메뉴 건너뛰기




Volumn 6, Issue 5, 2011, Pages 413-418

Binding and pK a modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein

Author keywords

[No Author keywords available]

Indexed keywords

ACTACP PROTEIN; ACTINORHODINE; ACYL CARRIER PROTEIN; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; MACROLIDE;

EID: 79957506998     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb200004k     Document Type: Conference Paper
Times cited : (24)

References (34)
  • 1
    • 66149105072 scopus 로고    scopus 로고
    • Biosynthesis of aromatic polyketides in bacteria
    • Das, A. and Khosla, C. (2009) Biosynthesis of aromatic polyketides in bacteria Acc. Chem. Res. 42, 631-639
    • (2009) Acc. Chem. Res. , vol.42 , pp. 631-639
    • Das, A.1    Khosla, C.2
  • 2
    • 64349124980 scopus 로고    scopus 로고
    • Structural enzymology of polyketide synthases
    • Tsai, S. C. and Ames, B. D. (2009) Structural enzymology of polyketide synthases Methods Enzymol. 459, 17-47
    • (2009) Methods Enzymol. , vol.459 , pp. 17-47
    • Tsai, S.C.1    Ames, B.D.2
  • 3
    • 33846923183 scopus 로고    scopus 로고
    • Type II polyketide synthases: Gaining a deeper insight into enzymatic teamwork
    • DOI 10.1039/b507395m
    • Hertweck, C., Luzhetskyy, A., Rebets, Y., and Bechthold, A. (2007) Type II PKS: Gaining a deeper insight into enzymatic teamwork Nat. Prod. Rep. 24, 162-190 (Pubitemid 46238594)
    • (2007) Natural Product Reports , vol.24 , Issue.1 , pp. 162-190
    • Hertweck, C.1    Luzhetskyy, A.2    Rebets, Y.3    Bechthold, A.4
  • 4
    • 0027382486 scopus 로고
    • Polyketide synthesis: Prospects for hybrid antibiotics
    • Katz, L. and Donadio, S. (1993) Polyketide synthesis: prospects for hybrid antibiotics Annu. Rev. Microbiol. 47, 875-912 (Pubitemid 23302956)
    • (1993) Annual Review of Microbiology , vol.47 , pp. 875-912
    • Katz, L.1    Donadio, S.2
  • 5
    • 34547102510 scopus 로고    scopus 로고
    • The ubiquitous carrier protein - A window to metabolite biosynthesis
    • DOI 10.1039/b603921a
    • Mercer, A. C. and Burkart, M. D. (2007) The ubiquitous carrier protein-a window to metabolite biosynthesis Nat. Prod.Rep. 24, 750-773 (Pubitemid 47106915)
    • (2007) Natural Product Reports , vol.24 , Issue.4 , pp. 750-773
    • Mercer, A.C.1    Burkart, M.D.2
  • 6
    • 33645968397 scopus 로고    scopus 로고
    • Solution structures of spinach acyl carrier protein with decanoate and stearate
    • Zornetzer, G. A., Fox, B. G., and Markley, J. L. (2006) Solution structures of spinach acyl carrier protein with decanoate and stearate Biochemistry 45, 5217-5227
    • (2006) Biochemistry , vol.45 , pp. 5217-5227
    • Zornetzer, G.A.1    Fox, B.G.2    Markley, J.L.3
  • 7
    • 0036277954 scopus 로고    scopus 로고
    • X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site
    • DOI 10.1016/S0969-2126(02)00775-X, PII S096921260200775X
    • Roujeinikova, A., Baldock, C., Simon, W. J., Gilroy, J., Baker, P. J., Stuitje, A. R., Rice, D. W., Slabas, A. R., and Rafferty, J. B. (2002) X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site Structure 10, 825-835 (Pubitemid 34628711)
    • (2002) Structure , vol.10 , Issue.6 , pp. 825-835
    • Roujeinikova, A.1    Baldock, C.2    Simon, W.J.3    Gilroy, J.4    Baker, P.J.5    Stuitje, A.R.6    Rice, D.W.7    Slabas, A.R.8    Rafferty, J.B.9
  • 8
    • 33751512907 scopus 로고    scopus 로고
    • Structural Studies of Fatty Acyl-(Acyl Carrier Protein) Thioesters Reveal a Hydrophobic Binding Cavity that Can Expand to Fit Longer Substrates
    • DOI 10.1016/j.jmb.2006.09.049, PII S0022283606012733
