Plasmacytoid dendritic cells and cancer

Journal of Leukocyte Biology

Volumn 90, Issue 4, 2011, Pages 681-690

  Vermi, William ^a   Soncini, Matias ^a   Melocchi, Laura ^a   Sozzani, Silvano ^a   Facchetti, Fabio ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Cancer immunosurveillance; Innate immunity; Interferon; TLR; Tumor microenvironment

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; TOLL LIKE RECEPTOR AGONIST;

ADAPTIVE IMMUNITY; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER IMMUNOTHERAPY; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL POPULATION; CYTOKINE PRODUCTION; HOST CELL; HUMAN; INNATE IMMUNITY; NEOPLASM; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; REVIEW; SKIN CANCER; STROMA CELL; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR REJECTION;

ANIMALS; CHEMOTHERAPY, ADJUVANT; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; INTERFERON TYPE I; MICE; PLASMA CELLS; SKIN NEOPLASMS;

MURINAE;

EID: 80053355926     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0411190     Document Type: Review

References (140)

1. Grivennikov, S. I., Greten, F. R., Karin, M. (2010) Immunity, inflammation, and cancer. Cell 140, 883-899.
2. Mantovani, A., Allavena, P., Sica, A., Balkwill, F. (2008) Cancer-related inflammation. Nature 454, 436-444.
3. Schreiber, R. D., Old, L. J., Smyth, M. J. (2011) Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331, 1565-1570.
4. Vesely, M. D., Kershaw, M. H., Schreiber, R. D., Smyth, M. J. (2011) Natural innate and adaptive immunity to cancer. Annu. Rev. Immunol. 29, 235-271.
5. Bui, J. D., Schreiber, R. D. (2007) Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes? Curr. Opin. Immunol. 19, 203-208.
6. Colonna, M., Trinchieri, G., Liu, Y. J. (2004) Plasmacytoid dendritic cells in immunity. Nat. Immunol. 5, 1219-1226.
7. Colonna, M., Cella, M. (2007) Crosspresentation: plasmacytoid dendritic cells are in the business. Immunity 27, 419-421.
8. Lennert, K., Remmele, W. (1958) Karyometric research on lymph node cells in man. I. Germinoblasts, lymphoblasts & lymphocytes. Acta Haematol. 19, 99-113.
9. Müller-Hermelink, H. K., Stein, H., Steinmann, G., Lennert, K. (1983) Malignant lymphoma of plasmacytoid T-cells. Morphologic and immunologic studies characterizing a special type of T-cell. Am. J. Surg. Pathol. 7, 849-862.
10. Facchetti, F., de Wolf-Peeters, C., Mason, D. Y., Pulford, K., van den Oord, J. J., Desmet, V. J. (1988) Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin. Am. J. Pathol. 133, 15-21.
11. Grouard, G., Rissoan, M. C., Filgueira, L., Durand, I., Banchereau, J., Liu, Y. J. (1997) The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185, 1101-1111.
12. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., Colonna, M. (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5, 919-923.
13. Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., Liu, Y. J. (1999) The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835-1837.
14. Asselin-Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter- Dambuyant, C., Vicari, A., O'Garra, A., Biron, C., Briere, F., Trinchieri, G. (2001) Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2, 1144-1150.
15. Nakano, H., Yanagita, M., Gunn, M. D. (2001) CD11c(+)B220(+)Gr- 1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194, 1171-1178.
16. Björck, P. (2001) Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood 98, 3520-3526.
17. Liu, K., Victora, G. D., Schwickert, T. A., Guermonprez, P., Meredith, M. M., Yao, K., Chu, F. F., Randolph, G. J., Rudensky, A. Y., Nussenzweig, M. (2009) In vivo analysis of dendritic cell development and homeostasis. Science 324, 392-397.
18. Naik, S. H., Sathe, P., Park, H. Y., Metcalf, D., Proietto, A. I., Dakic, A., Carotta, S., O'Keeffe, M., Bahlo, M., Papenfuss, A., Kwak, J. Y., Wu, L., Shortman, K. (2007) Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 8, 1217-1226.
19. Cao, W. (2009) Molecular characterization of human plasmacytoid dendritic cells. J. Clin. Immunol. 29, 257-264.
20. Cisse, B., Caton, M. L., Lehner, M., Maeda, T., Scheu, S., Locksley, R., Holmberg, D., Zweier, C., den Hollander, N. S., Kant, S. G., Holter, W., Rauch, A., Zhuang, Y., Reizis, B. (2008) Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135, 37-48.
