Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase

Biochemistry

Volumn 47, Issue 7, 2008, Pages 1837-1847

  Korman, Tyler Paz ^a   Tan, Yu Hong ^a   Wong, Justin ^a   Luo, Ray ^a   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC TETRACYCLINE; ANTITUMOR COMPOUND DOXORUBICIN; CARBONYL GROUP;

ANTIBIOTICS; AROMATIC COMPOUNDS; ENZYME INHIBITION; MOLECULAR DYNAMICS; PHARMACOKINETICS; TUMORS;

CRYSTAL STRUCTURE;

ACTINORHODINE; BLOCKING AGENT; EMODIN; FUNCTIONAL GROUP; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PANTETHEINE PHOSPHATE; POLYKETIDE KETOREDUCTASE; POLYKETIDE SYNTHASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEOMETRY; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; REDUCTION; SIMULATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ALCOHOL OXIDOREDUCTASES; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; EMODIN; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 39649122833     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7016427     Document Type: Article

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