메뉴 건너뛰기




Volumn 11, Issue 20, 2011, Pages 3962-3971

Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling

Author keywords

FGF 2; Human embryonic stem cells; MS; Phosphorylation; Quantitation; Systems biology

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN DPPA4; PROTEIN RIF1; PROTEIN SALL4; PTORIN DNAMT3B; SERINE; STAT3 PROTEIN; THREONINE; TITANIUM DIOXIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TYROSINE; UNCLASSIFIED DRUG;

EID: 80053940442     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201100048     Document Type: Article
Times cited : (30)

References (56)
  • 1
    • 39049087826 scopus 로고    scopus 로고
    • Mechanisms that mediate stem cell self-renewal and differentiation
    • Zhang, H., Wang, Z. Z., Mechanisms that mediate stem cell self-renewal and differentiation. J. Cell. Biochem. 2008, 103, 709-718.
    • (2008) J. Cell. Biochem. , vol.103 , pp. 709-718
    • Zhang, H.1    Wang, Z.Z.2
  • 2
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers, I., Colby, D., Robertson, M., Nichols, J. et al., Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003, 113, 643-655.
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4
  • 3
    • 27644483064 scopus 로고    scopus 로고
    • Regulatory networks in embryo-derived pluripotent stem cells
    • Boiani, M., Scholer, H. R., Regulatory networks in embryo-derived pluripotent stem cells. Nat. Rev. Mol. Cell Biol. 2005, 6, 872-884.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 872-884
    • Boiani, M.1    Scholer, H.R.2
  • 4
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H. et al., Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998, 95, 379-391.
    • (1998) Cell , vol.95 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3    Niwa, H.4
  • 5
    • 0037227099 scopus 로고    scopus 로고
    • Multipotent cell lineages in early mouse development depend on SOX2 function
    • Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L. et al., Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003, 17, 126-140.
    • (2003) Genes Dev. , vol.17 , pp. 126-140
    • Avilion, A.A.1    Nicolis, S.K.2    Pevny, L.H.3    Perez, L.4
  • 6
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E. et al., Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122, 947-956.
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3    Johnstone, S.E.4
  • 7
    • 33746773659 scopus 로고    scopus 로고
    • Dissecting self-renewal in stem cells with RNA interference
    • Ivanova, N., Dobrin, R., Lu, R., Kotenko, I. et al., Dissecting self-renewal in stem cells with RNA interference. Nature 2006, 442, 533-538.
    • (2006) Nature , vol.442 , pp. 533-538
    • Ivanova, N.1    Dobrin, R.2    Lu, R.3    Kotenko, I.4
  • 8
    • 33750977572 scopus 로고    scopus 로고
    • The regulation of self-renewal in human embryonic stem cells
    • Avery, S., Inniss, K., Moore, H., The regulation of self-renewal in human embryonic stem cells. Stem Cells Dev. 2006, 15, 729-740.
    • (2006) Stem Cells Dev. , vol.15 , pp. 729-740
    • Avery, S.1    Inniss, K.2    Moore, H.3
  • 9
    • 27644486756 scopus 로고    scopus 로고
    • Activin/nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
    • Vallier, L., Alexander, M., Pedersen, R. A., Activin/nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J. Cell Sci. 2005, 118, 4495-4509.
    • (2005) J. Cell Sci. , vol.118 , pp. 4495-4509
    • Vallier, L.1    Alexander, M.2    Pedersen, R.A.3
  • 10
    • 1842853507 scopus 로고    scopus 로고
    • BMP4 initiates human embryonic stem cell differentiation to trophoblast
    • Xu, R. H., Chen, X., Li, D. S., Li, R. et al., BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat. Biotechnol. 2002, 20, 1261-1264.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 1261-1264
    • Xu, R.H.1    Chen, X.2    Li, D.S.3    Li, R.4
  • 11
    • 28444475519 scopus 로고    scopus 로고
    • Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells
    • Pebay, A., Wong, R. C., Pitson, S. M., Wolvetang, E. J. et al., Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. Stem Cells 2005, 23, 1541-1548.
    • (2005) Stem Cells , vol.23 , pp. 1541-1548
    • Pebay, A.1    Wong, R.C.2    Pitson, S.M.3    Wolvetang, E.J.4
  • 12
    • 34548307176 scopus 로고    scopus 로고
    • IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
    • Bendall, S. C., Stewart, M. H., Menendez, P., George, D. et al., IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 2007, 448, 1015-1021.