21. Gilliet, M., Cao, W., Liu, Y. J. (2008) Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8, 594-606.
22. Ito, T., Wang, Y. H., Liu, Y. J. (2005) Plasmacytoid dendritic cell precursors/ type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. Springer Semin. Immunopathol. 26, 221-229.
23. Swiecki, M., Colonna, M. (2010) Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol. Rev. 234, 142-162.
24. Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y. H., Homey, B., Cao, W., Su, B., Nestle, F. O., Zal, T., Mellman, I., Schroder, J. M., Liu, Y. J., Gilliet, M. (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564-569.
25. Tian, J., Avalos, A. M., Mao, S. Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., Hua, J., An, L. L., Audoly, L., La Rosa, G., Bierhaus, A., Naworth, P., Marshak-Rothstein, A., Crow, M. K., Fitzgerald, K. A., Latz, E., Kiener, P. A., Coyle, A. J. (2007) Tolllike receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8, 487-496.
26. Guiducci, C., Ott, G., Chan, J. H., Damon, E., Calacsan, C., Matray, T., Lee, K. D., Coffman, R. L., Barrat, F. J. (2006) Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203, 1999-2008.
27. Schlecht, G., Garcia, S., Escriou, N., Freitas, A. A., Leclerc, C., Dadaglio, G. (2004) Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. Blood 104, 1808-1815.
28. Mouriès, J., Moron, G., Schlecht, G., Escriou, N., Dadaglio, G., Leclerc, C. (2008) Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation. Blood 112, 3713-3722.
29. Villadangos, J. A., Young, L. (2008) Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 29, 352-361.
30. Sapoznikov, A., Fischer, J. A., Zaft, T., Krauthgamer, R., Dzionek, A., Jung, S. (2007) Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J. Exp. Med. 204, 1923-1933.
31. Hoeffel, G., Ripoche, A. C., Matheoud, D., Nascimbeni, M., Escriou, N., Lebon, P., Heshmati, F., Guillet, J. G., Gannage, M., Caillat-Zucman, S., Casartelli, N., Schwartz, O., De la Salle, H., Hanau, D., Hosmalin, A., Maranon, C. (2007) Antigen crosspresentation by human plasmacytoid dendritic cells. Immunity 27, 481-492.
32. Rissoan, M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Malefyt, R., Liu, Y. J. (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183-1186.
33. Decalf, J., Fernandes, S., Longman, R., Ahloulay, M., Audat, F., Lefrerre, F., Rice, C. M., Pol, S., Albert, M. L. (2007) Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J. Exp. Med. 204, 2423-2437.
34. Liu, Y. J. (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23, 275-306.
35. Penna, G., Vulcano, M., Roncari, A., Facchetti, F., Sozzani, S., Adorini, L. (2002) Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells. J. Immunol. 169, 6673-6676.
36. Jego, G., Pascual, V., Palucka, A. K., Banchereau, J. (2005) Dendritic cells control B cell growth and differentiation. Curr. Dir. Autoimmun. 8, 124-139.
37. Chaperot, L., Blum, A., Manches, O., Lui, G., Angel, J., Molens, J. P., Plumas, J. (2006) Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. J. Immunol. 176, 248-255.
38. Stary, G., Bangert, C., Tauber, M., Strohal, R., Kopp, T., Stingl, G. (2007) Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J. Exp. Med. 204, 1441-1451.
39. Facchetti, F., Vermi, W., Mason, D., Colonna, M. (2003) The plasmacytoid monocyte/interferon producing cells. Virchows Arch. 443, 703-717.
40. Rissoan, M. C., Duhen, T., Bridon, J. M., Bendriss-Vermare, N., Peronne, C., de Saint Vis, B., Briere, F., Bates, E. E. (2002) Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood 100, 3295-3303.
41. Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pages, C., Tosolini, M., Camus, M., Berger, A., Wind, P., Zinzindohoue, F., Bruneval, P., Cugnenc, P. H., Trajanoski, Z., Fridman, W. H., Pages, F. (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964.
42. Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., Meatchi, T., Bruneval, P., Cugnenc, P. H., Trajanoski, Z., Fridman, W. H., Galon, J. (2005) Effector memory T cells, early metastasis, and survival in colorectal cancer. N. Engl. J. Med. 353, 2654-2666.
