Effects of manufactured nanomaterials on fishes: A target organ and body systems physiology approach

Journal of Fish Biology

Volumn 79, Issue 4, 2011, Pages 821-853

  Handy, R D ^a   Al Bairuty, G ^a   Al Jubory, A ^a   Ramsden, C S ^a   Boyle, D ^a   Shaw, B J ^a   Henry, T B ^a,b  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Behaviour; Blood cells; Cardiovascular system; Gastrointestinal tract; Nanoparticles; Nervous system

Indexed keywords

NANOMATERIAL;

ANIMAL; ANIMAL BEHAVIOR; ANIMAL EMBRYO; ANIMAL STRUCTURES; AQUACULTURE; CHEMISTRY; DRUG EFFECT; FISH; HUMAN; METABOLISM; REVIEW; WATER POLLUTANT;

ANIMAL STRUCTURES; ANIMALS; AQUACULTURE; BEHAVIOR, ANIMAL; EMBRYO, NONMAMMALIAN; FISHES; HUMANS; NANOSTRUCTURES; WATER POLLUTANTS, CHEMICAL;

ONCORHYNCHUS MYKISS; PISCES;

EID: 80053463403     PISSN: 00221112     EISSN: 10958649     Source Type: Journal    
DOI: 10.1111/j.1095-8649.2011.03080.x     Document Type: Review

References (112)

