The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

Reviews in the Neurosciences

Volumn 22, Issue 5, 2011, Pages 509-533

  Twohig, Jason P ^a   Cuff, Simone M ^a   Yong, Audrey A ^b   Wang, Eddie C Y ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

brain; cytokines; development; neuron; receptors; TNFRSF; TNFSF

Indexed keywords

TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; BRAIN DEVELOPMENT; BRAIN FUNCTION; HOMEOSTASIS; HUMAN; INFLAMMATION; MAMMAL; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION;

ANIMALS; BRAIN; HOMEOSTASIS; HUMANS; MAMMALS; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 80053577829     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/RNS.2011.041     Document Type: Article

References (269)

1. Akassoglou, K., Probert, L., Kontogeorgos, G., and Kollias, G. (1997). Astrocyte-specific but not neuron-specific transmem-brane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J. Immunol. 158, 438-445. (Pubitemid 127483886)
2. Albensi, B.C. and Mattson, M.P. (2000). Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse 35, 151-159. (Pubitemid 30036192)
3. Anderson, K.K., Ballok, D.A., Prasad, N., Szechtman, H., and Sakic, B. (2006). Impaired response to amphetamine and neuronal degeneration in the nucleus accumbens of autoimmune MRL-lpr mice. Behav. Brain Res. 166, 323-328.
4. Ashkenazi, A. and Dixit V.M. (1998). Death receptors: signaling and modulation. Science 281, 1305-1308. (Pubitemid 28406815)
5. Atwal, J.K., Pinkston-Gosse, J., Syken, J., Stawicki, S., Wu, Y. , Shatz, C., and Tessier-Lavigne, M. (2008). PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322, 967-970.
6. Ballok, D.A., Millward, J.M., and Sakic, B. (2003a). Neurode-generation in autoimmune MRL-lpr mice as revealed by Fluoro Jade B staining. Brain Res. 964, 200-210. (Pubitemid 36165144)
7. Ballok, D.A., Szechtman, H., and Sakic, B. (2003b). Taste responsiveness and diet preference in autoimmune MRL mice. Behav. Brain Res. 140, 119-130. (Pubitemid 36313247)
8. Ballok, D.A., Earls, A.M., Krasnik, C., Hoffman, S.A., and Sakic, B. (2004a). Autoimmune-induced damage of the midbrain dop-aminergic system in lupus-prone mice. J. Neuroimmunol. 152, 83-97. (Pubitemid 38829706)
9. Ballok, D.A., Woulfe, J., Sur, M., Cyr, M., and Sakic, B. (2004b). Hippocampal damage in mouse and human forms of systemic autoimmune disease. Hippocampus 14, 649-661. (Pubitemid 39107018)
10. Balosso, S., Ravizza, T., Perego, C., Peschon, J., Campbell, I.L., De Simoni, M.G., and Vezzani, A. (2005). Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. Ann. Neurol. 57, 804-812. (Pubitemid 40798618)
11. Balosso, S., Ravizza, T., Pierucci, M., Calcagno, E., Invernizzi, R., Di Giovanni, G., Esposito, E., and Vezzani, A. (2009). Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocam-pus: implications for seizure susceptibility. Neuroscience 161, 293-300.
12. Banner, D.W., D'Arcy, A., Janes, W., Gentz, R., Schoenfeld, H.J., Broger, C., Loetscher, H., and Lesslauer, W. (1993). Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 73, 431-445. (Pubitemid 23143344)
13. Baracchi, F. and Opp, M.R. (2008). Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav. Immun. 22, 982-993.
14. Barna, B.P., Barnett, G.H., Jacobs, B.S., and Estes, M.L. (1993). Divergent responses of human astrocytoma and non-neoplastic astrocytes to tumor necrosis factor alpha involve the 55 kDa tumor necrosis factor receptor. J. Neuroimmunol. 43, 185-190. (Pubitemid 23103655)
15. Barrett, G.L., Reid, C.A., Tsafoulis, C., Zhu, W., Williams, D.A., Paolini, A.G., Trieu, J., and Murphy, M. (2010). Enhanced spatial memory and hippocampal long-term potentiation in p75 neu-rotrophin receptor knockout mice. Hippocampus 20, 145-152.
16. Baune, B.T., Wiede, F., Braun, A., Golledge, J., Arolt, V. , and Koerner, H. (2008). Cognitive dysfunction in mice deficient for TNF-and its receptors. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B, 1056-1064.
17. Beattie, E.C., Stellwagen, D., Morishita, W., Bresnahan, J.C., Keun Ha, B., Von Zastrow, M., Beattie, M.S., and Malenka, R.C. (2002). Control of synaptic strength by glial TNFalpha. Science 295, 2282-2285. (Pubitemid 34258846)
18. Becher, B., Dodelet, V., Fedorowicz, V. , and Antel, J.P. (1996). Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest. 98, 1539-1543. (Pubitemid 26327862)
19. Bechmann, I., Mor, G., Nilsen, J., Eliza, M., Nitsch, R., and Naftolin, F. (1999). FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier. Glia 27, 62-74. (Pubitemid 29311507)
20. Bernardino, L., Agasse, F., Silva, B., Ferreira, R., Grade, S., and Malva, J.O. (2008). Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal sub-ventricular zone cell cultures. Stem Cells 26, 2361-2371.
21. Bishu, S., Madhavan, D., Perez, P., Civitello, L., Liu, S., Fessler, M., Holland, S.M., Jain, A., and Pao, M. (2009). CD40 ligand deficiency: neurologic sequelae with radiographic correlation. Pediatr. Neurol. 41, 419-427.
22. Bodmer, J.L., Burns, K., Schneider, P., Hofmann, K., Steiner, V. , Thome, M., Bornand, T., Hahne, M., Schröter, M., Becker, K., et al. (1997). TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity 6, 79-88. (Pubitemid 27130217)
23. Bodmer, J.L., Holler, N., Reynard, S., Vinciguerra, P., Schneider, P., Juo, P., Blenis, J., and Tschopp, J. (2000). TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell. Biol. 2, 241-243.
24. Bodmer, J.L., Schneider, P., and Tschopp, J. (2002). The molecular architecture of the TNF superfamily. Trends Biochem. Sci. 27, 19-26. (Pubitemid 34131621)
25. Boksa, P. (2010). Effects of prenatal infection on brain development and behavior: a review of findings from animal models. Brain Behav. Immun. 24, 881-897.
26. Bossen, C., Ingold, K., Tardivel, A., Bodmer, J.-L., Gaide, O., Hertig, S., Ambrose, C., Tschopp, J., and Schneider, P. (2006). Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J. Biol. Chem. 281, 13964-13971. (Pubitemid 43848322)
27. Bridgham, J.T. and Johnson, A.L. (2003). Characterization of chicken TNFR superfamily decoy receptors, DcR3 and osteoprotegerin. Biochem. Biophys. Res. Commun. 307, 956-961. (Pubitemid 36871665)
28. Bridgham, J.T., Bobe, J., Goetz, F.W., and Johnson, A.L. (2001). Conservation of death receptor-6 in avian and piscine vertebrates. Biochem. Biophys. Res. Commun. 284, 1109-1115. (Pubitemid 32917953)
29. Bui, N.T., Konig, H.G., Culmsee, C., Bauerbach, E., Poppe, M., Krieglstein, J., and Prehn, J.H. (2002). p75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones. J. Neurochem. 81, 594-605. (Pubitemid 34809338)
30. Bull, M.J., Williams, A.S., Mecklenburgh, Z., Calder, C.J., Twohig, J.P., Elford, C., Evans, B.A., Rowley, T.F., Slebioda, T.J., Taraban, V.Y., et al. (2008). The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. J. Exp. Med. 205, 2457-2464.