43. Sozzani, S., Vermi, W., Del Prete, A., Facchetti, F. (2010) Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol. 31, 270-277.
44. Tjomsland, V., Sandstrom, P., Spangeus, A., Messmer, D., Emilsson, J., Falkmer, U., Falkmer, S., Magnusson, K. E., Borch, K., Larsson, M. (2010) Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity? BMC Cancer 10, 87.
45. Yanagimoto, H., Takai, S., Satoi, S., Toyokawa, H., Takahashi, K., Terakawa, N., Kwon, A. H., Kamiyama, Y. (2005) Impaired function of circulating dendritic cells in patients with pancreatic cancer. Clin. Immunol. 114, 52-60.
46. Sakakura, K., Chikamatsu, K., Takahashi, K., Whiteside, T. L., Furuya, N. (2006) Maturation of circulating dendritic cells and imbalance of T-cell subsets in patients with squamous cell carcinoma of the head and neck. Cancer Immunol. Immunother. 55, 151-159.
47. Zou, W., Machelon, V., Coulomb-L'Hermin, A., Borvak, J., Nome, F., Isaeva, T., Wei, S., Krzysiek, R., Durand-Gasselin, I., Gordon, A., Pustilnik, T., Curiel, D. T., Galanaud, P., Capron, F., Emilie, D., Curiel, T. J. (2001) Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat. Med. 7, 1339-1346.
48. Lee, B. N., Follen, M., Rodriquez, G., Shen, D. Y., Malpica, A., Shearer, W. T., Reuben, J. M. (2006) Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer 107, 999-1007.
49. Beckebaum, S., Zhang, X., Chen, X., Yu, Z., Frilling, A., Dworacki, G., Grosse-Wilde, H., Broelsch, C. E., Gerken, G., Cicinnati, V. R. (2004) Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets. Clin. Cancer Res. 10, 7260-7269.
50. Sciarra, A., Lichtner, M., Autran, G. A., Mastroianni, C., Rossi, R., Mengoni, F., Cristini, C., Gentilucci, A., Vullo, V., Di Silverio, F. (2007) Characterization of circulating blood dendritic cell subsets DC123+ (lymphoid) and DC11C+ (myeloid) in prostate adenocarcinoma patients. Prostate 67, 1-7.
51. Mami, N. B., Mohty, M., Chambost, H., Gaugler, B., Olive, D. (2004) Blood dendritic cells in patients with acute lymphoblastic leukaemia. Br. J. Haematol. 126, 77-80.
52. Maecker, B., Mougiakakos, D., Zimmermann, M., Behrens, M., Hollander, S., Schrauder, A., Schrappe, M., Welte, K., Klein, C. (2006) Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients. Leukemia 20, 645-649.
53. Hishizawa, M., Imada, K., Kitawaki, T., Ueda, M., Kadowaki, N., Uchiyama, T. (2004) Depletion and impaired interferon-α-producing capacity of blood plasmacytoid dendritic cells in human T-cell leukaemia virus type I-infected individuals. Br. J. Haematol. 125, 568-575.
54. Mohty, M., Isnardon, D., Vey, N., Briere, F., Blaise, D., Olive, D., Gaugler, B. (2002) Low blood dendritic cells in chronic myeloid leukaemia patients correlates with loss of CD34+/CD38- primitive haematopoietic progenitors. Br. J. Haematol. 119, 115-118.
55. Morse, M. A., Nair, S., Fernandez-Casal, M., Deng, Y., St Peter, M., Williams, R., Hobeika, A., Mosca, P., Clay, T., Cumming, R. I., Fisher, E., Clavien, P., Proia, A. D., Niedzwiecki, D., Caron, D., Lyerly, H. K. (2000) Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer. J. Clin. Oncol. 18, 3883-3893.
56. Bellik, L., Gerlini, G., Parenti, A., Ledda, F., Pimpinelli, N., Neri, B., Pantalone, D. (2006) Role of conventional treatments on circulating and monocyte-derived dendritic cells in colorectal cancer. Clin. Immunol. 121, 74-80.
