IFN-alpha in the generation of dendritic cells for cancer immunotherapy

Handbook of Experimental Pharmacology

Volumn 188, Issue , 2009, Pages 295-317

  Santini, Stefano Maria ^a   Lapenta, Caterina ^b   Santodonato, Laura ^b   D'Agostino, Giuseppina ^b   Belardelli, Filippo ^b   Ferrantini, Maria ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BCG VACCINE; CANCER VACCINE; CD14 ANTIGEN; CD16 ANTIGEN; CD40 LIGAND; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 100; INTERFERON; INTERLEUKIN 4; MELAN A; RECOMBINANT ALPHA2B INTERFERON; RIBOMUNYL; SEROBIF; STAT PROTEIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG; IMMUNOLOGICAL ADJUVANT;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; BLOOD; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CYTOKINE PRODUCTION; DENDRITIC CELL; EX VIVO STUDY; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; LYMPH NODE; LYMPHOCYTE; MELANOMA; MONOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; THYROID CARCINOMA; ADOPTIVE IMMUNOTHERAPY; ANIMAL; CULTURE TECHNIQUE; IMMUNOLOGY; METABOLISM; NEOPLASM; TRANSPLANTATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CANCER VACCINES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; DENDRITIC CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-ALPHA; NEOPLASMS; PHENOTYPE;

EID: 60549101236     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-71029-5_14     Document Type: Review

References (82)

