Development of a cyclic adenosine monophosphate assay for G i-coupled G protein-coupled receptors by utilizing the endogenous calcitonin activity in chinese hamster ovary cells

Assay and Drug Development Technologies

Volumn 9, Issue 5, 2011, Pages 522-531

  Wang, Yuren ^a   Kong, Yan ^a   Shei, Gan Ju ^a   Kang, Liya ^a   Cvijic, Mary Ellen ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMYLIN; CALCITONIN; CALCITONIN RECEPTOR; CANNABINOID 1 RECEPTOR; CYCLIC AMP; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; DOPAMINE 2 RECEPTOR; EMONAPRIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETICLOPRIDE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR AGONIST; G PROTEIN COUPLED RECEPTOR ANTAGONIST; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; NALOXONZINE; NALTREXONE; QUINPIROLE; SALCATONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOMATION; BINDING KINETICS; CELL ASSAY; CHO CELL; CONCENTRATION RESPONSE; HIGH THROUGHPUT SCREENING; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR BINDING; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO;

1-METHYL-3-ISOBUTYLXANTHINE; ADENYLATE CYCLASE; ANIMALS; CALCITONIN; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; FEMALE; FORSKOLIN; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR TARGETED THERAPY; NALOXONE; NARCOTIC ANTAGONISTS; PHOSPHODIESTERASE INHIBITORS; RADIOLIGAND ASSAY; RATS; RECEPTORS, CALCITONIN; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, ISLET AMYLOID POLYPEPTIDE; RECEPTORS, OPIOID, MU; SALMON;

EID: 80053350616     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2010.0361     Document Type: Article

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