayashi, K.1    Mori, F.2    Tanji, K.3    Orimo, S.4    Takahashi, H.5
  • 25
    • 84886045090 scopus 로고    scopus 로고
    • Pathology of Parkinson's disease
    • A.H.V. Schapira, A.E.T. Lang, S. Fahn, Saunders-Elsevier Philadelphia
    • G. Halliday, and K. Murphy Pathology of Parkinson's disease A.H.V. Schapira, A.E.T. Lang, S. Fahn, Movement disorders 4 2010 Saunders-Elsevier Philadelphia 132 154
    • (2010) Movement Disorders 4 , pp. 132-154
    • Halliday, G.1    Murphy, K.2
  • 26
  • 28
    • 79953278999 scopus 로고    scopus 로고
    • Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease
    • 10.4061/2011/708404
    • I. Ferrer Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease Parkinsons Dis 2011 2011 708404 10.4061/2011/708404
    • (2011) Parkinsons Dis , vol.2011 , pp. 708404
    • Ferrer, I.1
  • 29
  • 30
    • 43649106356 scopus 로고    scopus 로고
    • Invited Article: Nervous system pathology in sporadic Parkinson disease
    • DOI 10.1212/01.wnl.0000312279.49272.9f, PII 0000611420080513000010
    • H. Braak, and K. Del Tredici Invited article: nervous system pathology in sporadic Parkinson disease Neurology 70 2008 1916 1925 (Pubitemid 351684646)
    • (2008) Neurology , vol.70 , Issue.20 , pp. 1916-1925
    • Braak, H.1    Del Tredici, K.2
  • 32
    • 77953433969 scopus 로고    scopus 로고
    • Evidence in favor of Braak staging of Parkinson's disease
    • D.W. Dickson, H. Uchikado, H. Fujishiro, and Y. Tsuboi Evidence in favor of Braak staging of Parkinson's disease Mov Disord 25 Suppl 1 2010 S78 S82
    • (2010) Mov Disord , vol.25 , Issue.SUPPL. 1
    • Dickson, D.W.1    Uchikado, H.2    Fujishiro, H.3    Tsuboi, Y.4
  • 34
    • 33750349255 scopus 로고    scopus 로고
    • Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease
    • G.M. Halliday, K. Del Tredici, and H. Braak Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease J Neural Transm Suppl 2006 99 103 (Pubitemid 44622185)
    • (2006) Journal of Neural Transmission, Supplement , Issue.70 , pp. 99-103
    • Halliday, G.M.1    Del Tredici, K.2    Braak, H.3
  • 35
    • 57749095477 scopus 로고    scopus 로고
    • A critical evaluation of the Braak staging scheme for Parkinson's disease
    • R.E. Burke, W.T. Dauer, and J.P. Vonsattel A critical evaluation of the Braak staging scheme for Parkinson's disease Ann Neurol 64 2008 485 491
    • (2008) Ann Neurol , vol.64 , pp. 485-491
    • Burke, R.E.1    Dauer, W.T.2    Vonsattel, J.P.3
  • 36
    • 67349279396 scopus 로고    scopus 로고
    • Unified staging system for Lewy body disorders: Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    • T.G. Beach, C.H. Adler, L. Lue, L.I. Sue, J. Bachalakuri, and J. Henry-Watson Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction Acta Neuropathol 117 2009 613 634
    • (2009) Acta Neuropathol , vol.117 , pp. 613-634
    • Beach, T.G.1    Adler, C.H.2    Lue, L.3    Sue, L.I.4    Bachalakuri, J.5    Henry-Watson, J.6
  • 37
    • 69549116777 scopus 로고    scopus 로고
    • Formation and development of Lewy pathology: A critical update
    • K.A. Jellinger Formation and development of Lewy pathology: a critical update J Neurol 256 Suppl 3 2009 270 279
    • (2009) J Neurol , vol.256 , Issue.SUPPL. 3 , pp. 270-279
    • Jellinger, K.A.1
  • 38
    • 42549125030 scopus 로고    scopus 로고
    • The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: A critical analysis of α-synuclein staging
    • DOI 10.1111/j.1365-2990.2007.00923.x
    • M.E. Kalaitzakis, M.B. Graeber, S.M. Gentleman, and R.K. Pearce The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging Neuropathol Appl Neurobiol 34 2008 284 295 (Pubitemid 351590870)
    • (2008) Neuropathology and Applied Neurobiology , vol.34 , Issue.3 , pp. 284-295
