메뉴 건너뛰기




Volumn 39, Issue 4, 2011, Pages 317-337

Vaginal irritation models: The current status of available alternative and in vitro tests

Author keywords

Alternatives to animal testing; In vitro assays; Vaginal irritation

Indexed keywords

MICROBICIDE; SPERMICIDAL AGENT;

EID: 80053394340     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291103900403     Document Type: Review
Times cited : (44)

References (88)
  • 2
    • 84859932411 scopus 로고
    • Center for Drug Evaluation and Research Silver Spring, MD, USA: US Department of Health and Human Services, Food and Drug Administration. Available at: Accessed 22.06.11
    • Center for Drug Evaluation and Research (1995). Guidance for Industry. Guidance for Development of Vaginal Contraceptive Drugs, 6pp. Silver Spring, MD, USA: US Department of Health and Human Services, Food and Drug Administration. Available at: http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/ WomensHealthResearch/UCM131211.pdf (Accessed 22.06.11).
    • (1995) Guidance for Industry. Guidance for Development of Vaginal Contraceptive Drugs , pp. 6
  • 3
    • 78449295622 scopus 로고    scopus 로고
    • Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (recast)
    • Anon. 22.12. 2009
    • Anon. (2009). Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (recast). Official Journal of the European Union L342, 22.12. 2009, 59-209.
    • (2009) Official Journal of the European Union , vol.L342 , pp. 59-209
  • 4
    • 24944481113 scopus 로고    scopus 로고
    • The in vitro acute skin irritation of chemicals: Optimisation of the EPISKIN prediction model within the framework of the ECVAM validation process
    • Cotovio, J., Grandidier, M.H., Portes, P., Roguet, R. & Rubinstenn, G. (2005). The in vitro skin irritation of chemicals: Optimisation of the EPISKIN prediction model within the framework of the ECVAM validation process. ATLA 33, 329-349. (Pubitemid 41330270)
    • (2005) ATLA Alternatives to Laboratory Animals , vol.33 , Issue.4 , pp. 329-349
    • Cotovio, J.1    Grandidier, M.-H.2    Portes, P.3    Roguet, R.4    Rubinstenn, G.5
  • 6
    • 85088742670 scopus 로고    scopus 로고
    • SkinEthic Laboratories Nice, France: SkinEthic laboratories. Available at: Accessed 22. 06.11
    • SkinEthic Laboratories (2009). SkinEthic Skin Irritation Test-42bis. Standard Operating Procedure (SOP), 43pp. Nice, France: SkinEthic laboratories. Available at: http://ecvam.jrc.it/ft-doc/SkinEthic-RHE-SOP%20INVITTOX%202.0.pdf (Accessed 22. 06.11).
    • (2009) -42bis. Standard Operating Procedure (SOP) , pp. 43
  • 7
    • 84859928460 scopus 로고    scopus 로고
    • MatTek Corporation Ashland, MA, USA: MatTek Corporation. Available at: Accessed 22.06.11
    • MatTek Corporation (2009). Protocol for In Vitro EpidermTM Skin Irritation Test (EPI-200-SIT), 37pp. Ashland, MA, USA: MatTek Corporation. Available at: http://ecvam.jrc.it/ft-doc/MK-24-007- 0023%20Modified%20EpiDerm%20SIT-SOP%202009-03-23.pdf (Accessed 22.06.11).
    • (2009) Protocol for in Vitro EpidermTM Skin Irritation Test (EPI-200-SIT) , pp. 37
  • 9
    • 5644283590 scopus 로고    scopus 로고
    • Intravaginal gels as drug delivery systems
    • DOI 10.1089/jwh.2004.13.834
    • Justin-Temu, M., Damian, F., Kinget, R. & van Den Mooter, G. (2004). Intravaginal gels as drug delivery systems. Journal of Women's Health 13, 834-844. (Pubitemid 39369265)
    • (2004) Journal of Women's Health , vol.13 , Issue.7 , pp. 834-844
    • Justin-Temu, M.1    Damain, F.2    Kinget, R.3    Van Den, M.G.4
  • 10
    • 14844314490 scopus 로고    scopus 로고
    • The vagina as a route for systemic drug delivery
    • DOI 10.1016/j.jconrel.2004.11.034, PII S0168365904006297
    • Hussain, A. & Ahsan, F. (2005). The vagina as a route for systemic drug delivery. Journal of Controlled Release 103, 301-313. (Pubitemid 40342532)
    • (2005) Journal of Controlled Release , vol.103 , Issue.2 , pp. 301-313
    • Hussain, A.1    Ahsan, F.2
  • 11
    • 0032739391 scopus 로고    scopus 로고
    • Prophylactic contraceptives for HIV/AIDS
    • DOI 10.1093/humupd/5.5.506
    • Uckun, F.M. & D'Cruz, O.J. (1999). Prophylactic contraceptives for HIV/AIDS. Human Reproduction Update 5, 506-514. (Pubitemid 29512137)
    • (1999) Human Reproduction Update , vol.5 , Issue.5 , pp. 506-514
    • Uckun, F.M.1    D'Cruz, O.J.2
  • 12
    • 0026196420 scopus 로고
    • The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa
    • Niruthisard, S., Roddy, R.E. & Chutivongse, S. (1991). The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa. Sexually Transmitted Diseases 18, 176-179.
