Cytokines

Asthma and COPD

Volumn , Issue , 2009, Pages 327-341

  Chung, Kian Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053386031     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374001-4.00027-4     Document Type: Chapter

References (121)

1. Bousquet J., Jeffery P.K., Busse W.W., Johnson M., Vignola A.M. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000, 161(5):1720-1745.
2. Hamid Q., Azzawi M., Ying S., Moqbel R., Wardlaw A.J., Corrigan C.J., et al. Expression of mRNA for interleukins in mucosal bronchial biopsies from asthma. J Clin Invest 1991, 87:1541-1546.
3. Broide D.H., Lotz M., Cuomo A.J., Coburn D.A., Federman E.C., Wasserman S.I. Cytokines in symptomatic asthmatic airways. J Allergy Clin Immunol 1992, 89:958-967.
4. Humbert M., Durham S.R., Kimmitt P., Powell N., AssoufiB., Pfister R., et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J Allergy Clin Immunol 1997, 99(5):657-665.
5. Robinson D.S., Hamid Q., Ying S., Tsigopoulos A., Barkans T., Bentley A.M., et al. Predominant Th2-type bronchoalveolar lavage T-lymphocyte population in atopic asthma. New Engl J Med 1992, 326:298-304.
6. Taylor A., Verhagen J., Blaser K., Akdis M., Akdis C.A. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells. Immunology 2006, 117(4):433-442.
7. + regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004, 363(9409):608-615.
8. Ying S., O'Connor B., RatoffJ., Meng Q., Mallett K., Cousins D., et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005, 174(12):8183-8190.
9. Bradding P., Roberts J.A., Britten K.M., Montefort S., Djukanovic R., Mueller R., et al. Interleukin-4, -5 and -6 and tumor necrosts factor-α in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994, 10:471-480.
10. Broide D., Paine M.M., Firestein G.S. Eosinophils express interleukin S and granulocyte-macrophage colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 1992, 90:1414-1424.
11. Moqbel R., Hamid Q., Ying S., Barkans J., Hartnell A., Tsicopoulos A., et al. Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils. J Exp Med 1991, 174:749-752.
12. John M., Lim S., Seybold J., Jose P., Robichaud A., O'Connor B., et al. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1998, 157(1):256-262.
13. Hallsworth M.P., Soh C.P.C., Lane S.J., Arm J.P., Lee T.H. Selective enhancement of GM-CSF, TNF-α, IL-1β and IL-8 production by monocytes and macrophages of asthmatic subjects. Eur Respir J 1994, 7:1096-1102.
14. Green J.M. The B7/CD28/CTLA4 T-cell activation pathway. Implications for inflammatory lung disease. Am J Respir Cell Mol Biol 2000, 22(3):261-264.
15. Mossman T.R., Coffman R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989, 7:145-173.
16. Spiteri M., Knight R.A., Jeremy J.Y., Barnes P.J., Chung K.F. Alveolar macrophage-induced suppression of T-cell hyperresponsiveness in bronchial asthma is reversed by allergen exposure. Eur Respir J 1994, 7:1431-1438.
17. Fischer H.G., Frosch S., Reske K., Reske-Kunz A.B. Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function. J Immunol 1988, 141:3882-3888.
18. Chang T.L., Shea C.H., Urioste S., Thompson R.C., Boom W.H., Abbas A.K. Heterogeneity of helper/inducer T lymphocytes: Lymphokine production and lymphokine responsiveness. J Immunol 1990, 145:2803-2808.
19. Minty A., Chalon P., Derocq J-M., Dumont X., Guillemot J-C., Kaghad M., et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993, 362:248-250.
20. Khuruna Hershey G.K., Friedrich M.F., Esswein L.A., Thomas M.L., Chatila T.A. The association of atopy with a gain-of-function mutation in the α-subunit of the IL-4 receptor. New Eng J Med 1997, 337:1720-1725.
21. Djukanovic R., Wilson S.J., Kraft M., Jarjour N.N., Steel M., Chung K.F., et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med 2004, 170(6):583-593.
22. Vercelli D., Jabara H.H., Lee B.W., Woodland N., Geha R.S., Leung D.Y. Human recombinant interleukin-4 induces FC4RII/CD23 on normal human monocytes. J Exp Med 1988, 167:1406-1416.
23. Sanderson C.J., Warren D.J., Strath M. Identification of a lumphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures. J Exp Med 1985, 162:60-74.
24. Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R., Totty N.F., et al. Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 1994, 179:881-887.
25. Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N., et al. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 1996, 183:2437-2448.
26. Collins P.D., Griffiths-Johnson D.A., Jose P.J., Williams T.J., Marleau S. Co-operation between interleukin-5 and the chemokine, eotaxin, to induce eosinophil accumulation in vivo. J Exp Med 1995, 182:1169-1174.
27. Rothenberg M.E., Owen W.F.J., Siberstein D.S. Human eosinophils have prolonged survival, enhanced functional properties and become hypodense when exposed to human interleukin. J Clin Invest 1988, 81:1986-1992.
28. Tosi M.F., Stark J.M., Smith W.C., Hamedani A., Gruenert D.C., Infeld M.D. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: Effects on neutrophil-epithelial cell adhesion. Am J Respir Cell Mol Biol 1992, 7:214-221.
29. Leckie M.J., ten B.A., Khan J., Diamant Z., O'Connor B.J., Walls C.M., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356(9248):2144-2148.
30. Hellings P.W., Kasran A., Liu Z., Vandekerckhove P., Wuyts A., Overbergh L., et al. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol 2003, 28(1):42-50.
31. Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002, 17(3):375-387.
32. Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Page N., et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001, 108(3):430-438.
33. Letuve S., Lajoie-Kadoch S., Audusseau S., Rothenberg M.E., Fiset P.O., Ludwig M.S., et al. IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J Allergy Clin Immunol 2006, 117(3):590-596.
34. Zhu Z., Homer R.J., Wang Z., Chen Q., Geba G.P., Wang J., et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999, 103(6):779-788.
35. Temann U.A., Geba G.P., Rankin J.A., Flavell R.A. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 1998, 188:1307-1320.
36. Rankin J.A., Picarella D.E., Geba G.P., Temann U.A., Prasad B., DiCosmo B., et al. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci USA 1996, 93(15):7821-7825.
37. Lee J.J., McGarry M.P., Farmer S.C., Denzler K.L., Larson K.A., Carrigan P.E., et al. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med 1997, 185(12):2143-2156.
38. Einarsson O., Geba G.P., Zhu Z., Landry M., Elias J.A. Interleukin-11: Stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J Clin Invest 1996, 97(4):915-924.
39. Flood-Page P., Menzies-Gow A., Phipps S., Ying S., Wangoo A., Ludwig M.S., et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003, 112(7):1029-1036.
40. Lee C.G., Homer R.J., Zhu Z., Lanone S., Wang X., Koteliansky V., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001, 194(6):809-821.
41. Boxall C., Holgate S.T., Davies D.E. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 2006, 27(1):208-229.
42. Brewster C.E.P., Howarth P.H., Djukanovic R., Wilson J., Holgate S.T., Roche W.R. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Resp Cell Mol Biol 1990, 3:507-511.
43. Hirst S.J., Martin J.G., Bonacci J.V., Chan V., Fixman E.D., Hamid Q.A., et al. Proliferative aspects of airway smooth muscle. J Allergy Clin Immunol 2004, 114(2 Suppl):S2-S17.
44. Leung S.Y., Niimi A., Noble A., Oates T., Williams A.S., Medicherla S., et al. Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther 2006, 319(2):586-594.
45. Simcock D.E., Kanabar V., Clarke G.W., O'Connor B.J., Lee T.H., Hirst S.J. Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma. Am J Respir Crit Care Med 2007, 176(2):146-153.
46. Minshall E.M., Leung D.Y.M., Martin R.J., Song Y.L., Cameron L., Ernst P., et al. Eosinophil-associated TGFβ1mRNA expression and airways fibrosis in asthma. Am J Respir Cell Mol Biol 1997, 17:326-333.
47. Xie S., Sukkar M.B., Issa R., Khorasani N.M., Chung K.F. Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol 2007, 293(1):L245-L253.
48. Vignola A.M., Chanez P., Chiappara G., Merendino A., Pace E., Rizzo A., et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997, 156(2 Pt 1):591-599.
49. Amishima M., Munakata M., Nasuhara Y., Sato A., Takahashi T., Homma Y., et al. Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med 1998, 157(6 Pt 1):1907-1912.
50. Howarth P.H., Knox A.J., Amrani Y., Tliba O., Panettieri R.A., Johnson M. Synthetic responses in airway smooth muscle. J Allergy Clin Immunol 2004, 114(2 Suppl):S32-S50.