31. Burd, I., Bentz, A.I., Chai, J., Gonzalez, J., Monnerie, H., Le Roux, P.D., Cohen, A.S., Yudkoff, M., and Elovitz, M.A. (2010). Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain. J. Neurosci. Res. 88, 1872-1881.
32. Butler, M.P., O'Connor, J.J., and Moynagh, P.N. (2004). Dissection of tumor-necrosis factor-alpha inhibition of long-term poten-tiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP. Neuroscience 124, 319-326. (Pubitemid 38229652)
33. Cafferty, W.B., Duffy, P., Huebner, E., and Strittmatter, S.M. (2010). MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma. J. Neurosci. 30, 6825-6837.
34. Calingasan, N.Y., Erdely, H.A., and Altar, C.A. (2002). Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury. Neurobiol. Aging 23, 31-39. (Pubitemid 34066533)
35. Casaccia-Bonnefil, P., Gu, C., Khursigara, G., and Chao, M.V. (1999). p75 neurotrophin receptor as a modulator of survival and death decisions. Microsc. Res. Tech. 45, 217-224. (Pubitemid 29264985)
36. Cearley, C., Churchill, L., and Krueger, J.M. (2003). Time of day differences in IL1beta and TNFalpha mRNA levels in specific regions of the rat brain. Neurosci. Lett. 352, 61-63. (Pubitemid 37412326)
37. Ceccatelli, S., Tamm, C., Sleeper, E., and Orrenius, S. (2004). Neural stem cells and cell death. Toxicol. Lett. 149, 59-66. (Pubitemid 38469821)
38. Ceni, C., Kommaddi, R.P., Thomas, R., Vereker, E., Liu, X., McPherson, P.S., Ritter, B., and Barker, P.A. (2010). The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. J. Cell. Sci. 123, 2299-2307.
39. Cha, S.S., Sung, B.J., Kim, Y.A., Song, Y.L., Kim, H.J., Kim, S., Lee, M.S., and Oh, B.H. (2000). Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity. J. Biol. Chem. 275, 31171-31177.
40. Chan, F.K. (2007). Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling. Cytokine 37, 101-107. (Pubitemid 46694340)
41. Chattopadhyay, K., Ramagopal, U.A., Mukhopadhaya, A., Malashkevich, V.N., DiLorenzo, T.P., Brenowitz, M., Nathenson, S.G., and Almo, S.C. (2007). Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function. Proc. Natl. Acad. Sci. USA 104, 19452-19457.
42. Chattopadhyay, K., Ramagopal, U.A., Brenowitz, M., Nathenson, S.G., and Almo, S.C. (2008). Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily. Proc. Natl. Acad. Sci. USA 105, 635-640. (Pubitemid 351171760)
43. Chen, E.Y., Mufson, E.J., and Kordower, J.H. (1996). TRK and p75 neurotrophin receptor systems in the developing human brain. J. Comp. Neurol. 369, 591-618. (Pubitemid 26164701)
44. Chen, J., Buchanan, J.B., Sparkman, N.L., Godbout, J.P., Freund, G.G., and Johnson, R.W. (2008). Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun. 22, 301-311. (Pubitemid 351172703)
45. Choi, S. and Friedman, W.J. (2009). Inflammatory cytokines IL-1beta and TNF-alpha regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms. ASN Neuro. 1 , 113-123 pii: e00010.
46. Clinton, M., Manson, J., McBride, D., and Miele, G. (2000). Gene expression changes during murine postnatal brain development. Genome Biol. 1, RESEARCH0005.
47. Collette, Y., Gilles, A., Pontarotti, P., and Olive, D.L. (2003). A co-evolution perspective of the TNFSF and TNFRSF families in the immune system. Trends Immunol. 24, 387-394. (Pubitemid 36830966)
48. Corsini, N.S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., et al. (2009). The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell 5, 178-190.
49. Corti, A., Fassina, G., Marcucci, F., Barbanti, E., and Cassani, G. (1992). Oligomeric tumour necrosis factor alpha slowly converts into inactive forms at bioactive levels. Biochem. J. 284, 905-910.
50. Culmsee, C., Gerling, N., Lehmann, M., Nikolova-Karakashian, M., Prehn, J.H.M., Mattson, M.P., and Krieglstein, J. (2002). Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75. Neuroscience 115, 1089-1108. (Pubitemid 35351700)
51. Cunningham, A.J., Murray, C.A., O'Neill, L.A., Lynch, M.A., and O'Connor, J.J. (1996). Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci. Lett. 203, 17-20.
52. Czeschik, J.C., Hagenacker, T., Schäfers, M., and Büsselberg, D. (2008). TNF-alpha differentially modulates ion channels of noci-ceptive neurons. Neurosci. Lett. 434, 293-298.
53. Dempsey, P.W., Doyle, S.E., He, J.Q., and Cheng, G. (2003). The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev. 14, 193-209. (Pubitemid 36693141)
54. Diem, R., Meyer, R., Weishaupt, J.H., and Bahr, M. (2001). Reduction of potassium currents and phosphatidylinositol 3-kinase-depen-dent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. J. Neurosci. 21, 2058-2066. (Pubitemid 32221388)
55. Dopp, J.M., Mackenzie-Graham, A., Otero, G.C., and Merrill, J.E. (1997). Differential expression, cytokine modulation, and spe-cific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia. J. Neuroimmunol. 75, 104-112. (Pubitemid 27170308)
56. Dziegielewska, K.M., Moller, J.E., Potter, A.M., Ek, J., Lane, M.A., and Saunders, N.R. (2000). Acute-phase cytokines IL-1beta and TNF-alpha in brain development. Cell Tissue Res. 299, 335-345. (Pubitemid 30160443)
57. Eby, M.T., Jasmin, A., Kumar, A., Sharma, K., and Chaudhary, P.M. (2000). TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. J. Biol. Chem. 275, 15336-15342. (Pubitemid 30337261)
58. Eck, M.J. and Sprang, S.R. (1989). The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. J. Biol. Chem. 264, 17595-17605. (Pubitemid 19255596)
59. Emerich, D.F., Winn, S.R., Harper, J., Hammang, J.P., Baetge, E.E., and Kordower, J.H. (1994). Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons. J. Comp. Neurol. 349, 148-164. (Pubitemid 24328525)
60. Ernfors, P., Ibanez, C.F., Ebendal, T., Olson, L., and Persson, H. (1990). Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc. Natl. Acad. Sci. USA 87, 5454-5458.
61. Fang, L., Adkins, B., Deyev, V. , and Podack, E.R. (2008). Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J. Exp. Med. 205, 1037-1048. (Pubitemid 351679680)
62. Farrell, M., Sakic, B., Szechtman, H., and Denburg, J.A. (1997). Effect of cyclophosphamide on leukocytic infiltration in the brain of MRL/lpr mice. Lupus 6, 268-274. (Pubitemid 27160647)
63. Fatemi, S.H., Reutiman, T.J., Folsom, T.D., Huang, H., Oishi, K., Mori, S., Smee, D.F., Pearce, D.A., Winter, C., Sohr, R., et al. (2008). Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders. Schizophr. Res. 99, 56-70.
64. Fatemi, S.H., Folsom, T.D., Reutiman, T.J., Abu-Odeh, D., Mori, S., Huang, H., and Oishi, K. (2009). Abnormal expression of myeli-nation genes and alterations in white matter fractional anisot-ropy following prenatal viral influenza infection at E16 in mice. Schizophr. Res. 11 2, 46-53.
65. Feldman, S.R., Kimball, A.B., Krueger, G.G., Woolley, J.M., Lalla, D., and Jahreis, A. (2005). Etanercept improves the health-related quality of life of patients with psoriasis: results of a phase III randomized clinical trial. J. Am. Acad. Dermatol. 53, 887-889. (Pubitemid 41501389)
66. Feldman, S.R., Gottlieb, A.B., Bala, M., Wu, Y., Eisenberg, D., Guzzo, C., Li, S., Dooley, L.T., and Menter, A. (2008). Infliximab improves health-related quality of life in the presence of comor-bidities among patients with moderate-to-severe psoriasis. Br. J. Dermatol. 159, 704-710.
