Altered early infant gut microbiota in children developing allergy up to 5 years of age

Clinical and Experimental Allergy

Volumn 39, Issue 4, 2009, Pages 518-526

  Sjogren Y M ^a   Jenmalm, M C ^b   Bottcher M F ^b   Bjorksten B ^c   Sverremark Ekstrom E ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Allergy; Bifidobacteria; Clostridium difficile; Endotoxin; Fel d 1; Gut microbiota; Infant; Lactobacilli; Siblings

Indexed keywords

BACTERIAL DNA; ENDOTOXIN;

ALLERGY; ARTICLE; BACTERIUM COLONY; BACTEROIDES FRAGILIS; BIFIDOBACTERIUM ADOLESCENTIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM BREVE; BIFIDOBACTERIUM LONGUM; BIRTH; CHILD; CLINICAL FEATURE; CLOSTRIDIUM DIFFICILE; DISEASE COURSE; DNA DETERMINATION; ENVIRONMENTAL FACTOR; FAMILY SIZE; FECES ANALYSIS; FEMALE; GROUPS BY AGE; HOUSE DUST; HUMAN; HUMAN EXPERIMENT; INFANT; INTESTINE FLORA; LACTOBACILLUS CASEI; LACTOBACILLUS PARACASEI; LACTOBACILLUS RHAMNOSUS; MALE; NONHUMAN; PRESCHOOL CHILD; PRICK TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SWEDEN;

ANIMALS; BACTEROIDES FRAGILIS; BIFIDOBACTERIUM; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; FECES; FEMALE; HUMANS; HYPERSENSITIVITY; INFANT; INTESTINES; LACTOBACILLUS; MALE; SWEDEN;

EID: 62449165965     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03156.x     Document Type: Article

References (41)