1. Albert ML, Sauter B, Bhardwaj N (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86-89
2. Banchereau J, Pascual V (2006) Type I IFN in systemic lupus erythematosus and other autoimmune diseases. Immunity 25:383-392
3. + progenitors and activated with type I interferon. J Immunother 28:505-516
4. Barnes E, Salio M, Cerundolo V, Medlin J, Murphy S, Dusheiko G, Klenerman P (2004) Impact of alpha interferon and ribavirin on the function of maturing dendritic cells. Antimicrob Agents Chemother 48:3382-3389
5. Bartholomé EJ,Willems F, Crusiaux A, Thielemans K, Schandene L, GoldmanM(1999) IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells: selective inhibition of CD40-dependent interleukin-12 secretion. J Interf Cytok Res 19:471-478
6. Belardelli F (1995) Role of interferons and other cytokines in the regulation of the immune response. APMIS 103:161-179
7. Belardelli F, Ferrantini M (2002) Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol 23:201-208
8. Belardelli F, Gresser I (1996) The neglected role of type I interferon in the T-cell response: implications for its clinical use. Immunol Today 17:369-372
9. Bell D, Young JW, Banchereau J (1999) Dendritic cells. Adv Immunol 72:255-324
10. Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J (2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294:1540-1543
11. Boccaccio C, Jacod S, Kaiser A, Boyer A, Abastado JP, Nardin A (2002) Identification of a clinicalgrade maturation factor for dendritic cells. J Immunother 25:88-96
12. Buelens C, Bartholome EJ, Amraoui Z, Boutriaux M, Salmon I, Thielemans K, Willems F, Goldman M (2002) Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood 99:993-998
13. Carbonneil C, Aouba A, Burgard M, Cardinaud S, Rouzioux C, Langlade-Demoyen P, Weiss L (2003) Dendritic cells generated in the presence of granulocyte-macrophage colony-stimulating factor and IFN-alpha are potent inducers of HIV-specific CD8 T cells. AIDS 17:1731-1740
14. Carbonneil C, Saidi H, Donkova-Petrini V,Weiss L (2004) Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells. Int Immunol 16:1037-1052
15. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J (1992) GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258-261
16. Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, Yoneda K, Imamura S, Schmitt D, Banchereau J (1996) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 184:695-706
17. Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, Colonna M (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 5:919-923
18. Della Bella S, Nicola S, Riva A, Biasin M, Clerici M, Villa ML (2004) Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferonalpha. J Leukoc Biol 75:106-116
19. Detournay O, Mazouz N, Goldman M, Toungouz M (2005) IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4+CD25+ regulatory T cells. Hum Immunol 66:460-468
20. Dickensheets HL, Donnelly RP (1999) Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons. Leukoc Biol 65:307-312
21. + T cells and monocyte/dendritic cell precursors. Cancer Res 66:4943-4951
22. Durelli L, Ferrero B, Oggero A, Verdun E, Bongioanni MR, Gentile E, Isoardo GL, Ricci A, Rota E, Bergamasco B, Durazzo M, Saracco G, Biava MA, Brossa PC, Giorda L, Pagni R, Aimo G (1999) Autoimmune events during interferon beta-1b treatment for multiple sclerosis. J Neurol Sci 162:74-83
23. Dussourd d'Hinterland L, Normier G, Durand J (1980) Ribosomal vaccines: preparation of subcellular fractions. Arzneimittelforschung 30:126-132
24. FerrantiniM, Capone I, Belardelli F (2007) Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 89:884-893
25. Ferrantini M, Capone I, Belardelli F (2008) Dendritic cells and cytokines in immune rejection ofcancer. Cytokine Growth Factor Rev 19:93-107
26. Gabriele L, Borghi P, Rozera C, Sestili P, Andreotti M, Guarini A, Montefusco E, Foà R, Belardelli F (2004) IFN-alpha promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment. Blood 103:980-987
27. Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002) Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells. J Immunol 169:3038-3045
28. Gilboa E (2007) DC-based cancer vaccines. J Clin Invest 117:1195-1203
29. Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, Tsoutsos D, Panagiotou P, Polyzos A, Papadopoulos O, Stratigos A, Markopoulos C, Bafaloukos D, Pectasides D, Fountzilas G, Kirkwood JM (2006) Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med 354:709-718
30. Heath WR, Carbone FR (2001) Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 19:47-64
31. Hermann P, Rubio M, Nakajima T, Delespesse G, Sarfati M (1998) IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL- 10 release and selectively enhances IL-12p70, CD80, and MHC class I expression. J Immunol 161:2011-2018
32. Huang YM, Kouwenhoven M, Jin YP, Press R, Huang WX, Link H (2001) Dendritic cells derived from patients with multiple sclerosis show high CD1a and low CD86 expression. Mult Scler 7:95-99
33. Hunter CA (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 5:521-531
34. Hussien Y, Sanna A, Soderstrom M, Link H, Huang YM (2001) Glatiramer acetate and IFN-beta act on dendritic cells in multiple sclerosis. J Neuroimmunol 121:102-110
35. Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S (2001) Differential regulation of human blood dendritic cell subsets by IFNs. J Immunol 166:2961-2969
36. Jonuleit H, Kühn U, Müller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH (1997a) Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27:3135-3142
37. Jonuleit H, Wiedemann K, Müller G, Degwert J, Hoppe U, Knop J, Enk AH (1997b) Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells. J Immunol 158:2610-2615
38. Kalinski P, Schuitemaker JHN, Hilkens CMU, Wierenga EA, Kapsenberg ML (1999) Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol 162:3231-3236
39. Korthals M, Safaian N, Kronenwett R, Maihöfer D, Schott M, Papewalis C, Diaz Blanco E, Winter M, Czibere A, Haas R, Kobbe G, Fenk R (2007) Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysis. J Transl Med 5:46
40. Langenkamp A, Messi M, Lanzavecchia A, Sallusto F (2000) Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1:311-316
41. Lapenta C, Santini SM, Logozzi M, Spada M, Andreotti M, Di Pucchio T, Parlato S, Belardelli F (2003) Potent immune response against HIV-1 and protection from virus challenge in hu-PBLSCID mice immunized with inactivated virus-pulsed dendritic cells generated in the presence of IFN-alpha. J Exp Med 198:361-367
42. Lapenta C, Santini SM, Spada M, Donati S, Urbani F, Accapezzato D, Franceschini D, Andreotti M, Barnaba V, Belardelli F (2006) IFN-alpha- conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens. Eur J Immunol 36:2046-2060
43. Larner AC, Petricoin EF, Nakagawa Y, Finbloom DS (1993) IL-4 attenuates the transcriptional activation of both IFN-alpha and IFN-gamma-induced cellular gene expression in monocytes and monocytic cell lines. J Immunol 150:1944-1950
