Probiotics, nuclear receptor signaling, and anti-inflammatory pathways

Gastroenterology Research and Practice

Volumn , Issue , 2011, Pages

  Sun, Jun ^a,b   Yoon, Sonia S ^a  

^a STRONG MEMORIAL HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; PROBIOTIC AGENT; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR; VITAMIN D RECEPTOR;

ANTIBIOTIC ASSOCIATED DIARRHEA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIFIDOBACTERIUM BIFIDUM; CLOSTRIDIUM DIFFICILE INFECTION; COLITIS; CROHN DISEASE; DIARRHEA; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; ENTERITIS; ESCHERICHIA COLI; GASTROENTERITIS; HUMAN; ILEITIS; IMMUNOMODULATION; IN VIVO STUDY; IRRITABLE COLON; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS CASEI; LACTOBACILLUS RHAMNOSUS; NONHUMAN; QUALITY OF LIFE; SACCHAROMYCES BOULARDII; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS;

EID: 80053507916     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2011/971938     Document Type: Article

References (159)

1. McFarland L. V., Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections Anaerobe 2009 15 6 274 280
2. Neish A. S., Microbes in gastrointestinal health and disease Gastroenterology 2009 136 1 65 80
3. Garrett W. S., Gordon J. I., Glimcher L. H., Homeostasis and Inflammation in the Intestine Cell 2010 140 6 859 870
4. Joossens M., Huys G., Cnockaert M., De Preter V., Verbeke K., Rutgeerts P., Vandamme P., Vermeire S., Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives Gut 2011 60 5 631 637
5. Sobhani I., Tap J., Roudot-Thoraval F., Roperch J. P., Letulle S., Langella P., Gérard C., van Nhieu J. T., Furet J. P., Microbial dysbiosis in colorectal cancer (CRC) patients PLoS ONE 2011 6 1
6. Sjgren Y. M., Jenmalm M. C., Bttcher M. F., Bjrkstén B., Sverremark-Ekstrm E., Altered early infant gut microbiota in children developing allergy up to 5 years of age Clinical and Experimental Allergy 2009 39 4 518 526
7. Bjrkstén B., Naaber P., Sepp E., Mikelsaar M., The intestinal microflora in allergic Estonian and Swedish 2-year-old children Clinical and Experimental Allergy 1999 29 3 342 346 (Pubitemid 29145134)
8. Yan A. W., Fouts D. E., Brandl J., Strkel P., Torralba M., Schott E., Tsukamoto H., Nelson K. E., Brenner D. A., Schnabl B., Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology 2011 53 1 96 105
9. Kassinen A., Krogius-Kurikka L., Mkivuokko H., Rinttil T., Paulin L., Corander J., Malinen E., Apajalahti J., Palva A., The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects Gastroenterology 2007 133 1 24 33 (Pubitemid 47031125)
10. Ley R. E., Turnbaugh P. J., Klein S., Gordon J. I., Microbial ecology: human gut microbes associated with obesity Nature 2006 444 7122 1022 1023 (Pubitemid 46018512)
11. Vijay-Kumar M., Aitken J. D., Carvalho F. A., Cullender T. C., Mwangi S., Srinivasan S., Sitaraman S. V., Knight R., Ley R. E., Gewirtz A. T., Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5 Science 2010 328 5975 228 231
12. Ley R. E., Obesity and the human microbiome Current Opinion in Gastroenterology 2010 26 1 5 11
13. Ley R. E., Bckhed F., Turnbaugh P., Lozupone C. A., Knight R. D., Gordon J. I., Obesity alters gut microbial ecology Proceedings of the National Academy of Sciences of the United States of America 2005 102 31 11070 11075 (Pubitemid 41105994)
14. Manichanh C., Rigottier-Gois L., Bonnaud E., Gloux K., Pelletier E., Frangeul L., Nalin R., Jarrin C., Chardon P., Marteau P., Roca J., Dore J., Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach Gut 2006 55 2 205 211 (Pubitemid 43117279)
15. Frank D. N., Amand A. L. S., Feldman R. A., Boedeker E. C., Harpaz N., Pace N. R., Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases Proceedings of the National Academy of Sciences of the United States of America 2007 104 34 13780 13785 (Pubitemid 350003397)
16. Conte M. P., Schippa S., Zamboni I., Penta M., Chiarini F., Seganti L., Osborn J., Falconieri P., Borrelli O., Cucchiara S., Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease Gut 2006 55 12 1760 1767 (Pubitemid 44893575)
17. Sartor R. B., Microbial influences in inflammatory bowel diseases Gastroenterology 2008 134 2 577 594 (Pubitemid 351173057)
18. Packey C. D., Sartor R. B., Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases Journal of Internal Medicine 2008 263 6 597 606 (Pubitemid 351678591)
