Toxoplasma gondii rhoptry kinase rop16 activates stat3 and stat6 resulting in cytokine inhibition and arginase-1-dependent growth control

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Butcher, Barbara A ^a   Fox, Barbara A ^b   Rommereim, Leah M ^b   Kim, Sung Guk ^a   Maurer, Kirk J ^a   Yarovinsky, Felix ^c   Herbert, De'Broski R ^d   Bzik, David J ^b   Denkers, Eric Y ^a  

^a Department of Obstetrics Gynecology   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; ARGININE; GAMMA INTERFERON; INTERLEUKIN 12P40; INTERLEUKIN 18; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; PROTOZOAL PROTEIN; ROP16 KINASE; STAT3 PROTEIN; STAT6 PROTEIN; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; ARG1 PROTEIN, MOUSE; ARGINASE; CYTOKINE; JANUS KINASE 2; MYD88 PROTEIN, MOUSE; PROTEIN TYROSINE KINASE; ROP16 PROTEIN, TOXOPLASMA GONDII; STAT3 PROTEIN, MOUSE; STAT6 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELETION MUTANT; ENZYME SYNTHESIS; FEMALE; FIBROBLAST; GENE DELETION; GENE INSERTION; GENETIC COMPLEMENTATION; GROWTH REGULATION; HOST CELL; IN VIVO STUDY; INHIBITION KINETICS; INTRACELLULAR SIGNALING; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; STARVATION; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; GENE INACTIVATION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOGENICITY; PHOSPHORYLATION; PLASMID; SIGNAL TRANSDUCTION; TOXOPLASMA;

TOXOPLASMA; TOXOPLASMA GONDII;

ANIMALS; ARGINASE; CELLS, CULTURED; CYTOKINES; FEMALE; GENE DELETION; GENE KNOCKOUT TECHNIQUES; INTERLEUKIN-12 SUBUNIT P40; JANUS KINASE 2; MACROPHAGES; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PLASMIDS; PROTEIN-TYROSINE KINASES; PROTOZOAN PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TOXOPLASMA;

EID: 80053460958     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002236     Document Type: Article

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