1. Aitken, R. J., Chaudhry, M. Q., Boxall, A. B. A. & Hull, M. (2006). Manufacture and use of nanomaterials: current status in the UK and global trends. Occupational Medicine (Oxford) 56, 300-306.
2. Ammann, M., Burtsscher, H. & Siegmann, H. C. (1990). Monitoring volcanic activity by characterization of ultrafine aerosol emissions. Journal of Aerosol Science 21, 5275-5278.
3. Bermudez, E., Mangum, J. B., Wong, B. A., Asgharian, B., Hext, P. M., Warheit, D. B. & Everitt, J. I. (2004). Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicological Sciences 77, 347-357.
4. Berntssen, M. H. G., Julshamn, K., & Lundebye, A.-K. (2010). Chemical contaminants in aquafeeds and Atlantic salmon (Salmo salar) following the use of traditional versus alternative feed ingredients. Chemosphere 78, 637-646.
5. Bilberg, K., Malte, H., Wang, T. & Baatrup, E. (2010). Silver nanoparticles and silver nitrate cause respiratory stress in Eurasian perch (Perca fluviatilis). Aquatic Toxicology 96, 159-165.
6. Biswas, P. & Wu, P. (2005). Nanoparticles and the environment. Journal of the Air and Waste Management Association 55, 708-746.
7. Borzsonyi, G., Johnson, R. S., Myles, A. J., Cho, J.-Y., Yamazaki, T., Beingessner, R. L., Kovalenko, A. & Fenniri, H. (2010) Rosette nanotubes with 1.4 nm inner diameter from a tricyclic variant of the Lehn-Mascal G ^ C base. Chemical Communication 46, 6527-6529.
8. Bouwmeester, H., Dekkers, S., Noordam, M. Y., Hagens, W. I., Bulder, A. S., de Heer, C., ten Voorde, S. E. C. G., Wijnhoven, S. W. P., MarvH. J. P. & Sips, A. J. A. M. (2009). Review of health safety aspects of nanotechnologies in food production. Regulatory Toxicology and Pharmacology 53, 52-62.
9. Bradford, A., Handy, R. D., Readman, J. W., Atfield, A. & Mühling, M. (2009). Impact of silver nanoparticle contamination on the genetic diversity of natural bacterial assemblages in estuarine sediments. Environmental Science and Technology 43, 4530-4536.
10. Brown, D. M., Kinloch, I. A., Bangert, U., Windle, A. H., Walter, D. M., Walker, G. S., Scotchford, C. A., Donaldson, K. & Stone, V. (2007). An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis. Carbon 45, 1743-1756.
11. Buffle, J. (2006). The key role of environmental colloids/nanoparticles for the sustainability of life. Environmental Chemistry 3, 155-158.
12. Camejo, G., WallB. & Enojärvi, M. (1998). Analysis of oxidation and antioxidants using microtiter plates. In Free Radical and Antioxidant Protocols. Methods in Molecular Biology, Vol. 108 (Armstrong, D., ed.), pp. 307-386. Totowa, NJ: Humana Press Inc.
13. Carriquiriborde, P., Handy, R. D. & Davies, S. J. (2004). Physiological modulation of iron metabolism in rainbow trout (Oncorhynchus mykiss) fed low and high iron diets. Journal of Experimental Biology 207, 75-86.
14. Chaudhry, Q., Scotter, M., Blackburn, J., Ross, B., Boxall, A., Castle, L., Aitken, R. & Watkins, R. (2008). Applications and implications of nanotechnologies for the food sector. Food Additives and Contaminants 25, 241-258.
15. Cheng, J., Chan, C. M., Veca, L. M., Poon, W. L., Chan, P. K., Qu, L., Sun, Y.-P. & Cheng, S. H. (2009). Acute and long-term effects after single loading of functionalized multi-walled carbon nanotubes into zebrafish (Danio rerio). Toxicology and Applied Pharmacology 235, 216-225.
16. Clearwater, S. J., Farag, A. M. & Meyer, J. S. (2002). Bioavailability and toxicity of dietborne copper and zinc to fish. Comparative Biochemistry and Physiology C 132, 269-313.
17. Crane, M., Handy, R. D., Garrod, J. & Owen, R. (2008). Ecotoxicity test methods and environmental hazard assessment for manufactured nanoparticles. Ecotoxicology 17, 421-437.
18. Derjaguin, B. V. & Landau, L. D. (1941). Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Acta Physicochimica 14, 733-762.
19. Donaldson, K. & Tran, C. L. (2002). Inflammation caused by particles and fibers. Inhalation Toxicology 14, 15-27.
20. Dobrovolskaia, M. A. & McNeil, S. E. (2007). Immunological properties of manufactured nanomaterials. Nature Nanotechnology 2, 469-478.
21. Duffin, R., Tran, L., Brown, D., Stone, V. & Donaldson, K. (2007). Effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhalation Toxicology 19, 849-856.
22. Eddy, F. B. (2005). Role of nitric oxide in larval and juvenile fish. Comparative Biochemistry and Physiology A 142, 221-230.
