Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease

Annals of the New York Academy of Sciences

Volumn 1173, Issue , 2009, Pages 757-765

  Waterhouse, Joyce C ^a   Perez, Thomas H ^a,b   Albert, Paul J ^c  

^a Autoimmunity Research Foundation   (United States)

^b U S PUBLIC HEALTH SERVICE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

1,25 dihydroxyvitamin D; 25 hydroxyvitamin D; Autoimmune diseases; Bacteria; Biofilm; Cholecalciferol; Immunosuppression; L form bacteria; Metagenomic; Natural immunity; Vitamin D; Vitamin D receptor

Indexed keywords

25 HYDROXYVITAMIN D; ANTIBIOTIC AGENT; CALCITRIOL; CELL NUCLEUS RECEPTOR; COLECALCIFEROL; IMMUNOSUPPRESSIVE AGENT; MINOCYCLINE; OLMESARTAN; POLYPEPTIDE ANTIBIOTIC AGENT; VITAMIN D; VITAMIN D RECEPTOR;

ANKYLOSING SPONDYLITIS; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; BACTERIAL CELL; BACTERIAL FLORA; BACTERIAL INFECTION; BACTERIOSTASIS; CELL DEATH; CONFERENCE PAPER; HUMAN; IMMUNE DYSREGULATION; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INTRACELLULAR BACTERIUM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PSORIASIS; REITER SYNDROME; RHEUMATOID ARTHRITIS; SARCOIDOSIS; SCLERODERMA; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; UVEITIS; VITAMIN D METABOLISM; VITAMIN SUPPLEMENTATION;

BACTERIA (MICROORGANISMS);

EID: 70049116466     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04637.x     Document Type: Conference Paper

References (42)