    • (2007) Nature , vol.448 , pp. 1015-1021
    • Bendall, S.C.1    Stewart, M.H.2    Menendez, P.3    George, D.4
  • 13
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger, J., Cell signaling by receptor tyrosine kinases. Cell 2000, 103, 211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 14
    • 0033786922 scopus 로고    scopus 로고
    • Protein tyrosine kinase structure and function
    • Hubbard, S. R., Till, J. H., Protein tyrosine kinase structure and function. Annu. Rev. Biochem. 2000, 69, 373-398.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 373-398
    • Hubbard, S.R.1    Till, J.H.2
  • 15
    • 33744746323 scopus 로고    scopus 로고
    • Basic fibroblast growth factor support of human embryonic stem cell self-renewal
    • Levenstein, M. E., Ludwig, T. E., Xu, R. H., Llanas, R. A. et al., Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells 2006, 24, 568-574.
    • (2006) Stem Cells , vol.24 , pp. 568-574
    • Levenstein, M.E.1    Ludwig, T.E.2    Xu, R.H.3    Llanas, R.A.4
  • 16
    • 18744375483 scopus 로고    scopus 로고
    • Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
    • Xu, R. H., Peck, R. M., Li, D. S., Feng, X. et al., Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods 2005, 2, 185-190.
    • (2005) Nat. Methods , vol.2 , pp. 185-190
    • Xu, R.H.1    Peck, R.M.2    Li, D.S.3    Feng, X.4
  • 17
    • 77956540297 scopus 로고    scopus 로고
    • FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling
    • Ding, V. M., Ling, L., Natarajan, S., Yap, M. G. et al., FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling. J. Cell. Physiol. 2010, 225, 417-428.
    • (2010) J. Cell. Physiol. , vol.225 , pp. 417-428
    • Ding, V.M.1    Ling, L.2    Natarajan, S.3    Yap, M.G.4
  • 18
    • 77954187374 scopus 로고    scopus 로고
    • Defined and serum-free media support undifferentiated human embryonic stem cell growth
    • Chin, A. C., Padmanabhan, J., Oh, S. K., Choo, A. B., Defined and serum-free media support undifferentiated human embryonic stem cell growth. Stem Cells Dev. 2010, 19, 753-761.
    • (2010) Stem Cells Dev. , vol.19 , pp. 753-761
    • Chin, A.C.1    Padmanabhan, J.2    Oh, S.K.3    Choo, A.B.4
  • 19
    • 33846931113 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal
    • Greber, B., Lehrach, H., Adjaye, J., Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells 2007, 25, 455-464.
    • (2007) Stem Cells , vol.25 , pp. 455-464
    • Greber, B.1    Lehrach, H.2    Adjaye, J.3
  • 20
    • 13444263240 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling during early vertebrate development
    • Bottcher, R. T., Niehrs, C., Fibroblast growth factor signaling during early vertebrate development. Endocr. Rev. 2005, 26, 63-77.
    • (2005) Endocr. Rev. , vol.26 , pp. 63-77
    • Bottcher, R.T.1    Niehrs, C.2
  • 21
    • 0036605185 scopus 로고    scopus 로고
    • Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome
    • Mann, M., Ong, S. E., Gronborg, M., Steen, H. et al., Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome. Trends Biotechnol. 2002, 20, 261-268.
    • (2002) Trends Biotechnol. , vol.20 , pp. 261-268
    • Mann, M.1    Ong, S.E.2    Gronborg, M.3    Steen, H.4
  • 22
    • 70349131530 scopus 로고    scopus 로고
    • The phosphoproteomics data explosion
    • Lemeer, S., Heck, A. J., The phosphoproteomics data explosion. Curr. Opin. Chem. Biol. 2009, 13, 414-420.
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 414-420
    • Lemeer, S.1    Heck, A.J.2
  • 23
    • 32644476662 scopus 로고    scopus 로고
    • Immortalized feeders for the scale-up of human embryonic stem cells in feeder and feeder-free conditions
    • Choo, A., Padmanabhan, J., Chin, A., Fong, W. J., Oh, S. K., Immortalized feeders for the scale-up of human embryonic stem cells in feeder and feeder-free conditions. J. Biotechnol. 2006, 122, 130-141.