    • (1991) Sexually Transmitted Diseases , vol.18 , pp. 176-179
    • Niruthisard, S.1    Roddy, R.E.2    Chutivongse, S.3
  • 16
    • 0031924987 scopus 로고    scopus 로고
    • Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1
    • Rosenstein, I.J., Stafford, M.K., Kitchen, V.S., Ward, H., Weber, J.N. & Taylor-Robinson, D. (1998). Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1. Journal of Infectious Diseases 177, 1386-1390. (Pubitemid 28194284)
    • (1998) Journal of Infectious Diseases , vol.177 , Issue.5 , pp. 1386-1390
    • Rosenstein, I.J.1    Stafford, M.K.2    Kitchen, V.S.3    Ward, H.4    Weber, J.N.5    Taylor-Robinson, D.6
  • 17
    • 0035882332 scopus 로고    scopus 로고
    • The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission
    • DOI 10.1086/322047
    • Fichorova, R.N., Tucker, L.D. & Anderson, D.J. (2001). The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. Journal of Infectious Diseases 184, 418-428. (Pubitemid 32718505)
    • (2001) Journal of Infectious Diseases , vol.184 , Issue.4 , pp. 418-428
    • Fichorova, R.N.1    Tucker, L.D.2    Anderson, D.J.3
  • 18
    • 0036843332 scopus 로고    scopus 로고
    • Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of chlamydia trachomatis
    • Achilles, S.L., Shete, P.B., Whaley, K.J., Moench, T.R. & Cone, R.A. (2002). Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis. Sexually Transmitted Diseases 29, 655-664. (Pubitemid 35266407)
    • (2002) Sexually Transmitted Diseases , vol.29 , Issue.11 , pp. 655-664
    • Achilles, S.L.1    Shete, P.B.2    Whaley, K.J.3    Moench, T.R.4    Cone, R.A.5
  • 19
    • 0036920022 scopus 로고    scopus 로고
    • Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07)
    • DOI 10.1093/jac/dkg001
    • D'Cruz, O.J. & Uckun, F.M. (2002). Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07). Journal of Antimicrobial Chemotherapy 50, 793-803. (Pubitemid 36032797)
    • (2002) Journal of Antimicrobial Chemotherapy , vol.50 , Issue.6 , pp. 793-803
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 21
    • 80053387889 scopus 로고
    • Harmlessness tests of chemical contraceptives in rhesus monkeys
    • London, UK: International Planned Parenthood Federation
    • Eckstein, P. (1959). Harmlessness tests of chemical contraceptives in rhesus monkeys. In Proceedings of the 6th International Conference Planned Parenthood, New Delhi, p. 620. London, UK: International Planned Parenthood Federation.
    • (1959) Proceedings of the 6th International Conference Planned Parenthood, New Delhi , pp. 620
    • Eckstein, P.1
  • 23
    • 0033026047 scopus 로고    scopus 로고
    • Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina)
    • DOI 10.1016/S0002-9378(99)70598-3
    • Patton, D.L., Kidder, G.G., Sweeney, Y.C., Rabe, L.K. & Hillier, S.L. (1999). Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina). American Journal of Obstetrics & Gynecology 180, 1080-1087. (Pubitemid 29258998)
    • (1999) American Journal of Obstetrics and Gynecology , vol.180 , Issue.5 , pp. 1080-1087
    • Patton, D.L.1    Kidder, G.G.2    Sweeney, Y.C.3    Rabe, L.K.4    Hillier, S.L.5
  • 24
    • 22244484135 scopus 로고    scopus 로고
    • A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate
    • DOI 10.1080/01926230590959866
    • D'Cruz, O.J., Erbeck, D. & Uckun, F.M. (2005). A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate. Toxicol ogic Pathology 33, 465-476. (Pubitemid 40995486)
    • (2005) Toxicologic Pathology , vol.33 , Issue.4 , pp. 465-476
    • D'Cruz, O.J.1    Erbeck, D.2    Uckun, F.M.3
  • 25
    • 80053414523 scopus 로고
    • Birth control studies. 2. Observation on the effects of common contraceptives on the vaginal and uterine mucosa
    • Carleton, H.M. & Florey, H. (1931). Birth control studies. 2. Observation on the effects of common contraceptives on the vaginal and uterine mucosa. Journal of Obstetrics & Gynaecology of the British Empire 38, 555.
