Clinical report - Probiotics and prebiotics in pediatrics

Pediatrics

Volumn 126, Issue 6, 2010, Pages 1217-1231

  Thomas, Dan W ^a   Greer, Frank R ^a   Bhatia, Jatinder J S ^a   Abrams, Steven A ^a   Daniels, Stephen R ^a   Schneider, Marcie Beth ^a   Silverstein, Janet ^a   Stettler, Nicolas ^a   Heitlinger, Leo A ^a   Baker Jr , Robert D ^a   Gremse, David A ^a   Gugig, Roberto ^a   Lightdale, Jenifer R ^a  

^a NONE

Author keywords

Nutrition; Pediatrics; Prebiotics; Probiotics; Supplements

Indexed keywords

ANTIBIOTIC AGENT; CORTICOSTEROID; LACTULOSE; MESALAZINE; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; ROTAVIRUS VACCINE; SIMETHICONE;

ACUTE DIARRHEA; ALLERGIC DISEASE; ALLERGY; ANTIBIOTIC ASSOCIATED DIARRHEA; ARTIFICIAL MILK; ATOPIC DERMATITIS; ATOPY; BACTERIAL COLONIZATION; BIFIDOBACTERIUM ANIMALIS; BIFIDOBACTERIUM BIFIDUM; CANCER PREVENTION; CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE INFECTION; COLIC; CONSTIPATION; CROHN DISEASE; DIARRHEA; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; EXTRAINTESTINAL INFECTION; GASTROINTESTINAL INFECTION; HELICOBACTER INFECTION; HUMAN; IMMUNE RESPONSE; INFECTION; INTESTINE MUCOSA; IRRITABLE COLON; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS CASEI; LACTOBACILLUS FERMENTUM; LACTOBACILLUS REUTERI; LOW DRUG DOSE; NAUSEA; NECROTIZING ENTEROCOLITIS; NEOPLASM; OTITIS MEDIA; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; ROTAVIRUS INFECTION; SKIN ALLERGY; STREPTOCOCCUS THERMOPHILUS; TREATMENT RESPONSE; ULCERATIVE COLITIS; VERY LOW BIRTH WEIGHT; VIRAL GASTROENTERITIS; VOMITING; CHILD; DIETETICS; GASTROINTESTINAL TRACT; HEALTH FOOD; METHODOLOGY; MICROBIOLOGY; NUTRITION; NUTRITIONAL VALUE; PHYSIOLOGY; UTILIZATION REVIEW;

CHILD; DIETETICS; GASTROINTESTINAL TRACT; HEALTH FOOD; HUMANS; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; NUTRITIVE VALUE; PREBIOTICS; PROBIOTICS;

EID: 78649662645     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-2548     Document Type: Review

References (130)