23. Eddy, F. B. & Talbot, C. (1985). Sodium balance in eggs and dechorionated embryos of the Atlantic salmon Salmo salar L. exposed to zinc, aluminium and acid waters. Comparative Biochemistry and Physiology C 81, 259-66.
24. Federici, G., Shaw, B. J. & Handy, R. D. (2007). Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. Aquatic Toxicology 84, 415-430.
25. Ferry, J. L., Craig, P., Hexel, C., Sisco, P., Frey, R., Pennington, P. L., Fulton, M. H., Scott, I. G., Decho, A. W., Kashiwada, S., Murphy, C. J. & Shaw, T. J. (2009). Transfer of gold nanoparticles from the water column to the estuarine food web. Nature Nanotechnology 4, 441-444.
26. 60) in rainbow trout (Oncorhynchus mykiss). Nanotoxicology 5, 98-108.
27. Gilbert, B., Lu, G. & Kim, C. S. (2007). Stable cluster formation in aqueous suspensions of iron oxyhydroxide nanoparticles. Journal of Colloid and Interface Science 313, 152-159.
28. Glover, C. N., Petri, D., Tollefsen, K.-E., Jørum, N., Handy, R. D. & Berntssen, M. H. G. (2007). Assessing the sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan exposure using tissue biochemistry and histology. Aquatic Toxicology 84, 346-355.
29. 2, ZnO, Ag, CNT, fullerenes) for different regions. Environmental Science and Technology 43, 9216-9222.
30. Griffitt, R. J., Weil, R., Hyndman, K. A., Denslow, N. D., Powers, K., Taylor, D. & Barber, D. S. (2007). Exposure to copper nanoparticles caused gill injury and acute lethality in zebrafish (Danio rerio). Environmental Science and Technology 41, 8178-8186.
31. Griffitt, R. J., Luo, J., Gao, J., Bonzongo, J. C. & Barber, D. S. (2008). Effects of particles composition and species on toxicity of metallic nanomaterials in aquatic organisms. Environmental Toxicology and Chemistry 27, 1972-1978.
32. Griffitt, R. J., Hyndman, K., Denslow, N. D. & Barber, D. S. (2009). Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles. Toxicological Sciences 107, 404-415.
33. 2 toxicity. Nanotoxicology 3, 91-97.
34. Handy, R. D. & Shaw, B. J. (2007). Toxic effects of nanoparticles and nanomaterials: implications for public health, risk assessment and the public perception of nanotechnology. Health, Risk and Society 9, 125-144.
35. Handy, R. D., Jha, A. N. & Depledge, M. H. (2002a). Biomarker approaches for ecotoxicological biomonitoring at different levels of biological organisation. In Handbook of Environmental Monitoring (Burden, K., McKelvie, I., Förstner, U. & Guenther, A., eds), pp 9.1-9.32. New York, NY: McGraw Hill.
36. Handy, R. D., Runnalls, T. & Russell, P. M. (2002b). Histopathologic biomarkers in three spined sticklebacks, Gasterosteus aculeatus, from several rivers in southern England that meet the Freshwater Fisheries Directive. Ecotoxicology 11, 467-479.
37. Handy, R. D., McGeer, J. C., Allen, H. E., Drevnick, P. E., Gorsuch, J. W., Green, A. S., Lundebye, A.-K., Hook, S. E., Mount, D. R. & Stubblefield, W. A. (2005). Toxic effects of dietborne metals: laboratory studies. In Toxicity of Dietborne Metals to Aquatic Organisms (Meyer, J. S., Adams, W. J., Brix, K. V., Luoma, S. N, Mount, D. R., Stubblefield, W. A. & Wood, C. M., eds), pp. 59-112. Pensacola, FL: SETAC Press.
38. Handy, R., Kammer, F. v., Lead, J., Hassellöv, M., Owen, R. & Crane, M. (2008a). The ecotoxicology and chemistry of manufactured nanoparticles. Ecotoxicology 17, 287-314.
39. Handy, R. D., Owen, R. & Valsami-Jones, E. (2008b). The ecotoxicology of nanoparticles and nanomaterials: Currentcurrent status, knowledge gaps, challenges, and future needs. Ecotoxicology 17, 315-325.
40. Handy, R. D., Henry, T. B., Scown, T. M., Johnston, B. D. & Tyler, C. R. (2008c). Manufactured nanoparticles: their uptake and effects on fish - a mechanistic analysis. Ecotoxicology 17, 396-409.
41. Handy, R. D., Cornelis, G., Fernandes, T., Tsyusko, O., Decho, A., Sabo-Attwood, T., Metcalfe, C., Steevens, J. A., Klaine, S. J., Koelmans, A. A. & Horne, N. (2011) Ecotoxicity test methods for engineered nanomaterials: practical experiences and recommendations from the bench. Environmental Toxicology and Chemistry (in press).
42. Hansen, S. F., Michelson, E. S., Kamper, A., Borling, P., Stuer-Lauridsen, F. & Baun, A. (2008). Categorization framework to aid exposure assessment of nanomaterials in consumer products. Ecotoxicology 17, 438-447.