    • (2006) J. Biotechnol. , vol.122 , pp. 130-141
    • Choo, A.1    Padmanabhan, J.2    Chin, A.3    Fong, W.J.4    Oh, S.K.5
  • 24
    • 76649110554 scopus 로고    scopus 로고
    • In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling
    • Boersema, P. J., Foong, L. Y., Ding, V. M., Lemeer, S. et al., In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling. Mol. Cell Proteomics 2010, 9, 84-99.
    • (2010) Mol. Cell Proteomics , vol.9 , pp. 84-99
    • Boersema, P.J.1    Foong, L.Y.2    Ding, V.M.3    Lemeer, S.4
  • 25
    • 64749108158 scopus 로고    scopus 로고
    • Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics
    • Boersema, P. J., Raijmakers, R., Lemeer, S., Mohammed, S., Heck, A. J., Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nat. Protoc. 2009, 4, 484-494.
    • (2009) Nat. Protoc. , vol.4 , pp. 484-494
    • Boersema, P.J.1    Raijmakers, R.2    Lemeer, S.3    Mohammed, S.4    Heck, A.J.5
  • 26
    • 66349106471 scopus 로고    scopus 로고
    • Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach
    • Gauci, S., Helbig, A. O., Slijper, M., Krijgsveld, J. et al., Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. 2009, 81, 4493-4501.
    • (2009) Anal. Chem. , vol.81 , pp. 4493-4501
    • Gauci, S.1    Helbig, A.O.2    Slijper, M.3    Krijgsveld, J.4
  • 27
    • 39749186759 scopus 로고    scopus 로고
    • 2-based phosphoproteomics applied to study endogenous phosphorylation in Drosophila melanogaster
    • 2-based phosphoproteomics applied to study endogenous phosphorylation in Drosophila melanogaster. J. Proteome Res. 2008, 7, 687-697.
    • (2008) J. Proteome Res. , vol.7 , pp. 687-697
    • Pinkse, M.W.1    Mohammed, S.2    Gouw, J.W.3    van Breukelen, B.4
  • 28
    • 33847630405 scopus 로고    scopus 로고
    • Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
    • Elias, J. E., Gygi, S. P., Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat. Methods 2007, 4, 207-214.
    • (2007) Nat. Methods , vol.4 , pp. 207-214
    • Elias, J.E.1    Gygi, S.P.2
  • 29
    • 79952366305 scopus 로고    scopus 로고
    • RockerBox: analysis and filtering of massive proteomics search results
    • van den Toorn, H. W., Munoz, J., Mohammed, S., Raijmakers, R. et al., RockerBox: analysis and filtering of massive proteomics search results. J. Proteome Res. 2010, 10, 1420-1424.
    • (2010) J. Proteome Res. , vol.10 , pp. 1420-1424
    • van den Toorn, H.W.1    Munoz, J.2    Mohammed, S.3    Raijmakers, R.4
  • 30
    • 73649131275 scopus 로고    scopus 로고
    • MSQuant, an open source platform for mass spectrometry-based quantitative proteomics
    • Mortensen, P., Gouw, J. W., Olsen, J. V., Ong, S. E. et al., MSQuant, an open source platform for mass spectrometry-based quantitative proteomics. J. Proteome Res. 9, 393-403.
    • J. Proteome Res. , vol.9 , pp. 393-403
    • Mortensen, P.1    Gouw, J.W.2    Olsen, J.V.3    Ong, S.E.4
  • 31
    • 1242276404 scopus 로고    scopus 로고
    • Feeder layer- and serum-free culture of human embryonic stem cells
    • Amit, M., Shariki, C., Margulets, V., Itskovitz-Eldor, J., Feeder layer- and serum-free culture of human embryonic stem cells. Biol. Reprod. 2004, 70, 837-845.
    • (2004) Biol. Reprod. , vol.70 , pp. 837-845
    • Amit, M.1    Shariki, C.2    Margulets, V.3    Itskovitz-Eldor, J.4
  • 32
    • 69249143719 scopus 로고    scopus 로고
    • mAb 84, a cytotoxic antibody that kills undifferentiated human embryonic stem cells via oncosis
    • Tan, H. L., Fong, W. J., Lee, E. H., Yap, M., Choo, A., mAb 84, a cytotoxic antibody that kills undifferentiated human embryonic stem cells via oncosis. Stem Cells 2009, 27, 1792-1801.