57. Porta, C., Bonomi, L., Lillaz, B., Paglino, C., Rovati, B., Imarisio, I., Morbini, P., Villa, C., Danova, M., Mensi, M., Rovereto, B. (2007) Renal cell carcinoma-induced immunosuppression: an immunophenotypic study of lymphocyte subpopulations and circulating dendritic cells. Anticancer Res. 27, 165-173.
58. Charles, J., Di Domizio, J., Salameire, D., Bendriss-Vermare, N., Aspord, C., Muhammad, R., Lefebvre, C., Plumas, J., Leccia, M. T., Chaperot, L. (2010) Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J. Invest. Dermatol. 130, 1646-1656.
59. Hasskamp, J. H., Elias, E. G., Zapas, J. L. (2006) In vivo effects of sequential granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-2 (IL-2) on circulating dendritic cells (DC) in patients with surgically resected high risk cutaneous melanoma. J. Clin. Immunol. 26, 331-338.
60. Gerlini, G., Urso, C., Mariotti, G., Di Gennaro, P., Palli, D., Brandani, P., Salvadori, A., Pimpinelli, N., Reali, U. M., Borgognoni, L. (2007) Plasmacytoid dendritic cells represent a major dendritic cell subset in sentinel lymph nodes of melanoma patients and accumulate in metastatic nodes. Clin. Immunol. 125, 184-193.
61. Faith, A., Peek, E., McDonald, J., Urry, Z., Richards, D. F., Tan, C., Santis, G., Hawrylowicz, C. (2007) Plasmacytoid dendritic cells from human lung cancer draining lymph nodes induce Tc1 responses. Am. J. Respir. Cell Mol. Biol. 36, 360-367.
62. Hartmann, E., Wollenberg, B., Rothenfusser, S., Wagner, M., Wellisch, D., Mack, B., Giese, T., Gires, O., Endres, S., Hartmann, G. (2003) Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res. 63, 6478-6487.
63. Thiel, A., Kesselring, R., Pries, R., Puzik, A., Wittkopf, N., Wollenberg, B. (2011) Expression of the T cell receptor αβ on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma. PLoS ONE 6, e15997.
64. Curiel, T. J., Cheng, P., Mottram, P., Alvarez, X., Moons, L., Evdemon-Hogan, M., Wei, S., Zou, L., Kryczek, I., Hoyle, G., Lackner, A., Carmeliet, P., Zou, W. (2004) Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Res. 64, 5535-5538.
65. Wei, S., Kryczek, I., Zou, L., Daniel, B., Cheng, P., Mottram, P., Curiel, T., Lange, A., Zou, W. (2005) Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma. Cancer Res. 65, 5020-5026.
66. Watkins, S. K., Zhu, Z., Riboldi, E., Shafer-Weaver, K. A., Stagliano, K. E., Sklavos, M. M., Ambs, S., Yagita, H., Hurwitz, A. A. (2011) FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer. J. Clin. Invest. 121, 1361-1372.
67. Kutzner, H., Kerl, H., Pfaltz, M. C., Kempf, W. (2009) CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: diagnostic and pathogenetic implications. Am. J. Surg. Pathol. 33, 1307-1313.
68. Facchetti, F., De Wolf-Peeters, C., van den Oord, J. J., Desmet, V. J. (1989) Plasmacytoid monocytes (so-called plasmacytoid T cells) in Hodgkin's disease. J. Pathol. 158, 57-65.
69. Chauhan, D., Singh, A. V., Brahmandam, M., Carrasco, R., Bandi, M., Hideshima, T., Bianchi, G., Podar, K., Tai, Y. T., Mitsiades, C., Raje, N., Jaye, D. L., Kumar, S. K., Richardson, P., Munshi, N., Anderson, K. C. (2009) Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. Cancer Cell 16, 309-323.
70. Bontkes, H. J., Ruizendaal, J. J., Kramer, D., Meijer, C. J., Hooijberg, E. (2005) Plasmacytoid dendritic cells are present in cervical carcinoma and become activated by human papillomavirus type 16 virus-like particles. Gynecol. Oncol. 96, 897-901.
71. Battaglia, A., Buzzonetti, A., Baranello, C., Ferrandina, G., Martinelli, E., Fanfani, F., Scambia, G., Fattorossi, A. (2009) Metastatic tumour cells favor the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer. Cancer Immunol. Immunother. 58, 1363-1373.