19. Reiff C., Kelly D., Inflammatory bowel disease, gut bacteria and probiotic therapy International Journal of Medical Microbiology 2010 300 1 25 33
20. Sartor R. B., Mechanisms of disease: pathogenesis of crohn's disease and ulcerative colitis Nature Clinical Practice Gastroenterology and Hepatology 2006 3 7 390 407 (Pubitemid 44018812)
21. Lilly D. M., Stillwell R. H., Probiotics: growth-promoting factors produced by microorganisms Science 1965 147 3659 747 748
22. Quigley E. M., Probiotics in gastrointestinal disorders Hospital Practice 2010 38 4 122 129
23. Oelschlaeger T. A., Mechanisms of probiotic actionsa review International Journal of Medical Microbiology 2010 300 1 57 62
24. Spyropoulos B. G., Misiakos E. P., Fotiadis C., Stoidis C. N., Antioxidant properties of probiotics and their protective effects in the pathogenesis of radiation-induced enteritis and coliti Digestive Diseases and Sciences 2010 52 2 285 294
25. Yan F., Polk D. B., Probiotics as functional food in the treatment of diarrhea Current Opinion in Clinical Nutrition and Metabolic Care 2006 9 6 717 721 (Pubitemid 44624619)
26. Madsen K., Probiotics in critically ill patients Journal of Clinical Gastroenterology 2008 42 supplement 3 S116 S118
27. Fotiadis C. I., Stoidis C. N., Spyropoulos B. G., Zografos E. D., Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer World Journal of Gastroenterology 2008 14 42 6453 6457
28. Francavilla R., Miniello V., Magist A. M., De Canio A., Bucci N., Gagliardi F., Lionetti E., Castellaneta S., Polimeno L., Peccarisi L., Indrio F., Cavallo L., A randomized controlled trial of lactobacillus GG in children with functional abdominal pain Pediatrics 2010 126 6 e1445 e1452
29. Thomas D. W., Greer F. R., Bhatia J. J. S., Abrams S. A., Daniels S. R., Schneider M. B., Silverstein J., Stettler N., Heitlinger L. A., Baker R. D., Gremse D. A., Gugig R., Lightdale J. R., Clinical reportprobiotics and prebiotics in pediatrics Pediatrics 2010 126 6 1217 1231
30. Damaskos D., Kolios G., Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope' British Journal of Clinical Pharmacology 2008 65 4 453 467 (Pubitemid 351365144)
31. Tursi A., Brandimarte G., Papa A., Giglio A., Elisei W., Giorgetti G. M., Forti G., Morini S., Hassan C., Pistoia M. A., Modeo M. E., Rodino' S., D'Amico T., Sebkova L., Sacca' N., Di Giulio E., Luzza F., Imeneo M., Larussa T., Di Rosa S., Annese V., Danese S., Gasbarrini A., Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study American Journal of Gastroenterology 2010 105 10 2218 2227
32. Vanderpool C., Yan F., Polk D. B., Mechanisms of probiotic action: implications for therapeutic applications in inflammatory bowel diseases Inflammatory Bowel Diseases 2008 14 11 1585 1596
33. Watanabe T., Nishio H., Tanigawa T., Yamagami H., Okazaki H., Watanabe K., Tominaga K., Fujiwara Y., Oshitani N., Asahara T., Nomoto K., Higuchi K., Takeuchi K., Arakawa T., Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid American Journal of Physiology 2009 297 3 G506 G513
34. Zhang L., Li N., Caicedo R., Neu J., Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor- -induced interleukin-8 production in Caco-2 cells Journal of Nutrition 2005 135 7 1752 1756 (Pubitemid 40980729)
35. Petrof E. O., Kojima K., Ropeleski M. J., Musch M. W., Tao Y., De Simone C., Chang E. B., Probiotics inhibit nuclear factor- B and induce heat shock proteins in colonic epithelial cells through proteasome inhibition Gastroenterology 2004 127 5 1474 1487 (Pubitemid 39457773)
36. Petrof E. O., Claud E. C., Sun J., Abramova T., Guo Y., Waypa T. S., He S. M., Nakagawa Y., Chang E. B., Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function Inflammatory Bowel Diseases 2009 15 10 1537 1547
37. Wang B., Li J., Chen J., Huang Q., Li N., Li J., Effect of live Lactobacillus plantarum L2 on TNF- -induced MCP-1 production in Caco-2 cells International Journal of Food Microbiology 2010 142 1-2 237 241
38. Tien M. T., Girardin S. E., Regnault B., Le Bourhis L., Dillies M. A., Coppée J. Y., B'Ourdet-Sicard R., Sansonetti P. J., Pédron T., Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells Journal of Immunology 2006 176 2 1228 1237 (Pubitemid 43099727)