1. Food and Agriculture Organization of the United Nations; World Health Organization. Guidelines for the evaluation of probiotics in food: joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. Available at: ftp://ftp.fao.org/es/esn/food/wgreport2. pdf. Accessed October 1, 2010
2. Food and Agriculture Organization of the United Nations; World Health Organization. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria: report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Available at: www.who.int/foodsafety/publications/fs-management/en/probiotics.pdf. Accessed October 1, 2010
3. Council for Agricultural Science and Technology. Probiotics: Their Potential to Impact Human Health. Ames, IA: Council for Agricultural Science and Technology; 2007. Available at: www.cast-science. org/websiteUploads/ publicationPDFs/ CAST%20Probiotics%20Issue%20Paper% 20FINAL144.pdf. Accessed October 1, 2010
4. Roberfroid M. Prebiotics: the concept revisited. J Nutr. 2007;137(3 suppl 2): 830S-837S
5. Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland IR. Effects of fermentation products of pro- and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer. 2005;51(1):102-109 (Pubitemid 40365988)
6. Falony G, Vlachou A, Verbrugghe K, De Vuyst L. Cross-feeding between Bifidobacterium longum BB536 and acetateconverting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol. 2006;72(12):7835-7841
7. Grönlund MM, Gueimonde M, Laitinen K, et al. Maternal breast-milk and intestinal bi- fidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin Exp Allergy. 2007;37(12):1764-1772
8. Kullen MJ, Bettler J. The delivery of probiotics and prebiotics to infants. Curr Pharm Des. 2005;11(1):55-74
9. Michail S, Sylvester F, Fuchs G, Issenman R. Clinical efficacy of probiotics: review of the evidence with focus on children. J Pediatr Gastroenterol Nutr. 2006;43(4): 550-557
10. Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks? Am J Clin Nutr. 2006;83(6): 1256 -1264; quiz 1446-1257
11. Szajewska H, Setty M, Mrukowicz J, Guandalini S. Probiotics in gastrointestinal diseases in children: hard and not-so-hard evidence of efficacy. J Pediatr Gastroenterol Nutr. 2006;42(5):454-475 (Pubitemid 43804722)
12. Agostoni C, Axelsson I, Braegger C, et al. Probiotic bacteria in dietetic products for infants: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2004;38(4):365-374
13. Saavedra JM. Clinical applications of probiotic agents. Am J Clin Nutr. 2001;73(6): 1147S-1151S
14. Matarese LE, Seidner DL, Steiger E. The role of probiotics in gastrointestinal disease. Nutr Clin Pract. 2003;18(6):507-516
15. Björkstén B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999;29(3):342-346
16. Heller F, Duchmann R. Intestinal flora and mucosal immune responses. Int J Med Microbiol. 2003;293(1):77-86
17. Berg RD. Bacterial translocation from the gastrointestinal tract. Adv Exp Med Biol. 1999;473:11-30
18. Quan R, Barness LA. Do infants need nucleotide supplemented formula for optimal nutrition? J Pediatr Gastroenterol Nutr. 1990;11(4):429-434
19. Boehm G, Stahl B. Oligosaccharides from milk. J Nutr. 2007;137(3 suppl 2): 847S-849S
20. Yoshioka H, Iseki K, Fujita K. Development and differences of intestinal flora in the neonatal period in breast-fed and bottlefed infants. Pediatrics. 1983;72(3):317-321 (Pubitemid 13051205)
21. Weng M, Walker W. Bacterial colonization, probiotics, and clinical disease. J Pediatr. 2006;149(5):S107-S114
22. Pietzak M. Bacterial colonization of the neonatal gut. J Pediatr Gastroenterol Nutr. 2004;38(4):389-391
23. Tannock G. The intestinal microflora. In: Fuller R, Perdigón G, eds. Gut Flora, Nutrition, Immunity and Health. Oxford, England: Blackwell Press; 2003:1-23
24. Turnbaugh PJ, Ley RE, Hamady M, Fraser- Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007; 449(7164):804-810
25. Winkler P, Ghadimi D, Schrezenmeir J, Kraehenbuhl JP. Molecular and cellular basis of microflora-host interactions. J Nutr. 2007;137(3 suppl 2):756S-772S
26. Calder PC. Immunological parameters: what do they mean? J Nutr. 2007;137(3 suppl 2):773S-780S
27. Corthésy B, Gaskins HR, Mercenier A. Cross-talk between probiotic bacteria and the host immune system. J Nutr. 2007; 137(3 suppl 2):781S-790S
28. Matsuzaki T, Takagi A, Ikemura H, Matsuguchi T, Yokokura T. Intestinal microflora: probiotics and autoimmunity. J Nutr. 2007; 137(3 suppl 2):798S-802S
29. Yuan Q, Walker WA. Innate immunity of the gut: mucosal defense in health and disease. J Pediatr Gastroenterol Nutr. 2004; 38(5):463-473
30. Donovan S. Role of human milk components in gastrointestinal development: current knowledge and future needs. J Pediatr. 2006;149(5):S49-S61
31. Perez PF, Doré J, Leclerc M, et al. Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics. 2007;119(3). Available at: www-.pediatrics.org/cgi/content/full/119/3/e724
