-
1
-
-
0029586743
-
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
-
Bouaboula M., Poinot-Chazel C., Bourrie B., Canat X., Calandra B., Rinaldi-Carmona M., Le Fur G., and Casellas P. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1 Biochem. J. 312 Pt 2 1995 637 641
-
(1995)
Biochem. J.
, vol.312
, Issue.PART 2
, pp. 637-641
-
-
Bouaboula, M.1
Poinot-Chazel, C.2
Bourrie, B.3
Canat, X.4
Calandra, B.5
Rinaldi-Carmona, M.6
Le Fur, G.7
Casellas, P.8
-
2
-
-
0030826705
-
A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions
-
Bouaboula M., Perrachon S., Milligan L., Canat X., Rinaldi-Carmona M., Portier M., Barth F., Calandra B., Pecceu F., Lupker J., Maffrand J.P., Le Fur G., and Casellas P. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions J. Biol. Chem. 272 35 1997 22330 22339
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.35
, pp. 22330-22339
-
-
Bouaboula, M.1
Perrachon, S.2
Milligan, L.3
Canat, X.4
Rinaldi-Carmona, M.5
Portier, M.6
Barth, F.7
Calandra, B.8
Pecceu, F.9
Lupker, J.10
Maffrand, J.P.11
Le Fur, G.12
Casellas, P.13
-
3
-
-
0031736065
-
In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum
-
Croci T., Manara L., Aureggi G., Guagnini F., Rinaldi-Carmona M., Maffrand J.P., Le Fur G., Mukenge S., and Ferla G. In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum Br. J. Pharmacol. 125 7 1998 1393 1395
-
(1998)
Br. J. Pharmacol.
, vol.125
, Issue.7
, pp. 1393-1395
-
-
Croci, T.1
Manara, L.2
Aureggi, G.3
Guagnini, F.4
Rinaldi-Carmona, M.5
Maffrand, J.P.6
Le Fur, G.7
Mukenge, S.8
Ferla, G.9
-
4
-
-
0026598734
-
Conformationally restrained analogues of pravadoline: Nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor
-
D'Ambra T.E., Estep K.G., Bell M.R., Eissenstat M.A., Josef K.A., Ward S.J., Haycock D.A., Baizman E.R., Casiano F.M., and Beglin N.C. Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor J. Med. Chem. 35 1 1992 124 135
-
(1992)
J. Med. Chem.
, vol.35
, Issue.1
, pp. 124-135
-
-
D'Ambra, T.E.1
Estep, K.G.2
Bell, M.R.3
Eissenstat, M.A.4
Josef, K.A.5
Ward, S.J.6
Haycock, D.A.7
Baizman, E.R.8
Casiano, F.M.9
Beglin, N.C.10
-
5
-
-
0024332759
-
Calculating receptor number from binding experiments using same compound as radioligand and competitor
-
DeBlasi A., O'Reilly K., and Motulsky H.J. Calculating receptor number from binding experiments using same compound as radioligand and competitor Trends Pharmacol. Sci. 10 1989 227 229
-
(1989)
Trends Pharmacol. Sci.
, vol.10
, pp. 227-229
-
-
Deblasi, A.1
O'Reilly, K.2
Motulsky, H.J.3
-
6
-
-
0027078685
-
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
-
Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., and Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 258 5090 1992 1946 1949
-
(1992)
Science
, vol.258
, Issue.5090
, pp. 1946-1949
-
-
Devane, W.A.1
Hanus, L.2
Breuer, A.3
Pertwee, R.G.4
Stevenson, L.A.5
Griffin, G.6
Gibson, D.7
Mandelbaum, A.8
Etinger, A.9
Mechoulam, R.10
-
7
-
-
0035848818
-
Leptin-regulated endocannabinoids are involved in maintaining food intake
-
Di Marzo V., Goparaju S.K., Wang L., Liu J., Batkai S., Jarai Z., Fezza F., Miura G.I., Palmiter R.D., Sugiura T., and Kunos G. Leptin-regulated endocannabinoids are involved in maintaining food intake Nature 410 6830 2001 822 825
-
(2001)
Nature
, vol.410
, Issue.6830
, pp. 822-825
-
-
Di Marzo, V.1
Goparaju, S.K.2
Wang, L.3
Liu, J.4
Batkai, S.5
Jarai, Z.6
Fezza, F.7
Miura, G.I.8
Palmiter, R.D.9
Sugiura, T.10
Kunos, G.11
-
8
-
-
0025878961
-
Molecular cloning of a human cannabinoid receptor which is also expressed in testis
-
Gerard C.M., Mollereau C., Vassart G., and Parmentier M. Molecular cloning of a human cannabinoid receptor which is also expressed in testis Biochem. J. 279 Pt 1 1991 129 134
-
(1991)
Biochem. J.