51. Brightling C.E., Bradding P., Symon F.A., Holgate S.T., Wardlaw A.J., Pavord I.D. Mast-cell infiltration of airway smooth muscle in asthma. New Engl J Med 2002, 346(22):1699-1705.
52. Brightling C.E., Ammit A.J., Kaur D., Black J.L., Wardlaw A.J., Hughes J.M., et al. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med 2005, 171(10):1103-1108.
53. Hogg J.C., Chu F., Utokaparch S., Woods R., Elliott W.M., Buzatu L., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. New Engl J Med 2004, 350(26):2645-2653.
54. Saetta M., Turato G., Facchini F.M., Corbino L., Lucchini R.E., Casoni G., et al. Inflammatory cells in the bronchial glands of smokers with chronic bronchitis. Am J Respir Crit Care Med 1997, 156(5):1633-1639.
55. Baraldo S., Turato G., Badin C., Bazzan E., Beghe B., Zuin R., et al. Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax 2004, 59(4):308-312.
56. Chanez P., Vignola A.M., O'Shaugnessy T., Enander I., Li D., Jeffery P.K., et al. Corticosteroid reversibility in COPD is related to features of asthma. Am J Respir Crit Care Med 1997, 155(5):1529-1534.
57. Saetta M., Mariani M., Panina-Bordignon P., Turato G., Buonsanti C., Baraldo S., et al. Increased Expression of the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2002, 165(10):1404-1409.
58. O'Shaughnessy T.C., Ansari T.W., Barnes N.C., Jeffery P.K. Inflammation in bronchial biopsies of subjects with chronic bronchitis: Inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med 1997, 155:852-857.
59. Keatings V.M., Collins P.D., Scott D.M., Barnes P.J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996, 153(2):530-534.
60. Traves S.L., Culpitt S.V., Russell R.E., Barnes P.J., Donnelly L.E. Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax 2002, 57(7):590-595.
61. Lim S., Roche N., Oliver B.G., Mattos W., Barnes P.J., Chung K.F. Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am J Respir Crit Care Med 2000, 162(4 Pt 1):1355-1360.
62. Morrison D., Strieter R.M., Donnelly S.C., Burdick M.D., Kunkel S.L., MacNee W. Neutrophil chemokines in bronchoalveolar lavage fluid and leukocyte-conditioned medium from nonsmokers and smokers. Eur Respir J 1998, 12(5):1067-1072.
63. Kuschner W.G., D'Alessandro A., Wong H., Blanc P.D. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J 1996, 9(10):1989-1994.
64. Pesci A., Balbi B., Majori M., Cacciani G., Bertacco S., Alciato P., et al. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J 1998, 12(2):380-386.
65. Balbi B., Bason C., Balleari E., Fiasella F., Pesci A., Ghio R., et al. Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis. Eur Respir J 1997, 10(4):846-850.
66. Franciosi L.G., Page C.P., Celli B.R., Cazzola M., Walker M.J., Danhof M., et al. Markers of disease severity in chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2006, 19(3):189-199.
67. Mio T., Romberger D.J., Thompson A.B., Robbins R.A., Heires A., Rennard S.I. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Am J Respir Crit Care Med 1997, 155(5):1770-1776.
68. Dubar V., Gosset P., Aerts C., Voisin C., Wallaert B., Tonnel A.B. In vitro acute effects of tobacco smoke on tumor necrosis factor alpha and interleukin-6 production by alveolar macrophages. Exp Lung Res 1993, 19(3):345-359.
69. Nishikawa M., Kakemizu N., Ito T., Kudo M., Kaneko T., Suzuki M., et al. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8mRNA expression in guinea pigs in vivo. Am J Respir Cell Mol Biol 1999, 20(2):189-198.
70. Masubuchi T., Koyama S., Sato E., Takamizawa A., Kubo K., Sekiguchi M., et al. Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. Am J Pathol 1998, 153(6):1903-1912.
71. de Boer W.I., Sont J.K., van Schadewijk A., Stolk J., van Krieken J.H., Hiemstra P.S. Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol 2000, 190(5):619-626.
72. Premack B.A., Schall T.J. Chemokine receptors: Gateways to inflammation and infection. Nat Med 1996, 2(11):1174-1178.
73. Traves S.L., Smith S.J., Barnes P.J., Donnelly L.E. Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: A role for CXCR2. J Leukoc Biol 2004, 76(2):441-450.