    • (1931) Journal of Obstetrics & Gynaecology of the British Empire , vol.38 , pp. 555
    • Carleton, H.M.1    Florey, H.2
  • 26
    • 0018824754 scopus 로고
    • Studies of nonoxynol-9. I. The effect on the vaginas of rabbits and rats
    • Chvapil, M., Droegemueller, W., Owen, J.A., Eskelson, C.D. & Betts, K. (1980). Studies of nonoxynol-9. I. The effect on the vaginas of rabbits and rats. Fertility & Sterility 33, 445-450. (Pubitemid 10110411)
    • (1980) Fertility and Sterility , vol.33 , Issue.4 , pp. 445-450
    • Chvapil, M.1    Droegemueller, W.2    Owen, J.A.3
  • 27
    • 0019960171 scopus 로고
    • pH and the potential irritancy of douche formulations to the vaginal mucosa of the albino rabbit and rat
    • DOI 10.1016/S0278-6915(82)80247-0
    • Kaminsky, M. & Willigan, D.A. (1982). pH and the potential irritancy of douche formulations to the vaginal mucosa of the albino rabbit and rat. Food & Chemical Toxicology 20, 193-196. (Pubitemid 12058513)
    • (1982) Food and Chemical Toxicology , vol.20 , Issue.2 , pp. 193-196
    • Kaminsky, M.1    Willigan, D.A.2
  • 28
    • 0022369912 scopus 로고
    • Comparison of the sensitivity of the vaginal mucous membranes of the albino rabbit and laboratory rat to nonoxynol-9
    • DOI 10.1016/0278-6915(85)90161-9
    • Kaminsky, M., Szivos, M.M., Brown, K.R. & Willigan, D.A. (1985). Comparison of the sensitivity of the vaginal mucous membranes of the albino rabbit and laboratory rat to nonoxynol-9. Food & Chemical Toxicology 23, 705-708. (Pubitemid 16240193)
    • (1985) Food and Chemical Toxicology , vol.23 , Issue.7 , pp. 705-708
    • Kaminsky, M.1    Szivos, M.M.2    Brown, K.R.3    Willigan, D.A.4
  • 29
    • 0036351434 scopus 로고    scopus 로고
    • Evaluation of an alternative mucosal irritation test using slugs
    • DOI 10.1006/taap.2002.9444
    • Adriaens, E. & Remon, J.P. (2002). Evaluation of an alternative mucosal irritation test using slugs. Toxicology & Applied Pharmacology 182, 169-175. (Pubitemid 34971721)
    • (2002) Toxicology and Applied Pharmacology , vol.182 , Issue.2 , pp. 169-175
    • Adriaens, E.1    Remon, J.P.2
  • 30
    • 1642463880 scopus 로고    scopus 로고
    • The Evaluation of the Local Tolerance of Vaginal Formulations, with or without Nonoxynol-9, Using the Slug Mucosal Irritation Test
    • DOI 10.1097/01.OLQ.0000118422.62336.FA
    • Dhondt, M.M., Adriaens, E. & Remon, J.P. (2004). The evaluation of the local tolerance of vaginal formulations, with or without nonoxynol-9, using the slug mucosal irritation test. Sexually Transmitted Diseases 31, 229-235. (Pubitemid 38401921)
    • (2004) Sexually Transmitted Diseases , vol.31 , Issue.4 , pp. 229-235
    • Dhondt, M.M.M.1    Adriaens, E.2    Remon, J.-P.3
  • 32
    • 0141478813 scopus 로고    scopus 로고
    • Qualitative and quantitative differences in normal vaginal flora of conventionally reared mice, rats, hamsters, rabbits, and dogs
    • Noguchi, K., Tsukumi, K. & Urano, T. (2003). Qualitative and quantitative differences in normal vaginal flora of conventionally reared mice, rats, hamsters, rabbits, and dogs. Comparative Medicine 53, 404-412. (Pubitemid 37129300)
    • (2003) Comparative Medicine , vol.53 , Issue.4 , pp. 404-412
    • Noguchi, K.1    Tsukumi, K.2    Urano, T.3
  • 33
    • 0035045255 scopus 로고    scopus 로고
    • Properties of a new, long-lasting vaginal delivery system (LASRS) for contraceptive and antimicrobial agents
    • Zaneveld, L.J., Waller, D.P., Ahmad, N., Quigg, K., Kaminski, J., Nikurs, A. & De Jonge, C. (2001). Properties of a new, long-lasting vaginal delivery system (LASRS) for contraceptive and antimicrobial agents. Journal of Andrology 22, 481-490. (Pubitemid 32322140)
    • (2001) Journal of Andrology , vol.22 , Issue.3 , pp. 481-490
    • Zaneveld, L.J.D.1    Waller, D.P.2    Ahmad, N.3    Quigg, J.4    Kaminski, J.5    Nikurs, A.6    De Jonge, C.7
  • 35
    • 0016622607 scopus 로고
    • Physiological aspects of sperm transport in the domestic pig, Sus scrofa. II. Regulation, survival and fate of cells
    • Hunter, R.H. (1975). Physiological aspects of sperm transport in the domestic pig, Sus scrofa. II. Regulation, survival and fate of cells. British Veterinary Journal 131, 681-690.