67. Fontaine, V. , Mohand-Said, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., and Eisel, U. (2002). Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J. Neurosci. 22, RC216.
68. French, L.E., Hahne, M., Viard, I., Radlgruber, G., Zanone, R., Becker, K., Müller, C., and Tschopp, J. (1996). Fas and fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J. Cell. Biol. 133, 335-343. (Pubitemid 26132532)
69. Gao, H.X., Campbell, S.R., Cui, M.H., Zong, P., Hee-Hwang, J., Gulinello, M., and Putterman, C. (2009). Depression is an early disease manifestation in lupus-prone MRL/lpr mice. J. Neuroimmunol. 207, 45-56.
70. Gil, V. , Bichler, Z., Lee, J.K., Seira, O., Llorens, F., Bribian, A., Morales, R., Claverol-Tinture, E., Soriano, E., Sumoy, L., et al. (2010). Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon. Cereb. Cortex 20, 1769-1779.
71. Golan, H., Levav, T., Mendelsohn, A., and Huleihel, M. (2004). Involvement of tumor necrosis factor alpha in hippocampal development and function. Cereb. Cortex 14, 97-105. (Pubitemid 38018058)
72. Green, D.R., Droin, N., and Pinkoski, M. (2003). Activation-induced cell death in T cells. Immunol. Rev. 193, 70-81. (Pubitemid 36688041)
73. Greferath, U., Bennie, A., Kourakis, A., and Barrett, G.L. (2000a). Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice. Eur. J. Neurosci. 12, 885-893. (Pubitemid 30168766)
74. Greferath, U., Bennie, A., Kourakis, A., Bartlett, P.F., Murphy, M., and Barrett, G.L. (2000b). Impaired spatial learning in aged rats is associated with loss of p75-positive neurons in the basal fore-brain. Neuroscience 100, 363-373.
75. Grenet, J., Valentine, V., Kitson, J., Li, H., Farrow, S.N., and Kidd, V.J. (1998). Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma. Genomics 49, 385-393. (Pubitemid 28268346)
76. Grota, L.J., Ader, R., and Cohen, N. (1987). Taste aversion learning in autoimmune Mrl-lpr/lpr and Mrl +/+ mice. Brain Behav. Immun. 1, 238-250.
77. Grota, L.J., Schachtman, T.R., Moynihan, J.A., Cohen, N., and Ader, R. (1989). Voluntary consumption of cyclophosphamide by Mrl mice. Brain Behav. Immun. 3, 263-273.
78. Gruss, H.J. and Dower, S.K. (1995). Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lympho-mas. Blood 85, 3378-3404.
79. Gurney, A.L., Marsters, S.A., Huang, R.M., Pitti, R.M., Mark, D.T., Baldwin, D.T., Gray, A.M., Dowd, A.D., Brush, A.D., Heldens, A.D., et al. (1999). Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9, 215-218. (Pubitemid 29120387)
80. Habecker, B.A., Bilimoria, P., Linick, C., Gritman, K., Lorentz, C.U., Woodward, W., and Birren, S.J (2008). Regulation of cardiac innervation and function via the p75 neurotrophin receptor. Auton. Neurosci. 140, 40-48.
81. Hagg, T. (1999). Neuronal cell death: retraction. Science 285, 340.
82. Hallbook, F., Ibanez, C.F., and Persson, H. (1991). Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6, 845-858.
83. Hamill, C.A., Michaelson, J.S., Hahm, K., Burkly, L.C., and Kessler, J.A. (2007). Age-dependent effects of TWEAK/Fn14 receptor activation on neural progenitor cells. J. Neurosci. Res. 85, 3535-3544. (Pubitemid 350228699)
84. Harrison, D.C., Roberts, J., Campbell, C.A., Crook, B., Davis, R., Deen, K., Meakin, J., Michalovich, D., Price, J., Stammers, M., et al. (2000). TR3 death receptor expression in the normal and ischaemic brain. Neuroscience 96, 147-160. (Pubitemid 30103613)
85. Harry, G.J., Lefebvre d'Hellencourt, C., McPherson, C.A., Funk, J.A., Aoyama, M., and Wine, R.N. (2008). Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apopto-sis of dentate granule neurons. J. Neurochem. 106, 281-298. (Pubitemid 351840211)
86. Hartig, W., Seeger, J., Naumann, T., Brauer, K., and Brückner, G. (1998). Selective in vivo fluorescence labelling of cholinergic neurons containing p75(NTR) in the rat basal forebrain. Brain Res. 808, 155-165. (Pubitemid 29009548)
87. Hattori, A., Tanaka, E., Murase, K., Ishida, N., Chatani, Y. , Tsujimoto, M., Hayashi, K., and Kohno, M. (1993). Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells. J. Biol. Chem. 268, 2577-2582. (Pubitemid 23057881)
88. Hayashi, S., Taira, A., Inoue, G., Koshi, T., Ito, T., Yamashita, M., Yamauchi, K., Suzuki, M., Takahashi, K., and Ohtori, S. (2008). TNF-alpha in nucleus pulposus induces sensory nerve growth: a study of the mechanism of discogenic low back pain using TNF-alpha-deficient mice. Spine (Phila Pa 1976) 33, 1542-1546.
89. Hefti, F., Hartikka, J., Salvatierra, A., Weiner, W.J., and Mash, D.C. (1986). Localization of nerve growth factor receptors in cholin-ergic neurons of the human basal forebrain. Neurosci. Lett. 69, 37-41. (Pubitemid 16071195)
90. Held-Feindt, J. and Mentlein, R. (2002). CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors. Int. J. Cancer 98, 352-356. (Pubitemid 34188677)
91. Heldmann, U., Thored, P., Claasen, J.H., Arvidsson, A., Kokaia, Z., and Lindvall, O. (2005). TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain. Exp. Neurol. 196, 204-208. (Pubitemid 41416663)
92. Hisaoka, T., Morikawa, Y., Kitamura, T., and Senba, E. (2003). Expression of a member of tumor necrosis factor receptor super-family, TROY, in the developing mouse brain. Brain Res. Dev. Brain Res. 143, 105-109. (Pubitemid 36588687)
93. Hisaoka, T., Morikawa, Y., Komori, T., Sugiyama, T., Kitamura, T., and Senba, E. (2006a). Characterization of TROY-expressing cells in the developing and postnatal CNS: the possible role in neuronal and glial cell development. Eur. J. Neurosci. 23, 3149-3160.
94. Hisaoka, T., Morikawa, Y. , and Senba, E. (2006b). Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain. Brain Res. 111 0, 81-94. (Pubitemid 44344597)
95. Hosaka, Y., Ueda, H., Yamasaki, T., Suzuki, D., Matsuda, N., and Takehana, K. (2005). Structure and component alteration of rabbit Achilles tendon in tissue culture. Biomed. Res. 26, 279-286. (Pubitemid 43137335)
96. Hou, H., Obregon, D., Lou, D., Ehrhart, J., Fernandez, F., Silver, A., and Tan, J. (2008). Modulation of neuronal differentiation by CD40 isoforms. Biochem. Biophys. Res. Commun. 369, 641-647.
97. Hurwitz, A.A., Lyman, W.D., Guida, M.P., Calderon, T.M., and Berman, J.W. (1992). Tumor necrosis factor alpha induces adhesion molecule expression on human fetal astrocytes. J. Exp. Med. 176, 1631-1636.