74. Demedts I.K., Bracke K.R., Van Pottelberge G., Testelmans D., Verleden G.M., Vermassen F.E., et al. Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007, 175(10):998-1005.
75. Ning W., Li C.J., Kaminski N., Feghali-Bostwick C.A., Alber S.M., Di Y.P., et al. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 2004, 101(41):14895-14900.
76. Zhu J., Qiu Y.S., Majumdar S., Gamble E., Matin D., Turato G., et al. Exacerbations of Bronchitis: Bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants. Am J Respir Crit Care Med 2001, 164(1):109-116.
77. Zhu J., Qiu Y., Valobra M., Qiu S., Majumdar S., Matin D., et al. Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007, 175(11):1125-1133.
78. Zheng T., Zhu Z., Wang Z., Homer R.J., Ma B., Riese R.J., et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest 2000, 106(9):1081-1093.
79. Hoshino T., Kato S., Oka N., Imaoka H., Kinoshita T., Takei S., et al. Pulmonary Inflammation and Emphysema: Role of the Cytokines IL-18 and IL-13. Am J Respir Crit Care Med 2007, 176(1):49-62.
80. Wang Z., Zheng T., Zhu Z., Homer R.J., Riese R.J., Chapman H.A., et al. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000, 192(11):1587-1600.
81. Boutten A., Bonay M., Laribe S., Leseche G., Castier Y., Lecon-Malas V., et al. Decreased expression of interleukin 13 in human lung emphysema. Thorax 2004, 59(10):850-854.
82. Panzner P., Lafitte J.J., Tsicopoulos A., Hamid Q., Tulic M.K. Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest 2003, 124(5):1909-1915.
83. Gan W.Q., Man S.F., Senthilselvan A., Sin D.D. Association between chronic obstructive pulmonary disease and systemic inflammation: A systematic review and a meta-analysis. Thorax 2004, 59(7):574-580.
84. de G.I., Donahoe M., Calhoun W.J., Mancino J., Rogers R.M. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996, 153(2):633-637.
85. Casadevall C., Coronell C., Ramirez-Sarmiento A.L., Martinez-Llorens J., Barreiro E., Orozco-Levi M., et al. Upregulation of proinflammatory cytokines in the intercostal muscles of COPD patients. Eur Respir J 2007.
86. Pinto-Plata V.M., Livnat G., Girish M., Cabral H., Masdin P., Linacre P., et al. Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPD. Chest 2007, 131(1):37-43.
87. Qiu Y., Zhu J., Bandi V., Atmar R.L., Hattotuwa K., Guntupalli K.K., et al. Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003, 168(8):968-975.
88. Saetta M., Di S.A., Maestrelli P., Turato G., Mapp C.E., Pieno M., et al. Airway eosinophilia and expression of interleukin-5 protein in asthma and in exacerbations of chronic bronchitis [see comments]. Clin Exp Allergy 1996, 26(7):766-774.
89. Wedzicha J.A., Seemungal T.A., MacCallum P.K., Paul E.A., Donaldson G.C., Bhowmik A., et al. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost 2000, 84(2):210-215.
90. Bocchino V., Bertorelli G., Bertrand C.P., Ponath P.D., Newman W., Franco C., et al. Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis. Allergy 2002, 57(1):17-22.
91. Khair O.A., Devalia J.L., Abdelaziz M.M., Sapsford R.J., Tarraf H., Davies R.J. Effect of Haemophilus influenzae endotoxin on the synthesis of IL-6, IL-8, TNF-alpha and expression of ICAM-1 in cultured human bronchial epithelial cells. Eur Respir J 1994, 7(12):2109-2116.
92. Inoue H., Hara M., Massion P.P., Grattan K.M., Lausier J.A., Chan B., et al. Role of recruited neutrophils in interleukin-8 production in dog trachea after stimulation with Pseudomonas in vivo. Am J Respir Cell Mol Biol 1995, 13(5):570-577.
93. Churg A., Dai J., Tai H., Xie C., Wright J.L. Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am J Respir Crit Care Med 2002, 166(6):849-854.
94. Takeyama K., Dabbagh K., Lee H.M., Agusti C., Lausier J.A., Ueki I.F., et al. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 1999, 96(6):3081-3086.
95. Riise G.C., Larsson S., Lofdahl C.G., Andersson B.A. Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis. Eur Respir J 1994, 7(9):1673-1677.
