Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use

Assay and Drug Development Technologies

Volumn 9, Issue 5, 2011, Pages 475-486

  Schutte, Maaike ^a   Fox, Bridget ^a   Baradez, Marc Olivier ^a   Devonshire, Alison ^a   Minguez, Jesus ^a   Bokhari, Maria ^b   Przyborski, Stefan ^b,c   Marshall, Damian ^a  

^a LGC   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

^c ReproCELL Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 3A2; PARACETAMOL;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL GROWTH; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER CELL; MONOLAYER CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; SENSITIVITY AND SPECIFICITY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; COLLAGEN; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; HEPATOCYTES; LIVER; POLYSTYRENES; RATS; RNA; SENSITIVITY AND SPECIFICITY; TESTOSTERONE; TISSUE SCAFFOLDS;

EID: 80053360260     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2011.0371     Document Type: Article

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