43. 2 nanoparticles on oxidative stress and histopathological changes in juvenile carp (Cyprinus carpio). Journal of Environmental Sciences 21, 1459-1466.
44. Hassellöv, M. & von der Kammer, F. (2008). Iron oxides as geochemical nanovectors for metal transport in soil-river systems. Elements 4, 401-406.
45. Hellstrand, E., Lynch, I., Andersson, A., Drakenberg, T., Dahlback, B., Dawson, K. A., Linse, S. & Cedervall, T. (2009). Complete high-density lipoproteins in nanoparticle corona. FEBS Journal 276, 3372-3381.
46. Henry, T. B., Menn, F. M., Fleming, J. T., Wilgus, J., Compton, R. N. & Sayler, G. S. (2007). Attributing effects of aqueous C-60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Environmental Health Perspectives 115, 1059-1065.
47. 2, and ZnO to fish. Environmental Science and Technology 44, 1144-1151.
48. Ju-Nam, Y. & Lead, J. R. (2008). Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications. Science of the Total Environment 400, 396-414.
49. Kahru, A. & Savolainen, K. (2010). Potential hazard of nanoparticles: from properties to biological and environmental effects. Toxicology 269, 89-91.
50. Kashiwada, S. (2006). Distribution of nanoparticles in the see-through medaka (Oryzias latipes). Environmental Health Perspectives 114, 1697-1702.
51. Kittler, S., Greulich, C., Diendorf, J., Koller, M. & Epple, M. (2010). Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. Chemistry of Materials 22, 4548-4554.
52. Klaine, S. J., Alvarez, P. J. J., Batley, G. E., Fernandes, T. F., Handy, R. D., Lyon, D. Y., Mahendra, S., McLaughlin, M. J. & Lead, J. R. (2008). Nanomaterials in the environment behavior, fate, bioavailability, and effects. Environmental Toxicology and Chemistry 27, 1825-1851.
53. Kooijman, S. A. L. M., Kooi, B. W. & Hallam, T. G. (1999). The application of mass and energy conservation laws in physiologically structured population models of heterotrophic organisms. Journal of Theoretical Biology 197, 371-392.
54. Koziara, J. M., Lockman, P. R., Allen, D. D. & Mumper, R. J. (2003). In situ blood-brain barrier transport of nanoparticles. Pharmaceutical Research 20, 1772-1778.
55. Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdörster, G. & Ziensenis, A. (2002). Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Toxicology and Environmental Health A 65, 1513-1530.
56. Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S. & Schirmer, K. (2009). Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line. Aquatic Toxicology 93, 91-99.
57. Laban, G., Nies, L. F., Turco, R. F., Bickham, J. W. & Sepulveda, M. S. (2010). The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Ecotoxicology 19, 185-195.
58. Lam, C. W., James, J. T., McCluskey, R. & Hunter, R. L. (2004). Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicological Sciences 77, 126-134.
59. Lam, C. W., James, J. T., McCluskey, R., Arepalli, S. & Hunter, R. L. (2006). A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Critical Reviews in Toxicology 36, 189-217.
60. Lead, J. R. & Wilkinson, K. J. (2006). Aquatic colloids and nanoparticles: current knowledge and future trends. Environmental Chemistry 3, 156-171.
61. van Leeuwen, H. P., Town, R. M., Buffle, J., Cleven, R. F. M. L., Davison, W., Puy, J., van Riemsdijk, W. H. & Sigg, L. (2005). Dynamic speciation analysis and bioavailability of metals in aquatic systems. Environmental Science and Technology 39, 8545-8556.
62. Li, H., Zhou, Q., Wu, Y., Fu, J., Wang, T. & Jiang, G. (2009). Effect of waterborne nano-iron on medaka (Oryzias latipes): antioxidant enzymatic activity, lipid peroxidation and histopathology. Ecotoxicology and Environmental Safety 72, 684-692.
63. Lu, S., Duffin, R., Poland, C., Daly, P., Murphy, F., Drost, E., MacNee, W., Stone, V. & Donaldson, K. (2009). Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation. Environmental Health Perspectives 117, 241-247.
64. Mallat, J. (1985). Fish gill structural changes induced by toxicants and other irritants: a statistical review. Canadian Journal of Fisheries and Aquatic Sciences 42, 630-648.
65. Masciangioli, T. & Zhang, W. X. (2003). Environmental technologies at the nanoscale. Environmental Science and Technology 37, 102A-108A.
66. Moger, J., Johnston, B. D. & Tyler, C. R. (2008). Imaging metal oxide nanoparticles in biological structures with CARS microscopy. Optics Express 16, 3408-3419.
