Dopexamine reduces the incidence of acute inflammation in the gut mucosa after abdominal surgery in high-risk patients

Critical Care Medicine

Volumn 27, Issue 9, 1999, Pages 1787-1793

  Byers, Richard J ^a   Eddleston, Jane M ^b   Pearson, Robert C ^b   Bigley, Graham ^a   McMahon, Ray F T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Abdominal surgery; Dopexamine; Endoscopy; Intestinal mucosa; Ischemia; Mast cells; Nitric oxide; Polymorphonuclear leukocytes; Reperfusion injury; Systemic inflammatory response syndrome

Indexed keywords

DOPEXAMINE; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE;

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; BLOOD FLOWMETRY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL MUCOSA; HIGH RISK POPULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; INFLAMMATION; MALE; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM;

ABDOMEN; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; DOPAMINE; DOUBLE-BLIND METHOD; ENDOSCOPY, GASTROINTESTINAL; EUROPE; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTESTINAL MUCOSA; MALE; MAST CELLS; MIDDLE AGED; MULTICENTER STUDIES; NEUTROPHILS; NITRIC OXIDE SYNTHASE; POSTOPERATIVE COMPLICATIONS; REPERFUSION INJURY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0032833576     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199909000-00014     Document Type: Article

References (24)

1. 1. Haglund U: Systemic mediators released from the gut in critical illness. Crit Care Med 1993; 21:S15-S18
2. 2. Dahn MS, Lange P, Hans B, et al: Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 1987; 101:69-80
3. 3. Kubes P: Intestinal ischemia/reperfusion: A role for mast cells and neutrophils. In: 1996 Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed). Berlin, Springer-Verlag, 1996, pp 197-207
4. 4. Eddleston JM, Pearson RC, Holland J, et al: Prospective endoscopic study of stress erosions and ulcers in critically ill adult patients treated with either sucralfate or placebo. Crit Care Med 1994; 22:1949-1954
5. 5. Stannard VA, Hutchinson A, Morris DL, et al: Gastric exocrine "failure" in critically ill patients: Incidence and associated features. BMJ 1988; 296:155-156
6. 6. Brown RA, Dixon J, Farmer JB, et al: Dopexamine: A novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors. Br J Pharmacol 1985; 85:599-608
7. 7. Brown RA, Farmer JB, Hall JC, et al: The effects of dopexamine on the cardiovascular system of the dog. Br J Pharmacol 1985; 85:609-619
8. 8. Boyd O, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high risk surgical patients. JAMA 1993; 270:2699-2707
9. 9. Schmidt W, Schmidt H, Hacker A, et al: Influence of dopexamine on leukocyte adherence and vascular permeability in postcapillary venules during endotoxemia. Intensive Care Med 1997; 23(Suppl 1):82
10. 10. Tighe D, Moss R, Heywood G, et al: Goal-directed therapy with dopexamine, dobutamine, and volume expansion: Effects of systemic oxygen transport on hepatic ultrastructure in porcine sepsis. Crit Care Med 1995; 23:1997-2007
11. 11. Shoemaker WC, Appel PL, Kram HB, et al: Prospective trial of supranormal values of survivors as therapeutic goals in high risk surgical patients. Chest 1988; 94:1176-1186
12. 12. Price AB: The Sydney system: Histological division. J Gastroenterol Hepatol 1991; 6:209-222
13. 13. Shoemaker WC, Montgomery E, Kaplan E, et al: Physiologic patterns in surviving and non-surviving patients. Arch Surg 1973; 106: 630-636
14. 14. Bishop MH, Shoemaker WC, Appel PL, et al: Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 1995; 38:780-787
15. 15. Hayes MA, Timmins AC, Yau EHS, et al: Oxygen transport patterns in patients with sepsis syndrome or septic shock: Influence of treatment and relationship to outcome. Crit Care Med 1997; 25:926-936
16. 16. Doglio GR, Pusajo JF, Egurrola MA, et al: Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 1991; 19:1037-1040
17. 17. Kanwar S, Kubes P: Mast cells contribute to ischemia/reperfusion-induced granulocyte infiltration and intestinal dysfunction. Am J Physiol 1994; 267:G316-G321
18. 18. Blum H, Summers JJ, Schnall MD, et al: Acute intestinal ischemia studies by phosphorous nuclear magnetic resonance spectroscopy. Ann Surg 1986; 204:83-88
19. 19. Boros M, Kaszaki J, Nagy S: Oxygen free radical-induced histamine release during intestinal ischemia and reperfusion. Eur Surg Res 1989; 21:297-304
20. 20. Ialenti A, Ianaro A, Moncada S, et al: Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 1992; 211: 177-182
21. 21. Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6:3051-3064
22. 22. Kilbourn RG, Griffith OW: Overproduction of nitric oxide in cytokine mediated and septic shock. J Natl Cancer Inst 1992; 84:827-831
23. 23. Hibbs JB, Westenfelder C, Taintor R, et al: Evidence for cytokine inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. Clin Invest 1992; 89:867-877
24. 24. Cook HT, Bune AJ, Jansen AS, et al: Cellular localisation of inducible nitric oxide synthase in experimental endotoxic shock in the rat. Clin Sci 1994; 87:179-186