, vol.279
, Issue.PART 1
, pp. 129-134
-
-
Gerard, C.M.1
Mollereau, C.2
Vassart, G.3
Parmentier, M.4
-
9
-
-
0027489995
-
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor
-
Hanus L., Gopher A., Almog S., and Mechoulam R. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor J. Med. Chem. 36 20 1993 3032 3034
-
(1993)
J. Med. Chem.
, vol.36
, Issue.20
, pp. 3032-3034
-
-
Hanus, L.1
Gopher, A.2
Almog, S.3
Mechoulam, R.4
-
10
-
-
0035957425
-
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
-
Hanus L., Abu-Lafi S., Fride E., Breuer A., Vogel Z., Shalev D.E., Kustanovich I., and Mechoulam R. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor Proc. Natl. Acad. Sci. U. S. A. 98 7 2001 3662 3665
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, Issue.7
, pp. 3662-3665
-
-
Hanus, L.1
Abu-Lafi, S.2
Fride, E.3
Breuer, A.4
Vogel, Z.5
Shalev, D.E.6
Kustanovich, I.7
Mechoulam, R.8
-
11
-
-
0025236913
-
Cannabinoid receptor localization in brain
-
Herkenham M., Lynn A.B., Little M.D., Johnson M.R., Melvin L.S., de Costa B.R., and Rice K.C. Cannabinoid receptor localization in brain Proc. Natl. Acad. Sci. U. S. A. 87 5 1990 1932 1936
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, Issue.5
, pp. 1932-1936
-
-
Herkenham, M.1
Lynn, A.B.2
Little, M.D.3
Johnson, M.R.4
Melvin, L.S.5
De Costa, B.R.6
Rice, K.C.7
-
12
-
-
0029846519
-
Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor
-
Huffman J.W., Yu S., Showalter V., Abood M.E., Wiley J.L., Compton D.R., Martin B.R., Bramblett R.D., and Reggio P.H. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor J. Med. Chem. 39 20 1996 3875 3877
-
(1996)
J. Med. Chem.
, vol.39
, Issue.20
, pp. 3875-3877
-
-
Huffman, J.W.1
Yu, S.2
Showalter, V.3
Abood, M.E.4
Wiley, J.L.5
Compton, D.R.6
Martin, B.R.7
Bramblett, R.D.8
Reggio, P.H.9
-
13
-
-
0033555839
-
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
-
Ledent C., Valverde O., Cossu G., Petitet F., Aubert J.F., Beslot F., Bohme G.A., Imperato A., Pedrazzini T., Roques B.P., Vassart G., Fratta W., and Parmentier M. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice Science 283 5400 1999 401 404
-
(1999)
Science
, vol.283
, Issue.5400
, pp. 401-404
-
-
Ledent, C.1
Valverde, O.2
Cossu, G.3
Petitet, F.4
Aubert, J.F.5
Beslot, F.6
Bohme, G.A.7
Imperato, A.8
Pedrazzini, T.9
Roques, B.P.10
Vassart, G.11
Fratta, W.12
Parmentier, M.13
-
14
-
-
33845950577
-
Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1- methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity
-
Lin L.S., Lanza T.J. Jr., Jewell J.P., Liu P., Shah S.K., Qi H., Tong X., Wang J., Xu S.S., Fong T.M., Shen C.P., Lao J., Xiao J.C., Shearman L.P., Stribling D.S., Rosko K., Strack A., Marsh D.J., Feng Y., Kumar S., Samuel K., Yin W., Van der Ploeg L.H., Goulet M.T., and WK H. Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl] -2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity J. Med. Chem. 49 26 2006 7584 7587
-
(2006)
J. Med. Chem.
, vol.49
, Issue.26
, pp. 7584-7587
-
-
Lin, L.S.1
Lanza Jr., T.J.2
Jewell, J.P.3
Liu, P.4
Shah, S.K.5
Qi, H.6
Tong, X.7
Wang, J.8
Xu, S.S.9
Fong, T.M.10
Shen, C.P.11
Lao, J.12
Xiao, J.C.13
Shearman, L.P.14
Stribling, D.S.15
Rosko, K.16
Strack, A.17
Marsh, D.J.18
Feng, Y.19
Kumar, S.20
Samuel, K.21
Yin, W.22
Van Der Ploeg, L.H.23
Goulet, M.T.24
Wk, H.25
more..