    • Roujeinikova, A., Simon, W. J., Gilroy, J., Rice, D. W., Rafferty, J. B., and Slabas, A. R. (2007) Structural studies on fatty acyl-(acyl carrier protein) thioesters reveal a hydrophobic binding cavity that can expand to fit larger substrates J. Mol. Biol. 365, 135-145 (Pubitemid 44830032)
    • (2007) Journal of Molecular Biology , vol.365 , Issue.1 , pp. 135-145
    • Roujeinikova, A.1    Simon, W.J.2    Gilroy, J.3    Rice, D.W.4    Rafferty, J.B.5    Slabas, A.R.6
  • 9
    • 0001747786 scopus 로고    scopus 로고
    • Genetic contributions to understanding polyketide synthases
    • Hopwood, D. A. (1997) Genetic contributions to understanding polyketide synthases Chem. Rev. 97, 2465-2498
    • (1997) Chem. Rev. , vol.97 , pp. 2465-2498
    • Hopwood, D.A.1
  • 11
    • 39649122833 scopus 로고    scopus 로고
    • Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
    • DOI 10.1021/bi7016427
    • Korman, T. P., Tan, Y. H., Wong, J., Luo, R., and Tsai, S. C. (2008) Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry 47, 1837-1847 (Pubitemid 351287110)
    • (2008) Biochemistry , vol.47 , Issue.7 , pp. 1837-1847
    • Korman, T.P.1    Tan, Y.-H.2    Wong, J.3    Luo, R.4    Tsai, S.-C.5
  • 12
    • 0021238139 scopus 로고
    • Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host
    • Malpartida, F. and Hopwood, D. A. (1984) Molecular cloning of the whole biosynthetic pathway of a streptomyces antibiotic and its expression in a heterologous host Nature 309, 462-464 (Pubitemid 14102453)
    • (1984) Nature , vol.309 , Issue.5967 , pp. 462-464
    • Malpartida, F.1    Hopwood, D.A.2
  • 13
    • 0033609915 scopus 로고    scopus 로고
    • Kinetic analysis of the actinorhodin aromatic polyketide synthase
    • Dreier, J., Shah, A. N., and Khosla, C. (1999) Kinetic analysis of the actinorhodin aromatic polyketide synthase J. Biol. Chem. 274, 25108-25112
    • (1999) J. Biol. Chem. , vol.274 , pp. 25108-25112
    • Dreier, J.1    Shah, A.N.2    Khosla, C.3
  • 14
    • 4344715857 scopus 로고    scopus 로고
    • Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase
    • DOI 10.1021/np0499564
    • Kalaitzis, J. A. and Moore, B. S. (2004) Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase J. Nat. Prod. 67, 1419-1422 (Pubitemid 39145656)
    • (2004) Journal of Natural Products , vol.67 , Issue.8 , pp. 1419-1422
    • Kalaitzis, J.A.1    Moore, B.S.2
  • 15
    • 65649101867 scopus 로고    scopus 로고
    • Probing the interactions of early polyketide intermediates with the actinorhodin ACP from S. coelicolor A3(2)
    • Evans, S. E., Williams, C., Arthur, C. J., Cox, R. J., Crosby, J., Crump, M. P., and Simpson, T. J. (2009) Probing the interactions of early polyketide intermediates with the actinorhodin ACP from S. coelicolor A3(2) J. Mol. Biol. 389, 511-528
    • (2009) J. Mol. Biol. , vol.389 , pp. 511-528
    • Evans, S.E.1    Williams, C.2    Arthur, C.J.3    Cox, R.J.4    Crosby, J.5    Crump, M.P.6    Simpson, T.J.7
  • 16
    • 1542320193 scopus 로고    scopus 로고
    • Manipulation of carrier proteins in antibiotic biosynthesis
    • DOI 10.1016/S1074-5521(04)00032-8, PII S1074552104000328
    • La Clair, J. J., Foley, T. L., Schegg, T. R., Regan, C. M., and Burkart, M. D. (2004) Manipulation of carrier proteins in antibiotic biosynthesis Chem. Biol. 11, 195-201 (Pubitemid 38300290)
    • (2004) Chemistry and Biology , vol.11 , Issue.2 , pp. 195-201
    • La Clair, J.J.1    Foley, T.L.2    Schegg, T.R.3    Regan, C.M.4    Burkart, M.D.5
  • 17
    • 33645699855 scopus 로고    scopus 로고
    • One-pot chemo-enzymatic synthesis of reporter-modified proteins
    • Worthington, A. S. and Burkart, M. D. (2006) One-pot chemo-enzymatic synthesis of reporter-modified proteins Org. Biomol. Chem. 4, 44-46