39. Ruiz P. A., Hoffmann M., Szcesny S., Blaut M., Haller D., Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats Immunology 2005 115 4 441 450 (Pubitemid 41032432)
40. Martins F. S., Dalmasso G., Arantes R. M. E., Doye A., Lemichez E., Lagadec P., Imbert V., Peyron J. F., Rampal P., Nicoli J. R., Czerucka D., Interaction of Saccharomyces boulardii with Salmonella enterica serovar typhimurium protects mice and modifies T84 cell response to the infection PLoS ONE 2010 5 1
41. Schlee M., Harder J., Kten B., Stange E. F., Wehkamp J., Fellermann K., Probiotic lactobacilli and VSL#3 induce enterocyte -defensin 2 Clinical and Experimental Immunology 2008 151 3 528 535 (Pubitemid 351160737)
42. Wehkamp J., Harder J., Wehkamp K., Wehkamp-Von Meissner B., Schlee M., Enders C., Sonnenborn U., Nuding S., Bengmark S., Fellermann K., Schrder J. M., Stange E. F., NF- B- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium Infection and Immunity 2004 72 10 5750 5758 (Pubitemid 39303685)
43. Tao Y., Drabik K. A., Waypa T. S., Musch M. W., Alverdy J. C., Schneewind O., Chang E. B., Petrof E. O., Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells American Journal of Physiology 2006 290 4 C1018 C1030
44. Chen X., Fruehauf J., Goldsmith J. D., Xu H., Katchar K. K., Koon H. W., Zhao D., Kokkotou E. G., Pothoulakis C., Kelly C. P., Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice Gastroenterology 2009 137 3 914 923
45. Ghadimi D., De Vrese M., Heller K. J., Schrezenmeir J., Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells Inflammatory Bowel Diseases 2010 16 3 410 427
46. Vizoso Pinto M. G., Rodriguez Gmez M., Seifert S., Watzl B., Holzapfel W. H., Franz C. M. A. P., Lactobacilli stimulate the innate immune response and modulate the TLR expression of HT29 intestinal epithelial cells in vitro International Journal of Food Microbiology 2009 133 1-2 86 93
47. Rachmilewitz D., Katakura K., Karmeli F., Hayashi T., Reinus C., Rudensky B., Akira S., Takeda K., Lee J., Takabayashi K., Raz E., Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis Gastroenterology 2004 126 2 520 528 (Pubitemid 38182309)
48. Grabig A., Paclik D., Guzy C., Dankof A., Baumgart D. C., Erckenbrecht J., Raupach B., Sonnenborn U., Eckert J., Schumann R. R., Wiedenmann B., Dignass A. U., Sturm A., Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways Infection and Immunity 2006 74 7 4075 4082 (Pubitemid 43993340)
49. Kaji R., Kiyoshima-Shibata J., Nagaoka M., Nanno M., Shida K., Bacterial teichoic acids reverse predominant IL-12 production induced by certain lactobacillus strains into predominant IL-10 production via TLR2-dependent ERK activation in macrophages Journal of Immunology 2010 184 7 3505 3513
50. Seth A., Yan F., Polk D. B., Rao R. K., Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- And MAP kinase-dependent mechanism American Journal of Physiology 2008 294 4 G1060 G1069
51. Ewaschuk J. B., Diaz H., Meddings L., Diederichs B., Dmytrash A., Backer J., Langen M. L.-V., Madsen K. L., Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function American Journal of Physiology 2008 295 5 G1025 G1034
52. Anderson R. C., Cookson A. L., McNabb W. C., Park Z., McCann M. J., Kelly W. J., Roy N. C., Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation BMC Microbiology 2010 10, article 316
53. Zhou Y., Qin H., Zhang M., Shen T., Chen H., Ma Y., Chu Z., Zhang P., Liu Z., Lactobacillus plantarum inhibits intestinal epithelial barrier dysfunction induced by unconjugated bilirubin British Journal of Nutrition 2010 104 3 390 401
54. Anderson R. C., Cookson A. L., McNabb W. C., Kelly W. J., Roy N. C., Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function FEMS Microbiology Letters 2010 309 2 184 192
55. Karczewski J., Troost F. J., Konings I., Dekker J., Kleerebezem M., Brummer R. -J.M., Wells J. M., Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier American Journal of Physiology 2010 298 6 G851 G859
56. Khailova L., Dvorak K., Arganbright K. M., Halpern M. D., Kinouchi T., Yajima M., Dvorak B., Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis American Journal of Physiology 2009 297 5 G940 G949
57. Mennigen R., Nolte K., Rijcken E., Utech M., Loeffler B., Senninger N., Bruewer M., Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis American Journal of Physiology 2009 296 5 G1140 G1149