98. Hymowitz, S.G., Christinger, H.W., Fuh, G., Ultsch, M., O'Connell, M., Kelley, R.F., Ashkenazi, A., and de Vos, A.M. (1999). Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol. Cell. 4, 563-571. (Pubitemid 29531136)
99. Hymowitz, S.G., O'Connell, M.P., Ultsch, M.H., Hurst, A., Totpal, K., Ashkenazi, A., de Vos, A.M., and Kelley, R.F. (2000). A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry 39, 633-640. (Pubitemid 30065031)
100. Iglesias, M., Barreiro de Acosta, M., Vázquez, I., Figueiras, A., Nieto, L., Lorenzo, A., and Domínguez-Mu ñ oz, J.E. (2009). Psychological impact of Crohn's disease on patients in remission: anxiety and depression risks. Rev. Esp. Enferm. Dig. 101, 249-257.
101. Iha, K., Omatsu, T., Watanabe, S., Ueda, N., Taniguchi, S., Fujii, H., Ishii, Y., Kyuwa, S., Akashi, H., and Yoshikawa, Y. (2009). Molecular cloning and sequencing of the cDNAs encoding the bat interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12p40, and tumor necrosis factor-alpha. J. Vet. Med. Sci. 71, 1691-1695.
102. Iosif, R.E., Ekdahl, C.T., Ahlenius, H., Pronk, C.J., Bonde, S., Kokaia, Z., Jacobsen, S.E., and Lindvall, O. (2006). Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J. Neurosci. 26 , 9703-9712. (Pubitemid 44427709)
103. Johansson, S., Price, J., and Modo, M. (2008). Effect of inflamma-tory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells. Stem Cells 26, 2444-2454.
104. Johnson, D., Lanahan, A., Buck, C.R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., and Chao, M. (1986). Expression and structure of the human NGF receptor. Cell 47, 545-554. (Pubitemid 17215345)
105. Jones, E.Y., Stuart, D.I., and Walker, N.P.C. (1989). Structure of tumour necrosis factor. Nature 338, 225-228. (Pubitemid 19086923)
106. Kajiwara, K., Ogata, S., and Tanihara, M. (2005). Promotion of neu-rite outgrowth from fetal hippocampal cells by TNF-alpha receptor 1-derived peptide. Cell Transplant. 14, 665-672. (Pubitemid 43053757)
107. Kapas, L. and Krueger, J.M. (1992). Tumor necrosis factor-beta induces sleep, fever, and anorexia. Am. J. Physiol. 263, R703-R707.
108. Kapas, L., Bohnet, S.G., Traynor, T.R., Majde, J.A., Szentirmai, E., Magrath, P., Taishi, P., and Krueger, J.M. (2008). Spontaneous and influenza virus-induced sleep are altered in TNF-alpha double-receptor deficient mice. J. Appl. Physiol. 105, 1187-1198.
109. Karlen, A., Karlsson, T.E., Mattsson,A., Lundströmer, K., Codeluppi, S., Pham, T.M., Bäckman, C.M.,ögren, S.O., Å berg, E., Hoffman, A.F., et al. (2009). Nogo receptor 1 regulates formation of lasting memories. Proc. Natl. Acad. Sci. USA 106, 20476-20481.
110. Karpusas, M., Hsu, Y.M., Wang, J.H., Thompson, J., Lederman, S., Chess, L., and Thomas, D. (1995). 2 A crystal structure of an extracellular fragment of human CD40 ligand. Structure 3, 1426.
111. Kato, K., Awasaki, T., and Ito, K. (2009). Neuronal programmed cell death induces glial cell division in the adult Drosophila brain. Development 136, 51-59.
112. Kauppila, S., Maaty, W.S., Chen, P., Tomar, R.S., Eby, M.T., Chapo, J., Chew, S., Rathore, N., Zachariah, S., Sinha, S.K., et al. (2003). Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene 22, 4860-4867. (Pubitemid 36981274)
113. Kawaja, M.D. (1998). Sympathetic and sensory innervation of the extracerebral vasculature: roles for p75NTR neuronal expression and nerve growth factor. J. Neurosci. Res. 52, 295-306. (Pubitemid 28196647)
114. Keohane, A., Ryan, S., Maloney, E., Sullivan, A.M., and Nolan, Y.M. (2010). Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: role of Hes1. Mol. Cell Neurosci. 43, 127-135.
115. Kere, J. and Elomaa, O. (2002). Healing a natural knockout of epithelial organogenesis. Trends Mol. Med. 8, 197-200. (Pubitemid 34493632)
116. Khosla, S. (2001). Minireview: the OPG/RANKL/RANK system. Endocrinology 142, 5050-5055. (Pubitemid 33131929)
117. Kitson, J., Raven, T., Jiang, Y.P., Goeddel, D.V., Giles, K.M., Pun, K.T., Grinham, C.J., Brown, R., and Farrow, S.N. (1996). A death-domain- containing receptor that mediates apoptosis. Nature 384, 372-375. (Pubitemid 26408521)
118. Knight, J.C., Scharf, E.L., and Mao-Draayer, Y. (2010). Fas activation increases neural progenitor cell survival. J. Neurosci. Res. 88, 746-757.
119. Kodama, K., Hokama, M., Kawaguchi, K., Tanaka, Y., and Hongo, K. (2009). Primary ALK-1-negative anaplastic large cell lym-phoma of the brain: case report and review of the literature. Neuropathology 29, 166-1671.
120. Kojima, T., Morikawa, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Senba, E., and Kitamura, T. (2000). TROY, a newly identi-fied member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J. Biol. Chem. 275, 20742-20747. (Pubitemid 30457663)
121. Koller, H., Thiem, K., and Siebler, M. (1996). Tumour necrosis factor-alpha increases intracellular Ca 2+ and induces a depolarization in cultured astroglial cells. Brain 119 , 2021-2027.
122. Kordower, J.H., Bartus, R.T., Bothwell, M., Schatteman, G., and Gash, D.M. (1988). Nerve growth factor receptor immunoreac-tivity in the nonhuman primate (Cebus apella): distribution, morphology, and colocalization with cholinergic enzymes. J. Comp. Neurol. 277, 465-486. (Pubitemid 18268002)
123. Kordower, J.H., Winn, S.R., Liu, Y.T., Mufson, E.J., Sladek, J.R., Hammang, J.P., Baetge, E.E., and Emerich, D.F. (1994). The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc. Natl. Acad. Sci. USA 91, 10898-10902. (Pubitemid 24349592)
124. Krishnan, R., Cella, D., Leonardi, C., Papp, K., Gottlieb, A.B., Dunn, M., Chiou, C.F., Patel, V. , and Jahreis, A. (2007). Effects of etan-ercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks. Br. J. Dermatol. 157, 1275-1277. (Pubitemid 350115684)
125. Kurumiya, S., Miura, Y. , Nakatsuji, K., Dodo, M., Hori, M., and Ito, T. (1990). General pharmacology of recombinant human tumor necrosis factor. 2nd communication: effects on central nervous system functions. Arzneimittelforschung 40, 225-231. (Pubitemid 20071875)
126. Landgren, H. and Curtis, M.A. (2011). Locating and labeling neural stem cells in the brain. J. Cell Physiol. 226, 1-7.
127. Laurikkala, J., Pispa, J., Jung, H.S., Nieminen, P., Mikkola, M., Wang, X., Saarialho-Kere, U., Galceran, J., Grosschedl, R., and Thesleff, I. (2002). Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129, 2541-2553. (Pubitemid 34863859)
128. Lee, K.F., Li, E., Huber. L.J., Landis. S.C., Sharpe, A.H., Chao, M.V., and Jaenisch, R. (1992). Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
129. Lee, S.C., Liu, W., Roth, P., Dickson, D.W., Berman, J.W., and Brosnan, C.F. (1993). Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia. J. Immunol. 150, 594-604. (Pubitemid 23133637)
130. Lesch, K.P., Zeng, Y., Reif, A., and Gutknecht, L. (2003). Anxiety-related traits in mice with modified genes of the serotonergic pathway. Eur. J. Pharmacol. 480, 185-204. (Pubitemid 37410371)
131. Li, L., Qiu, L., Song, L., Song, X., Zhao, J., Wang, L., Mu, C., and Zhang, H. (2009). First molluscan TNFR homologue in Zhikong scallop: molecular characterization and expression analysis. Fish Shellfish Immunol. 27, 625-632.