72. Fiore, F., Von Bergwelt-Baildon, M. S., Drebber, U., Beyer, M., Popov, A., Manzke, O., Wickenhauser, C., Baldus, S. E., Schultze, J. L. (2006) Dendritic cells are significantly reduced in non-Hodgkin's lymphoma and express less CCR7 and CD62L. Leuk. Lymphoma 47, 613-622.
73. Mühleisen, B., Petrov, I., Gachter, T., Kurrer, M., Scharer, L., Dummer, R., French, L. E., Hofbauer, G. F. (2009) Progression of cutaneous squamous cell carcinoma in immunosuppressed patients is associated with reduced CD123+ and FOXP3+ cells in the perineoplastic inflammatory infiltrate. Histopathology 55, 67-76.
74. O'Donnell, R. K., Mick, R., Feldman, M., Hino, S., Wang, Y., Brose, M. S., Muschel, R. J. (2007) Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response. Cancer Lett. 255, 145-152.
75. Tang, T. J., Vukosavljevic, D., Janssen, H. L., Binda, R. S., Mancham, S., Tilanus, H. W., Ijzermans, J. N., Drexhage, H., Kwekkeboom, J. (2006) Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma. Hum. Pathol. 37, 332-338.
76. Treilleux, I., Blay, J. Y., Bendriss-Vermare, N., Ray-Coquard, I., Bachelot, T., Guastalla, J. P., Bremond, A., Goddard, S., Pin, J. J., Barthelemy-Dubois, C., Lebecque, S. (2004) Dendritic cell infiltration and prognosis of early stage breast cancer. Clin. Cancer Res. 10, 7466-7474.
77. Vermi, W., Bonecchi, R., Facchetti, F., Bianchi, D., Sozzani, S., Festa, S., Berenzi, A., Cella, M., Colonna, M. (2003) Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas. J. Pathol. 200, 255-268.
78. Molenkamp, B. G., van Leeuwen, P. A., Meijer, S., Sluijter, B. J., Wijnands, P. G., Baars, A., van den Eertwegh, A. J., Scheper, R. J., de Gruijl, T. D. (2007) Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients. Clin. Cancer Res. 13, 2961-2969.
79. Marafioti, T., Paterson, J. C., Ballabio, E., Reichard, K. K., Tedoldi, S., Hollowood, K., Dictor, M., Hansmann, M. L., Pileri, S. A., Dyer, M. J., Sozzani, S., Dikic, I., Shaw, A. S., Petrella, T., Stein, H., Isaacson, P. G., Facchetti, F., Mason, D. Y. (2008) Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood 111, 3778-3792.
80. Vermi, W., Fisogni, S., Salogni, L., Scharer, L., Kutzner, H., Sozzani, S., Lonardi, S., Rossini, C., Calzavara-Pinton, P., LeBoit, P. E., Facchetti, F. (2011) Spontaneous regression of highly immunogenic Molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J. Invest. Dermatol. 131, 426-434.
81. Vermi, W., Lonardi, S., Morassi, M., Rossini, C., Tardanico, R., Venturini, M., Sala, R., Tincani, A., Poliani, P. L., Calzavara-Pinton, P. G., Cerroni, L., Santoro, A., Facchetti, F. (2009) Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage. Immunobiology 214, 877-886.
82. Penna, G., Sozzani, S., Adorini, L. (2001) Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J. Immunol. 167, 1862-1866.
83. Krug, A., Uppaluri, R., Facchetti, F., Dorner, B. G., Sheehan, K. C., Schreiber, R. D., Cella, M., Colonna, M. (2002) IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J. Immunol. 169, 6079-6083.
84. Vanbervliet, B., Bendriss-Vermare, N., Massacrier, C., Homey, B., de Bouteiller, O., Briere, F., Trinchieri, G., Caux, C. (2003) The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12. J. Exp. Med. 198, 823-830.
85. Cicinnati, V. R., Kang, J., Sotiropoulos, G. C., Hilgard, P., Frilling, A., Broelsch, C. E., Gerken, G., Beckebaum, S. (2008) Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: role of α interferon. J. Gen. Virol. 89, 1243-1253.
86. Bendriss-Vermare, N., Chaperot, L., Peoc'h, M., Vanbervliet, B., Jacob, M. C., Briere, F., Bensa, J. C., Caux, C., Plumas, J. (2004) In situ leukemic plasmacytoid dendritic cells pattern of chemokine receptors expression and in vitro migratory response. Leukemia 18, 1491-1498.
