메뉴 건너뛰기




Volumn 108, Issue 1, 2011, Pages 141-150

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research

Author keywords

Hepatocytes; Nano; Pharmacology; Polymer scaffolds; Tissue engineering; Toxicology

Indexed keywords

HEPATOCYTES; NANO; PHARMACOLOGY; POLYMER SCAFFOLDS; TOXICOLOGY;

EID: 78649427926     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22924     Document Type: Article
Times cited : (63)

References (43)
  • 1
    • 0036346357 scopus 로고    scopus 로고
    • Structural polarity and functional bile canaliculi in rat hepatocyte spheroids
    • Abu-Absi SF, Friend JR, Hansen LK, Hu WS. 2002. Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Exp Cell Res 274(1): 56-67.
    • (2002) Exp Cell Res , vol.274 , Issue.1 , pp. 56-67
    • Abu-Absi, S.F.1    Friend, J.R.2    Hansen, L.K.3    Hu, W.S.4
  • 2
    • 67651051837 scopus 로고    scopus 로고
    • Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in isolated rat hepatocytes
    • Aly HA, Domenech O. 2009. Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in isolated rat hepatocytes. Toxicology 262(3): 175-183.
    • (2009) Toxicology , vol.262 , Issue.3 , pp. 175-183
    • Aly, H.A.1    Domenech, O.2
  • 3
    • 0347760206 scopus 로고    scopus 로고
    • Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores
    • Chen VJ, Ma PX. 2004. Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores. Biomaterials 25(11): 2065-2073.
    • (2004) Biomaterials , vol.25 , Issue.11 , pp. 2065-2073
    • Chen, V.J.1    Ma, P.X.2
  • 4
    • 33745942548 scopus 로고    scopus 로고
    • Bone regeneration on computer-designed nano-fibrous scaffolds
    • Chen VJ, Smith LA, Ma PX. 2006. Bone regeneration on computer-designed nano-fibrous scaffolds. Biomaterials 27(21): 3973-3979.
    • (2006) Biomaterials , vol.27 , Issue.21 , pp. 3973-3979
    • Chen, V.J.1    Smith, L.A.2    Ma, P.X.3
  • 5
    • 77954931185 scopus 로고    scopus 로고
    • Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents
    • Dean S, Tang JI, Seckl JR, Nyirenda MJ. 2010. Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents. Gene Expr 14(6): 337-344.
    • (2010) Gene Expr , vol.14 , Issue.6 , pp. 337-344
    • Dean, S.1    Tang, J.I.2    Seckl, J.R.3    Nyirenda, M.J.4
  • 6
    • 0037272197 scopus 로고    scopus 로고
    • Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: Focus on in vitro studies
    • Donato MT, Castell JV. 2003. Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: Focus on in vitro studies. Clin Pharmacokinet 42(2): 153-178.
    • (2003) Clin Pharmacokinet , vol.42 , Issue.2 , pp. 153-178
    • Donato, M.T.1    Castell, J.V.2
  • 7
    • 0041859380 scopus 로고    scopus 로고
    • Liver tissue engineering within alginate scaffolds: Effects of cell-seeding density on hepatocyte viability, morphology, and function
    • Dvir-Ginzberg M, Gamlieli-Bonshtein I, Agbaria R, Cohen S. 2003. Liver tissue engineering within alginate scaffolds: Effects of cell-seeding density on hepatocyte viability, morphology, and function. Tissue Eng 9(4): 757-766.
    • (2003) Tissue Eng , vol.9 , Issue.4 , pp. 757-766
    • Dvir-Ginzberg, M.1    Gamlieli-Bonshtein, I.2    Agbaria, R.3    Cohen, S.4
  • 9
    • 67249084776 scopus 로고    scopus 로고
    • Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
    • Fanning AS, Anderson JM. 2009. Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci 1165: 113-120.
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 113-120
    • Fanning, A.S.1    Anderson, J.M.2
  • 10
    • 10744231826 scopus 로고    scopus 로고
    • New hepatocyte in vitro systems for drug metabolism: Metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures
    • Gebhardt R, Hengstler JG, Muller D, Glockner R, Buenning P, Laube B, Schmelzer E, Ullrich M, Utesch D, Hewitt N, et al. 2003. New hepatocyte in vitro systems for drug metabolism: Metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev 35(2-3): 145-213.
