Experimental determination and prediction of bilitranslocase transport activity

Analytica Chimica Acta

Volumn 705, Issue 1-2, 2011, Pages 322-333

  Župerl, Špela ^a   Fornasaro, Stefano ^b   Novič, Marjana ^a   Passamonti, Sabina ^b  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Applicability domain; Artificial neural network; Bilitranslocase transport activity; Classification; Drug target; Inhibition constants; Predictive models; Variable selection

Indexed keywords

APPLICABILITY DOMAIN; ARTIFICIAL NEURAL NETWORK; BILITRANSLOCASE TRANSPORT ACTIVITY; DRUG TARGETS; INHIBITION CONSTANTS; PREDICTIVE MODELS; VARIABLE SELECTION;

CELL MEMBRANES; CLASSIFICATION (OF INFORMATION); CYTOLOGY; MOLECULAR GRAPHICS; NEURAL NETWORKS;

COMPUTATIONAL CHEMISTRY;

ACETAZOLAMIDE; ADENINE; ADENOSINE; BILIRUBIN; BILITRANSLOCASE; BILIVERDIN; CARRIER PROTEIN; CYTOSINE; DICLOFENAC; DRUG; ENALAPRIL MALEATE; FLUOROURACIL; FUROSEMIDE; HYDROCORTISONE; IBUPROFEN; INDOMETACIN; KETOPROFEN; MEFENAMIC ACID; METHOTREXATE; NAPROXEN; PIROXICAM; PRAVASTATIN; PROBENECID; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; THYMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL; URIC ACID; URIDINE;

ACCURACY; ANALYTICAL ERROR; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME INHIBITION; MEMBRANE TRANSPORT; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN TRANSPORT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SENSITIVITY AND SPECIFICITY; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; LIVER; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PURINES; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, WISTAR;

EID: 80053386882     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2011.07.004     Document Type: Article

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