87. Vermi, W., Riboldi, E., Wittamer, V., Gentili, F., Luini, W., Marrelli, S., Vecchi, A., Franssen, J. D., Communi, D., Massardi, L., Sironi, M., Mantovani, A., Parmentier, M., Facchetti, F., Sozzani, S. (2005) Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. J. Exp. Med. 201, 509-515.
88. Wittamer, V., Franssen, J. D., Vulcano, M., Mirjolet, J. F., Le Poul, E., Migeotte, I., Brezillon, S., Tyldesley, R., Blanpain, C., Detheux, M., Mantovani, A., Sozzani, S., Vassart, G., Parmentier, M., Communi, D. (2003) Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J. Exp. Med. 198, 977-985.
89. Wenzel, J., Uerlich, M., Haller, O., Bieber, T., Tueting, T. (2005) Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist Imiquimod. J. Cutan. Pathol. 32, 257-262.
90. Wenzel, J., Bekisch, B., Uerlich, M., Haller, O., Bieber, T., Tuting, T. (2005) Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions. Am. J. Clin. Pathol. 124, 37-48.
91. Di Pucchio, T., Chatterjee, B., Smed-Sorensen, A., Clayton, S., Palazzo, A., Montes, M., Xue, Y., Mellman, I., Banchereau, J., Connolly, J. E. (2008) Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat. Immunol. 9, 551-557.
92. Belardelli, F., Ferrantini, M., Proietti, E., Kirkwood, J. M. (2002) Interferon- α in tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 13, 119-134.
93. Dunn, G. P., Bruce, A. T., Sheehan, K. C., Shankaran, V., Uppaluri, R., Bui, J. D., Diamond, M. S., Koebel, C. M., Arthur, C., White, J. M., Schreiber, R. D. (2005) A critical function for type I interferons in cancer immunoediting. Nat. Immunol. 6, 722-729.
94. Hirsch, I., Caux, C., Hasan, U., Bendriss-Vermare, N., Olive, D. (2010) Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol. 31, 391-397.
95. Fallarino, F., Gizzi, S., Mosci, P., Grohmann, U., Puccetti, P. (2007) Tryptophan catabolism in IDO+ plasmacytoid dendritic cells. Curr. Drug Metab. 8, 209-216.
96. Perrot, I., Blanchard, D., Freymond, N., Isaac, S., Guibert, B., Pacheco, Y., Lebecque, S. (2007) Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage. J. Immunol. 178, 2763-2769.
97. Röck, J., Schneider, E., Grun, J. R., Grutzkau, A., Kuppers, R., Schmitz, J., Winkels, G. (2007) CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCγ2. Eur. J. Immunol. 37, 3564-3575.
98. Dzionek, A., Sohma, Y., Nagafune, J., Cella, M., Colonna, M., Facchetti, F., Gunther, G., Johnston, I., Lanzavecchia, A., Nagasaka, T., Okada, T., Vermi, W., Winkels, G., Yamamoto, T., Zysk, M., Yamaguchi, Y., Schmitz, J. (2001) BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction. J. Exp. Med. 194, 1823-1834.
99. Fuchs, A., Cella, M., Kondo, T., Colonna, M. (2005) Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. Blood 106, 2076-2082.
100. Cao, W., Rosen, D. B., Ito, T., Bover, L., Bao, M., Watanabe, G., Yao, Z., Zhang, L., Lanier, L. L., Liu, Y. J. (2006) Plasmacytoid dendritic cellspecific receptor ILT7-Fc εRI γ inhibits Toll-like receptor-induced interferon production. J. Exp. Med. 203, 1399-1405.
101. Meyer-Wentrup, F., Benitez-Ribas, D., Tacken, P. J., Punt, C. J., Figdor, C. G., de Vries, I. J., Adema, G. J. (2008) Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-α production. Blood 111, 4245-4253.
102. Kupzig, S., Korolchuk, V., Rollason, R., Sugden, A., Wilde, A., Banting, G. (2003) Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic 4, 694-709.
103. Blasius, A. L., Giurisato, E., Cella, M., Schreiber, R. D., Shaw, A. S., Colonna, M. (2006) Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J. Immunol. 177, 3260-3265.
104. Cao, W., Bover, L. (2010) Signaling and ligand interaction of ILT7: receptor- mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol. Rev. 234, 163-176.