-
15
-
-
3042780243
-
Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist
-
Luk T., Jin W., Zvonok A., Lu D., Lin X.Z., Chavkin C., Makriyannis A., and Mackie K. Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist Br. J. Pharmacol. 142 3 2004 495 500
-
(2004)
Br. J. Pharmacol.
, vol.142
, Issue.3
, pp. 495-500
-
-
Luk, T.1
Jin, W.2
Zvonok, A.3
Lu, D.4
Lin, X.Z.5
Chavkin, C.6
Makriyannis, A.7
MacKie, K.8
-
16
-
-
0028823316
-
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
-
Mackie K., Lai Y., Westenbroek R., and Mitchell R. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor J. Neurosci. 15 10 1995 6552 6561
-
(1995)
J. Neurosci.
, vol.15
, Issue.10
, pp. 6552-6561
-
-
MacKie, K.1
Lai, Y.2
Westenbroek, R.3
Mitchell, R.4
-
17
-
-
0025325535
-
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
-
Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., and Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 6284 1990 561 564
-
(1990)
Nature
, vol.346
, Issue.6284
, pp. 561-564
-
-
Matsuda, L.A.1
Lolait, S.J.2
Brownstein, M.J.3
Young, A.C.4
Bonner, T.I.5
-
18
-
-
0029012014
-
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
-
Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., and Compton D.R. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors Biochem. Pharmacol. 50 1 1995 83 90
-
(1995)
Biochem. Pharmacol.
, vol.50
, Issue.1
, pp. 83-90
-
-
Mechoulam, R.1
Ben-Shabat, S.2
Hanus, L.3
Ligumsky, M.4
Kaminski, N.E.5
Schatz, A.R.6
Gopher, A.7
Almog, S.8
Martin, B.R.9
Compton, D.R.10
-
19
-
-
0029585847
-
Structure-activity relationships defining the ACD-tricyclic cannabinoids: Cannabinoid receptor binding and analgesic activity
-
Melvin L.S., Milne G.M., Johnson M.R., Wilken G.H., and Howlett A.C. Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity Drug Des. Discov. 13 2 1995 155 166
-
(1995)
Drug Des. Discov.
, vol.13
, Issue.2
, pp. 155-166
-
-
Melvin, L.S.1
Milne, G.M.2
Johnson, M.R.3
Wilken, G.H.4
Howlett, A.C.5
-
20
-
-
0035010955
-
Cannabinoids and the gastrointestinal tract
-
Pertwee R.G. Cannabinoids and the gastrointestinal tract Gut 48 6 2001 859 867
-
(2001)
Gut
, vol.48
, Issue.6
, pp. 859-867
-
-
Pertwee, R.G.1
-
21
-
-
0036260823
-
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor
-
Porter A.C., Sauer J.M., Knierman M.D., Becker G.W., Berna M.J., Bao J., Nomikos G.G., Carter P., Bymaster F.P., Leese A.B., and Felder C.C. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor J. Pharmacol. Exp. Ther. 301 3 2002 1020 1024
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, Issue.3
, pp. 1020-1024
-
-
Porter, A.C.1
Sauer, J.M.2
Knierman, M.D.3
Becker, G.W.4
Berna, M.J.5
Bao, J.6
Nomikos, G.G.7
Carter, P.8
Bymaster, F.P.9
Leese, A.B.10
Felder, C.C.11
-
22
-
-
0028129936
-
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
-
Rinaldi-Carmona M., Barth F., Heaulme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Neliat G., and Caput D. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor FEBS. Lett. 350 2-3 1994 240 244
-
(1994)
FEBS. Lett.
