Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway

Biochemistry

Volumn 50, Issue 39, 2011, Pages 8392-8406

  Ames, Brian D ^a   Lee, Ming Yue ^a   Moody, Colleen ^a   Zhang, Wenjun ^b   Tang, Yi ^b   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; BIOCHEMICAL CHARACTERIZATION; BIOLOGICAL ACTIVITIES; CRITICAL CONTROL POINTS; CYCLIZATIONS; ENGINEERED BIOSYNTHESIS; ENZYME FUNCTIONS; IN-VITRO; MOLECULAR MECHANISM; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; POLYKETIDES; REGIOSPECIFIC; SITE DIRECTED MUTAGENESIS; TYPE II;

AROMATIC COMPOUNDS; AROMATIZATION; BIOCHEMISTRY; BIOSYNTHESIS; CYCLIZATION; KETONES;

CRYSTAL STRUCTURE;

AROMATASE; HYDROLYASE; POLYKETIDE; UNCLASSIFIED DRUG; ZHUL AROMATASE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CRYSTAL STRUCTURE; CYCLIZATION; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AROMATASE; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; POLYKETIDE SYNTHASES; SEQUENCE ALIGNMENT; STREPTOMYCES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 80053420377     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200593m     Document Type: Article

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