    • Kalaitzakis, M.E.1    Graeber, M.B.2    Gentleman, S.M.3    Pearce, R.K.B.4
  • 39
    • 41149141259 scopus 로고    scopus 로고
    • Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
    • L. Parkkinen, T. Pirttila, and I. Alafuzoff Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance Acta Neuropathol 115 2008 399 407
    • (2008) Acta Neuropathol , vol.115 , pp. 399-407
    • Parkkinen, L.1    Pirttila, T.2    Alafuzoff, I.3
  • 40
    • 33646082266 scopus 로고    scopus 로고
    • Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    • A. Bloch, A. Probst, H. Bissig, H. Adams, and M. Tolnay Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects Neuropathol Appl Neurobiol 32 2006 284 295
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 284-295
    • Bloch, A.1    Probst, A.2    Bissig, H.3    Adams, H.4    Tolnay, M.5
  • 41
    • 7944238570 scopus 로고    scopus 로고
    • Lewy body-related α-synucleinopathy in the aged human brain
    • DOI 10.1007/s00702-004-0138-7, Parkinson's Research in Progress
    • K.A. Jellinger Lewy body-related alpha-synucleinopathy in the aged human brain J Neural Transm 111 2004 1219 1235 (Pubitemid 39468387)
    • (2004) Journal of Neural Transmission , vol.111 , Issue.10-11 , pp. 1219-1235
    • Jellinger, K.A.1
  • 43
    • 74149090746 scopus 로고    scopus 로고
    • Olfactory system pathology as a model of Lewy neurodegenerative disease
    • J.E. Duda Olfactory system pathology as a model of Lewy neurodegenerative disease J Neurol Sci 289 2010 49 54
    • (2010) J Neurol Sci , vol.289 , pp. 49-54
    • Duda, J.E.1
  • 44
    • 67651160628 scopus 로고    scopus 로고
    • Biopsies of olfactory epithelium in patients with Parkinson's disease
    • M. Witt, K. Bormann, V. Gudziol, K. Pehlke, K. Barth, and A. Minovi Biopsies of olfactory epithelium in patients with Parkinson's disease Mov Disord 24 2009 906 914
    • (2009) Mov Disord , vol.24 , pp. 906-914
    • Witt, M.1    Bormann, K.2    Gudziol, V.3    Pehlke, K.4    Barth, K.5    Minovi, A.6
  • 47
    • 77949903007 scopus 로고    scopus 로고
    • REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions
    • B.F. Boeve REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions Ann NY Acad Sci 1184 2010 15 54
    • (2010) Ann NY Acad Sci , vol.1184 , pp. 15-54
    • Boeve, B.F.1
  • 49
    • 80054099602 scopus 로고    scopus 로고
    • REM sleep behaviour disorder in Parkinson's disease
    • K.R. Chaudhuri, E. Tolosa, A. Schapira, W. Poewe, Oxford Univ. Press Oxford
    • A. Iranzo, and E. Tolosa REM sleep behaviour disorder in Parkinson's disease K.R. Chaudhuri, E. Tolosa, A. Schapira, W. Poewe, Non-motor symptoms of Parkinson's disease 2009 Oxford Univ. Press Oxford 177 193
    • (2009) Non-motor Symptoms of Parkinson's Disease , pp. 177-193
    • Iranzo, A.1    Tolosa, E.2
  • 50
    • 79955485357 scopus 로고    scopus 로고
    • Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder
    • R.B. Postuma, J.F. Gagnon, M. Vendette, C. Desjardins, and J.Y. Montplaisir Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder Ann Neurol 69 2010 811 818
    • (2010) Ann Neurol , vol.69 , pp. 811-818
    • Postuma, R.B.1    Gagnon, J.F.2    Vendette, M.3    Desjardins, C.4    Montplaisir, J.Y.5
  • 51
    • 68149152818 scopus 로고    scopus 로고
    • Historical overview of REM sleep behavior disorder in relation to its pathophysiology
    • N. Tachibana Historical overview of REM sleep behavior disorder in relation to its pathophysiology Brain Nerve 61 2009 558 568
    • (2009) Brain Nerve , vol.61 , pp. 558-568
    • Tachibana, N.1
  • 52
    • 77649121099 scopus 로고    scopus 로고
    • The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder
    • Y.K. Kim, I.Y. Yoon, J.M. Kim, S.H. Jeong, K.W. Kim, and Y.K. Shin The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder Eur J Neurol 17 2010 487 492