    • (1975) British Veterinary Journal , vol.131 , pp. 681-690
    • Hunter, R.H.1
  • 36
    • 0017537578 scopus 로고
    • Physiological factors influencing ovulation, fertilization, early embryonic development and establishment of pregnancy in pigs
    • Hunter, R.H. (1977). Physiological factors influencing ovulation, fertilization, early embryonic development and establishment of pregnancy in pigs. British Veterinary Journal 133, 461-470.
    • (1977) British Veterinary Journal , vol.133 , pp. 461-470
    • Hunter, R.H.1
  • 37
    • 22044441722 scopus 로고
    • Reproductive phys iology
    • ed. W. Pond & K. Houpt New York, NY, USA: Cornell University Press
    • Pond, W.G. & Houpt, K.A. (1988). Reproductive phys iology. In The Biology of the Pig (ed. W. Pond & K. Houpt), pp. 129-180. New York, NY, USA: Cornell University Press.
    • (1988) The Biology of the Pig , pp. 129-180
    • Pond, W.G.1    Houpt, K.A.2
  • 40
    • 0342313696 scopus 로고    scopus 로고
    • Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: Impact on the search for vaginal microbicides
    • DOI 10.1002/(SICI)1096-9071(200005)61:1<107::AID-JMV17>3.0.CO;2-W
    • Neyts, J., Kristmundsdottir, T., De Clercq, E. & Thormar, H. (2000). Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: Impact on the search for vaginal microbicides. Journal of Medical Virology 61, 107-110. (Pubitemid 30191234)
    • (2000) Journal of Medical Virology , vol.61 , Issue.1 , pp. 107-110
    • Neyts, J.1    Kristmundsdottir, T.2    De Clercq, E.3    Thormar, H.4
  • 41
    • 0034766237 scopus 로고    scopus 로고
    • Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles
    • DOI 10.1016/S0010-7824(01)00233-5, PII S0010782401002335
    • D'Cruz, O.J. & Uckun, F.M. (2001). Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles. Contraception 64, 113-123. (Pubitemid 33042598)
    • (2001) Contraception , vol.64 , Issue.2 , pp. 113-123
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 42
    • 0035174131 scopus 로고    scopus 로고
    • Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide
    • DOI 10.1016/S0015-0282(00)01636-8, PII S0015028200016368
    • D'Cruz, O.J., Yiv, S.H., Waurzyniak, B. & Uckun, F.M. (2001). Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide. Fertility & Sterility 75, 115-124. (Pubitemid 32041232)
    • (2001) Fertility and Sterility , vol.75 , Issue.1 , pp. 115-124
    • D'Cruz, O.J.1    Yiv, S.H.2    Waurzyniak, B.3    Uckun, F.M.4
  • 43
    • 33645784598 scopus 로고    scopus 로고
    • Preclinical evaluation of synthetic-2 RANTES as a candidate vaginal microbicide to target CCR5
    • Kish-Catalone, T.M., Lu, W., Gallo, R.C. & DeVico, A.L. (2006). Preclinical evaluation of synthetic-2 RANTES as a candidate vaginal microbicide to target CCR5. Antimicrobial Agents & Chemotherapy 50, 1497-1509.
