Structural Studies of Fatty Acyl-(Acyl Carrier Protein) Thioesters Reveal a Hydrophobic Binding Cavity that Can Expand to Fit Longer Substrates

Journal of Molecular Biology

Volumn 365, Issue 1, 2007, Pages 135-145

  Roujeinikova, Anna ^a   Simon, William J ^b   Gilroy, John ^b   Rice, David W ^a   Rafferty, John B ^a   Slabas, Antoni R ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

acyl carrier protein; acyl chain binding; conformational changes; fatty acid biosynthesis; hydrophobic binding pocket

Indexed keywords

ACYL CARRIER PROTEIN; FATTY ACID; PANTETHEINE PHOSPHATE; SERINE;

ACYLATION; ALPHA HELIX; ARTICLE; CHEMICAL BOND; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; HYDROPHOBICITY; LIPOGENESIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ESCHERICHIA COLI;

EID: 33751512907     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.09.049     Document Type: Article

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