    • (2010) Eur J Neurol , vol.17 , pp. 487-492
    • Kim, Y.K.1    Yoon, I.Y.2    Kim, J.M.3    Jeong, S.H.4    Kim, K.W.5    Shin, Y.K.6
  • 53
    • 32544442518 scopus 로고    scopus 로고
    • Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • DOI 10.1016/j.neulet.2005.11.012, PII S0304394005012814
    • H. Braak, R.A. de Vos, J. Bohl, and K. Del Tredici Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology Neurosci Lett 396 2006 67 72 (Pubitemid 43233790)
    • (2006) Neuroscience Letters , vol.396 , Issue.1 , pp. 67-72
    • Braak, H.1    De Vos, R.A.I.2    Bohl, J.3    Del Tredici, K.4
  • 54
    • 33947200337 scopus 로고    scopus 로고
    • Parkinson's disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons
    • DOI 10.1007/s00401-007-0193-x
    • H. Braak, M. Sastre, J.R. Bohl, R.A. de Vos, and K. Del Tredici Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons Acta Neuropathol 113 2007 421 429 (Pubitemid 46421631)
    • (2007) Acta Neuropathologica , vol.113 , Issue.4 , pp. 421-429
    • Braak, H.1    Sastre, M.2    Bohl, J.R.E.3    Vos, R.A.I.4    Del Tredici, K.5
  • 55
    • 41149110768 scopus 로고    scopus 로고
    • Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?
    • R.J. Phillips, G.C. Walter, S.L. Wilder, E.A. Baronowsky, and T.L. Powley Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease? Neuroscience 153 2008 733 750
    • (2008) Neuroscience , vol.153 , pp. 733-750
    • Phillips, R.J.1    Walter, G.C.2    Wilder, S.L.3    Baronowsky, E.A.4    Powley, T.L.5
  • 58
    • 71449128214 scopus 로고    scopus 로고
    • Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: An anatomical study
    • E. Ghebremedhin, K. Del Tredici, J.W. Langston, and H. Braak Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study Acta Neuropathol 118 2009 777 784
    • (2009) Acta Neuropathol , vol.118 , pp. 777-784
    • Ghebremedhin, E.1    Del Tredici, K.2    Langston, J.W.3    Braak, H.4
  • 59
    • 33847205751 scopus 로고    scopus 로고
    • Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    • S. Orimo, A. Takahashi, T. Uchihara, F. Mori, A. Kakita, and K. Wakabayashi Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease Brain Pathol 17 2007 24 30
    • (2007) Brain Pathol , vol.17 , pp. 24-30
    • Orimo, S.1    Takahashi, A.2    Uchihara, T.3    Mori, F.4    Kakita, A.5    Wakabayashi, K.6
  • 60
    • 39749123263 scopus 로고    scopus 로고
    • Axonal α-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • DOI 10.1093/brain/awm302
    • S. Orimo, T. Uchihara, A. Nakamura, F. Mori, A. Kakita, and K. Wakabayashi Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease Brain 131 2008 642 650 (Pubitemid 351294710)
    • (2008) Brain , vol.131 , Issue.3 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3    Mori, F.4    Kakita, A.5    Wakabayashi, K.6    Takahashi, H.7
  • 61
    • 13544264770 scopus 로고    scopus 로고
    • Profound cardiac sympathetic denervation occurs in Parkinson disease
    • T. Amino, S. Orimo, Y. Itoh, A. Takahashi, T. Uchihara, and H. Mizusawa Profound cardiac sympathetic denervation occurs in Parkinson disease Brain Pathol 15 2005 29 34 (Pubitemid 40224064)
    • (2005) Brain Pathology , vol.15 , Issue.1 , pp. 29-34
    • Amino, T.1    Orimo, S.2    Itoh, Y.3    Takahashi, A.4    Uchihara, T.5    Mizusawa, H.6
  • 62
    • 77952884581 scopus 로고    scopus 로고
    • Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease
    • K. Kashihara, T. Imamura, and T. Shinya Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease Parkinsonism Relat Disord 16 2010 252 255
    • (2010) Parkinsonism Relat Disord , vol.16 , pp. 252-255
    • Kashihara, K.1    Imamura, T.2    Shinya, T.3
  • 63
    • 79951555463 scopus 로고    scopus 로고