58. Moorthy G., Murali M. R., Devaraj S. N., Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats Nutrition 2009 25 3 350 358
59. Putaala H., Salusjrvi T., Nordstrm M., Saarinen M., Ouwehand A. C., Bech Hansen E., Rautonen N., Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression Research in Microbiology 2008 159 9-10 692 698
60. Ukena S. N., Singh A., Dringenberg U., Engelhardt R., Seidler U., Hansen W., Bleich A., Bruder D., Franzke A., Rogler G., Suerbaum S., Buer J., Gunzer F., Westendorf A. M., Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity PLoS ONE 2007 2 12
61. Zyrek A. A., Cichon C., Helms S., Enders C., Sonnenborn U., Schmidt M. A., Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKC redistribution resulting in tight junction and epithelial barrier repair Cellular Microbiology 2007 9 3 804 816 (Pubitemid 46231983)
62. Johnson-Henry K. C., Donato K. A., Shen-Tu G., Gordanpour M., Sherman P. M., Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function Infection and Immunity 2008 76 4 1340 1348 (Pubitemid 351561979)
63. Resta-Lenert S., Barrett K. E., Probiotics and commensals reverse TNF- -and IFN- -induced dysfunction in human intestinal epithelial cells Gastroenterology 2006 130 3 731 746 (Pubitemid 43374524)
64. Matsumoto S., Hara T., Hori T., Mitsuyama K., Nagaoka M., Tomiyasu N., Suzuki A., Sata M., Probiotic Lactobacillus-induced improvement in murine chronic inflammatory bowel disease is associated with the down-regulation of pro-inflammatory cytokines in lamina propria mononuclear cells Clinical and Experimental Immunology 2005 140 3 417 426 (Pubitemid 40813951)
65. Jandu N., Zeng Z. J., Johnson-Henry K. C., Sherman P. M., Probiotics prevent enterohaemorrhagic Escherichia coli O157: H7-mediated inhibition of interferon- -induced tyrosine phosphorylation of STAT-1 Microbiology 2009 155 Pt 2 531 540
66. Martins F. S., Elian S. D. A., Vieira A. T., Tiago F. C.P., Martins A. K.S., Silva F. C.P., Souza T. L.S., Sousa L. P., Arajo H. R.C., Pimenta P. F., Bonjardim C. A., Arantes R. M., Teixeira M. M., Nicoli J. R., Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever International Journal of Medical Microbiology 2011 301 4 359 364
67. Reiff C., Delday M., Rucklidge G., Reid M., Duncan G., Wohlgemuth S., Hrmannsperger G., Loh G., Blaut M., Collie-Duguid E., Haller D., Kelly D., Balancing inflammatory, lipid, and xenobiotic signaling pathways by VSL#3, a biotherapeutic agent, in the treatment of inflammatory bowel disease Inflammatory Bowel Diseases 2009 15 11 1721 1736
68. Rooj A. K., Kimura Y., Buddington R. K., Metabolites produced by probiotic Lactobacilli rapidly increase glucose uptake by Caco-2 cells BMC Microbiology 2010 10, article 16
69. Lin P. W., Myers L. E. S., Ray L., Song S. C., Nasr T. R., Berardinelli A. J., Kundu K., Murthy N., Hansen J. M., Neish A. S., Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation Free Radical Biology and Medicine 2009 47 8 1205 1211
70. Eiseman B., Silen W., Bascom G. S., Kauvar A. J., Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis Surgery 1958 44 5 854 859
71. Aas J., Gessert C. E., Bakken J. S., Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube Clinical Infectious Diseases 2003 36 5 580 585 (Pubitemid 36259562)
72. Persky S. E., Brandt L. J., Treatment of recurrent Clostridium difficile-associated diarrhea by administration of donated stool directly through a colonoscope American Journal of Gastroenterology 2000 95 11 3283 3285
73. Yoon S. S., Brandt L. J., Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients Journal of Clinical Gastroenterology 2010 44 8 562 566
74. Russell G., Kaplan J., Ferraro M., Michelow I. C., Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol Pediatrics 2010 126 1 e239 e242
75. Khoruts A., Dicksved J., Jansson J. K., Sadowsky M. J., Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent clostridium difficile-associated diarrhea Journal of Clinical Gastroenterology 2010 44 5 354 360
76. Gao X. W., Mubasher M., Fang C. Y., Reifer C., Miller L. E., Dose-response efficacy of a proprietary probiotic formula of lactobacillus acidophilus CL1285 and lactobacillus casei LBC80R for antibiotic-associated diarrhea and clostridium difficile-associated diarrhea prophylaxis in adult patients American Journal of Gastroenterology 2010 105 7 1636 1641
