Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC

Journal of Neuroscience

Volumn 25, Issue 19, 2005, Pages 4879-4888

  Radovanovic, Ivan ^a,b   Braun, Nathalie ^a   Giger, Olivier T ^a   Mertz, Kirsten ^a   Miele, Gino ^a   Prinz, Marco ^a,c   Navarro, Beatriz ^a,d   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

Cerebellum; Doppel; Leukoencephalopathy; Neurodegeneration; Prion protein; Spinal cord

Indexed keywords

CELL PROTEIN; CELL PROTEIN DOPPEL; MYELIN; MYELIN BASIC PROTEIN; NEURON SPECIFIC ENOLASE; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GRANULE CELL; HISTOPATHOLOGY; LEUKOENCEPHALOPATHY; MOUSE; NERVE FIBER DEGENERATION; NEUROTOXICITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WHITE MATTER; WILD TYPE;

AGE FACTORS; ANIMALS; BLOTTING, WESTERN; CENTRAL NERVOUS SYSTEM DISEASES; GLIAL FIBRILLARY ACIDIC PROTEIN; IN SITU NICK-END LABELING; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; MYELIN BASIC PROTEINS; NERVE DEGENERATION; NEURONS; OLIGODENDROGLIA; PHOSPHOPYRUVATE HYDRATASE; PRIONS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PRPC PROTEINS;

EID: 18644383026     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0328-05.2005     Document Type: Article

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