    • (2009) Stem Cells , vol.27 , pp. 1792-1801
    • Tan, H.L.1    Fong, W.J.2    Lee, E.H.3    Yap, M.4    Choo, A.5
  • 33
    • 67849106825 scopus 로고    scopus 로고
    • Phosphorylation dynamics during early differentiation of human embryonic stem cells
    • Van Hoof, D., Munoz, J., Braam, S. R., Pinkse, M. W. et al., Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 2009, 5, 214-226.
    • (2009) Cell Stem Cell , vol.5 , pp. 214-226
    • Van Hoof, D.1    Munoz, J.2    Braam, S.R.3    Pinkse, M.W.4
  • 34
    • 67849121794 scopus 로고    scopus 로고
    • Phosphoproteomic analysis of human embryonic stem cells
    • Brill, L. M., Xiong, W., Lee, K. B., Ficarro, S. B. et al., Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 2009, 5, 204-213.
    • (2009) Cell Stem Cell , vol.5 , pp. 204-213
    • Brill, L.M.1    Xiong, W.2    Lee, K.B.3    Ficarro, S.B.4
  • 35
    • 51649083519 scopus 로고    scopus 로고
    • Plasma membrane proteomics of human embryonic stem cells and human embryonal carcinoma cells
    • Dormeyer, W., van Hoof, D., Braam, S. R., Heck, A. J. et al., Plasma membrane proteomics of human embryonic stem cells and human embryonal carcinoma cells. J. Proteome Res. 2008, 7, 2936-2951.
    • (2008) J. Proteome Res. , vol.7 , pp. 2936-2951
    • Dormeyer, W.1    van Hoof, D.2    Braam, S.R.3    Heck, A.J.4
  • 36
    • 33646807832 scopus 로고    scopus 로고
    • The P53 pathway: what questions remain to be explored?
    • Levine, A. J., Hu, W., Feng, Z., The P53 pathway: what questions remain to be explored? Cell Death Differ. 2006, 13, 1027-1036.
    • (2006) Cell Death Differ. , vol.13 , pp. 1027-1036
    • Levine, A.J.1    Hu, W.2    Feng, Z.3
  • 37
    • 0027475421 scopus 로고
    • Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
    • Hughes, K., Nikolakaki, E., Plyte, S. E., Totty, N. F., Woodgett, J. R., Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J. 1993, 12, 803-808.
    • (1993) EMBO J. , vol.12 , pp. 803-808
    • Hughes, K.1    Nikolakaki, E.2    Plyte, S.E.3    Totty, N.F.4    Woodgett, J.R.5
  • 38
    • 33646264528 scopus 로고    scopus 로고
    • Expanding the protein catalogue in the proteome reference map of human breast cancer cells
    • Pucci-Minafra, I., Cancemi, P., Fontana, S., Minafra, L. et al., Expanding the protein catalogue in the proteome reference map of human breast cancer cells. Proteomics 2006, 6, 2609-2625.
    • (2006) Proteomics , vol.6 , pp. 2609-2625
    • Pucci-Minafra, I.1    Cancemi, P.2    Fontana, S.3    Minafra, L.4
  • 39
    • 0034677220 scopus 로고    scopus 로고
    • Model for stathmin/OP18 binding to tubulin
    • Wallon, G., Rappsilber, J., Mann, M., Serrano, L., Model for stathmin/OP18 binding to tubulin. EMBO J. 2000, 19, 213-222.
    • (2000) EMBO J. , vol.19 , pp. 213-222
    • Wallon, G.1    Rappsilber, J.2    Mann, M.3    Serrano, L.4
  • 40
    • 0035859010 scopus 로고    scopus 로고
    • The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway
    • Abe, K., Hirai, M., Mizuno, K., Higashi, N. et al., The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway. Oncogene 2001, 20, 3464-3474.
    • (2001) Oncogene , vol.20 , pp. 3464-3474
    • Abe, K.1    Hirai, M.2    Mizuno, K.3    Higashi, N.4
  • 41
    • 65649102572 scopus 로고    scopus 로고
    • Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression
    • Yuri, S., Fujimura, S., Nimura, K., Takeda, N. et al., Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression. Stem Cells 2009, 27, 796-805.
    • (2009) Stem Cells , vol.27 , pp. 796-805
    • Yuri, S.1    Fujimura, S.2    Nimura, K.3    Takeda, N.4
  • 42
    • 33749173803 scopus 로고    scopus 로고
    • Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
    • Zhang, J., Tam, W. L., Tong, G. Q., Wu, Q. et al., Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat. Cell. Biol. 2006, 8, 1114-1123.