    • (2006) Antimicrobial Agents & Chemotherapy , vol.50 , pp. 1497-1509
    • Kish-Catalone, T.M.1    Lu, W.2    Gallo, R.C.3    DeVico, A.L.4
  • 44
    • 0035145666 scopus 로고    scopus 로고
    • Reproductive endocrinology and toxicological pathology over the life span of the female rodent
    • DOI 10.1080/019262301301418874
    • Davis, B.J., Traylos, G. & McShane, T. (2001). Reproductive endocrinology and toxicological pathology over the life span of the female rodent. Toxicologic Pathology 29, 77-83. (Pubitemid 32127325)
    • (2001) Toxicologic Pathology , vol.29 , Issue.1 , pp. 77-83
    • Davis, B.J.1    Travlos, G.2    McShane, T.3
  • 46
    • 0032854630 scopus 로고    scopus 로고
    • Gastropods as an evaluation tool for screening the irritating potency of absorption enhancers and drugs
    • DOI 10.1023/A:1014801714590
    • Adriaens, E. & Remon, J.P. (1999). Gastropods as an evaluation tool for screening the irritating potency of absorption enhancers and drugs. Pharmaceutical Research 16, 1240-1244. (Pubitemid 29393613)
    • (1999) Pharmaceutical Research , vol.16 , Issue.8 , pp. 1240-1244
    • Adriaens, E.1    Remon, J.P.2
  • 47
    • 0034872948 scopus 로고    scopus 로고
    • The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs
    • DOI 10.1023/A:1010928025753
    • Adriaens, E., Dierckens, K., Bauters, T.G., Nelis, H.J., van Goethem, F., vanparys, P. & Remon, J.P. (2001). The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs. Pharmaceutical Research 18, 937-942. (Pubitemid 32799937)
    • (2001) Pharmaceutical Research , vol.18 , Issue.7 , pp. 937-942
    • Adriaens, E.1    Dierckens, K.2    Bauters, T.G.M.3    Nelis, H.J.4    Van Goethem, F.5    Vanparys, P.6    Remon, J.P.7
  • 48
    • 0035856772 scopus 로고    scopus 로고
    • Evaluation of a mucoadhesive tablet for ocular use
    • DOI 10.1016/S0168-3659(01)00522-3, PII S0168365901005223
    • Ceulemans, J., Vermeire, A., Adriaens, E., Remon, J.P. & Ludwig, A. (2001). Evaluation of a mucoadhesive tablet for ocular use. Journal of Controlled Release 77, 333-344. (Pubitemid 33145484)
    • (2001) Journal of Controlled Release , vol.77 , Issue.3 , pp. 333-344
    • Ceulemans, J.1    Vermeire, A.2    Adriaens, E.3    Remon, J.P.4    Ludwig, A.5
  • 49
    • 0037467213 scopus 로고    scopus 로고
    • Evaluation of the mucosal irritation potency of co-spray dried Amioca/poly(acrylic acid) and Amioca/Carbopol974P mixtures
    • DOI 10.1016/S0168-3659(03)00012-9
    • Adriaens, E., Ameye, D., Dhondt, M.M., Foreman, P. & Remon, J.P. (2003). Evaluation of the mucosal irritation potency of co-spray dried Amioca/poly(acrylic acid) and Amioca/Carbopol 974P mixtures. Journal of Controlled Release 88, 393-399. (Pubitemid 36331881)
    • (2003) Journal of Controlled Release , vol.88 , Issue.3 , pp. 393-399
    • Adriaens, E.1    Ameye, D.2    Dhondt, M.M.M.3    Foreman, P.4    Remon, J.P.5
  • 51
    • 21544451416 scopus 로고    scopus 로고
    • The evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the rabbit vaginal irritation test
    • DOI 10.1016/j.ejpb.2005.01.012, PII S0939641105000688
    • Dhondt, M.M., Adriaens, E., Roey, J.V. & Remon, J.P. (2005). The evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the Rabbit Vaginal Irritation test. European Journal of Pharmaceutics & Biopharmaceutics 60, 419-425. (Pubitemid 40922840)
    • (2005) European Journal of Pharmaceutics and Biopharmaceutics , vol.60 , Issue.3 , pp. 419-425
    • Dhondt, M.M.M.1    Adriaens, E.2    Roey, J.V.3    Remon, J.P.4
  • 54
    • 38549116136 scopus 로고    scopus 로고
    • Differentiating normal from abnormal rates of genital epithelial findings in vaginal microbicide trials
    • van de Wijgert, J.H., Kilmarx, P.H., Jones, H.E., Karon, J.M. & Chaikummao, S. (2008). Differentiating normal from abnormal rates of genital epithelial findings in vaginal microbicide trials. Cont raception 77, 122-129.
