Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07)

Journal of Antimicrobial Chemotherapy

Volumn 50, Issue 6, 2002, Pages 793-803

  D'Cruz, Osmond J ^a,b   Uckun, Faith M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

^b Paradigm Pharmaceuticals   (United States)

Author keywords

Antiviral drugs; HIV AIDS; Microbicide; Nucleoside analogues; Spermicide

Indexed keywords

5 BROMO 6 METHOXY 5,6 DIHYDRO 3' AZIDOTHYMIDINE 5' (PARA BROMOPHENYL) METHOXYALANINYL PHOSPHATE; 5 BROMO 6 METHOXY 5,6 DIHYDRO 3' AZIDOTHYMIDINE 5' (PARA METHOXYPHENYL) METHOXYALANINYL PHOSPHATE; NUCLEOSIDE ANALOG; SPERMICIDAL AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; CARCINOGENICITY; CONCENTRATION (PARAMETERS); CONTRACEPTION; CYTOTOXICITY; DRUG ABSORPTION; DRUG DESIGN; DRUG FORMULATION; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; EPITHELIUM CELL; FEMALE; FEMALE GENITAL SYSTEM; GENITAL SYSTEM DISEASE; GENOTOXICITY; HEMATOLOGIC DISEASE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; LETHAL DOSE; MICROEMULSION; MONKEY; MOUSE; MUTAGENICITY; NONHUMAN; RABBIT; REVIEW; SEXUAL TRANSMISSION; SYSTEMIC DISEASE;

ANIMALS; ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; CELL LINE; CONTRACEPTIVE AGENTS, FEMALE; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; MACACA FASCICULARIS; MICE; NUCLEOSIDES; PREGNANCY; RABBITS; THYMIDINE MONOPHOSPHATE; ZIDOVUDINE;

EID: 0036920022     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg001     Document Type: Review

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