    • (2003) Drug Metab Rev , vol.35 , Issue.2-3 , pp. 145-213
    • Gebhardt, R.1    Hengstler, J.G.2    Muller, D.3    Glockner, R.4    Buenning, P.5    Laube, B.6    Schmelzer, E.7    Ullrich, M.8    Utesch, D.9    Hewitt, N.10
  • 11
    • 0034803066 scopus 로고    scopus 로고
    • Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions
    • Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S, LeCluyse EL. 2001. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tissue Res 306(1): 85-99.
    • (2001) Cell Tissue Res , vol.306 , Issue.1 , pp. 85-99
    • Hamilton, G.A.1    Jolley, S.L.2    Gilbert, D.3    Coon, D.J.4    Barros, S.5    LeCluyse, E.L.6
  • 12
    • 0033863669 scopus 로고    scopus 로고
    • High-throughput screening: New technology for the 21st century
    • Hertzberg RP, Pope AJ. 2000. High-throughput screening: New technology for the 21st century. Curr Opin Chem Biol 4(4): 445.
    • (2000) Curr Opin Chem Biol , vol.4 , Issue.4 , pp. 445
    • Hertzberg, R.P.1    Pope, A.J.2
  • 13
    • 33847018050 scopus 로고    scopus 로고
    • Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
    • Hewitt NJ, Lechon MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, et al. 2007. Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 39(1): 159-234.
    • (2007) Drug Metab Rev , vol.39 , Issue.1 , pp. 159-234
    • Hewitt, N.J.1    Lechon, M.J.2    Houston, J.B.3    Hallifax, D.4    Brown, H.S.5    Maurel, P.6    Kenna, J.G.7    Gustavsson, L.8    Lohmann, C.9    Skonberg, C.10
  • 14
    • 0034972339 scopus 로고    scopus 로고
    • Expression of cell adhesion molecule and albumin genes in primary culture of rat hepatocytes
    • Hou DX, Arimura M, Fukuda M, Oka T, Fujii M. 2001. Expression of cell adhesion molecule and albumin genes in primary culture of rat hepatocytes. Cell Biol Int 25(3): 239-244.
    • (2001) Cell Biol Int , vol.25 , Issue.3 , pp. 239-244
    • Hou, D.X.1    Arimura, M.2    Fukuda, M.3    Oka, T.4    Fujii, M.5
  • 16
    • 67651147959 scopus 로고    scopus 로고
    • Engineering liver tissue spheroids with inverted colloidal crystal scaffolds
    • Lee J, Cuddihy MJ, Cater GM, Kotov NA. 2009. Engineering liver tissue spheroids with inverted colloidal crystal scaffolds. Biomaterials 30(27): 4687-4694.
    • (2009) Biomaterials , vol.30 , Issue.27 , pp. 4687-4694
    • Lee, J.1    Cuddihy, M.J.2    Cater, G.M.3    Kotov, N.A.4
  • 17
    • 0034090310 scopus 로고    scopus 로고
    • Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
    • Li J, Ning G, Duncan SA. 2000. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev 14(4): 464-474.
    • (2000) Genes Dev , vol.14 , Issue.4 , pp. 464-474
    • Li, J.1    Ning, G.2    Duncan, S.A.3
  • 18
    • 61349179433 scopus 로고    scopus 로고
    • The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury
    • Li Y, Qi XM, Xue X, Wu XF, Wu YF, Chen M, Xing GZ, Luan Y, Ren J. 2009. The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury. Toxicol Lett 186(2): 111-114.
    • (2009) Toxicol Lett , vol.186 , Issue.2 , pp. 111-114
    • Li, Y.1    Qi, X.M.2    Xue, X.3    Wu, X.F.4    Wu, Y.F.5    Chen, M.6    Xing, G.Z.7    Luan, Y.8    Ren, J.9
  • 19
    • 0030808426 scopus 로고    scopus 로고
    • Zonal distribution of transcripts of four hepatic transcription factors in the mature rat liver
    • Lindros KO, Oinonen T, Issakainen J, Nagy P, Thorgeirsson SS. 1997. Zonal distribution of transcripts of four hepatic transcription factors in the mature rat liver. Cell Biol Toxicol 13(4-5): 257-262.
    • (1997) Cell Biol Toxicol , vol.13 , Issue.4-5 , pp. 257-262
    • Lindros, K.O.1    Oinonen, T.2    Issakainen, J.3    Nagy, P.4    Thorgeirsson, S.S.5
  • 20
    • 33745967583 scopus 로고    scopus 로고
    • Porogen-induced surface modification of nano-fibrous poly(L-lactic acid) scaffolds for tissue engineering
    • Liu X, Won Y, Ma PX. 2006. Porogen-induced surface modification of nano-fibrous poly(L-lactic acid) scaffolds for tissue engineering. Biomaterials 27(21): 3980-3987.