132. Lichtenstein, G.R., Bala, M., Han, C., DeWoody, K., and Schaible, T. (2002). Infliximab improves quality of life in patients with Crohn's disease. Inflamm. Bowel Dis. 8, 237-243. (Pubitemid 34784975)
133. Lim, Y.S., McLaughlin, T., Sung, T.C., Santiago, A., Lee, K.F., and O'Leary, D.D. (2008). p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron 59, 746-758.
134. Liu, B.P., Fournier, A., GrandPré, T., and Strittmatter, S.M. (2002). Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297, 1190-1193. (Pubitemid 36193355)
135. Locksley, R.M., Killeen, N., and Lenardo, M.J. (2001). The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501. (Pubitemid 32201945)
136. Lorentz, C.U., Alston, E.N., Belcik, T., Lindner, J.R., Giraud, G.D., and Habecker, B.A. (2010). Heterogeneous ventricular sympathetic innervation, altered beta-adrenergic receptor expression, and rhythm instability in mice lacking the p75 neurotrophin receptor. Am. J. Physiol. Heart Circ. Physiol. 298, H1652-H1660.
137. Lotz, M., Setareh, M., von Kempis, J., and Schwarz, H. (1996). The nerve growth factor/tumor necrosis factor receptor family. J. Leukoc. Biol. 60, 1-7. (Pubitemid 26248876)
138. Lung, H.L., Leung, K.N., Stadlin, A., Ma, C.M., and Tsang, D. (2001). Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-alpha in rat primary astro-cytes. Life Sci. 68, 2081-2091. (Pubitemid 32289390)
139. Ma, X., Foster, J., and Sakic, B. (2006). Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mice. J. Neuroimmunol. 179, 26-36. (Pubitemid 44441595)
140. MacEwan, D.J. (2002a). TNF ligands and receptors-a matter of life and death. Br. J. Pharmacol. 135, 855-875. (Pubitemid 34214444)
141. MacEwan, D.J. (2002b). TNF receptor subtype signalling: differences and cellular consequences. Cell Signal 14, 477-492. (Pubitemid 34230583)
142. MacFarlane, M., Ahmad, M., Srinivasula, S.M., Fernandes-Alnemri, T., Cohen, G.M., and Alnemri, E.S. (1997). Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 272, 25417-25420. (Pubitemid 27438841)
143. Mathis, C., Schroter, A., Thallmair M., and Schwab M.E. (2010). Nogo-A regulates neural precursor migration in the embryonic mouse cortex. Cereb. Cortex 20, 2380-2390.
144. Matsuyama, T., Hata, R., Tagaya, M., Yamamoto, Y., Nakajima, T., Furuyama, J.-i., Wanaka, A., and Sugita, M. (1994). Fas antigen mRNA induction in postischemic murine brain. Brain Res. 657, 342-346. (Pubitemid 24281286)
145. Matysiak, M., Jurewicz, A., Jaskolski, D., and Selmaj, K. (2002). TRAIL induces death of human oligodendrocytes isolated from adult brain. Brain 125, 2469-2480. (Pubitemid 35303506)
146. McAfoose, J., Korner, H., and Baune, B.T. (2009). The effects of TNF deficiency on age-related cognitive performance. Psychoneuroendocrinology 34, 615-619.
147. Meylan, F., Davidson, T.S., Kahle, E., Kinder, M., Acharya, K., Jankovic, D., Bundoc, V. , Hodges, M., Shevach, E.M., Keane-Myers, A., et al. (2008). The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29, 79-89.
148. Mi, S. (2008). Troy/Taj and its role in CNS axon regeneration. Cytokine Growth Factor Rev. 19, 245-251.
149. Migone, T.S., Zhang, J., Luo, X., Zhuang, L., Chen, C., Hu, B., Hong, J.S., Perry, J.W., Chen, S.F., Zhou, J.X., et al. (2002). TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 16, 479-492. (Pubitemid 34260924)
150. Misko, T.P., Radeke, M.J., and Shooter, E.M. (1987). Nerve growth factor in neuronal development and maintenance. J. Exp. Biol. 132, 177-190.
151. Mongkolsapaya, J., Grimes, J.M., Chen, N., Xu, X.N., Stuart, D.I., Jones, E.Y., and Screaton, G.R. (1999). Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. Nat. Struct. Biol. 6, 1048-1053. (Pubitemid 29519600)
152. Moretto, G., Yoo, A., and Kim, S.U. (1993). Human astrocytes and cytokines: tumor necrosis factor alpha and interferon gamma do not promote astrocytic proliferation. Neurosci. Lett. 151, 17-20. (Pubitemid 23144975)
153. Mufson, E.J. and Kordower, J.H. (1992). Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease. Proc. Natl. Acad. Sci. USA 89, 569-573.
154. Mufson, E.J., Bothwell, M., and Kordower, J.H. (1989). Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain. Exp. Neurol. 105, 221-232. (Pubitemid 19232573)
155. Nagahara, A.H., Bernot, T., Moseanko, R., Brignolo, L., Blesch, A., Conner, J.M., Ramirez, A., Gasmi, M., and Tuszynski, M.H. (2009). Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp. Neurol. 215, 153-159.
156. Naumann, T., Casademunt, E., Hollerbach, E., Hofmann, J., Dechant, G., Frotscher, M., and Barde, Y.A. (2002). Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons. J. Neurosci. 22, 2409-2418. (Pubitemid 37465788)
157. Neumann, H., Schweigreiter, E., Yamashita, T., Rosenkranz, K., Wekerle, H., and Barde, Y.A. (2002). Tumor necrosis factor inhibits neurite outgrowth and branching of hippocam-pal neurons by a rho-dependent mechanism. J. Neurosci. 22, 854-862. (Pubitemid 34141766)
158. Newman, S.J., Bond, B., Crook, B., Darker, J., Edge, C., and Maycox, P.R. (2000). Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease. Brain Res. 857, 131-140. (Pubitemid 30107798)
159. Nielsen, D.M. and Crnic, L.S. (2002). Elevated plus maze behavior, auditory startle response, and shock sensitivity in predisease and in early stage autoimmune disease MRL/lpr mice. Brain Behav. Immun. 16, 46-61. (Pubitemid 35435453)
160. Nocentini, G., Bartoli, A., Ronchetti, S., Giunchi, L., Cupelli, A., Delfino, D., Migliorati, G., and Riccardi, C. (2000a). Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family. DNA Cell Biol. 19, 205-217. (Pubitemid 30228439)
161. Nocentini, G., Ronchetti, S., Bartoli, A., Spinicelli, S., Delfino, D., Brunetti, L., Migliorati, G., and Riccardi, C. (2000b). Identification of three novel mRNA splice variants of GITR. Cell Death Differ. 7, 408-410. (Pubitemid 30209669)
162. O'Keeffe, G.W., Gutierrez, H., Pandolfi, P.P., Riccardi, C., and Davies, A.M. (2008). NGF-promoted axon growth and target innervation requires GITRL-GITR signaling. Nat. Neurosci. 11, 135-142. (Pubitemid 351170494)
163. Ogoshi, F., Yin, H.Z., Kuppumbatti, Y., Song, B., Amindari, S., and Weiss, J.H. (2005). Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca 2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole- propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp. Neurol. 193, 384-393. (Pubitemid 40616188)
164. Oldreive, C.E. and Doherty, G.H. (2010). Effects of tumour necrosis factor-alpha on developing cerebellar granule and Purkinje neurons in vitro. J. Mol. Neurosci. 42, 44-52.
165. Ouwe-Missi-Oukem-Boyer, O., Porchet, E., Capron, A., and Dissous, C. (1994). Characterization of immunoreactive TNF alpha molecules in the gastropod Biomphalaria glabrata. Dev. Comp. Immunol. 18, 211-218.