    • (2008) Cont Raception , vol.77 , pp. 122-129
    • Van De Wijgert, J.H.1    Kilmarx, P.H.2    Jones, H.E.3    Karon, J.M.4    Chaikummao, S.5
  • 55
    • 0018563363 scopus 로고
    • Human vaginal epithelial multilayer tissue culture
    • Sobel, J.D., Tchao, R., Bozzola, J., Levison, M.E. & Kaye, D. (1979). Human vaginal epithelial multilayer tissue culture. In Vitro 15, 993-1000. (Pubitemid 10121934)
    • (1979) In Vitro , vol.15 , Issue.12 , pp. 993-1000
    • Sobel, J.D.1    Tchao, R.2    Bozzola, J.3
  • 56
    • 0033918345 scopus 로고    scopus 로고
    • Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: Comparative sensitivity of primary human vaginal keratinocytes
    • DOI 10.1128/AAC.44.7.1954-1960.2000
    • Krebs, F.C., Miller, S.R., Catalone, B.J., Welsh, P.A., Malamud, D., Howett, M.K. & Wigdahl, B. (2000). Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: Comparative sensitivity of primary human vaginal keratinocytes. Antimicrobial Agents & Chemotherapy 44, 1954-1960. (Pubitemid 30422954)
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , Issue.7 , pp. 1954-1960
    • Krebs, F.C.1    Miller, S.R.2    Catalone, B.J.3    Welsh, P.A.4    Malamud, D.5    Howett, M.K.6    Wigdahl, B.7
  • 58
    • 0030961161 scopus 로고    scopus 로고
    • Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins
    • DOI 10.1095/biolreprod57.4.847
    • Fichorova, R.N., Rheinwald, J.G. & Anderson, D.J. (1997). Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biology of Reproduction 57, 847-855. (Pubitemid 27407205)
    • (1997) Biology of Reproduction , vol.57 , Issue.4 , pp. 847-855
    • Fichorova, R.N.1    Rheinwald, J.G.2    Anderson, D.J.3
  • 59
    • 4243077564 scopus 로고    scopus 로고
    • Interleukin (IL)-1, IL-6 and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives
    • DOI 10.1095/biolreprod.104.029603
    • Fichorova, R.N., Bajpai, M., Chandra, N., Hsiu, J.G., Spangler, M., Ratnam, V. & Doncel, G.F. (2004). Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biology of Reproduction 71, 761-769. (Pubitemid 39108635)
    • (2004) Biology of Reproduction , vol.71 , Issue.3 , pp. 761-769
    • Fichorova, R.N.1    Bajpai, M.2    Chandra, N.3    Hsiu, J.G.4    Spangler, M.5    Ratnam, V.6    Doncel, G.F.7
  • 60
    • 0035984827 scopus 로고    scopus 로고
    • Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate
    • DOI 10.1128/AAC.46.7.2292-2298.2002
    • Krebs, F.C., Miller, S.R., Catalone, B.J., Fichorova, R., Anderson, D., Malamud, D., Howett, M.K. & Wigdahl, B. (2002). Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate. Antimicrobial Agents & Chemotherapy 46, 2292-2298. (Pubitemid 34665935)
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , Issue.7 , pp. 2292-2298
    • Krebs, F.C.1    Miller, S.R.2    Catalone, B.J.3    Fichorova, R.4    Anderson, D.5    Malamud, D.6    Howett, M.K.7    Wigdahl, B.8
  • 61
    • 84859928499 scopus 로고    scopus 로고
    • OECD Guideline for the Testing of Chemicals. Draft Proposal for a New Guideline
    • Paris, France: Organisation for Economic Co-operation and Development. Available at: Accessed 22.06.11
    • OECD (2009). OECD Guideline for the Testing of Chemicals. Draft Proposal for a New Guideline. In Vitro Skin Irritation: Reconstructed Human Epidermis (RhE) Test Method, 19pp. Paris, France: Organisation for Economic Co-operation and Development. Available at: http://www.oecd.org/dataoecd/1/59/43664841.pdf (Accessed 22.06.11).
    • (2009) Vitro Skin Irritation: Reconstructed Human Epidermis (RhE) Test Method , pp. 19
  • 62
    • 3242689431 scopus 로고    scopus 로고
    • HIV-1 infection of langerhans cells in a reconstructed vaginal mucosa
    • DOI 10.1086/421704
    • Sivard, P., Berlier, W., Picard, B., Sabido, O., Genin, C. & Misery, L. (2004). HIV-1 infection of Langerhans cells in a reconstructed vaginal mucosa. Journal of Infectious Diseases 190, 227-235. (Pubitemid 38951960)
    • (2004) Journal of Infectious Diseases , vol.190 , Issue.2 , pp. 227-235
    • Sivard, P.1    Berlier, W.2    Picard, B.3    Sabido, O.4    Genin, C.5    Misery, L.6
  • 66
    • 77953116144 scopus 로고    scopus 로고
    • Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model
    • Hjelm, B.E., Berta, A.N., Nickerson, C.A., Arntzen, C.J. & Herbst-Kralovetz, M.M. (2010). Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model. Biology of Reproduction 82, 617-627.