44. Liu YJ (2001) Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106:259-262
45. Luft T, Pang KC, Thomas E, Bradley CJ, Savoia H, Trapani J, Cebon J (1998a) A serum-free culture model for studying the differentiation of human dendritic cells from adult CD34+ progenitor cells. Exp Hematol 26:489-500
46. Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J, Cebon J (1998b) Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 161:1947-1953
47. Luft T, Luetjens P, Hochrein H, Toy T, Masterman KA, Rizkalla M, Maliszewski C, Shortman K, Cebon J, Maraskovsky E (2002) IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells. Int Immunol 14:367-380
48. Mazouz N, Detournay O, Buelens C, Renneson J, Trakatelli M, Lambermont M, Goldman M, Toungouz M (2005) Immunostimulatory properties of human dendritic cells generated using IFN-beta associated either with IL-3 or GM-CSF. Cancer Immunol Immunother 54:1010-1017
49. McRae BL, Beilfuss BA, van Seventer GA (2000a) IFN-beta differentially regulates CD40-induced cytokine secretion by human dendritic cells. J Immunol 164:23-28
50. McRae BL, Nagai T, Semnani RT, van Seventer JM, van Seventer GA (2000b) Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors. Blood 96:210-217
51. Melero I, Arina A, Murillo O, Dubrot J, Alfaro C, Pérez-Gracia JL, Bendandi M, Hervás-Stubbs S (2006) Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena. Clin Cancer Res 12:2385-2389
52. MohtyM, Vialle-Castellano A, Nunes JA, Isnardon D, Olive D, Gaugler B (2003) IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities. J Imm 171:3385-3393
53. Nagai T, Devergne O, Mueller TF, Perkins DL, van Seventer JM, van Seventer GA (2003) Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol 171:5233-5243
54. Napolitani G, Rinaldi A, Bertoni F, Sallusto F and Lanzavecchia A (2005) Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6:769-776
55. Ohmori Y, Hamilton TA (1998) STAT6 is required for the anti-inflammatory activity of interleukin- 4 in mouse peritoneal macrophages. J Biol Chem 273:29202-29209
56. Padovan E, Spagnoli GC, Ferrantini M, Heberer M (2002) IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells. J Leuk Biol 71:669-676
57. Papewalis C, Jacobs B, Wuttke M, Ullrich E, Baehring T, Fenk R, Willenberg HS, Schinner S, Cohnen M, Seissler J, Zacharowski K, Scherbaum WA, Schott M (2008a) IFN-alpha skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo. J Immunol 180:1462-1470
58. Papewalis C, Wuttke M, Jacobs B, Domberg J, Willenberg H, Baehring T, Cupisti K, Raffel A, Chao L, Fenk R, Seissler J, Scherbaum WA, Schott M (2008b) Dendritic cell vaccination induces tumor epitope-specific Th1 immune response in medullary thyroid carcinoma. Horm Metab Res 40:108-116
59. Paquette RL, Hsu NC, Kiertscher SM, Park AN, Tran L, Roth MD, Glaspy JA (1998) Interferonalpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells. J Leukoc Biol 64:358-367
60. Parlato S, Santini SM, Lapenta C, Di Pucchio T, Logozzi M, Spada M, Giammarioli AM, MalorniW, Fais S, Belardelli F (2001) Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities. Blood 98:3022-3029
61. Pogue SL, Preston BT, Stalder J, Bebbington CR, Cardarelli PM (2004) The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res 24:131-139
62. Preziati D, La Rosa L, Covini G, Marcelli R, Rescalli S, Persani L, Del Ninno E, Meroni PL, Colombo M, Beck-Peccoz P (1995) Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2a. Eur J Endocrinol 132:587-593
63. Radvanyi LG, Banerjee A, Weir M, Messner H (1999) Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells. Scand J Immunol 50:499-509
64. Renneson J, Salio M, Mazouz N, Goldman M, Marchant A, Cerundolo V (2005) Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells. Clin Exp Immunol 139:468-475
65. Rivoltini L, Barracchini KC, Viggiano V, Kawakami Y, Smith A, Mixon A, Restifo NP, Topalian SL, Simonis TB, Rosenberg SA, Francesco MM (1995) Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res 55:3149-3157
66. Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, Konwalinka G, Fritsch PO, Steinman RM, Schuler G (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83-93
67. Ronnblom LE, Alm GV, Oberg K (1991) Autoimmune phenomena in patients with malignant carcinoid tumors during interferon-alpha treatment. Acta Oncol 30:537-540
68. Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109-1118
69. Sallusto F, Mackay CR, Lanzavecchia A (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18:593-620
70. Santini SM, Lapenta C, Logozzi M, Parlato S, Spada M, Di Pucchio T, Belardelli F (2000) Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 191:1777-1788
71. Santodonato L, D'Agostino G, Nisini R, Mariotti S, Monque DM, Spada M, Lattanzi L, Perrone MP, Andreotti M, Belardelli F, Ferrantini M (2003) Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colonystimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response. J Immunol 170:5195-5202
72. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S, Liu YJ (1999) The nature of the principal type 1 interferon-producing cells in human blood. Science 284:1835-1837
73. Steinbrink K,WolflM, Jonuleit H, Knop J, Enk AH (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159:4772-4780
74. Steinbrink K, Jonuleit H, Muller G, Schuler G, Knop J, Enk AH (1999) Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells. Blood 93:1634-1642
75. Steinman RM (2003) The control of immunity and tolerance by dendritic cell. Pathol Biol 51:59-60
76. Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419-426
77. Steinman RM, Hemmi H (2006) Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311:17-58
78. Tesniere A, Panaretakis T, Kepp O, Apetoh L, Ghiringhelli F, Zitvogel L, Kroemer G (2008) Molecular characteristics of immunogenic cancer cell death. Cell Death Differ 15:3-12
79. Thurnher M, Zelle-Rieser C, Ramoner R, Bartsch G, Holtl L (2001) The disabled dendritic cell. Faseb J 15:1054-1061
80. Tosi D, Valenti R, Cova A, Sovena G, Huber V, Pilla L, Arienti F, Belardelli F, Parmiani G, Rivoltini L (2004) Role of cross-talk between IFN-alpha-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T cell responses against human tumor antigens. J Immunol 172:5363-5370
81. Trakatelli M, Toungouz M, Blocklet D, Dodoo Y, Gordower L, Laporte M, Vereecken P, Sales F, Mortier L,Mazouz N, Lambermont M, Goldman S, Coulie P, GoldmanM, Velu T (2006) A new dendritic cell vaccine generated with interleukin-3 and interferon-beta induces CD8+ T cell responses against NA17-A2 tumor peptide in melanoma patients. Cancer Immunol Immunother 55:469-474
82. Wiesemann E, Sonmez D, Heidenreich F, Windhagen A (2002) Interferon-beta increases the stimulatory capacity of monocyte-derived dendritic cells to induce IL-13, IL-5 and IL-10 in autologous T-cells. J Neuroimmunol 123:160-169