77. McFarland L. V., Systematic review and meta-analysis of saccharomyces boulardii in adult patients World Journal of Gastroenterology 2010 16 18 2202 2222
78. Guglielmetti S., Mora D., Gschwender M., Popp K., Randomised clinical trial: bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of lifea double-blind, placebo-controlled study Alimentary Pharmacology and Therapeutics 2011 33 10 1123 1132
79. Choi C. H., Jo S. Y., Park H. J., Chang S. K., Byeon J.-S., Myung S.-J., A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritablebowel syndrome: effect on quality of life. Journal of Clinical Gastroenterology. In press
80. Parkes G. C., Sanderson J. D., Whelan K., Treating irritable bowel syndrome with probiotics: the evidence Proceedings of the Nutrition Society 2010 69 2 187 194
81. Moayyedi P., Ford A. C., Talley N. J., Cremonini F., Foxx-Orenstein A. E., Brandt L. J., Quigley E. M. M., The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review Gut 2010 59 3 325 332
82. Brenner D. M., Moeller M. J., Chey W. D., Schoenfeld P. S., The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review American Journal of Gastroenterology 2009 104 4 1033 1049
83. Sood A., Midha V., Makharia G. K., Ahuja V., Singal D., Goswami P., Tandon R. K., The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis Clinical Gastroenterology and Hepatology 2009 7 11 1202 1209
84. Bibiloni R., Fedorak R. N., Tannock G. W., Madsen K. L., Gionchetti P., Campieri M., De Simone C., Sartor R. B., VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis American Journal of Gastroenterology 2005 100 7 1539 1546 (Pubitemid 41032360)
85. Kruis W., Fri P., Pokrotnieks J., Luk M., Fixa B., Kak M., Kamm M. A., Weismueller J., Beglinger C., Stolte M., Wolff C., Schulze J., Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine Gut 2004 53 11 1617 1623 (Pubitemid 39434105)
86. Zocco M. A., Dal Verme L. Z., Cremonini F., Piscaglia A. C., Nista E. C., Candelli M., Novi M., Rigante D., Cazzato I. A., Ojetti V., Armuzzi A., Gasbarrini G., Gasbarrini A., Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis Alimentary Pharmacology and Therapeutics 2006 23 11 1567 1574 (Pubitemid 43727463)
87. Gionchetti P., Rizzello F., Helwig U., Venturi A., Lammers K. M., Brigidi P., Vitali B., Poggioli G., Miglioli M., Campieri M., Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial Gastroenterology 2003 124 5 1202 1209 (Pubitemid 36531796)
88. Mimura T., Rizzello F., Helwig U., Poggioli G., Schreiber S., Talbot I. C., Nicholls R. J., Gionchetti P., Campieri M., Kamm M. A., Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis Gut 2004 53 1 108 114 (Pubitemid 38083018)
89. Prantera C., Scribano M. L., Falasco G., Andreoli A., Luzi C., Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG Gut 2002 51 3 405 409
90. Garcia Vilela E., De Lourdes De Abreu Ferrari M., Oswaldo Da Gama Torres H., Guerra Pinto A., Carolina Carneiro Aguirre A., Paiva Martins F., Marcos Andrade Goulart E., Sales Da Cunha A., Influence of Saccharomyces boulardii on the intestinal permeability of patients with Crohn's disease in remission Scandinavian Journal of Gastroenterology 2008 43 7 842 848 (Pubitemid 351918523)
91. Guslandi M., Mezzi G., Sorghi M., Testoni P. A., Saccharomyces boulardii in maintenance treatment of Crohn's disease Digestive Diseases and Sciences 2000 45 7 1462 1464 (Pubitemid 30636526)
92. Ewaschuk J. B., Dieleman L. A., Probiotics and prebiotics in chronic inflammatory bowel diseases World Journal of Gastroenterology 2006 12 37 5941 5950 (Pubitemid 44608471)
93. Hedin C., Whelan K., Lindsay J. O., Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials Proceedings of the Nutrition Society 2007 66 3 307 315 (Pubitemid 47076227)
94. Ng S. C., Hart A. L., Kamm M. A., Stagg A. J., Knight S. C., Mechanisms of action of probiotics: recent advances Inflammatory Bowel Diseases 2009 15 2 300 310
95. Alfaleh K., Bassler D., Probiotics for prevention of necrotizing enterocolitis in preterm infants Cochrane Database of Systematic Reviews 2008 1, article CD005496
96. Bousvaros A., Guandalini S., Baldassano R. N., Botelho C., Evans J., Ferry G. D., Goldin B., Hartigan L., Kugathasan S., Levy J., Murray K. F., Oliva-Hemker M., Rosh J. R., Tolia V., Zholudev A., Vanderhoof J. A., Hibberd P. L., A randomized, double-blind trial of lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease Inflammatory Bowel Diseases 2005 11 9 833 839 (Pubitemid 41368272)