    • (2006) Biomaterials , vol.27 , Issue.21 , pp. 3980-3987
    • Liu, X.1    Won, Y.2    Ma, P.X.3
  • 21
    • 33745966193 scopus 로고    scopus 로고
    • Tissue engineering
    • Hoboken, NJ, John Wiley and Sons, Inc.
    • Ma PX. 2003. Tissue engineering. Hoboken, NJ: John Wiley and Sons, Inc.
    • (2003)
    • Ma, P.X.1
  • 22
    • 1942516513 scopus 로고    scopus 로고
    • Scaffolds for tissue fabrication
    • Ma PX. 2004. Scaffolds for tissue fabrication. Mater Today 7(5): 30-40.
    • (2004) Mater Today , vol.7 , Issue.5 , pp. 30-40
    • Ma, P.X.1
  • 23
    • 37049029660 scopus 로고    scopus 로고
    • Biomimetic materials for tissue engineering
    • Ma PX. 2008. Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 60(2): 184.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.2 , pp. 184
    • Ma, P.X.1
  • 24
    • 0035119040 scopus 로고    scopus 로고
    • Biodegradable polymer scaffolds with well-defined interconnected spherical pore network
    • Ma PX, Choi JW. 2001. Biodegradable polymer scaffolds with well-defined interconnected spherical pore network. Tissue Eng 7(1): 23-33.
    • (2001) Tissue Eng , vol.7 , Issue.1 , pp. 23-33
    • Ma, P.X.1    Choi, J.W.2
  • 25
    • 0032949079 scopus 로고    scopus 로고
    • Synthetic nano-scale fibrous extracellular matrix
    • Ma PX, Zhang R. 1999. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 46(1): 60-72.
    • (1999) J Biomed Mater Res , vol.46 , Issue.1 , pp. 60-72
    • Ma, P.X.1    Zhang, R.2
  • 26
    • 0026817401 scopus 로고
    • Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation
    • Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R. 1993. Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. J Biomed Mater Res 27(2): 183-189.
    • (1993) J Biomed Mater Res , vol.27 , Issue.2 , pp. 183-189
    • Mikos, A.G.1    Bao, Y.2    Cima, L.G.3    Ingber, D.E.4    Vacanti, J.P.5    Langer, R.6
  • 28
    • 78649431455 scopus 로고    scopus 로고
    • Engineering of liver tissue within a dynamic flow culture bioreactor for transplantation. University Medical Center Hamburg-Eppendorf
    • Pollok JM. 2003. Engineering of liver tissue within a dynamic flow culture bioreactor for transplantation. University Medical Center Hamburg-Eppendorf.
    • (2003)
    • Pollok, J.M.1
  • 30
    • 42749086051 scopus 로고    scopus 로고
    • A method for the design of 3D scaffolds for high-density cell attachment and determination of optimum perfusion culture conditions
    • Provin C, Takano K, Sakai Y, Fujii T, Shirakashi R. 2008. A method for the design of 3D scaffolds for high-density cell attachment and determination of optimum perfusion culture conditions. J Biomech 41(7): 1436-1449.
    • (2008) J Biomech , vol.41 , Issue.7 , pp. 1436-1449
    • Provin, C.1    Takano, K.2    Sakai, Y.3    Fujii, T.4    Shirakashi, R.5
  • 32
    • 0036200587 scopus 로고    scopus 로고
    • Liver-enriched transcription factors in liver function and development. Part I: The hepatocyte nuclear factor network and liver-specific gene expression
    • Schrem H, Klempnauer J, Borlak J. 2002. Liver-enriched transcription factors in liver function and development. Part I: The hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev 54(1): 129-158.
    • (2002) Pharmacol Rev , vol.54 , Issue.1 , pp. 129-158
    • Schrem, H.1    Klempnauer, J.2    Borlak, J.3
  • 33
    • 66649093237 scopus 로고    scopus 로고
    • Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats
    • Shitara Y, Nagamatsu Y, Wada S, Sugiyama Y, Horie T. 2009. Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats. Drug Metab Dispos 37(6): 1172-1178.
    • (2009) Drug Metab Dispos , vol.37 , Issue.6 , pp. 1172-1178
    • Shitara, Y.1    Nagamatsu, Y.2    Wada, S.3    Sugiyama, Y.4    Horie, T.5
  • 34
    • 8844263768 scopus 로고    scopus 로고
    • Nano-fibrous scaffolds for tissue engineering
