Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 19, 2010, Pages 8772-8777

  Peyrin Biroulet, Laurent ^a,b   Beisner, Julia ^c,d   Wang, Guoxing ^c,d   Nuding, Sabine ^c,d,e   Oommen, Sajit Thottathil ^f   Kelly, Denise ^g   Parmentier Decrucq, Erika ^a,h   Dessein, Rodrigue ^h,i,j   Merour, Emilie ^a   Chavatte, Philipe ^h   Grandjean, Teddy ^h,i,j   Bresseno, Aude ^k   Desreumaux, Pierre ^a,h   Colombel, Jean Frédéric ^a,h   Desvergne, Béatrice ^f   Stange, Eduard F ^e   Wehkamp, Jan ^c,d,e   Chamaillard, Mathias ^h,i,j  

^a INSERM   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e ROBERT BOSCH HOSPITAL   (Germany)

^f UNIVERSITY OF LAUSANNE   (Switzerland)

^g ROWETT RESEARCH INSTITUTE   (United Kingdom)

^h UNIV LILLE   (France)

ⁱ INSERM U1019   (France)

^j CNRS   (France)

^k UNIVERSITY HOSPITAL OF NANCY   (France)

more..

Author keywords

defensin 1; Crohn's disease; Microbiota; Nutrition; PPAR

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEROIDES FRAGILIS; CANDIDA ALBICANS; COLON CROHN DISEASE; COLON MUCOSA; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; EPITHELIUM CELL; ESCHERICHIA COLI; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BACTERIA; BETA-DEFENSINS; CELL LINE; COLON; CROHN DISEASE; FUNGI; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENOTYPE; HUMANS; ILEUM; IMMUNITY, INNATE; MICE; MICE, INBRED C57BL; MODELS, IMMUNOLOGICAL; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING;

ANIMALIA; BACTEROIDES FRAGILIS; CANDIDA ALBICANS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; MUS;

EID: 77952683762     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905745107     Document Type: Article

References (24)

1. Loftus EV, Jr. (2004) Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126:1504-1517. (Pubitemid 38649869)
2. Koslowski MJ, et al. (2009) Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One 4:e4496.
3. Wehkamp J, Koslowski M, Wang G, Stange EF (2008) Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. Mucosal Immunol 1 (Suppl 1):S67-S74.
4. Nuding S, Fellermann K, Wehkamp J, Stange EF (2007) Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut 56:1240-1247. (Pubitemid 47300425)
5. Dubuquoy L, et al. (2006) PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 55:1341-1349.
6. Lewis JD, et al., Rosiglitazone for Ulcerative Colitis Study Group (2008) Rosiglitazone for active ulcerative colitis: A randomized placebo-controlled trial. Gastroenterology 134:688-695.
7. Peyrin-Biroulet L, et al. (2006) NODs in defence: From vulnerable antimicrobial peptides to chronic inflammation. Trends Microbiol 14:432-438. (Pubitemid 44375023)
8. Sartor RB (2008) Microbial influences in inflammatory bowel diseases. Gastroenterology 134:577-594. (Pubitemid 351173057)
9. Bouskra D, et al. (2008) Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456:507-510. (Pubitemid 352759006)
10. Varnat F, et al. (2006) PPARbeta/delta regulates Paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology 131:538-553. (Pubitemid 44160696)
11. Swidsinski A, et al. (2002) Mucosal flora in inflammatory bowel disease. Gastroenterology 122:44-54.
12. Lakatos PL, et al., Hungarian IBD Study Group (2008) Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease: Is there a role for defensins? Tissue Antigens 71:552-559.
13. Kocsis AK, et al. (2008) Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease. Scand J Gastroenterol 43:299-307.
14. Peyrin-Biroulet L, Standaert-Vitse A, Branche J, Chamaillard M (2007) IBD serological panels: Facts and perspectives. Inflamm Bowel Dis 13:1561-1566.
15. Valore EV, et al. (1998) Human beta-defensin-1: An antimicrobial peptide of urogenital tissues. J Clin Invest 101:1633-1642. (Pubitemid 28198492)
16. Shi J, et al. (1999) Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect Immun 67:3121-3127. (Pubitemid 29244738)
17. Feng Z, et al. (2005) Human beta-defensins: Differential activity against candidal species and regulation by Candida albicans. J Dent Res 84:445-450. (Pubitemid 43827877)
18. Jurevic RJ, Bai M, Chadwick RB, White TC, Dale BA (2003) Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: High-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J Clin Microbiol 41:90-96. (Pubitemid 36098559)
19. Standaert-Vitse A, et al. (2006) Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease. Gastroenterology 130:1764-1775.
20. Kalus AA, et al. (2009) Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes. BMC Oral Health 9:21.
21. Ogino S, et al. (2009) Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. Gastroenterology 136:1242-1250.
22. Jansson EA, et al. (2005) The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. Proc Natl Acad Sci USA 102:1460-1465.
23. Braissant O, Foufelle F, Scotto C, Dauça M, Wahli W (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137:354-366.
24. Wehkamp J, et al. (2007) The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol 179:3109-3118.