97. Schultz M., Timmer A., Herfarth H. H., Sartor R. B., Vanderhoof J. A., Rath H. C., Lactobacillus GG in inducing and maintaining remission of Crohn's disease BMC Gastroenterology 2004 4, article 5
98. Mohamadzadeh M., Olson S., Kalina W. V., Ruthel G., Demmin G. L., Warfield K. L., Bavari S., Klaenhammer T. R., Lactobacilli active human dendritic cells that skew T cells toward T helper 1 polarization Proceedings of the National Academy of Sciences of the United States of America 2005 102 8 2880 2885 (Pubitemid 40299885)
99. Hart A. L., Lammers K., Brigidi P., Vitali B., Rizzello F., Gionchetti P., Campieri M., Kamm M. A., Knight S. C., Stagg A. J., Modulation of human dendritic cell phenotype and function by probiotic bacteria Gut 2004 53 11 1602 1609 (Pubitemid 39434103)
100. Fernandez E. M., Valenti V., Rockel C., Hermann C., Pot B., Boneca I. G., Grangette C., Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide Gut 2011 60 8 1050 1059
101. Chamaillard M., Girardin S. E., Viala J., Philpott D. J., Nods, nalps and naip: intracellular regulators of bacterial-induced inflammation Cellular Microbiology 2003 5 9 581 592 (Pubitemid 37080669)
102. Wehkamp J., Stange E. F., Is there a role for defensins in IBD? Inflammatory Bowel Diseases 2008 14 supplement 2 S85 S87
103. Schlee M., Wehkamp J., Altenhoefer A., Oelschlaeger T. A., Stange E. F., Fellermann K., Induction of human -defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin Infection and Immunity 2007 75 5 2399 2407 (Pubitemid 46744330)
104. Hollander D., Crohn's diseasea permeability disorder of the tight junction? Gut 1988 29 12 1621 1624
105. Schulzke J. D., Ploeger S., Amasheh M., Fromm A., Zeissig S., Troeger H., Richter J., Bojarski C., Schumann M., Fromm M., Epithelial tight junctions in intestinal inflammation Annals of the New York Academy of Sciences 2009 1165 294 300
106. Weber C. R., Nalle S. C., Tretiakova M., Rubin D. T., Turner J. R., Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation Laboratory Investigation 2008 88 10 1110 1120
107. Zeissig S., Brgel N., Gnzel D., Richter J., Mankertz J., Wahnschaffe U., Kroesen A. J., Zeitz M., Fromm M., Schulzke J. D., Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease Gut 2007 56 1 61 72 (Pubitemid 46044890)
108. Arnott I. D. R., Kingstone K., Ghosh S., Abnormal intestinal permeability predicts relapse in inactive Crohn disease Scandinavian Journal of Gastroenterology 2000 35 11 1163 1169
109. Wyatt J., Vogelsang H., Hubl W., Waldhoer T., Lochs H., Intestinal permeability and the prediction of relapse in Crohn's disease Lancet 1993 341 8858 1437 1439 (Pubitemid 23161445)
110. Lovato P., Brender C., Agnholt J., Kelsen J., Kaltoft K., Svejgaard A., Eriksen K. W., Woetmann A., dum N., Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease Journal of Biological Chemistry 2003 278 19 16777 16781 (Pubitemid 36799545)
111. Yeganegi M., Leung C. G., Martins A., Kim S. O., Reid G., Challis J. R. G., Bocking A. D., Lactobacillus rhamnosus GR-1-induced IL-10 production in human placental trophoblast cells involves activation of JAK/STAT and MAPK pathways Reproductive Sciences 2010 17 11 1043 1051
112. Giuliani A., Pirri G., Nicoletto S. F., Antimicrobial peptides: an overview of a promising class of therapeutics Central European Journal of Biology 2007 2 1 1 33 (Pubitemid 46450753)
113. Boman H. G., Peptide antibiotics and their role in innate immunity Annual Review of Immunology 1995 13 61 92
114. Zasloff M., Antimicrobial peptides of multicellular organisms Nature 2002 415 6870 389 395 (Pubitemid 34100944)
115. Peters B. M., Shirtliff M. E., Jabra-Rizk M. A., Antimicrobial peptides: primeval molecules or future drugs? PLoS Pathogens 2010 6 10
116. Wehkamp J., Stange E. F., Fellermann K., Defensin-immunology in inflammatory bowel disease Gastroentérologie Clinique et Biologique 2009 33 supplement 3 S137 144
117. Tang Y. Q., Yuan J., sapay G., sapay K., Tran D., Miller C. J., Ouellette A. J., Selsted M. E., A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated -defensins Science 1999 286 5439 498 502