96. Churg A., Wang R.D., Tai H., Wang X., Xie C., Dai J., et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med 2003, 167(8):1083-1089.
97. Di F.M., Barbier D., Mege J.L., Orehek J. Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994, 150(5 Pt 1):1453-1455.
98. Schols A.M., Buurman W.A., Staal van den Brekel A.J., Dentener M.A., Wouters E.F. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996, 51(8):819-824.
99. de G.I., Donahoe M., Calhoun W.J., Mancino J., Rogers R.M. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996, 153(2):633-637.
100. Reid M.B., Lannergren J., Westerblad H. Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: Involvement of muscle myofilaments. Am J Respir Crit Care Med 2002, 166(4):479-484.
101. Li Y.P., Lecker S.H., Chen Y., Waddell I.D., Goldberg A.L., Reid M.B. TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J 2003, 17(9):1048-1057.
102. Rennard S.I., Fogarty C., Kelsen S., Long W., Ramsdell J., Allison J., et al. The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007, 175(9):926-934.
103. Koto H., Mak J.C., Haddad E.B., Xu W.B., Salmon M., Barnes P.J., et al. Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat. J Clin Invest 1996, 98(8):1780-1787.
104. Beeh K.M., Kornmann O., Buhl R., Culpitt S.V., Giembycz M.A., Barnes P.J. Neutrophil chemotactic activity of sputum from patients with COPD: Role of interleukin 8 and leukotriene B4. Chest 2003, 123(4):1240-1247.
105. Woolhouse I.S., Bayley D.L., Stockley R.A. Sputum chemotactic activity in chronic obstructive pulmonary disease: Effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8. Thorax 2002, 57(8):709-714.
106. Wang B., Cleary P.P., Xu H., Li J.D. Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. Infect Immun 2003, 71(10):5523-5530.
107. Nakamura H., Yoshimura K., McElvaney N.G., Crystal R.G. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 1992, 89:1478-1484.
108. Mahler D.A., Huang S., Tabrizi M., Bell G.M. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: A pilot study. Chest 2004, 126(3):926-934.
109. Howat W.J., Holgate S.T., Lackie P.M. TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair. Am J Physiol Lung Cell Mol Physiol 2002, 282(1):L115-L123.
110. Chambers R.C., Leoni P., Kaminski N., Laurent G.J., Heller R.A. Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Am J Pathol 2003, 162(2):533-546.
111. Goldsmith A.M., Bentley J.K., Zhou L., Jia Y., Bitar K.N., Fingar D.C., et al. Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol 2006, 34(2):247-254.
112. Eickelberg O., Kohler E., Reichenberger F., Bertschin S., Woodtli T., Erne P., et al. Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3. Am J Physiol 1999, 276(5 Pt 1):L814-L824.
113. Coutts A., Chen G., Stephens N., Hirst S., Douglas D., Eichholtz T., et al. Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagen. Am J Physiol Lung Cell Mol Physiol 2001, 280(5):L999-L1008.
114. Takizawa H., Tanaka M., Takami K., Ohtoshi T., Ito K., Satoh M., et al. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001, 163(6):1476-1483.
115. Vignola A.M., Chanez P., Chiappara G., Merendino A., Pace E., Rizzo A., et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997, 156(2 Pt 1):591-599.
116. de Boer W.I., van Schadewijk A., Sont J.K., Sharma H.S., Stolk J., Hiemstra P.S., et al. Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998, 158(6):1951-1957.
117. Vignola A.M., Chanez P., Chiappara G., Merendino A., Zinnanti E., Bousquet J., et al. Release of transforming growth factor-beta (TGF-beta) and fibronectin by alveolar macrophages in airway diseases. Clin Exp Immunol 1996, 106(1):114-119.
118. Kanazawa H., Asai K., Hirata K., Yoshikawa J. Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Am J Med 2003, 114(5):354-358.
119. Santos S., Peinado V.I., Ramirez J., Morales-Blanhir J., Bastos R., Roca J., et al. Enhanced expression of vascular endothelial growth factor in pulmonary arteries of smokers and patients with moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003, 167(9):1250-1256.
120. Kasahara Y., Tuder R.M., Taraseviciene-Stewart L., Le Cras T.D., Abman S., Hirth P.K., et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000, 106(11):1311-1319.
121. Tuder R.M., Zhen L., Cho C.Y., Taraseviciene-Stewart L., Kasahara Y., Salvemini D., et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 2003, 29(1):88-97.