    • (2010) Biology of Reproduction , vol.82 , pp. 617-627
    • Hjelm, B.E.1    Berta, A.N.2    Nickerson, C.A.3    Arntzen, C.J.4    Herbst-Kralovetz, M.M.5
  • 67
    • 33744530518 scopus 로고    scopus 로고
    • Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products
    • DOI 10.1016/j.tiv.2005.10.002, PII S0887233305002171
    • Ayehunie, S., Cannon, C., Lamore, S., Kubilus, J., Anderson, D.J., Pudney, J. & Klausner, M. (2006). Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products. Toxicology in Vitro 20, 689-698. (Pubitemid 43816250)
    • (2006) Toxicology in Vitro , vol.20 , Issue.5 , pp. 689-698
    • Ayehunie, S.1    Cannon, C.2    Lamore, S.3    Kubilus, J.4    Anderson, D.J.5    Pudney, J.6    Klausner, M.7
  • 68
    • 33746696607 scopus 로고    scopus 로고
    • Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells
    • DOI 10.1086/505712
    • Canny, G.O., Trifonova, R.T., Kindelberger, D.W., Colgan, S.P. & Fichorova, R.N. (2006). Expression and function of bactericidal/permeability- increasing protein in human genital tract epithelial cells. Journal of Infectious Diseases 194, 498-502. (Pubitemid 44162662)
    • (2006) Journal of Infectious Diseases , vol.194 , Issue.4 , pp. 498-502
    • Canny, G.O.1    Trifonova, R.T.2    Kindelberger, D.W.3    Colgan, S.P.4    Fichorova, R.N.5
  • 69
    • 33749263019 scopus 로고    scopus 로고
    • Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells
    • DOI 10.1128/IAI.00631-06
    • Fichorova, R.N., Trifonova, R.T., Gilbert, R.O., Costello, C.E., Hayes, G.R., Lucas, J.J. & Singh, B.N. (2006). Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infection & Immunity 74, 5773-5779. (Pubitemid 44484563)
    • (2006) Infection and Immunity , vol.74 , Issue.10 , pp. 5773-5779
    • Fichorova, R.N.1    Trifonova, R.T.2    Gilbert, R.O.3    Costello, C.E.4    Hayes, G.R.5    Lucas, J.J.6    Singh, B.N.7
  • 70
    • 33845239887 scopus 로고    scopus 로고
    • Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo
    • DOI 10.1128/AAC.00588-06
    • Trifonova, R.T., Pasicznyk, J.M. & Fichorova, R.N. (2006). Biocompatibility of solid-dosage forms of antihuman immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo. Antimicrobial Agents & Chemotherapy 50, 4005-4010. (Pubitemid 44865142)
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.12 , pp. 4005-4010
    • Trifonova, R.T.1    Pasicznyk, J.-M.2    Fichorova, R.N.3
  • 71
    • 78650005338 scopus 로고    scopus 로고
    • Development of an in vitro alternative assay method for vaginal irritation
    • Ayehunie, S., Cannon, C., Larosa, K., Pudney, J., Anderson, D.J. & Klausner, M. (2011). Development of an in vitro alternative assay method for vaginal irritation. Toxicology 279, 130-138.