    • Cardiac (123)I-MIBG accumulation in Parkinson's disease differs in association with REM sleep behavior disorder
    • T. Miyamoto, M. Miyamoto, M. Iwanami, and K. Hirata Cardiac (123)I-MIBG accumulation in Parkinson's disease differs in association with REM sleep behavior disorder Parkinsonism Relat Disord 17 2011 219 220
    • (2011) Parkinsonism Relat Disord , vol.17 , pp. 219-220
    • Miyamoto, T.1    Miyamoto, M.2    Iwanami, M.3    Hirata, K.4
  • 65
    • 23644433306 scopus 로고    scopus 로고
    • α-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy
    • DOI 10.1007/s00401-005-1013-9
    • M. Sone, M. Yoshida, Y. Hashizume, N. Hishikawa, and G. Sobue alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy Acta Neuropathol 110 2005 19 26 (Pubitemid 41131193)
    • (2005) Acta Neuropathologica , vol.110 , Issue.1 , pp. 19-26
    • Sone, M.1    Yoshida, M.2    Hashizume, Y.3    Hishikawa, N.4    Sobue, G.5
  • 66
    • 51649116697 scopus 로고    scopus 로고
    • Pain as a nonmotor symptom of Parkinson disease: Evidence from a case-control study
    • G. Defazio, A. Berardelli, G. Fabbrini, D. Martino, E. Fincati, and A. Fiaschi Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study Arch Neurol 65 2008 1191 1194
    • (2008) Arch Neurol , vol.65 , pp. 1191-1194
    • Defazio, G.1    Berardelli, A.2    Fabbrini, G.3    Martino, D.4    Fincati, E.5    Fiaschi, A.6
  • 71
    • 67651149794 scopus 로고    scopus 로고
    • Lesions outside the CNS in Parkinson's disease
    • R. Djaldetti, N. Lev, and E. Melamed Lesions outside the CNS in Parkinson's disease Mov Disord 24 2009 793 800
    • (2009) Mov Disord , vol.24 , pp. 793-800
    • Djaldetti, R.1    Lev, N.2    Melamed, E.3
  • 72
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
    • M.A. Hely, W.G. Reid, M.A. Adena, G.M. Halliday, and J.G. Morris The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years Mov Disord 23 2008 837 844
    • (2008) Mov Disord , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.5
  • 73
    • 33750435203 scopus 로고    scopus 로고
    • The morphological basis of mental dysfunction in Parkinson's disease
    • DOI 10.1016/j.jns.2006.05.002, PII S0022510X06002127
    • K.A. Jellinger The morphological basis of mental dysfunction in Parkinson's disease J Neurol Sci 248 2006 167 172 (Pubitemid 44647294)
    • (2006) Journal of the Neurological Sciences , vol.248 , Issue.1-2 , pp. 167-172
    • Jellinger, K.A.1
  • 74
    • 77649182100 scopus 로고    scopus 로고
    • The neuropathologic substrate of Parkinson disease dementia
    • K.A. Jellinger The neuropathologic substrate of Parkinson disease dementia Acta Neuropathol 119 2010 151 153
    • (2010) Acta Neuropathol , vol.119 , pp. 151-153
    • Jellinger, K.A.1
  • 75
    • 70449523595 scopus 로고    scopus 로고
    • The morbid anatomy of dementia in Parkinson's disease
    • M.E. Kalaitzakis, and R.K. Pearce The morbid anatomy of dementia in Parkinson's disease Acta Neuropathol 118 2009 587 598
    • (2009) Acta Neuropathol , vol.118 , pp. 587-598
    • Kalaitzakis, M.E.1    Pearce, R.K.2
  • 76
    • 78349310514 scopus 로고    scopus 로고
    • Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease
    • A.A. Kehagia, R.A. Barker, and T.W. Robbins Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease Lancet Neurol 9 2010 1200 1213
    • (2010) Lancet Neurol , vol.9 , pp. 1200-1213
    • Kehagia, A.A.1    Barker, R.A.2    Robbins, T.W.3
  • 78
    • 72849115874 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms in Parkinson's disease
    • D. Aarsland, L. Marsh, and A. Schrag Neuropsychiatric symptoms in Parkinson's disease Mov Disord 24 2009 2175 2186
    • (2009) Mov Disord , vol.24 , pp. 2175-2186
    • Aarsland, D.1    Marsh, L.2    Schrag, A.3
  • 79
    • 43049145789 scopus 로고    scopus 로고