    • (2006) Org. Biomol. Chem. , vol.4 , pp. 44-46
    • Worthington, A.S.1    Burkart, M.D.2
  • 18
    • 43549087362 scopus 로고    scopus 로고
    • An orthogonal purification strategy for isolating crosslinked domains of modular synthases
    • DOI 10.1016/j.bmcl.2008.01.026, PII S0960894X08000401
    • Haushalter, R. W., Worthington, A. S., Hur, G. H., and Burkart, M. D. (2008) An orthogonal purification strategy for isolating crosslinked domains of modular synthases Bioorg. Med. Chem. Lett. 18, 3039-3042 (Pubitemid 351680393)
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , Issue.10 , pp. 3039-3042
    • Haushalter, R.W.1    Worthington, A.S.2    Hur, G.H.3    Burkart, M.D.4
  • 19
    • 0020478991 scopus 로고
    • Molecular properties of short chain acyl thioesters of acyl carrier protein
    • Cronan, J. E. (1982) Molecular properties of short chain acyl thioesters of acyl carrier protein J. Biol. Chem. 257, 5013-5017
    • (1982) J. Biol. Chem. , vol.257 , pp. 5013-5017
    • Cronan, J.E.1
  • 20
    • 0026058320 scopus 로고
    • In vivo pools of free and acylated acyl carrier proteins in spinach
    • Post-Beittenmiller, D., Jaworksi, J. G., and Ohlrogge, J. B. (1991) In vivo pools of free and acylated acyl carrier proteins in spinach J. Biol. Chem. 266, 1858-1865
    • (1991) J. Biol. Chem. , vol.266 , pp. 1858-1865
    • Post-Beittenmiller, D.1    Jaworksi, J.G.2    Ohlrogge, J.B.3
  • 21
    • 0031023531 scopus 로고    scopus 로고
    • Structural homology of spinach acyl carrier protein and Escherichia coli acyl carrier protein based on NMR data
    • DOI 10.1002/(SICI)1097-0134(199701)27:1<131::AID-PROT13>3.0.CO;2-O
    • Oswood, M. C., Kim, Y., Ohlrogge, J. B., and Prestegard, J. H. (1997) Structural homology of spinach acyl carrier protein and Escherichia coli acyl carrier protein based on NMR data Proteins 27, 131-143 (Pubitemid 27069261)
    • (1997) Proteins: Structure, Function and Genetics , vol.27 , Issue.1 , pp. 131-143
    • Oswood, M.C.1    Kim, Y.2    Ohlrogge, J.B.3    Prestegard, J.H.4
  • 22
    • 0030972114 scopus 로고    scopus 로고
    • Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)
    • DOI 10.1021/bi970006+
    • Crump, M. P., Crosby, J., Dempsey, C. E., Parkinson, J. A., Murray, M., Hopwood, D. A., and Simpson, T. J. (1997) Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) Biochemistry 36, 6000-6008 (Pubitemid 27257866)
    • (1997) Biochemistry , vol.36 , Issue.20 , pp. 6000-6008
    • Crump, M.P.1    Crosby, J.2    Dempsey, C.E.3    Parkinson, J.A.4    Murray, M.5    Hopwood, D.A.6    Simpson, T.J.7
  • 23
    • 0034886054 scopus 로고    scopus 로고
    • Solution structure of B. subtilis acyl carrier protein
    • DOI 10.1016/S0969-2126(01)00586-X, PII S096921260100586X
    • Xu, G. Y., Tam, A., Lin, L., Hixon, J., Fritz, C. C., and Powers, R. (2001) Solution structure of B. subtilis acyl carrier protein Structure 9, 277-287 (Pubitemid 32772573)
    • (2001) Structure , vol.9 , Issue.4 , pp. 277-287
    • Xu, G.-Y.1    Tam, A.2    Lin, L.3    Hixon, J.4    Fritz, C.C.5    Powers, R.6
  • 24
    • 0037472114 scopus 로고    scopus 로고
    • Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein
    • DOI 10.1021/bi0274120
    • Li, Q., Khosla, C., Puglisi, J. D., and Liu, C. W. (2003) Solution structure and backbone dynamics of the holo form of the Frenolicin acyl carrier protein Biochemistry 42, 4648-4657 (Pubitemid 36506020)
    • (2003) Biochemistry , vol.42 , Issue.16 , pp. 4648-4657
    • Li, Q.1    Khosla, C.2    Puglisi, J.D.3    Liu, C.W.4
  • 25
    • 54349095025 scopus 로고    scopus 로고