    • (2011) Toxicology , vol.279 , pp. 130-138
    • Ayehunie, S.1    Cannon, C.2    Larosa, K.3    Pudney, J.4    Anderson, D.J.5    Klausner, M.6
  • 72
    • 0037767275 scopus 로고    scopus 로고
    • The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium
    • DOI 10.1128/IAI.71.6.3227-3234.2003
    • Schaller, M., Bein, M., Korting, H.C., Baur, S., Hamm, G., Monod, M., Beinhauer, S. & Hube, B. (2003). The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal reconstituted human vaginal epithelium. Infection & Immunity 71, 3227-3234. (Pubitemid 36637547)
    • (2003) Infection and Immunity , vol.71 , Issue.6 , pp. 3227-3234
    • Schaller, M.1    Bein, M.2    Korting, H.C.3    Baur, S.4    Hamm, G.5    Monod, M.6    Beinhauer, S.7    Hube, B.8
  • 73
    • 17644403191 scopus 로고    scopus 로고
    • Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis
    • DOI 10.1128/IAI.73.5.2758-2765.2005
    • Schaller, M., Korting, H.C., Borelli, C., Hamm, G. & Hube, B. (2005). Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infection & Immunity 73, 2758-2765. (Pubitemid 40570342)
    • (2005) Infection and Immunity , vol.73 , Issue.5 , pp. 2758-2765
    • Schaller, M.1    Korting, H.C.2    Borelli, C.3    Hamm, G.4    Hube, B.5
  • 76
    • 34248325562 scopus 로고    scopus 로고
    • Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture
    • DOI 10.1128/AAC.01129-06
    • Cummins, J.E., Jr, Guarner, J., Flowers, L., Guenthner, P.C., Bartlett, J., Morken, T., Grohskopf, L.A., Paxton, L. & Dezzutti, C.S. (2007). Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture. Antimicrobial Agents & Chemotherapy 51, 1770-1779. (Pubitemid 46744157)
    • (2007) Antimicrobial Agents and Chemotherapy , vol.51 , Issue.5 , pp. 1770-1779
    • Cummins Jr., J.E.1    Guarner, J.2    Flowers, L.3    Guenthner, P.C.4    Bartlett, J.5    Morken, T.6    Grohskopf, L.A.7    Paxton, L.8    Dezzutti, C.S.9
  • 78
    • 73649108902 scopus 로고    scopus 로고
    • Caveats associated with the use of human cervical tissue for HIV and microbicide research
    • Anderson, D.J., Pudney, J. & Schust, D.J. (2010). Caveats associated with the use of human cervical tissue for HIV and microbicide research. AIDS 24, 1-4.
    • (2010) AIDS , vol.24 , pp. 1-4
    • Anderson, D.J.1    Pudney, J.2    Schust, D.J.3
  • 80
    • 0031308372 scopus 로고    scopus 로고
    • Comparative permeability of human vaginal and buccal mucosa to water
    • van der Bijl, P., Thompson, I.O. & Squier, C.A. (1997). Comparative permeability of human vaginal and buccal mucosa to water. European Journal of Oral Sciences 105, 571-575. (Pubitemid 127760549)
    • (1997) European Journal of Oral Sciences , vol.105 , Issue.6 , pp. 571-575
    • Van Der, B.P.1    Thompson, I.O.C.2    Squier, C.A.3
  • 81
    • 0035184191 scopus 로고    scopus 로고
    • A comparative light-microscopic, electron-microscopic and chemical study of human vaginal and buccal epithelium
    • DOI 10.1016/S0003-9969(01)00082-6, PII S0003996901000826
    • Thompson, I.O., van der Bijl, P., van Wyk, C.W. & van Eyk, A.D. (2001). A comparative light-microscopic, electron-microscopic and chemical study of human vaginal and buccal epithelium. Archives of Oral Biology 46, 1091-1098. (Pubitemid 33086338)
    • (2001) Archives of Oral Biology , vol.46 , Issue.12 , pp. 1091-1098
    • Thompson, I.O.C.1    Van Der, B.P.2    Van Wyk, C.W.3    Van Eyk, A.D.4
  • 82
    • 27644562361 scopus 로고    scopus 로고
    • Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa
    • van Eyk, A.D. & van den Bijl, P. (2005). Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa. International Journal of Pharmaceutics 305, 105-111.
    • (2005) International Journal of Pharmaceutics , vol.305 , pp. 105-111
    • Van Eyk, A.D.1    Van Den Bijl, P.2
  • 84
    • 0027741485 scopus 로고
    • Studies on the contraceptive efficacy of Praneem polyherbal cream
    • DOI 10.1016/0010-7824(93)90120-V
    • Garg, S., Taluja, V., Upadhyay, S.N. & Talwar, G.P. (1993). Studies on the contraceptive efficacy of Praneem polyherbal cream. Contraception 48, 591-596. (Pubitemid 24029757)
    • (1993) Contraception , vol.48 , Issue.6 , pp. 591-596
    • Garg, S.1    Taluja, V.2    Upadhyay, S.N.3    Talwar, G.P.4
  • 86
    • 33749864595 scopus 로고    scopus 로고
    • Cyclic changes in the vaginal epithelium of normal rhesus macaques
    • DOI 10.1677/joe.1.06873
    • Poonia, B., Walter, L., Dufour, J., Harrison, R., Marx, P.A. & Veazey, R.S. (2006). Cyclic changes in the vaginal epithelium of normal rhesus macaques. Journal of Endocrinology 190, 829-835. (Pubitemid 44560256)
    • (2006) Journal of Endocrinology , vol.190 , Issue.3 , pp. 829-835
    • Poonia, B.1    Walter, L.2    Dufour, J.3    Harrison, R.4    Marx, P.A.5    Veazey, R.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.