105. Cai, D., Cao, J., Li, Z., Zheng, X., Yao, Y., Li, W., Yuan, Z. (2009) Upregulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis. BMC Cancer 9, 102.
106. Wang, W., Nishioka, Y., Ozaki, S., Jalili, A., Abe, S., Kakiuchi, S., Kishuku, M., Minakuchi, K., Matsumoto, T., Sone, S. (2009) HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody. Cancer Immunol. Immunother. 58, 967-976.
107. Ito, T., Yang, M., Wang, Y. H., Lande, R., Gregorio, J., Perng, O. A., Qin, X. F., Liu, Y. J., Gilliet, M. (2007) Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J. Exp. Med. 204, 105-115.
108. Boasso, A., Herbeuval, J. P., Hardy, A. W., Anderson, S. A., Dolan, M. J., Fuchs, D., Shearer, G. M. (2007) HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. Blood 109, 3351-3359.
109. Gerlini, G., Di Gennaro, P., Mariotti, G., Urso, C., Chiarugi, A., Pimpinelli, N., Borgognoni, L. (2010) Indoleamine 2,3-dioxygenase+ cells correspond to the BDCA2+ plasmacytoid dendritic cells in human melanoma sentinel nodes. J. Invest. Dermatol. 130, 898-901.
110. Sharma, M. D., Baban, B., Chandler, P., Hou, D. Y., Singh, N., Yagita, H., Azuma, M., Blazar, B. R., Mellor, A. L., Munn, D. H. (2007) Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J. Clin. Invest. 117, 2570-2582.
111. Munn, D. H., Sharma, M. D., Hou, D., Baban, B., Lee, J. R., Antonia, S. J., Messina, J. L., Chandler, P., Koni, P. A., Mellor, A. L. (2004) xpression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114, 280-290.
112. Puccetti, P., Fallarino, F. (2008) Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism. Blood Cells Mol. Dis. 40, 101-105.
113. Mellor, A. L., Baban, B., Chandler, P. R., Manlapat, A., Kahler, D. J., Munn, D. H. (2005) Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenasedependent T cell regulatory functions via IFN Type 1 signaling. J. Immunol. 175, 5601-5605.
114. Johnson III, B. A., Kahler, D. J., Baban, B., Chandler, P. R., Kang, B., Shimoda, M., Koni, P. A., Pihkala, J., Vilagos, B., Busslinger, M., Munn, D. H., Mellor, A. L. (2010) B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc. Natl. Acad. Sci. USA 107, 10644-10648.
115. Vermi, W., Facchetti, F., Rosati, S., Vergoni, F., Rossi, E., Festa, S., Remotti, D., Grigolato, P., Massarelli, G., Frizzera, G. (2004) Nodal and extranodal tumor-forming accumulation of plasmacytoid monocytes/ interferon-producing cells associated with myeloid disorders. Am. J. Surg. Pathol. 28, 585-595.
116. Santoro, A., Majorana, A., Roversi, L., Gentili, F., Marrelli, S., Vermi, W., Bardellini, E., Sapelli, P., Facchetti, F. (2005) Recruitment of dendritic cells in oral lichen planus. J. Pathol. 205, 426-434.
117. Facchetti, F., Vermi, W., Santoro, A., Vergoni, F., Chilosi, M., Doglioni, C. (2003) Neoplasms derived from plasmacytoid monocytes/interferonproducing cells: variability of CD56 and granzyme B expression. Am. J. Surg. Pathol. 27, 1489-1492, author reply 1492-1493.
118. Jahrsdörfer, B., Vollmer, A., Blackwell, S. E., Maier, J., Sontheimer, K., Beyer, T., Mandel, B., Lunov, O., Tron, K., Nienhaus, G. U., Simmet, T., Debatin, K. M., Weiner, G. J., Fabricius, D. (2010) Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion. Blood 115, 1156-1165.
119. Wolf, I. H., Kodama, K., Cerroni, L., Kerl, H. (2007) Nature of inflammatory infiltrate in superficial cutaneous malignancies during topical Imiquimod treatment. Am. J. Dermatopathol. 29, 237-241.
120. Urosevic, M., Dummer, R., Conrad, C., Beyeler, M., Laine, E., Burg, G., Gilliet, M. (2005) Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following Imiquimod treatment. J. Natl. Cancer Inst. 97, 1143-1153.