67. Moore, M. N. (2006). Do nanoparticles present ecotoxicological risk for the health of the aquatic environment? Environment International 32, 967-976.
68. Mühling, M., Bradford, A., Readman, J. W., Somerfield, P. J. & Handy, R. D. (2009). An investigation into the effects of silver nanoparticles on antibiotic resistance of naturally occurring bacteria in an estuarine sediment. Marine Environmental Research 68, 278-83.
69. Nel, A., Xia, T., Madler, L. & Li, N. (2006). Toxic potential of materials at the nanolevel. Science 311, 622-627.
70. Nelson, S. M., Mahmoud, T., Beaux Ii, M., Shapiro, P., McIlroy, D. N. & Stenkamp, D. L. (2010). Toxic and teratogenic silica nanowires in developing vertebrate embryos. Nanomedicine: Nanotechnology, Biology and Medicine 6, 93-102.
71. Nowack, B. & Bucheli, T. D. (2007). Occurrence, behavior and effects of nanoparticles in the environment. Environmental Pollution 150, 5-22.
72. 60) induce oxidative stress in the brain of juvenile largemouth bass. Environmental Health Perspectives 112, 1058-1062.
73. Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., Olin, S., Monteiro-Riviere, N., Warheit, D. & Yang, H. (2005). Principles for characterizing the potential human health effects from exposure to nano materials: elements of a screening strategy. Particle and Fibre Toxicology 2, 8.
74. 60) on aquatic organisms. Carbon 44, 1112-1120.
75. Oberdörster, G., Oberdörster, E. & Oberdörster, J. (2007). Concepts of nanoparticles dose metric and response metric. Environmental Health Perspectives 115, 187-194.
76. Owen, R. & Handy, R. D. (2007). Formulating the problems for environmental risk assessment of nanomaterials. Environmental Science and Technology 41, 5582-5588.
77. Patel, A. P., Moody, A. J., Sneyd, J. R. & Handy, R. D. (2004). Carbon monoxide exposure in rat heart: evidence for two modes of toxicity. Biochemical and Biophysical Research Communications 321, 241-246.
78. Paquin, P. R., Gorsuch, J. W., Apte, S., Batley, G. E., Bowles, K. C., Campbell, P. G. C., Delos, C. G., Di Toro, D. M., Dwyer, R. L., Galvez, F., Gensemer, R. W., Goss, G. G., Hogstrand, C., Janssen, C. R., McGeer, J. C., Naddy, R. B., Playle, R. C., Santore, R. C., Schneider, U., Stubblefield, W. A., Wood, C. M. & Wu, K. B. (2002). The biotic ligand model: a historical overview. Comparative Biochemistry and Physiology C 133, 3-35.
79. Pérez, S., la Farré, M. & Barceló, D. (2009). Analysis, behavior and ecotoxicity of carbon-based nanomaterials in the aquatic environment. Trends in Analytical Chemistry 28, 820-832.
80. Peters, G. & Schwarzer, R. (1985). Changes in hemopoietic tissue of rainbow trout under influence of stress. Diseases of Aquatic Organisms 1, 1-10.
81. Ramsden, C. S., Smith, T. J., Shaw, B. S. & Handy, R. D. (2009). Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brain. Ecotoxicology 18, 939-951.
82. 2) nanoparticle induced cytotoxicity and oxidative DNA damage in fish cells. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 640, 113-122.
83. Roco, M. C. (2003). Nanotechnology: convergence with modern biology and medicine. Current Opinion in Biotechnology 14, 337-346.
84. Schlenk, D., Handy, R., Steinert, S., Depledge, M. H. & Benson, W. (2008). Biomarkers. In The Toxicology of Fishes (Di Giulio, R. T. & Hinton, D. E., eds), pp. 683-731. Boca Raton, FL: CRC Press.
85. Scott, G. R. & Sloman, K. A. (2004). The effects of environmental pollutants on complex fish behaviour: integrating behavioural and physiological indicators of toxicity. Aquatic Toxicology 68, 369-392.
86. Scown, T. M., van Aerle, R., Johnston, B. D., Cumberland, S., Lead, J. R., Owen, R. & Tyler, C. R. (2009). High doses of intravenously administered titanium dioxide nanoparticles accumulate in the kidneys of rainbow trout but with no observable impairment of renal function. Toxicological Sciences 109, 372-380.
87. Shaw, B. J. & Handy, R. D. (2006). Dietary copper exposure and recovery in Nile tilapia, Oreochromis niloticus. Aquatic Toxicology 76, 111-121.
88. 60 nanoparticles in the brains of Cyprinus carpio? Environmental Science and Technology 43, 948-953.
89. Smith, C. J., Shaw, B. J. & Handy, R. D. (2007). Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effects. Aquatic Toxicology 82, 94-109.
