CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2

BMC Evolutionary Biology

Volumn 11, Issue 1, 2011, Pages

  Uno, Yasuhiro ^a   Osada, Naoki ^b,c  

^a SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIVERGENCE; DRUG; EVOLUTIONARY BIOLOGY; GENE EXPRESSION; GENETIC VARIATION; GENOMICS; METABOLISM; POLYMORPHISM; PRIMATE; SUBSTRATE;

CATARRHINI; MACACA; MACACA FASCICULARIS; MACACA MULATTA; MAMMALIA; PLATYRRHINI; PRIMATES; SIMIAE;

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOLOGY; CLUSTER ANALYSIS; COMPARATIVE STUDY; CPG ISLAND; DNA SEQUENCE; GENE CONVERSION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; MACACA; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; CPG ISLANDS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; EVOLUTION, MOLECULAR; GENE CONVERSION; GENETIC VARIATION; MACACA; MOLECULAR SEQUENCE DATA; PHYLOGENY; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 80053346683     PISSN: None     EISSN: 14712148     Source Type: Journal    
DOI: 10.1186/1471-2148-11-283     Document Type: Article

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