Development of a sensitive and HTS-compatible reporter gene assay for functional analysis of human adenosine A2a receptors in CHO-K1 cells

Assay and Drug Development Technologies

Volumn 2, Issue 3, 2004, Pages 281-289

  Tang, Yuting ^a   Luo, Jingqing ^b   Fleming, Charles R ^b   Kong, Yan ^a   Olini Jr , Gilbert C ^b   Wildey, Mary Jo ^a   Cavender, Druie E ^b   Demarest, Keith T ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b Drug Discovery Raritan   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 8 [4 (2 AMINOETHYLCARBAMOYL)METHOXYPHENYL] 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE DEAMINASE; ADENOSINE RECEPTOR; ADENYLATE CYCLASE; BETA GALACTOSIDASE; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; RECEPTOR SUBTYPE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL CULTURE; CHO CELL; COLORIMETRY; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE FUNCTION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; QUALITY CONTROL; RECEPTOR DOWN REGULATION; REPORTER GENE; ROBOTICS; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION;

EID: 4043085005     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/1540658041410650     Document Type: Article

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