166. Palmiter, R.D. (2008). Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice. Ann. N. Y. Acad. Sci. 1129, 35-46. (Pubitemid 351990274)
167. Pan, G., Bauer, J.H., Haridas, V. , Wang, S., Liu, D., Yu, G., Vincenz, C., Aggarwal, B.B., Ni, J., and Dixit, V.M. (1998). Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431, 351-356. (Pubitemid 28352389)
168. Pappu, B.P., Borodovsky, A., Zheng, T.S., Yang, X., Wu, P., Dong, X., Weng, S., Browning, B., Scott, M.L., Ma, L., et al. (2008). TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J. Exp. Med. 205, 1049-1062. (Pubitemid 351679681)
169. Park, C., Sakamaki, K., Tachibana, O., Yamashima, T., Yamashita, J., and Yonehara, S. (1998). Expression of fas antigen in the normal mouse brain. Biochem. Biophys. Res. Commun. 252, 623-628. (Pubitemid 28556826)
170. Park, J.B., Yiu, G., Kaneko, S., Wang, J., Chang, J., He, X.L., Garcia, K.C., and He, Z. (2005). A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 45, 345-351. (Pubitemid 40188202)
171. Park, K.J., Grosso, C.A., Aubert, I., Kaplan, D.R., and Miller, F.D. (2010). p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain. Nat. Neurosci. 13, 559-566.
172. Patel, J.R. and Brewer, G.J. (2008a). Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid. J. Neurosci. Res. 86, 2303-2313.
173. Patel, J.R. and Brewer, G.J. (2008b). Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Exp. Neurol. 213, 93-100.
174. Peng, H., Huang, Y. , Duan, Z., Erdmann, N., Xu, D., Herek, S., and Zheng, J. (2005). Cellular IAP1 regulates TRAIL-induced apop-tosis in human fetal cortical neural progenitor cells. J. Neurosci. Res. 82, 295-305. (Pubitemid 41552481)
175. Peterson, D.A., Dickinson-Anson, H.A., Leppert, J.T., Lee, K.F., and Gage, F.H. (1999). Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75. J. Comp. Neurol. 404, 1-20. (Pubitemid 29021515)
176. Peterson, D.A., Leppert, J.T., Lee, K.F., and Gage, F.H. (1997). Basal forebrain neuronal loss in mice lacking neurotrophin receptor p75. Science 277, 837-839.
177. Pioro, E.P. and Cuello, A.C. (1990a). Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholin-ergic system-I. Forebrain. Neuroscience 34, 57-87. (Pubitemid 20097897)
178. Pioro, E.P. and Cuello, A.C. (1990b). Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system-II. Brainstem, cerebellum and spinal cord. Neuroscience 34, 89-110. (Pubitemid 20097898)
179. Pispa, J., Mikkola, M.L., Mustonen, T., and Thesleff, I. (2003). Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis. Gene Expr. Patterns 3, 675-679. (Pubitemid 37074925)
180. Pispa, J., Pummila, M., Barker, P.A., Thesleff, I., and Mikkola, M.L. (2008). Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum. Mol. Genet. 17, 3380-3391.
181. Poole, E., King, C.A., Sinclair, J.H., and Alcami, A. (2006). The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism. EMBO J. 25, 4390-4399. (Pubitemid 44435236)
182. Poulton, L.D., Nolan, K.F., Anastasaki, C., Waldmann, H., and Patton, E.E. (2010). A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. Int. J. Dev. Biol. 54, 815-825.
183. Probert, L., Akassoglou, K., Pasparakis, M., Kontogeorgos, G., and Kollias, G. (1995). Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc. Natl. Acad. Sci. USA 92, 11294-11298.
184. Quintana, A., Molinero, A., Florit, S., Manso, Y., Comes, G., Carrasco, J., Giralt, M., Borup, R., Nielsen, F.C., Campbell, I.L., et al. (2007). Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: from gene to behavior. J. Neurosci. Res. 85, 2668-2685. (Pubitemid 47344569)
185. Radeke, M.J., Misko, T.P., Hsu, C., Herzenberg, L.A., and Shooter, E.M. (1987). Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325, 593-597. (Pubitemid 17055681)
186. Rieger, J., Ohgaki, H., Kleihues, P., and Weller, M. (1999). Human astrocytic brain tumors express AP02L/TRAIL. Acta. Neuropathol. 97, 1-4. (Pubitemid 29132639)
187. Rodriguez-Tebar, A., Dechant, G., Götz, R., and Barde, Y.A. (1992). Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. EMBO J. 11, 917-922.
188. Romero, R., Gotsch, F., Pineles, B., and Kusanovic, J.P. (2007). Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr. Rev. 65, S194-S202.
189. Rosch, H., Schweigreiter, R., Bonhoeffer, T., Barde, Y.A., and Korte, M. (2005). The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus. Proc. Natl. Acad. Sci. USA 102, 7362-7367. (Pubitemid 40696383)
190. Ruan, W., Lee, C.T., and Desbarats, J. (2008). A novel juxtamem-brane domain in tumor necrosis factor receptor superfamily molecules activates Rac1 and controls neurite growth. Mol. Biol. Cell 19, 3192-3202.
191. Sakic, B., Szechtman, H., Keffer, M., Talangbayan, H., Stead, R., and Denburg, JA. (1992). A behavioral profile of autoimmune lupus-prone MRL mice. Brain Behav. Immun. 6, 265-285.
192. Sakic, B., Szechtman, H., Denburg, S., Carbotte, R., and Denburg, J.A. (1993). Spatial learning during the course of autoimmune disease in MRL mice. Behav. Brain Res. 54, 57-66. (Pubitemid 23134666)
193. Sakic, B., Szechtman, H., Talangbayan, H., Denburg, S.D., Carbotte, R.M., and Denburg, J.A. (1994a). Behavior and immune status of MRL mice in the postweaning period. Brain Behav. Immun. 8, 1-13. (Pubitemid 24163516)
194. Sakic, B., Szechtman, H., Talangbayan, H., Denburg, S.D., Carbotte, R.M., and Denburg, J.A. (1994b). Disturbed emotionality in autoimmune MRL-lpr mice. Physiol. Behav. 56, 609-617. (Pubitemid 24269588)
195. Sakic, B., Szechtman, H., Denburg, S.D., and Denburg, J.A. (1995). Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr mice. Physiol. Behav. 58, 797-802.
196. Sakic, B., Szechtman, H., Stead, R.H., and Denburg, J.A. (1996). Joint pathology and behavioral performance in autoimmune MRL-lpr Mice. Physiol. Behav. 60, 901-905. (Pubitemid 26284294)
197. Sakic, B., Szechtman, H., Braciak, T., Richards, C., Gauldie, J., and Denburg, J.A. (1997). Reduced preference for sucrose in autoimmune mice: a possible role of interleukin-6. Brain Res. Bull. 44, 155-165. (Pubitemid 27381818)
198. Sakic, B., Szechtman, H., Denburg, J.A., Gorny,G., Kolb, B., and Whishaw, I.Q. (1998). Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice. J. Neuroimmunol. 87, 162-170. (Pubitemid 28319857)
199. Sakic, B., Kolb, B., Whishaw, I.Q., Gorny, G., Szechtman, H., and Denburg, J.A. (2000a). Immunosuppression prevents neuronal atrophy in lupus-prone mice: evidence for brain damage induced by autoimmune disease ? J. Neuroimmunol. 111, 93-101.