32. Oberhelman RA, Gilman RH, Sheen P, et al. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. J Pediatr. 1999;134(1): 15-20 (Pubitemid 29048673)
33. Hatakka K, Savilahti E, Ponka A, et al. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ. 2001;322(7298):1327
34. Thibault H, Aubert-Jacquin C, Goulet O. Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants. J Pediatr Gastroenterol Nutr. 2004;39(2):147-152
35. Saavedra JM, Abi-Hanna A, Moore N, Yolken RH. Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety. Am J Clin Nutr. 2004;79(2):261-267
36. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005;115(1):5-9
37. Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Pract. 2000;54(9):568-571
38. Szajewska H, Kotowska M, Mrukowicz JZ, Armanska M, Mikolajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr. 2001; 138(3):361-365
39. Cortese MM, Parashar UD. Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP) [published correction appears in MMWR Recomm Rep. 2010;59(33): 1074]. MMWR Recomm Rep. 2009;58(RR-2): 1-25
40. Szymański H, Pejcz J, Jawień M, Chmielarczyk A, Strus M, Heczko PB. Treatment of acute infectious diarrhoea in infants and children with a mixture of three Lactobacillus rhamnosus strains: a randomized, double-blind, placebo-controlled trial. Aliment Pharmacol Ther. 2006;23(2):247-253 (Pubitemid 43382034)
41. Szajewska H, Mrukowicz JZ. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr. 2001; 33(suppl 2):S17-S25
42. Van Niel CW, Feudtner C, Garrison MM, Christakis DA. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics. 2002;109(4): 678-684
43. Huang JS, Bousvaros A, Lee JW, Diaz A, Davidson EJ. Efficacy of probiotic use in acute diarrhea in children: a meta-analysis. Dig Dis Sci. 2002;47(11):2625-2634
44. Allen SJ, Okoko B, Martinez E, Gregorio G, Dans LF. Probiotics for treating infectious diarrhoea. Cochrane Database Syst Rev. 2004;(2):CD003048
45. Szajewska H, Ruszczynski M, Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr. 2006;149(3):367-372
46. Corrêa NB, Péret Filho LA, Penna FJ, Lima FM, Nicoli JR. A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants. J Clin Gastroenterol. 2005;39(5): 385-389
47. Hawrelak JA, Whitten DL, Myers SP. Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review. Digestion. 2005;72(1):51-56
48. D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002;324(7350):1361
49. Neaville WA, Tisler C, Bhattacharya A, et al. Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life. J Allergy Clin Immunol. 2003;112(4): 740-746
50. Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997;99(2): 179-185
51. Kalliomäki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol. 2001;107(1): 129-134
52. Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003;361(9372):1869-1871
53. Kopp MV, Salfeld P. Probiotics and prevention of allergic disease. Curr Opin Clin Nutr Metab Care. 2009;12(3):298-303
54. Taylor AL, Dunstan JA, Prescott SL. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol. 2007;119(1): 184-191
55. Prescott SL, Björkstén B. Probiotics for the prevention or treatment of allergic diseases. J Allergy Clin Immunol. 2007;120(2): 255-262
56. Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. 2007;(4):CD006475
57. Penders J, Stobberingh EE, van den Brandt PA, Thijs C. The role of the intestinal microbiota in the development of atopic disorders. Allergy. 2007;62(11):1223-1236 (Pubitemid 47537504)
58. Weston S, Halbert A, Richmond P, Prescott SL. Effects of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child. 2005;90(9):892-897
59. Viljanen M, Savilahti E, Haahtela T, et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy. 2005;60(4):494-500
60. Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, Murrell DF, Tang ML. Probiotics for treating eczema. Cochrane Database Syst Rev. 2008;(4):CD006135
61. Gewolb IH, Schwalbe RS, Taciak VL, Harrison TS, Panigrahi P. Stool microflora in extremely low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1999;80(3): F167-173
62. Penders J, Thijs C, Vink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118(2):511-521
63. Kliegman RM. The relationship of neonatal feeding practices and the pathogenesis and prevention of necrotizing enterocolitis. Pediatrics. 2003;111(3):671-672
64. Cotten CM, Taylor S, Stoll B, et al; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123(1):58-66
65. Alfaleh K, Bassler D. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2008;(1):CD005496
66. Bin-Nun A, Bromiker R, Wilschanski M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr. 2005;147(2):192-196
67. Costalos C, Skouteri V, Gounaris A, et al. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev. 2003;74(2):89-96
68. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants: a prospective doubleblind study. Biol Neonate. 2002;82(2): 103-108
69. Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 1997; 76(2):F101-F107
70. Li Y, Shimizu T, Hosaka A, Kaneko N, Ohtsuka Y, Yamashiro Y. Effects of Bifidobacterium breve supplementation on intestinal flora of low birth weight infants. Pediatr Int. 2004;46(5):509-515
71. Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2005;115(1): 1-4
72. Manzoni P, Mostert M, Leonessa ML, et al. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis. 2006;42(12):1735-1742 (Pubitemid 43839439)
73. Millar MR, Bacon C, Smith SL, Walker V, Hall MA. Enteral feeding of premature infants with Lactobacillus GG. Arch Dis Child. 1993; 69(5 spec No.):483-487 (Pubitemid 23357107)
74. Reuman PD, Duckworth DH, Smith KL, Kagan R, Bucciarelli RL, Ayoub EM. Lack of effect of Lactobacillus on gastrointestinal bacterial colonization in premature infants. Pediatr Infect Dis. 1986;5(6): 663-668
75. Lin HC, Hsu CH, Chen HL, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics. 2008;122(4):693-700
76. Lesbros-Pantoflickova D, Corthesy-Theulaz I, Blum AL. Helicobacter pylori and probiotics. J Nutr. 2007;137(3 suppl 2):812S-818S
77. Sýkora J, Valeckova K, Amlerova J, et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. J Clin Gastroenterol. 2005;39(8):692-698
78. Day AS, Whitten KE, Bohane TD. Use of complementary and alternative medicines by children and adolescents with inflammatory bowel disease. J Paediatr Child Health. 2004;40(12):681-684
79. Heuschkel R, Afzal N, Wuerth A, et al. Complementary medicine use in children and young adults with inflammatory bowel disease. Am J Gastroenterol. 2002;97(2): 382-388
80. Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology. 2004; 126(6):1620-1633
81. Kruis W, Schutz E, Fric P, Fixa B, Judmaier G, Stolte M. Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther. 1997;11(5):853-858 (Pubitemid 27445670)
82. Rembacken BJ, Snelling AM, Hawkey PM, Chalmers DM, Axon AT. Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet. 1999;354(9179):635-639
83. Kruis W, Fric P, Pokrotnieks J, et al. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut. 2004;53(11):1617-1623
84. Ishikawa H, Akedo I, Umesaki Y, Tanaka R, Imaoka A, Otani T. Randomized controlled trial of the effect of bifidobacteriafermented milk on ulcerative colitis. J Am Coll Nutr. 2003;22(1):56-63
85. Mallon P, McKay D, Kirk S, Gardiner K. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007;(4):CD005573
86. Mimura T, Rizzello F, Helwig U, et al. Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut. 2004;53(1): 108-114
87. Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009;104(2):437-443
88. Bousvaros A, Guandalini S, Baldassano RN, et al. A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease. Inflamm Bowel Dis. 2005;11(9):833-839
89. Schultz M, Timmer A, Herfarth HH, Sartor RB, Vanderhoof JA, Rath HC. Lactobacillus GG in inducing and maintaining remission of Crohn's disease. BMC Gastroenterol. 2004;4:5
90. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea: a pilot study. Z Gastroenterol. 1993;31(2):129-134
91. Malchow HA. Crohn's disease and Escherichia coli: a new approach in therapy to maintain remission of colonic Crohn's disease? J Clin Gastroenterol. 1997;25(4): 653-658
92. Prantera C, Scribano ML, Falasco G, Andreoli A, Luzi C. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Gut. 2002;51(3):405-409
93. Rolfe VE, Fortun PJ, Hawkey CJ, Bath- Hextall F. Probiotics for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2006;(4):CD004826
94. Bausserman M, Michail S. The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. J Pediatr. 2005;147(2): 197-201
95. Kim HJ, Vazquez Roque MI, Camilleri M, et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil. 2005;17(5): 687-696 (Pubitemid 41400717)
96. O'Mahony L, McCarthy J, Kelly P, et al. Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology. 2005;128(3):541-551
97. Kim HJ, Camilleri M, McKinzie S, et al. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2003; 17(7):895-904
98. Banaszkiewicz A, Szajewska H. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebocontrolled randomized trial. J Pediatr. 2005;146(3):364-369
99. Hill DJ, Roy N, Heine RG, et al. Effect of a low-allergen maternal diet on colic among breastfed infants: a randomized, controlled trial. Pediatrics. 2005;116(5). Available at: www.pediatrics.org/cgi/content/full/116/5/e709
100. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007;119(1). Available at: www.pediatrics.org/cgi/content/full/119/1/e124
101. Reid G. Probiotic therapy and functional foods for prevention of urinary tract infections: state of the art and science. Curr Infect Dis Rep. 2000;2(6):518-522
102. Tagg JR, Dierksen KP. Bacterial replacement therapy: adapting "germ warfare" to infection prevention. Trends Biotechnol. 2003;21(5):217-223