118. Ouellette A. J., Bevins C. L., Paneth cell defensins and innate immunity of the small bowel Inflammatory Bowel Diseases 2001 7 1 43 50
119. Wehkamp J., Fellermann K., Herrlinger K. R., Bevins C. L., Stange E. F., Mechanisms of disease: defensins in gastrointestinal diseases Nature Clinical Practice Gastroenterology and Hepatology 2005 2 9 406 415 (Pubitemid 41486093)
120. Jager S., Stange E. F., Wehkamp J., Antimicrobial peptides in gastrointestinal inflammation International Journal of Inflammation 2010 2010 11
121. Wilson C. L., Ouellette A. J., Satchell D. P., Ayabe T., Lpez-Boado Y. S., Stratman J. L., Hultgren S. J., Matrisian L. M., Parks W. C., Regulation of intestinal -defensin activation by the metalloproteinase matrilysin in innate host defense Science 1999 286 5437 113 117 (Pubitemid 29484488)
122. Peyrin-Biroulet L., Beisner J., Wang G., Nuding S., Oommen S. T., Kelly D., Parmentier-Decrucq E., Dessein R., Merour E., Chavatte P., Grandjean T., Bresseno A., Desreumaux P., Colombel J. F., Desvergne B., Stange E. F., Wehkamp J., Chamaillard M., Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon Proceedings of the National Academy of Sciences of the United States of America 2010 107 19 8772 8777
123. Lala S., Ogura Y., Osborne C., Hor S. Y., Bromfield A., Davies S., Ogunbiyi O., Nuez G., Keshav S., Crohn's disease and the NOD2 gene: a role for paneth cells Gastroenterology 2003 125 1 47 57 (Pubitemid 36799106)
124. Wehkamp J., Harder J., Weichenthal M., Schwab M., Schffeler E., Schlee M., Herrlinger K. R., Stallmach A., Noack F., Fritz P., Schrder J. M., Bevins C. L., Fellermann K., Stange E. F., NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal -defensin expression Gut 2004 53 11 1658 1664 (Pubitemid 39434112)
125. Wehkamp J., Harder J., Weichenthal M., Mueller O., Herrlinger K. R., Fellermann K., Schroeder J. M., Stange E. F., Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis Inflammatory Bowel Diseases 2003 9 4 215 223
126. Boman H. G., Innate immunity and the normal microflora Immunological Reviews 2000 173 5 16 (Pubitemid 30095206)
127. Liu P. T., Schenk M., Walker V. P., Dempsey P. W., Kanchanapoomi M., Wheelwright M., Vazirnia A., Zhang X., Steinmeyer A., Zgel U., Hollis B. W., Cheng G., Modlin R. L., Convergence of IL-1 and VDR activation pathways in human TLR2/1-induced antimicrobial responses PLoS ONE 2009 4 6
128. Evans R. M., The steroid and thyroid hormone receptor superfamily Science 1988 240 4854 889 895
129. Bensinger S. J., Tontonoz P., Integration of metabolism and inflammation by lipid-activated nuclear receptors Nature 2008 454 7203 470 477
130. Wang K., Wan Y. J. Y., Nuclear receptors and inflammatory diseases Experimental Biology and Medicine 2008 233 5 496 506 (Pubitemid 351657351)
131. Mangelsdorf D. J., Thummel C., Beato M., Herrlich P., Schtz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R. M., The nuclear receptor super-family: the second decade Cell 1995 83 6 835 839
132. Glass C. K., Ogawa S., Combinatorial roles of nuclear receptors in inflammation and immunity Nature Reviews Immunology 2006 6 1 44 55 (Pubitemid 43279752)
133. Fajas L., Auboeuf D., Raspé E., Schoonjans K., Lefebvre A. M., Saladin R., Najib J., Laville M., Fruchart J. C., Deeb S., Vidal-Puig A., Flier J., Briggs M. R., Staels B., Vidal H., Auwerx J., The organization, promoter analysis, and expression of the human PPAR gene Journal of Biological Chemistry 1997 272 30 18779 18789 (Pubitemid 27318225)
134. Adachi M., Kurotani R., Morimura K., Shah Y., Sanford M., Madison B. B., Gumucio D. L., Marin H. E., Peters J. M., Young H. A., Gonzalez F. J., Peroxisome proliferator activated receptor in colonic epithelial cells protects against experimental inflammatory bowel disease Gut 2006 55 8 1104 1113 (Pubitemid 44085676)
135. Bassaganya-Riera J., Reynolds K., Martino-Catt S., Cui Y., Hennighausen L., Gonzalez F., Rohrer J., Benninghoff A. U., Hontecillas R., Activation of PPAR and by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease Gastroenterology 2004 127 3 777 791 (Pubitemid 39208411)
136. Dubuquoy L., Jansson E., Deeb S., Rakotobe S., Karoui M., Colombel J. F., Auwerx J., Pettersson S., Desreumaux P., Impaired expression of peroxisome proliferator-activated receptor in ulcerative colitis Gastroenterology 2003 124 5 1265 1276 (Pubitemid 36531802)