200. Sakic, B., Maric, I., Koeberle, P.D., Millward, J.M., Szechtman, H., Maric, D., and Denburg, J.A. (2000b). Increased TUNEL staining in brains of autoimmune Fas-deficient mice. J. Neuroimmunol. 104, 147-154. (Pubitemid 30125405)
201. Sakic, B., Lacosta, S., Denburg, J.A., and Szechtman, H. (2002). Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidence. J. Neuroimmunol. 129, 84-96. (Pubitemid 34874913)
202. Salama-Cohen, P., Arevalo, M.A., Meier, J., Grantyn, R., and Rodríguez-Tébar, A. (2005). NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch. Mol. Biol. Cell. 16, 339-347. (Pubitemid 40024315)
203. Salama-Cohen, P., Arevalo, M.A., Grantyn, R., and Rodríguez- Tébar, A. (2006). Notch and NGF/p75NTR control dendrite morphology and the balance of excitatory/inhibitory synaptic input to hippocampal neurones through Neurogenin 3. J. Neurochem. 97, 1269-1278. (Pubitemid 43725567)
204. Satoh, J., Tabunoki, H., Yamamura, T., Arima, K., and Konno, H. (2007). TROY and LINGO-1 expression in astrocytes and mac-rophages/microglia in multiple sclerosis lesions. Neuropathol. Appl. Neurobiol. 33, 99-107. (Pubitemid 46090314)
205. Schwartz, D., Engelhard, D., Gallily, R., Matoth, I., and Brenner, T. (1998). Glial cells production of inflammatory mediators induced by Streptococcus pneumoniae: inhibition by pentoxifylline, low-molecular-weight heparin and dexamethasone. J. Neurol. Sci. 155, 13-22. (Pubitemid 28141053)
206. Screaton, G.R., Mongkolsapaya, J., Xu, X.N., Cowper, A.E., McMichael, A.J., and Bell J.I. (1997a). TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. Curr. Biol. 7, 693-696. (Pubitemid 27408868)
207. Screaton, G.R., Xu, X.N., Olsen, A.L., Cowper, A.E., Tan, R., McMichael, A.J., and Bell, J.I. (1997b). LARD: a new lym-phoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 94, 4615-4619. (Pubitemid 27194291)
208. Seguin, J.A., Brennan, J., Mangano, E., and Hayley, S. (2009). Proinflammatory cytokines differentially influence adult hip-pocampal cell proliferation depending upon the route and chro-nicity of administration. Neuropsychiatr. Dis. Treat. 5, 5-14.
209. Selmaj, K.W., Farooq, M., Norton, W.T., Raine, C.S., and Brosnan, C.F. (1990). Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J. Immunol. 144, 129-135. (Pubitemid 20030466)
210. Shao, Z., Browning, J.L., Lee, X., Scott, M.L., Shulga-Morskaya, S., Allaire, N., Thill, G., Levesque, M., Sah, D., McCoy, J.M., et al. (2005). TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 45, 353-359. (Pubitemid 40188203)
211. Sheng, W.S., Hu, S., Ni, H.T., Rowen, T.N., Lokensgard, J.R., and Peterson, P.K. (2005). TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells. J. Leukoc. Biol. 78, 1233-1241. (Pubitemid 41779229)
212. Shibata, M. and Blatteis, C.M., (1991). Human recombinant tumor necrosis factor and interferon affect the activity of neurons in the organum vasculosum laminae terminalis. Brain Res. 562, 323-326.
213. Shibata, A., Zelivyanskaya, M., Limoges, J., Carlson, K.A., Gorantla, S., Branecki, C., Bishu, S., Xiong, H., and Gendelman, H.E. (2003). Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function. J. Neuroimmunol. 142, 112-129. (Pubitemid 38368594)
214. Shoham, S., Davenne, D., Cady, A.B., Dinarello, C.A., and Krueger, J.M. (1987). Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Am. J. Physiol. 253, R142-R149.
215. Siegel, R.M., Frederiksen, J.K., Zacharias, D.A., Chan, F.K.M., Johnson, M., Lynch, D., Tsien, R.Y., and Lenardo, M.J. (2000). Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288, 2354-2357. (Pubitemid 30448157)
216. Simen, B.B., Duman, C.H., Simen, A.A., and Duman, R.S. (2006). TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting. Biol. Psychiatry 59, 775-785.
217. Sled, J.G., Spring, S., van Eede, M., Lerch, J.P., Ullal, S., and Sakic, B. (2009). Time course and nature of brain atrophy in the MRL mouse model of central nervous system lupus. Arthritis. Rheum. 60, 1764-1774.
218. Song, X.Y., Zhang, F.H., Zhou, F.H., Zhong, J., and Zhou, X.F. (2009). Deletion of p75NTR impairs regeneration of peripheral nerves in mice. Life Sci. 84, 61-68.
219. Srivastava, A.K., Pispa, J., Hartung, A.J., Du, Y., Ezer, S., Jenks, T., Shimada, T., Pekkanen, M., Mikkola, M.L., Ko, M.S.H., et al. (1997). The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc. Natl. Acad. Sci. USA 94, 13069-13074. (Pubitemid 27518477)
220. Stanojcic, M., Loheswaran, G., Xu, L., Hoffman, S.A., and Sakic, B. (2010). Intrathecal antibodies and brain damage in autoimmune MRL mice. Brain Behav. Immun. 24, 289-297.
221. Stellwagen, D., Beattie, E.C., Seo, J.Y., and Malenka, R.C. (2005). Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J. Neurosci. 25, 3219-3228. (Pubitemid 40463557)
222. Strasser, A., Jost, P.J., and Nagata, S. (2009). The many roles of FAS receptor signaling in the immune system. Immunity 30, 180-192.
223. Su, X., Morris, D.D., Crowe, N.A., Moore, J.N., Fischer, K.J., and McGraw, R.A. (1992). Equine tumor necrosis factor alpha: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and development of a sensitive enzyme-linked immu-nosorbent assay. Hybridoma 11, 715-727. (Pubitemid 23065183)
224. Szechtman, H., Sakic, B., and Denburg, J.A. (1997). Behaviour of MRL mice: an animal model of disturbed behaviour in systemic autoimmune disease. Lupus 6, 223-229. (Pubitemid 27160639)
225. Takahashi, T., Tanaka, M., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Suda, T., and Nagata, S. (1994). Generalized lymphopro-liferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76, 969-976. (Pubitemid 24106378)
226. Takahashi, S., Tooley, D.D., Kapás, L., Fang, J., Seyer, J.M., and Krueger, J.M. (1995a). Inhibition of tumor necrosis factor in the brain suppresses rabbit sleep. Pflugers Arch. 431, 155-160. (Pubitemid 26017984)
227. Takahashi, S., Kapas, L., Fang, J., and Krueger, J.M. (1995b). An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits. Brain Res. 690, 241-244.
228. Takahashi, S., Kapas, L., and Krueger, J.M. (1996a). A tumor necrosis factor (TNF) receptor fragment attenuates TNF-alpha-and muramyl dipeptide-induced sleep and fever in rabbits. J. Sleep Res. 5, 106-114. (Pubitemid 26236002)
229. Takahashi, S., Kapas, L., Takahashi, S., Kapás, L., Seyer, J.M., Wang, Y. , and Krueger, J.M. (1996b). Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits. Neuroreport 7, 642-646. (Pubitemid 26105053)
230. Takedatsu, H., Michelsen, K.S., Wei, B., Landers, C.J., Thomas, L.S., Dhall, D., Braun, J., and Targan, S.R. (2008). TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 135, 552-567.