1. Sonnenburg JL, Angenent LT, Gordon JI. Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Nat Immunol 2004 5 : 569 73.
2. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997 159 : 1739 45.
3. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004 118 : 229 41.
4. Mackie RI, Sghir A, Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 1999 69 : 1035S 45S.
5. Sepp E, Julge K, Vasar M, Naaber P, Björkstén B, Mikelsaar M. Intestinal microflora of Estonian and Swedish infants. Acta Paediatr 1997 86 : 956 61.
6. Bennet R, Eriksson M, Tafari N, Nord CE. Intestinal bacteria of newborn Ethiopian infants in relation to antibiotic treatment and colonisation by potentially pathogenic gram-negative bacteria. Scand J Infect Dis 1991 23 : 63 9.
7. Adlerberth I, Carlsson B, de Man P et al. Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants. Acta Paediatr Scand 1991 80 : 602 10.
8. Kalliomäki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001 107 : 129 34.
9. Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001 108 : 516 20.
10. Penders J, Thijs C, van den Brandt PA et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut 2007 56 : 661 7.
11. Adlerberth I, Strachan DP, Matricardi PM et al. Gut microbiota and development of atopic eczema in 3 European birth cohorts. J Allergy Clin Immunol 2007 120 : 343 50.
12. Penders J, Thijs C, Vink C et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006 118 : 511 21.
13. Böttcher MF, Björkstén B, Gustafson S, Voor T, Jenmalm MC. Endotoxin levels in Estonian and Swedish house dust and atopy in infancy. Clin Exp Allergy 2003 33 : 295 300.
14. Heinrich J, Gehring U, Douwes J et al. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001 31 : 1839 45.
15. Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax 2000 55 : S2 10.
16. Braun-Fahrländer C, Riedler J, Herz U et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002 347 : 869 77.
17. He F, Ouwehand AC, Isolauri E, Hashimoto H, Benno Y, Salminen S. Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants. FEMS Immunol Med Microbiol 2001 30 : 43 7.
18. Matsuki T, Watanabe K, Tanaka R. Genus- and species-specific PCR primers for the detection and identification of bifidobacteria. Curr Issues Intest Microbiol 2003 42 : 61 9.
19. Ahrné S, Lönnermark E, Wold AE et al. Lactobacilli in the intestinal microbiota of Swedish infants. Microbes Infect 2005 7 : 1256 62.
20. Sakata S, Tonooka T, Ishizeki S et al. Culture-independent analysis of fecal microbiota in infants, with special reference to Bifidobacterium species. FEMS Microbiol Lett 2005 243 : 417 23.
21. Mazmanian SK, Kasper DL. The love-hate relationship between bacterial polysaccharides and the host immune system. Nat Rev Immunol 2006 6 : 849 58.
22. Voor T, Julge K, Böttcher MF, Jenmalm MC, Duchén K, Björkstén B. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin Exp Allergy 2005 35 : 153 9.
23. Klein G. International committee on systematics of prokaryotes; subcommittee on the taxonomy of Bifidobacterium, Lactobacillus and related organisms: minutes of the meetings, 1 and 2 April 2005, Stuttgart-Hohenheim, Germany. Int J Syst Evol Microbiol 2006 56 : 2501 3.
24. Song Y, Kato N, Liu C, Matsumiya Y, Kato H, Watanabe K. Rapid identification of 11 human intestinal Lactobacillus species by multiplex PCR assays using group- and species-specific primers derived from the 16S-23S rRNA intergenic spacer region and its flanking 23S rRNA. FEMS Microbiol Lett 2000 187 : 167 73.
25. Grönlund MM, Gueimonde M, Laitinen K et al. Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin Exp Allergy 2007 37 : 1764 72.
26. Suzuki S, Shimojo N, Tajiri Y, Kumemura M, Kohno Y. Differences in the composition of intestinal Bifidobacterium species and the development of allergic diseases in infants in rural Japan. Clin Exp Allergy 2007 37 : 506 11.
27. Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001 357 : 1076 9.
28. Abrahamsson TR, Jakobsson T, Böttcher MF et al. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2007 119 : 1174 80.
29. Lowe AJ, Hosking CS, Bennett CM et al. Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis. Clin Exp Allergy 2007 37 : 1624 31.
30. Stsepetova J, Sepp E, Julge K, Vaughan E, Mikelsaar M, de Vos WM. Molecularly assessed shifts of Bifidobacterium ssp. and less diverse microbial communities are characteristic of 5-year-old allergic children. FEMS Immunol Med Microbiol 2007 51 : 260 9.
31. Garn H, Renz H. Epidemiological and immunological evidence for the hygiene hypothesis. Immunobiology 2007 212 : 441 52.
32. Gore C, Munro K, Lay C et al. Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. J Allergy Clin Immunol 2008 121 : 135 40.
33. Young SL, Simon MA, Baird MA et al. Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood. Clin Diagn Lab Immunol 2004 11 : 686 90.
34. He F, Morita H, Ouwehand AC et al. Stimulation of the secretion of pro-inflammatory cytokines by Bifidobacterium strains. Microbiol Immunol 2002 46 : 781 5.
35. Böttcher MF, Nordin EK, Sandin A, Midtvedt T, Björkstén B. Microflora-associated characteristics in faeces from allergic and nonallergic infants. Clin Exp Allergy 2000 30 : 1590 6.
36. Wang M, Karlsson C, Olsson C et al. Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immunol 2008 121 : 129 34.
37. Midtvedt T, Carlstedt-Duke B, Hoverstad T, Midtvedt AC, Norin KE, Saxerholt H. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. Appl Environ Microbiol 1987 53 : 2866 71.
38. Adlerberth I, Lindberg E, Åberg N et al. Reduced enterobacterial and increased staphylococcal colonization of the infantile bowel: an effect of hygienic lifestyle? Pediatr Res 2006 59 : 96 101.
39. Matsuki T, Watanabe K, Fujimoto J et al. Quantitative PCR with 16S rRNA-gene-targeted species-specific primers for analysis of human intestinal bifidobacteria. Appl Environ Microbiol 2004 70 : 167 73.
40. Haarman M, Knol J. Quantitative real-time PCR assays to identify and quantify fecal Bifidobacterium species in infants receiving a prebiotic infant formula. Appl Environ Microbiol 2005 71 : 2318 24.
41. Rinttilä T, Kassinen A, Malinen E, Krogius L, Palva A. Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. J Appl Microbiol 2004 97 : 1166 77.