137. Rousseaux C., Lefebvre B., Dubuquoy L., Lefebvre P., Romano O., Auwerx J., Metzger D., Wahli W., Desvergne B., Naccari G. C., Chavatte P., Farce A., Bulois P., Cortot A., Colombel J. F., Desreumaux P., Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator- activated receptor- Journal of Experimental Medicine 2005 201 8 1205 1215 (Pubitemid 40629065)
138. Haussler M. R., Whitfield G. K., Haussler C. A., Hsieh J. C., Thompson P. D., Selznick S. H., Dominguez C. E., Jurutka P. W., The nuclear vitamin D receptor: biological and molecular regulatory properties revealed Journal of Bone and Mineral Research 1998 13 3 325 349 (Pubitemid 28146215)
139. Kato S., The function of vitamin D receptor in vitamin D action Journal of Biochemistry 2000 127 5 717 722 (Pubitemid 30317893)
140. Kamen D. L., Tangpricha V., Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity Journal of Molecular Medicine 2010 88 5 441 450
141. Waterhouse J. C., Perez T. H., Albert P. J., Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease Annals of the New York Academy of Sciences 2009 1173 757 765
142. Liu P. T., Krutzik S. R., Modlin R. L., Therapeutic implications of the TLR and VDR partnership Trends in Molecular Medicine 2007 13 3 117 124 (Pubitemid 46341960)
143. Gombart A. F., Borregaard N., Koeffler H. P., Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3 FASEB Journal 2005 19 9 1067 1077 (Pubitemid 40946432)
144. Kong J., Zhang Z., Musch M. W., Ning G., Sun J., Hart J., Bissonnette M., Yan C. L., Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier American Journal of Physiology 2008 294 1 G208 G216
145. Lagishetty V., Misharin A. V., Liu N. Q., Lisse T. S., Chun R. F., Ouyang Y., McLachlan S. M., Adams J. S., Hewison M., Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis Endocrinology 2010 151 6 2423 2432
146. Von Essen M. R., Kongsbak M., Schjerling P., Olgaard K., dum N., Geisler C., Vitamin D controls T cell antigen receptor signaling and activation of human T cells Nature Immunology 2010 11 4 344 349
147. Sun J., Vitamin D and mucosal immune function Current Opinion in Gastroenterology 2010 26 6 591 595
148. Wu S., Sun J., Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection Discovery Medicine 2011 11 59 325 335
149. Cantorna M. T., Munsick C., Bemiss C., Mahon B. D., 1,25- Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease Journal of Nutrition 2000 130 11 2648 2652
150. Sentongo T. A., Semaeo E. J., Stettler N., Piccoli D. A., Stallings V. A., Zemel B. S., Vitamin D status in children, adolescents, and young adults with Crohn disease American Journal of Clinical Nutrition 2002 76 5 1077 1081 (Pubitemid 35244680)
151. Abreu M. T., Kantorovich Y., Vasiliauskas E. A., Gruntmanis U., Matuk R., Daigle K., Chen S., Zehnder D., Lin Y. C., Yang H., Hewison M., Adams J. S., Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density Gut 2004 53 8 1129 1136 (Pubitemid 38961967)
152. Farraye F. A., Use of a novel vitamin d bioavailability test demonstrates that vitamin D absorption is decreased in patients with quiescent crohn's disease Inflammatory Bowel Diseases
153. Wu S., Liao A. P., Xia Y., Li Y. C., Li J. D., Sartor R. B., Sun J., Vitamin D receptor negatively regulates bacterial-stimulated NF- B activity in intestine American Journal of Pathology 2010 177 2 686 697
154. Liu X., Lu R., Xia Y., Sun J., Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo BMC Genomics 2010 11 1 722
155. Kelly D., Campbell J. I., King T. P., Grant G., Jansson E. A., Coutts A. G.P., Pettersson S., Conway S., Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shutting of PPAR- and ReIA Nature Immunology 2004 5 1 104 112 (Pubitemid 38081475)
156. Yoon S., Wu S., Zhang Y., Probiotic regulation of vitamin D receptor in intestinal inflammation. Oral Presentation DDW, 2011
157. Gocek E., Studzinski G. P., Vitamin D and differentiation in cancer Signaling differentiation E. Gocek and G. P. Studzinski Critical Reviews in Clinical Laboratory Sciences 2009 46 4 190 209
158. Samuel S., Sitrin M. D., Vitamin D's role in cell proliferation and differentiation Nutrition Reviews 2008 66 10 supplement 2 S116 S124
159. Demay M. B., Mechanism of vitamin D receptor action Annals of the New York Academy of Sciences 2006 1068 1 204 213 (Pubitemid 43824151)