90. Sozer, N. & Kokini, J. L. (2009). Nanotechnology and its applications in the food sector. Trends in Biotechnology 27, 82-89.
91. 60 fullerene: a powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays. Environmental Pollution 157, 1134-1139.
92. Spry, D. J. & Wiener, J. G. (1991). Metal bioavailability and toxicity to fish in low-alkalinity lakes: a critical review. Environmental Pollution 71, 243-304.
93. Stolpe, B. & Hassellöv, M. (2007). Changes in size distribution of freshwater nanoscale colloidal matter and associated elements on mixing with seawater. Geochimica et Cosmochimica Acta 71, 3292-3301.
94. Stone, V., Nowack, B., Baun, A., van den Brink, N., von der Kammer, F., Dusinska, M., Handy, R., Hankin, S., Hassellöv, M., Joner, E. & Fernandes, T. F. (2010). Nanomaterials for environmental studies: classification, reference material issues, and strategies for physico-chemical characterisation. Science of the Total Environment 408, 1745-1754.
95. Sun, H. W., Zhang, X. Z., Niu, Q., Chen, Y. S. & Crittenden, J. C. (2007). Enhanced accumulation of arsenate in carp in the presence of titanium dioxide nanoparticles. Water Air and Soil Pollution 178, 245-254.
96. Takenaka, S., Karg, E., Roth, C., Schulz, H., Ziesenis, A. & Heyder, J. (2001). Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environmental Health Perspectives 109, 547-551.
97. Toranzo, A. E., Magarinõs, T. B. & Romalde, J. L. (2005). A review of the main bacterial fish diseases in mariculture systems. Aquaculture 246, 37-61.
98. Usenko, C. Y., Harper, S. L. & Tanguay, R. L. (2007). In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon 45, 1891-1898.
99. Usenko, C. Y., Harper, S. L. & Tanguay, R. L. (2008). Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Toxicology and Applied Pharmacology 229, 44-55.
100. Verwey, E. J. W., Overbeek, J. Th. G. & van Nes, K. (1948). Theory of the Stability of Lyophobic Colloids: The Interaction of Sol Particles having an Electric Double Layer. New York, NY: Elsevier Publishing.
101. 2) nanoparticles on fish cells in vitro. Ecotoxicology 17, 410-420.
102. Warheit, D. B., Laurence, B. R., Reed, K. L., Roach, D. H., Reynolds, G. A. M. & Webb, T. R. (2004). Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicological Sciences 77, 117-125.
103. 2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicological Sciences 91, 227-236.
104. Wild, E. & Jones, K. C. (2009). Novel method for the direct visualization of in vivo nanomaterials and chemical interactions in plants. Environmental Science and Technology 43, 5290-5294.
105. Wilson, R. W. & Taylor, E. W. (1993). The physiological responses of freshwater rainbow trout, Oncorhynchus mykiss, during acutely lethal copper exposure. Journal of Comparative Physiology B 163, 38-47.
106. Yu, X., Du, Q., Zhu, P. F., Hu, D. D. & Yang, L. (2011) Study on the photocatalytic degradation of diesel pollutants in seawater by a stannum-doped nanometer titania. Advanced Materials Research 197/198, 780-785.
107. Zhu, S. Q., Oberdörster, E. & Haasch, M. L. (2006). Toxicity of an manufactured nanoparticle (fullerene, C-60) in two aquatic species, Daphnia and fathead minnow. Marine Environmental Research 62, S5-S9.
108. 60) and fullerol. Environmental Toxicology and Chemistry 26, 976-979.
109. Zhu, X., Zhu, L., Duan, Z., Oi, R., Li, Y. & Lang, Y. (2008). Comparative toxicity of several metal oxide nanoparticle aqueous suspension to zebrafish (Danio rerio) early developmental stage. Journal of Environmental Science Health A 43, 278-284.
110. Boxall, A. B. A., Chaundhry, Q., Sinclair, C., Jones, A., Aitken, R., Jefferson, B. & Watts, C. (2007). Current and Future Predicted Environmental Exposure to Manufactured Nanoparticles. Report by the Central Science Laboratory (CSL) York for the Department of the Environment and Rural Affairs (DEFRA), UK. Available at
111. Defra (2009). A Strategic Review of the Potential for Aquaculture to Contribute to the Future Security of Food and Non-food Products and Services in the UK and Specifically England. Available at
112. SCHENIR (2007). Opinion on the Appropriateness of The risk Assessment Methodology in Accordance with Technical Guidance Documents for New and Existing Substances for Assessing the Risks of Nanomaterials. Scientific Committee on Emerging and Newly-Identified Health Risks (SCENIHR), European Commission. Available at