    • (2006) Nat. Cell. Biol. , vol.8 , pp. 1114-1123
    • Zhang, J.1    Tam, W.L.2    Tong, G.Q.3    Wu, Q.4
  • 43
    • 66349098651 scopus 로고    scopus 로고
    • The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis
    • Madan, B., Madan, V., Weber, O., Tropel, P. et al., The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis. Mol. Cell. Biol. 2009, 29, 3186-3203.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3186-3203
    • Madan, B.1    Madan, V.2    Weber, O.3    Tropel, P.4
  • 44
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M., Bell, D. W., Haber, D. A., Li, E., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 45
    • 18444411948 scopus 로고    scopus 로고
    • Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38
    • Ouwens, D. M., de Ruiter, N. D., van der Zon, G. C., Carter, A. P. et al., Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J. 2002, 21, 3782-3793.
    • (2002) EMBO J. , vol.21 , pp. 3782-3793
    • Ouwens, D.M.1    de Ruiter, N.D.2    van der Zon, G.C.3    Carter, A.P.4
  • 46
    • 0033542460 scopus 로고    scopus 로고
    • Role of the ATFa/JNK2 complex in Jun activation
    • De Graeve, F., Bahr, A., Sabapathy, K. T., Hauss, C. et al., Role of the ATFa/JNK2 complex in Jun activation. Oncogene 1999, 18, 3491-3500.
    • (1999) Oncogene , vol.18 , pp. 3491-3500
    • De Graeve, F.1    Bahr, A.2    Sabapathy, K.T.3    Hauss, C.4
  • 47
    • 37049008721 scopus 로고    scopus 로고
    • Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
    • Wang, L., Schulz, T. C., Sherrer, E. S., Dauphin, D. S. et al., Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood 2007, 110, 4111-4119.
    • (2007) Blood , vol.110 , pp. 4111-4119
    • Wang, L.1    Schulz, T.C.2    Sherrer, E.S.3    Dauphin, D.S.4
  • 48
    • 17544376741 scopus 로고    scopus 로고
    • Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors
    • Feng, X. H., Derynck, R., Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J. Biol. Chem. 1996, 271, 13123-13129.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13123-13129
    • Feng, X.H.1    Derynck, R.2
  • 49
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi, Y., Massague, J., Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113, 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 50
    • 25444503012 scopus 로고    scopus 로고
    • Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells
    • Dvorak, P., Dvorakova, D., Koskova, S., Vodinska, M. et al., Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells. Stem Cells 2005, 23, 1200-1211.
    • (2005) Stem Cells , vol.23 , pp. 1200-1211
    • Dvorak, P.1    Dvorakova, D.2    Koskova, S.3    Vodinska, M.4
  • 51
    • 33744758028 scopus 로고    scopus 로고
    • The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    • Armstrong, L., Hughes, O., Yung, S., Hyslop, L. et al., The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum. Mol. Genet. 2006, 15, 1894-1913.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1894-1913
    • Armstrong, L.1    Hughes, O.2    Yung, S.3    Hyslop, L.4
  • 52
    • 0033593470 scopus 로고    scopus 로고
    • A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway
    • Yao, Z., Zhou, G., Wang, X. S., Brown, A. et al., A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J. Biol. Chem. 1999, 274, 2118-2125.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2118-2125
    • Yao, Z.1    Zhou, G.2    Wang, X.S.3    Brown, A.4
  • 53
    • 33846251988 scopus 로고    scopus 로고
    • Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions
    • Cai, L., Ye, Z., Zhou, B. Y., Mali, P. et al., Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions. Cell Res. 2007, 17, 62-72.
    • (2007) Cell Res. , vol.17 , pp. 62-72
    • Cai, L.1    Ye, Z.2    Zhou, B.Y.3    Mali, P.4
  • 54
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu, C., Li, Y., Semenov, M., Han, C. et al., Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002, 108, 837-847.
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4
  • 55
    • 0036571011 scopus 로고    scopus 로고
    • Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
    • Amit, S., Hatzubai, A., Birman, Y., Andersen, J. S. et al., Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 2002, 16, 1066-1076.
    • (2002) Genes Dev. , vol.16 , pp. 1066-1076
    • Amit, S.1    Hatzubai, A.2    Birman, Y.3    Andersen, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.