121. Santini, S. M., Di Pucchio, T., Lapenta, C., Parlato, S., Logozzi, M., Belardelli, F. (2003) A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells. Stem Cells 21, 357-362.
122. Santini, S. M., Lapenta, C., Logozzi, M., Parlato, S., Spada, M., Di Pucchio, T., Belardelli, F. (2000) Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J. Exp. Med. 191, 1777-1788.
123. Santini, S. M., Lapenta, C., Santodonato, L., D'Agostino, G., Belardelli, F., Ferrantini, M. (2009) IFN-α in the generation of dendritic cells for cancer immunotherapy. Handb. Exp. Pharmacol. 295-317.
124. Farkas, L., Beiske, K., Lund-Johansen, F., Brandtzaeg, P., Jahnsen, F. L. (2001) Plasmacytoid dendritic cells (natural interferon- α/β-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am. J. Pathol. 159, 237-243.
125. Schiavoni, G., Mattei, F., Sestili, P., Borghi, P., Venditti, M., Morse III, H. C., Belardelli, F., Gabriele, L. (2002) ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8α(+) dendritic cells. J. Exp. Med. 196, 1415-1425.
126. Tsujimura, H., Tamura, T., Ozato, K. (2003) Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J. Immunol. 170, 1131-1135.
127. Aliberti, J., Schulz, O., Pennington, D. J., Tsujimura, H., Reis e Sousa, C., Ozato, K., Sher, A. (2003) Essential role for ICSBP in the in vivo development of murine CD8α + dendritic cells. Blood 101, 305-310.
128. Bergqvist, I., Eriksson, M., Saarikettu, J., Eriksson, B., Corneliussen, B., Grundstrom, T., Holmberg, D. (2000) The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development. Eur. J. Immunol. 30, 2857-2863.
129. Ghosh, H. S., Cisse, B., Bunin, A., Lewis, K., Reizis, B. (2010) Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 33, 905-916.
130. Allman, D., Dalod, M., Asselin-Paturel, C., Delale, T., Robbins, S. H., Trinchieri, G., Biron, C. A., Kastner, P., Chan, S. (2006) Ikaros is required for plasmacytoid dendritic cell differentiation. Blood 108, 4025-4034.
131. Palamara, F., Meindl, S., Holcmann, M., Luhrs, P., Stingl, G., Sibilia, M. (2004) Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with Imiquimod. J. Immunol. 173, 3051-3061.
132. Liu, C., Lou, Y., Lizee, G., Qin, H., Liu, S., Rabinovich, B., Kim, G. J., Wang, Y. H., Ye, Y., Sikora, A. G., Overwijk, W. W., Liu, Y. J., Wang, G., Hwu, P. (2008) Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J. Clin. Invest. 118, 1165-1175.
133. Inglefield, J. R., Dumitru, C. D., Alkan, S. S., Gibson, S. J., Lipson, K. E., Tomai, M. A., Larson, C. J., Vasilakos, J. P. (2008) TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN. J. Interferon Cytokine Res. 28, 253-263.
134. Persson, C. M., Chambers, B. J. (2010) Plasmacytoid dendritic cell-induced migration and activation of NK cells in vivo. Eur. J. Immunol. 40, 2155-2164.
135. Krieg, A. M. (2002) CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760.
136. Schmitz, F., Heit, A., Guggemoos, S., Krug, A., Mages, J., Schiemann, M., Adler, H., Drexler, I., Haas, T., Lang, R., Wagner, H. (2007) Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-β production in myeloid dendritic cells. Eur. J. Immunol. 37, 315-327.
137. Hoshino, K., Sasaki, I., Sugiyama, T., Yano, T., Yamazaki, C., Yasui, T., Kikutani, H., Kaisho, T. (2010) Critical role of IκB kinase α in TLR7/9- induced type I IFN production by conventional dendritic cells. J. Immunol. 184, 3341-3345.
138. Dunn, G. P., Koebel, C. M., Schreiber, R. D. (2006) Interferons, immunity and cancer immunoediting. Nat. Rev. Immunol. 6, 836-848.
139. Barchet, W., Cella, M., Colonna, M. (2005) Plasmacytoid dendritic cells-virus experts of innate immunity. Semin. Immunol. 17, 253-261.
140. Swiecki, M., Gilfillan, S., Vermi, W., Wang, Y., Colonna, M. (2010) Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity 33, 955-966.