    • Alteration of dopaminergic markers in gastrointestinal tract of different rodent models of Parkinson's disease
    • Y.M. Tian, X. Chen, D.Z. Luo, X.H. Zhang, H. Xue, and L.F. Zheng Alteration of dopaminergic markers in gastrointestinal tract of different rodent models of Parkinson's disease Neuroscience 153 2008 634 644
    • (2008) Neuroscience , vol.153 , pp. 634-644
    • Tian, Y.M.1    Chen, X.2    Luo, D.Z.3    Zhang, X.H.4    Xue, H.5    Zheng, L.F.6
  • 80
    • 34548230441 scopus 로고    scopus 로고
    • Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
    • DOI 10.1016/j.expneurol.2007.05.010, PII S0014488607002087
    • G. Anderson, A.R. Noorian, G. Taylor, M. Anitha, D. Bernhard, and S. Srinivasan Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease Exp Neurol 207 2007 4 12 (Pubitemid 47332479)
    • (2007) Experimental Neurology , vol.207 , Issue.1 , pp. 4-12
    • Anderson, G.1    Noorian, A.R.2    Taylor, G.3    Anitha, M.4    Bernhard, D.5    Srinivasan, S.6    Greene, J.G.7
  • 81
    • 58849098133 scopus 로고    scopus 로고
    • Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism
    • T. Chaumette, T. Lebouvier, P. Aubert, B. Lardeux, C. Qin, and Q. Li Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism Neurogastroenterol Motil 21 2009 215 222
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 215-222
    • Chaumette, T.1    Lebouvier, T.2    Aubert, P.3    Lardeux, B.4    Qin, C.5    Li, Q.6
  • 82
    • 77955402231 scopus 로고    scopus 로고
    • The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future
    • S.H. Fox, and J.M. Brotchie The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future Prog Brain Res 184 2010 133 157
    • (2010) Prog Brain Res , vol.184 , pp. 133-157
    • Fox, S.H.1    Brotchie, J.M.2
  • 83
    • 43249106066 scopus 로고    scopus 로고
    • Abnormal colonic motility in mice overexpressing human wild-type α-synuclein
    • DOI 10.1097/WNR.0b013e3282ffda5e, PII 0000175620080528000016
    • L. Wang, S.M. Fleming, M.F. Chesselet, and Y. Tache Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein Neuroreport 19 2008 873 876 (Pubitemid 351655158)
    • (2008) NeuroReport , vol.19 , Issue.8 , pp. 873-876
    • Wang, L.1    Fleming, S.M.2    Chesselet, M.-F.3    Tache, Y.4
  • 84
    • 77952478217 scopus 로고    scopus 로고
    • Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes
    • Y.M. Kuo, Z. Li, Y. Jiao, N. Gaborit, A.K. Pani, and B.M. Orrison Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes Hum Mol Genet 19 2010 1633 1650
    • (2010) Hum Mol Genet , vol.19 , pp. 1633-1650
    • Kuo, Y.M.1    Li, Z.2    Jiao, Y.3    Gaborit, N.4    Pani, A.K.5    Orrison, B.M.6
  • 85
    • 67349122370 scopus 로고    scopus 로고
    • Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    • J.G. Greene, A.R. Noorian, and S. Srinivasan Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease Exp Neurol 218 2009 154 161
    • (2009) Exp Neurol , vol.218 , pp. 154-161
    • Greene, J.G.1    Noorian, A.R.2    Srinivasan, S.3
  • 86
    • 69749124032 scopus 로고    scopus 로고
    • Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
    • R.E. Drolet, J.R. Cannon, L. Montero, and J.T. Greenamyre Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology Neurobiol Dis 36 2009 96 102
    • (2009) Neurobiol Dis , vol.36 , pp. 96-102
    • Drolet, R.E.1    Cannon, J.R.2    Montero, L.3    Greenamyre, J.T.4
  • 87
    • 80055106119 scopus 로고    scopus 로고
    • Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system
    • F.J. Pan-Montojo, and R.H. Funk Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system J Vis Exp 2010
    • (2010) J Vis Exp
    • Pan-Montojo, F.J.1    Funk, R.H.2
  • 88
    • 67649379066 scopus 로고    scopus 로고
    • Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity
    • T.N. Taylor, W.M. Caudle, K.R. Shepherd, A. Noorian, C.R. Jackson, and P.M. Iuvone Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity J Neurosci 29 2009 8103 8113
    • (2009) J Neurosci , vol.29 , pp. 8103-8113
    • Taylor, T.N.1    Caudle, W.M.2    Shepherd, K.R.3    Noorian, A.4    Jackson, C.R.5    Iuvone, P.M.6
  • 89
    • 58349099832 scopus 로고    scopus 로고
    • Functional models of Parkinson's disease: A valuable tool in the development of novel therapies
    • P. Jenner Functional models of Parkinson's disease: a valuable tool in the development of novel therapies Ann Neurol 64 Suppl 2 2008 S16 S29
    • (2008) Ann Neurol , vol.64 , Issue.SUPPL. 2
    • Jenner, P.1
  • 90
    • 70350461640 scopus 로고    scopus 로고
    • Mice with reduced vesicular monoamine storage content display nonmotor features of Parkinson's disease
    • A.C. Vernon Mice with reduced vesicular monoamine storage content display nonmotor features of Parkinson's disease J Neurosci 29 2009 12,842 12,844
    • (2009) J Neurosci , vol.29 , pp. 12
    • Vernon, A.C.1
  • 91
    • 77954661235 scopus 로고    scopus 로고
    • Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure
    • S. Stemberger, W. Poewe, G.K. Wenning, and N. Stefanova Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure Exp Neurol 224 2010 459 464
    • (2010) Exp Neurol , vol.224 , pp. 459-464
    • Stemberger, S.1    Poewe, W.2    Wenning, G.K.3    Stefanova, N.4
  • 92
    • 0029097763 scopus 로고
    • Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation
    • C. Singaram, W. Ashraf, E.A. Gaumnitz, C. Torbey, A. Sengupta, and R. Pfeiffer Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation Lancet 346 1995 861 864
    • (1995) Lancet , vol.346 , pp. 861-864
    • Singaram, C.1    Ashraf, W.2    Gaumnitz, E.A.3    Torbey, C.4    Sengupta, A.5    Pfeiffer, R.6
  • 93
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease
    • DOI 10.1056/NEJM199810083391506
    • A.E. Lang, and A.M. Lozano Parkinson's disease. First of two parts N Engl J Med 339 1998 1044 1053 (Pubitemid 28457867)
    • (1998) New England Journal of Medicine , vol.339 , Issue.15 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 94
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
    • H. Bernheimer, W. Birkmayer, O. Hornykiewicz, K. Jellinger, and F. Seitelberger Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations J Neurol Sci 20 1973 415 455
    • (1973) J Neurol Sci , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 95
    • 77952926102 scopus 로고    scopus 로고
    • Clinical progression in Parkinson disease and the neurobiology of axons
    • H.C. Cheng, C.M. Ulane, and R.E. Burke Clinical progression in Parkinson disease and the neurobiology of axons Ann Neurol 67 2010 715 725
    • (2010) Ann Neurol , vol.67 , pp. 715-725
    • Cheng, H.C.1    Ulane, C.M.2    Burke, R.E.3
  • 97
    • 0014525843 scopus 로고
    • Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): Relationship to parkinsonism
    • L.S. Forno Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism J Am Geriatr Soc 17 1969 557 575
    • (1969) J Am Geriatr Soc , vol.17 , pp. 557-575
    • Forno, L.S.1
  • 98
    • 33644830518 scopus 로고    scopus 로고
    • Widespread and abundant α-synuclein pathology in a neurologically unimpaired subject
    • DOI 10.1111/j.1440-1789.2005.00644.x
    • L. Parkkinen, T. Pirttila, M. Tervahauta, and I. Alafuzoff Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subject Neuropathology 25 2005 304 314 (Pubitemid 43943239)
    • (2005) Neuropathology , vol.25 , Issue.4 , pp. 304-314
    • Parkkinen, L.1    Pirttila, T.2    Tervahauta, M.3    Alafuzoff, I.4
  • 99


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.