Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-d-Ala-Phe-Gly-NH 2 using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6538-6547

  De Wachter, Rien ^a   De Graaf, Chris ^b,c   Keresztes, Atilla ^d   Vandormael, Bart ^a   Ballet, Steven ^a   Tóth, Géza ^d   Rognan, Didier ^b   Tourwé, Dirk ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO1,24,5 TETRAHYDRO 2 BENZAZEPIN 3 ONE; BENZAZEPINE DERIVATIVE; DERMORPHIN DERIVATIVE; MU OPIATE RECEPTOR AGONIST; OPIATE PEPTIDE; PHENYLALANINE; SIGMA OPIATE RECEPTOR; TETRAPEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA TURN; BINDING AFFINITY; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR DOCKING; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; SIMULATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAZEPINES; BRAIN; MODELS, MOLECULAR; OPIOID PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053898753     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2003574     Document Type: Article

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