, vol.350
, Issue.2-3
, pp. 240-244
-
-
Rinaldi-Carmona, M.1
Barth, F.2
Heaulme, M.3
Shire, D.4
Calandra, B.5
Congy, C.6
Martinez, S.7
Maruani, J.8
Neliat, G.9
Caput, D.10
-
23
-
-
0030440971
-
Characterization of two cloned human CB1 cannabinoid receptor isoforms
-
Rinaldi-Carmona M., Calandra B., Shire D., Bouaboula M., Oustric D., Barth F., Casellas P., Ferrara P., and Le Fur G. Characterization of two cloned human CB1 cannabinoid receptor isoforms J. Pharmacol. Exp. Ther. 278 2 1996 871 878
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.278
, Issue.2
, pp. 871-878
-
-
Rinaldi-Carmona, M.1
Calandra, B.2
Shire, D.3
Bouaboula, M.4
Oustric, D.5
Barth, F.6
Casellas, P.7
Ferrara, P.8
Le Fur, G.9
-
24
-
-
11144263163
-
Identification and characterisation of a novel splice variant of the human CB1 receptor
-
Ryberg E., Vu H.K., Larsson N., Groblewski T., Hjorth S., Elebring T., Sjogren S., and Greasley P.J. Identification and characterisation of a novel splice variant of the human CB1 receptor FEBS. Lett. 579 1 2005 259 264
-
(2005)
FEBS. Lett.
, vol.579
, Issue.1
, pp. 259-264
-
-
Ryberg, E.1
Vu, H.K.2
Larsson, N.3
Groblewski, T.4
Hjorth, S.5
Elebring, T.6
Sjogren, S.7
Greasley, P.J.8
-
25
-
-
0028931849
-
An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing
-
Shire D., Carillon C., Kaghad M., Calandra B., Rinaldi-Carmona M., Le Fur G., Caput D., and Ferrara P. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing J. Biol. Chem. 270 8 1995 3726 3731
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.8
, pp. 3726-3731
-
-
Shire, D.1
Carillon, C.2
Kaghad, M.3
Calandra, B.4
Rinaldi-Carmona, M.5
Le Fur, G.6
Caput, D.7
Ferrara, P.8
-
26
-
-
0035042362
-
Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart
-
Szabo B., Nordheim U., and Niederhoffer N. Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart J. Pharmacol. Exp. Ther. 297 2 2001 819 826
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, Issue.2
, pp. 819-826
-
-
Szabo, B.1
Nordheim, U.2
Niederhoffer, N.3
-
27
-
-
0031929438
-
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
-
Tsou K., Brown S., Sanudo-Pena M.C., Mackie K., and Walker J.M. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system Neuroscience 83 2 1998 393 411
-
(1998)
Neuroscience
, vol.83
, Issue.2
, pp. 393-411
-
-
Tsou, K.1
Brown, S.2
Sanudo-Pena, M.C.3
MacKie, K.4
Walker, J.M.5
-
28
-
-
0035816432
-
Hemodynamic effects of cannabinoids: Coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
-
Wagner J.A., Jarai Z., Batkai S., and Kunos G. Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors Eur. J. Pharmacol. 423 2-3 2001 203 210
-
(2001)
Eur. J. Pharmacol.
, vol.423
, Issue.2-3
, pp. 203-210
-
-
Wagner, J.A.1
Jarai, Z.2
Batkai, S.3
Kunos, G.4
-
29
-
-
7044227445
-
Aberrant cannabinoid signaling impairs oviductal transport of embryos
-
Wang H., Guo Y., Wang D., Kingsley P.J., Marnett L.J., Das S.K., DuBois R.N., and Dey S.K. Aberrant cannabinoid signaling impairs oviductal transport of embryos Nat. Med. 10 10 2004 1074 1080
-
(2004)
Nat. Med.
, vol.10
, Issue.10
, pp. 1074-1080
-
-
Wang, H.1
Guo, Y.2
Wang, D.3
Kingsley, P.J.4
Marnett, L.J.5
Das, S.K.6
Dubois, R.N.7
Dey, S.K.8
-
30
-
-
0033545866
-
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
-
Zimmer A., Zimmer A.M., Hohmann A.G., Herkenham M., and Bonner T.I. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice Proc. Natl. Acad. Sci. U. S. A. 96 10 1999 5780 5785
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, Issue.10
, pp. 5780-5785
-
-
Zimmer, A.1
Zimmer, A.M.2
Hohmann, A.G.3
Herkenham, M.4
Bonner, T.I.5
|