1. Ponsonby, A.L., R. M. Lucas & I.A. Van Der Mei. 2005. UVR, vitamin D and three autoimmune diseases-multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochem. Photobiol. 81: 1267-1275.
2. Marshall, T.G. 2008. Vitamin D discovery outpaces FDA decision making. Bioessays 30: 173-182.
3. Marshall, T.G. & F.E. Marshall. 2004. Sarcoido-sis succumbs to antibiotics-implications for autoimmune disease. Autoimmun. Rev. 3: 295-300.
4. Arasaki, K. 2006. Report on a case of systemic sar-coidosis treated according to the Marshall Protocol. The 26th Conference of the Japan Society of Sar-coidosis and Other Granulomatous Diseases. Tokyo, Japan, October 6.
5. Marshall, T.G. 2006. VDR nuclear receptor competence is the key to recovery from chronic inflammatory and autoimmune disease. Days of Molecular Medicine. Stockholm, Sweden, May 24-27.
6. Marshall, T.G. 2008. VDR receptor competence induces recovery from chronic autoimmune disease. 6th International Congress on Autoimmunity. Porto, Portugal, September 11.
7. Waterhouse, J. et al. 2006. High levels of active 1, 25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor-implications of dys-regulated vitamin D for diagnosis and treatment of chronic disease. In Vitamin D: New Research: 1-23. Nova Science Publishers. New York.
8. Perez, T. 2008. Bacteria induced vitamin D receptor dysfunction in autoimmune disease: theoretical and practical implications for interpretation of serum vitamin D metabolite levels. 6th International Congress on Autoimmunity. Porto, Portugal, September 11.
9. Wang, T.T. et al. 2005. Large-scale in silico and microarray-based identification of direct 1, 25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 19: 2685-2695.
10. Liu, P.T. et al. 2006. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311: 1770-1773.
11. Wen, L. & F.S. Wong. 2005. How can the innate immune system influence autoimmunity in type 1 diabetes and other autoimmune disorders? Crit. Rev. Immunol. 25: 225-250.
12. Fredricks, D.N. & D.A. Relman. 1998. Infectious agents and the etiology of chronic idiopathic diseases. Curr. Clin. Top. Infect. Dis. 18: 180-200.
13. Pordeus V. et al. 2008. Infections and autoimmunity: a panorama. Clin. Rev. Allergy Immunol. 34: 283-299.
14. Shoenfeld, Y. & D.A. Isenberg. 1989. The mosaic of autoimmunity. Immunol. Today 10: 123-126.
15. Casadesus, J. 2007. Bacterial L-forms require pep-tidoglycan synthesis for cell division. Bioessays 29: 1189-1191.
16. Domingue, G.J., .Sr & H.B. Woody. 1997. Bacterial persistence and expression of disease. Clin. Microbiol. Rev. 10: 320-344.
17. Mattman, L. 2000. Cell Wall Deficient Forms: Stealth Pathogens. CRC Press. Boca Raton, FL.
18. Lewis, K. 2007. Persister cells, dormancy and infectious disease. Nat. Rev. Microbiol. 5: 48-56.
19. Wirostko, E., L. Johnson & W. Wirostko. 1989. Juvenile rheumatoid arthritis inflammatory eye disease. Parasitization of ocular leukocytes by mollicute-like organisms. J. Rheumatol. 16: 1446-1453.
20. Dowd, S.E. et al. 2008. Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC Microbiol. 8: 43.
21. Macfarlane, S. et al. 2007. Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagus. Clin. Infect. Dis. 45: 29-38.
22. Blaney, G. 2008. Vitamin D metabolites as clinical markers in autoimmune and chronic illness. 6th International Congress on Autoimmunity. Porto, Portugal, September 11.
23. Bell, N.H., S. Shaw & R.T. Turner. 1984. Evidence that 1, 25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J. Clin. Invest. 74: 1540-1544.
24. Yoshizawa, T. et al. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat. Genet. 16: 391-396.
25. Cutolo, M. et al. 2006. Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe. Clin. Exp. Rheuma-tol. 24: 702-704.
26. Peacock, M. et al. 2000. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J. Clin. Endocrinol. Metab. 85: 3011-3019.
27. Tuohimaa, P. et al. 2004. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int. J. Cancer 108: 104-108.
28. Stolzenberg-Solomon, R.Z. et al. 2006. A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res. 66: 10213-10219.
29. Efird, J.T. et al. 2002. Risk of subsequent cancer following invasive or in situ squamous cell skin cancer. Ann. Epidemiol. 12: 469-475.
30. Freedman, D.M. et al. 2007. Prospective study of serum vitamin D and cancer mortality in the United States. J. Natl. Cancer Inst. 99: 1594-1602.
31. Ramos-Remus, C. et al. 2007. Latitude gradient influences the age of onset in rheumatoid arthritis patients. Clin. Rheumatol. 26: 1725-1728.
32. Payne, M.E., J.J.B. Anderson & D.C. Steffens. 2008. Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and non-depressed elders. Nutr. Res. 28: 285-292.
33. Martineau, A.R. et al. 2007. A single dose of vitamin D enhances immunity to mycobacteria. Am. J. Respir. Crit. Care Med. 176: 208-213.
34. Yesudian, P.D. et al. 2008. The effect of ultraviolet B-induced vitamin D levels on host resistance to My-cobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom. Photoder-matol. Photoimmunol. Photomed. 24: 97-98.
35. Onwuamaegbu, M.E., R.A. Belcher & C. Soare. 2005. Cell wall-deficient bacteria as a cause of infections: a review of the clinical significance. J. I n t . Med. Res. 33: 1-20.
36. Labro, M.T. 2000. Interference of antibacterial agents with phagocyte functions: immunomodula-tion or "immuno-fairy tales"? Clin. Microbiol. Rev. 13: 615-650.
37. Milatovic, D. 1982. Effect of subinhibitory antibiotic concentrations on the phagocytosis of Staphylococ-cus aureus. Eur. J. Clin. Microbiol. 1: 97-101.
38. Proal, A.D., P.J. Albert & T.G. Marshall. Dysregu-lation of the Vitamin D Nuclear Receptor may contribute to the higher prevalence of some autoimmune diseases in women. Ann. N. Y. Acad. Sci. in press.
39. Cannell, J.J. 2008. Discovering the obvious, damaging the defenseless. Nutr. Res. 28: 809.
40. Payne, M.E., J.J. Anderson & D.C. Steffens. 2008. Discovering the obvious, damaging the defenseless-Reply. Nutr. Res. 28: 809-810.
41. Baio, P. et al. 2008. Autoimmune diseases and infections: controversial issues. Clin. Exp. Rheumatol. 26: S74-80.
42. Ercolini, A.M. & S.D. Miller. 2009. The role of infections in autoimmune disease. Clin. Exp. Immunol. 155: 1-15.