231. Tamm, C., Robertson, J.D., Sleeper, E., Enoksson, M., Emgård, M., Orrenius, S., and Ceccatelli, S. (2004). Differential regulation of the mitochondrial and death receptor pathways in neural stem cells. Eur. J. Neurosci. 19, 2613-2621. (Pubitemid 38746378)
232. Tamura, S., Morikawa, Y., Iwanishi, H., Hisaoka, T., and Senba, E. (2004). Foxp1 gene expression in projection neurons of the mouse striatum. Neuroscience 124, 261-267. (Pubitemid 38229647)
233. Tan, J., Town, T., Mori, T., Obregon, D., Wu, Y. , DelleDonne, A., Rojiani, A., Crawford, F., Flavell, R.A., and Mullan, M. (2002). CD40 is expressed and functional on neuronal cells. EMBO J. 21, 643-652. (Pubitemid 34174045)
234. Tan, K.B., Harrop, J., Reddy, M., Young, P., Terrett, J., Emery. J., Moore, G., and Truneh, A. (1997). Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. Gene 204, 35-46. (Pubitemid 28022168)
235. Tancredi, V. , D'Arcangelo, G., Grassi, F., Tarroni, P., Palmieri, G., Santoni, A., and Eusebi, F. (1992). Tumor necrosis factor alters synaptic transmission in rat hippocampal slices. Neurosci. Lett. 146, 176-178.
236. Thesleff, I. and Mikkola, M.L. (2002). Death receptor signaling giving life to ectodermal organs. Sci. STKE 2002, pe22.
237. Todd Roach, J., Volmar, C.H., Dwivedi, S., Town, T., Crescentini, R., Crawford, F., Tan, J., and Mullan, M. (2004). Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain Res. 1015, 161-168. (Pubitemid 38829750)
238. Tone, M., Tone, Y., Fairchild, P.J., Wykes, M., and Waldmann, H. (2001). Regulation of CD40 function by its isoforms generated through alternative splicing. Proc. Natl. Acad. Sci. USA 98, 1751-1756. (Pubitemid 32165570)
239. Tookman, A.J., Jones, C.L., DeWitte, M., and Lodge, P.J. (2008). Fatigue in patients with advanced cancer: a pilot study of an intervention with infliximab. Support. Care Cancer 16i, 1131-1140.
240. Trabzuni, D., Famulski, K.S., and Ahmad, M. (2000). Functional analysis of tumour necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumori-cidal cytokine. Biochem. J. 350, 505-510.
241. Trifunovski, A., Josephson, A., Bickford, P.C., Olson, L., and Brené, S. (2006). Selective decline of Nogo mRNA in the aging brain. Neuroreport 17, 913-916. (Pubitemid 43869958)
242. Tuszynski, M.H. (2000). Intraparenchymal NGF infusions rescue degenerating cholinergic neurons. Cell Transplant. 9, 629-636. (Pubitemid 32004658)
243. Twohig, J.P., Roberts, M.I., Gavalda, N., Rees-Taylor, E.L., Giralt, A., Adams, D., Brooks, S.P., Bull, M.J., Calder, C.J., Cuff, S., et al. (2010). Age-dependent maintenance of motor control and corticos-triatal innervation by death receptor 3. J. Neurosci. 30, 3782-3792.
244. Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006). Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet 367, 29-35. (Pubitemid 43038667)
245. Umeuchi, H., Kawashima, Y. , Aoki, C.A., Kurokawa, T., Nakao, K., Itoh, M., Kikuchi, K., Kato, T., Okano, K., Gershwin, M.E., et al. (2005). Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and anti-pruritic activity of a novel kappa-opioid receptor agonist nal-furafine hydrochloride. Eur. J. Pharmacol. 518, 133-139. (Pubitemid 41133636)
246. Van der Zee, C.E., Ross, G.M., Riopelle, R.J., and Hagg, T. (1996). Survival of cholinergic forebrain neurons in developing p75NG-FR-deficient mice. Science 274, 1729-1732. (Pubitemid 26414909)
247. von Schack, D., Casademunt, E., Schweigreiter, R., Meyer, M., Bibel, M., and Dechant, G. (2001). Complete ablation of the neu-rotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat. Neurosci. 4, 977-978. (Pubitemid 32924135)
248. Wang, E.C., Kitson, J., Thern, A., Williamson, J., Farrow, S.N., and Owen, M.J. (2001). Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 53, 59-63. (Pubitemid 32209415)
249. Wang, H., Cai, Y., Chia, W., and Yang, X. (2006). Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J. 25, 5783-5793. (Pubitemid 44967762)
250. Wang, K.C., Kim, J.A., Sivasankaran, R., Segal, R., and He, Z. (2002). P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 420, 74-78. (Pubitemid 35291442)
251. Ward, N.L. and Hagg, T. (1999). p75(NGFR) and cholinergic neurons in the developing forebrain: a re-examination. Brain Res. Dev. Brain Res. 11 8 , 79-91. (Pubitemid 30009640)
252. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., and Nagata, S. (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
253. Watts, T.H. (2005). TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23, 23-68. (Pubitemid 40563164)
254. Wen, L., Zhuang, L., Luo, X., and Wei, P. (2003). TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. J. Biol. Chem. 278, 39251-39258. (Pubitemid 37221829)
255. Williams, K.C., Dooley, N.P., Ulvestad, E., Waage, A., Blain, M., Yong, V.W., and Antel, J.P. (1995). Antigen presentation by human fetal astrocytes with the cooperative effect of micro-glia or the microglial-derived cytokine IL-1. J. Neurosci. 15, 1869-1878.
256. Williams, S., Sakic, B., and Hoffman, S.A. (2010). Circulating brain-reactive autoantibodies and behavioral deficits in the MRL model of CNS lupus. J. Neuroimmunol. 218, 73-82.
257. Wilson, N.S., Dixit, V. , and Ashkenazi, A. (2009). Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat, Immunol. 10, 348-355.
258. Wu, G.S., Burns, T.F., Zhan, Y., Alnemri, E.S., and El-Deiry, W.S. (1999). Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 59, 2770-2775. (Pubitemid 29283105)
259. Yamashita, T., Higuchi, H., and Tohyama, M. (2002). The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J. Cell Biol. 157, 565-570. (Pubitemid 34839785)
260. Yamashita, T., Fujitani, M., Yamagishi, S., Hata, K., and Mimura, F. (2005). Multiple signals regulate axon regeneration through the Nogo receptor complex. Mol. Neurobiol. 32, 105-111. (Pubitemid 41397179)
261. Yamasu, K., Onoe, H., Soma, G., Oshima, H., and Mizuno, D. (1989). Secretion of tumor necrosis factor during fetal and neonatal development of the mouse: ontogenic inflammation. J. Biol. Response Mod. 8, 644-655. (Pubitemid 20026030)
262. Yan, Q. and Johnson, E.M. Jr. (1988). An immunohistochemical study of the nerve growth factor receptor in developing rats. J. Neurosci. 8, 3481-3498.
263. Yang, C., Lai, H., Zhan, C., Xiao, Y., and Zheng, W. (2002a). nNOS expression of hippocampal neurons in aged rats after brain isch-emia/reperfusion and its role in DND development. Chin. J. Traumatol. 5, 232-236. (Pubitemid 43026792)
264. Yang, L., Lindholm, K., Konishi, Y., Li, R., and Shen, Y. (2002b). Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways. J. Neurosci. 22, 3025-3032. (Pubitemid 35379191)
265. Yano, H. and Chao, M.V. (2000). Neurotrophin receptor structure and interactions. Pharm. Acta. Helv. 74, 253-260. (Pubitemid 30182578)
266. Yeo, T.T., Chua-Couzens, J., Butcher, L.L., Bredesen, D.E., Cooper, J.D., Valletta,J.S., Mobley, W.C., and Longo, .M. (1997). Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J. Neurosci. 17, 7594-7605. (Pubitemid 27426199)
267. Yu, K.Y., Kwon, B., Ni, J., Zhai, Y. , Ebner, R., and Kwon, B.S. (1999). A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apop-tosis. J. Biol. Chem. 274, 13733-13736.
268. Zhou, Q.Y. and Palmiter, R.D. (1995). Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83, 1197-1209. (Pubitemid 26007810)
269. Zuliani, C., Kleber, S., Klussmann, S., Wenger, T., Kenzelmann, M., Schreglmann, N., Martinez, A., del Rio, J.A., Soriano, E., Vodrazka, P., et al. (2006). Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ. 13, 31-40.