103. Golledge CL, Riley TV. "Natural" therapy for infectious diseases. Med J Aust. 1996; 164(2):94-95
104. Burns AJ, Rowland IR. Anti-carcinogenicity of probiotics and prebiotics. Curr Issues Intest Microbiol. 2000;1(1):13-24
105. Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. 2007;(4):CD006474
106. Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr. 2008;138(6): 1091-1095 (Pubitemid 351769134)
107. van der Aa LB, Heymans HS, van Aalderen WM, Sprikkelman AB. Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. Pediatr Allergy Immunol. 2010;21(2 pt 2):e355-e367
108. Brown KH, Perez F, Peerson JM, et al. Effect of dietary fiber (soy polysaccharide) on the severity, duration, and nutritional outcome of acute, watery diarrhea in children. Pediatrics. 1993;92(2):241-247 (Pubitemid 23226840)
109. Hanai H, Kanauchi O, Mitsuyama K, et al. Germinated barley foodstuff prolongs remission in patients with ulcerative colitis. Int J Mol Med. 2004;13(5):643-647
110. Kukkonen K, Savilahti E, Haahtela T, et al. Probiotics and prebiotic galactooligosaccharides in the prevention of allergic diseases: a randomized, doubleblind, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(1):192-198
111. European Commission, Scientific Committee on Food. Report of the Scientific Committee on Food on the Revision of Essential Requirements of Infant Formulae and on Formulae. Brussels, Belgium: European Commission; 2003. Available at: http://ec. europa.eu/food/fs/sc/scf/out199-en.pdf. Accessed October 12, 2010
112. Arslanoglu S, Moro GE, Boehm G. Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J Nutr. 2007;137(11):2420-2424
113. Boehm G, Lidestri M, Casetta P, et al. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2002;86(3):F178-F181
114. Moro G, Minoli I, Mosca M, et al. Dosagerelated bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr. 2002;34(3):291-295 (Pubitemid 34437523)
115. Schmelzle H, Wirth S, Skopnik H, et al. Randomized double-blind study of the nutritional efficacy and bifidogenicity of a new infant formula containing partially hydrolyzed protein, a high beta-palmitic acid level, and nondigestible oligosaccharides. J Pediatr Gastroenterol Nutr. 2003;36(3): 343-351
116. Bettler J, Euler R. An evaluation of the growth of term infants fed formula supplemented with fructo-oligosaccharides. Int J Probiotics. 2006;1:19-26
117. Scholtens PA, Alles MS, Bindels JG, van der Linde EG, Tolboom JJ, Knol J. Bifidogenic effects of solid weaning foods with added prebiotic oligosaccharides: a randomised controlled clinical trial. J Pediatr Gastroenterol Nutr. 2006;42(5):553-559
118. Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr. 2004;38(4): 457-458
119. Thompson C, McCarter YS, Krause PJ, Herson VC. Lactobacillus acidophilus sepsis in a neonate. J Perinatol. 2001;21(4):258-260
120. Broughton RA, Gruber WC, Haffar AA, Baker CJ. Neonatal meningitis due to Lactobacillus. Pediatr Infect Dis. 1983;2(5):382-384
121. Perapoch J, Planes AM, Querol A, et al. Fungemia with Saccharomyces cerevisiae in two newborns, only one of whom had been treated with ultra-levura. Eur J Clin Microbiol Infect Dis. 2000;19(6):468-470
122. Salminen MK, Rautelin H, Tynkkynen S, et al. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG. Clin Infect Dis. 2004;38(1):62-69 (Pubitemid 38045874)
123. Kalima P, Masterton RG, Roddie PH, Thomas AE. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect. 1996;32(2): 165-167 (Pubitemid 26131703)
124. Soleman N, Laferl H, Kneifel W, et al. How safe is safe? A case of Lactobacillus paracasei ssp. paracasei endocarditis and discussion of the safety of lactic acid bacteria. Scand J Infect Dis. 2003;35(10): 759-762
125. Salminen MK, Tynkkynen S, Rautelin H, et al. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland. Clin Infect Dis. 2002;35(10):1155-1160
126. Land MH, Rouster-Stevens K, Woods CR, Cannon ML, Cnota J, Shetty AK. Lactobacillus sepsis associated with probiotic therapy. Pediatrics. 2005;115(1):178-181
127. Petschow BW, Figueroa R, Harris CL, Beck LB, Ziegler E, Goldin B. Effects of feeding an infant formula containing Lactobacillus GG on the colonization of the intestine: a dose-response study in healthy infants. J Clin Gastroenterol. 2005;39(9):786-790 (Pubitemid 41361896)
128. European Food Safety Authority. Microorganisms in food and feed: qualified presumption of safety-QPS. Available at: www.efsa.europa. eu/en/events/event/colloque041213.htm. Accessed October 12, 2010
129. Infant Formula Act of 1980. Available at: http://thomas.loc.gov/cgi-bin/ bdquery/ z?d096:HR06940:@@@L&summ2=m&. Accessed October 12, 2010
130. American Academy of Pediatrics, Work Group on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 1997; 100(6):1035-1039