    • Smith LA, Ma PX. 2004. Nano-fibrous scaffolds for tissue engineering. Colloids Surf B Biointerfaces 39(3): 125-131.
    • (2004) Colloids Surf B Biointerfaces , vol.39 , Issue.3 , pp. 125-131
    • Smith, L.A.1    Ma, P.X.2
  • 35
    • 17744382574 scopus 로고    scopus 로고
    • Optimization of hepatocyte spheroid formation for hepatic tissue engineering on three-dimensional biodegradable polymer within a flow bioreactor prior to implantation
    • Torok E, Pollok JM, Ma PX, Kaufmann PM, Dandri M, Petersen J, Burda MR, Kluth D, Perner F, Rogiers X. 2001a. Optimization of hepatocyte spheroid formation for hepatic tissue engineering on three-dimensional biodegradable polymer within a flow bioreactor prior to implantation. Cells Tissues Organs 169(1): 34-41.
    • (2001) Cells Tissues Organs , vol.169 , Issue.1 , pp. 34-41
    • Torok, E.1    Pollok, J.M.2    Ma, P.X.3    Kaufmann, P.M.4    Dandri, M.5    Petersen, J.6    Burda, M.R.7    Kluth, D.8    Perner, F.9    Rogiers, X.10
  • 37
    • 20244371456 scopus 로고    scopus 로고
    • Pre-implantation optimization of culture conditions for hepatocytes in a flow bioreactor for hepatic tissue engineering on 3-dimensional biodegradable polymers
    • Torok E, Pollok JM, Ma PX, Kaufmann PM, Dandri M, Petersen J, Burda MR, Kluth D, Perner F, Rogiers X. 2002. Pre-implantation optimization of culture conditions for hepatocytes in a flow bioreactor for hepatic tissue engineering on 3-dimensional biodegradable polymers. Zentralbl Kinderchir 11: 188-194.
    • (2002) Zentralbl Kinderchir , vol.11 , pp. 188-194
    • Torok, E.1    Pollok, J.M.2    Ma, P.X.3    Kaufmann, P.M.4    Dandri, M.5    Petersen, J.6    Burda, M.R.7    Kluth, D.8    Perner, F.9    Rogiers, X.10
  • 38
    • 33746700168 scopus 로고    scopus 로고
    • Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor
    • Torok E, Vogel C, Lutgehetmann M, Ma PX, Dandri M, Petersen J, Burda MR, Siebert K, Dullmann J, Rogiers X, et al. 2006. Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor. Tissue Eng 12(7): 1881-1890.
    • (2006) Tissue Eng , vol.12 , Issue.7 , pp. 1881-1890
    • Torok, E.1    Vogel, C.2    Lutgehetmann, M.3    Ma, P.X.4    Dandri, M.5    Petersen, J.6    Burda, M.R.7    Siebert, K.8    Dullmann, J.9    Rogiers, X.10
  • 39
    • 29244437496 scopus 로고    scopus 로고
    • Effects of cell culture conditions on primary rat hepatocytes-Cell morphology and differential gene expression
    • Tuschl G, Mueller SO. 2006. Effects of cell culture conditions on primary rat hepatocytes-Cell morphology and differential gene expression. Toxicology 218(2-3): 205-215.
    • (2006) Toxicology , vol.218 , Issue.2-3 , pp. 205-215
    • Tuschl, G.1    Mueller, S.O.2
  • 40
    • 33745936923 scopus 로고    scopus 로고
    • Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres
    • Wei G, Ma PX. 2006. Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres. J Biomed Mater Res A 78(2): 306-315.
    • (2006) J Biomed Mater Res A , vol.78 , Issue.2 , pp. 306-315
    • Wei, G.1    Ma, P.X.2
  • 41
    • 0346864790 scopus 로고    scopus 로고
    • Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment
    • 67A ():
    • Woo KM, Chen VJ, Ma PX. 2003. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A 67A (2): 531-537.
    • (2003) J Biomed Mater Res A , Issue.2 , pp. 531-537
    • Woo, K.M.1    Chen, V.J.2    Ma, P.X.3
  • 43
    • 0035811286 scopus 로고    scopus 로고
    • Novel cell immobilization method utilizing centrifugal force to achieve high-density hepatocyte culture in porous scaffold
    • Yang TH, Miyoshi H, Ohshima N. 2001. Novel cell immobilization method utilizing centrifugal force to achieve high-density hepatocyte culture in porous scaffold. J Biomed Mater Res 55(3): 379-386.
    • (2001) J Biomed Mater Res , vol.55 , Issue.3 , pp. 379-386
    • Yang, T.H.1    Miyoshi, H.2    Ohshima, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.