    • An ACP structural switch: Conformational differences between the apo and holo forms of the actinorhodin polyketide synthase acyl carrier protein
    • Evans, S. E., Williams, C., Arthur, C. J., Burston, S. G., Simpson, T. J., Crosby, J., and Crump, M. P. (2008) An ACP structural switch: conformational differences between the apo and holo forms of the actinorhodin polyketide synthase acyl carrier protein ChemBioChem. 9, 2424-2432
    • (2008) ChemBioChem. , vol.9 , pp. 2424-2432
    • Evans, S.E.1    Williams, C.2    Arthur, C.J.3    Burston, S.G.4    Simpson, T.J.5    Crosby, J.6    Crump, M.P.7
  • 26
    • 1242340502 scopus 로고    scopus 로고
    • New applications of 2D filtered/edited NOESY for assignment and structure elucidation of RNA and RNA-protein complexes
    • DOI 10.1023/B:JNMR.0000012861.95939.05
    • Peterson, R. D., Theimer, C. A., Wu, H. H., and Feigon, J. (2004) New applications of 2D filtered/edited NOESY for assignment and structure elucidation of RNA and RNA-protein complexes J. Biomol. NMR 28, 59-67 (Pubitemid 38220160)
    • (2004) Journal of Biomolecular NMR , vol.28 , Issue.1 , pp. 59-67
    • Peterson, R.D.1    Theimer, C.A.2    Wu, H.3    Feigon, J.4
  • 27
    • 0026619586 scopus 로고
    • Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments
    • DOI 10.1016/0014-5793(92)81517-P
    • Logan, T. M., Olejniczak, E. T., Xu, R. X., and Fesik, S. W. (1992) Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments FEBS Lett. 314, 413-418 (Pubitemid 23005701)
    • (1992) FEBS Letters , vol.314 , Issue.3 , pp. 413-418
    • Logan, T.M.1    Olejniczak, E.T.2    Xu, R.X.3    Fesik, S.W.4
  • 28
    • 0034867972 scopus 로고    scopus 로고
    • Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases
    • DOI 10.1021/np010067f
    • Wohlert, S., Wendt-Pienkowski, E., Bao, W., and Hutchinson, C. R. (2001) Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases J. Nat. Prod. 64, 1077-1080 (Pubitemid 32800343)
    • (2001) Journal of Natural Products , vol.64 , Issue.8 , pp. 1077-1080
    • Wohlert, S.-E.1    Wendt-Pienkowski, E.2    Bao, W.3    Hutchinson, C.R.4
  • 30
    • 58149114916 scopus 로고    scopus 로고
    • Mechanical features of Plasmodium falciparum acyl carrier protein in the delivery of substrates
    • Colizzi, F., Recanatini, M., and Cavalli, A. (2008) Mechanical features of Plasmodium falciparum acyl carrier protein in the delivery of substrates J. Chem. Inf. Model 12, 2289-2293
    • (2008) J. Chem. Inf. Model , vol.12 , pp. 2289-2293
    • Colizzi, F.1    Recanatini, M.2    Cavalli, A.3
  • 32
    • 75749140876 scopus 로고    scopus 로고
    • A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase
    • Yasgar, A., Foley, T. L., Jadhav, A., Inglese, J., Burkart, M. D., and Simeonov, A. (2010) A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase Mol. Biosyst. 6, 365-375
    • (2010) Mol. Biosyst. , vol.6 , pp. 365-375
    • Yasgar, A.1    Foley, T.L.2    Jadhav, A.3    Inglese, J.4    Burkart, M.D.5    Simeonov, A.6
  • 33
    • 0031872017 scopus 로고    scopus 로고
    • Acylation of Streptomyces type II polyketide synthase acyl carrier proteins
    • DOI 10.1016/S0014-5793(98)00840-0, PII S0014579398008400
    • Crosby, J., Byrom, K. J., Hitchman, T. S., Cox, R. J., Crump, M. P., Findlow, I. S., Bibb, M. J., and Simpson, T. J. (1998) Acylation of streptomyces type II polyketide synthase acyl carrier proteins FEBS Lett. 433, 132-138 (Pubitemid 28392272)
    • (1998) FEBS Letters , vol.433 , Issue.1-2 , pp. 132-138
    • Crosby, J.1    Byrom, K.J.2    Hitchman, T.S.3    Cox, R.J.4    Crump, M.P.5    Findlow, I.S.C.6    Bibb, M.J.7    Simpson, T.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.