HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Mechanisms of Ageing and Development

Volumn 124, Issue 4, 2003, Pages 563-567

  Ross, Owen A ^a,b   Curran, Martin D ^a,c   Rea, I Maeve ^c   Hyland, Paul ^b   Duggan, Orla ^b   Barnett, Christopher R ^b   Annett, Kathryn ^b   Patterson, Chris ^c   Barnett, Yvonne A ^b   Middleton, Derek ^a,b,c  

^a BELFAST CITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

HLA; Immunosenescence; Polymorphism; TNF

Indexed keywords

HLA A1 ANTIGEN; HLA B8 ANTIGEN; HLA DR ANTIGEN; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA POLYMORPHISM; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENOTYPE; HAPLOTYPE; HUMAN; IRELAND; LONGEVITY; MALE; PRIORITY JOURNAL;

EID: 0037398764     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(03)00037-X     Document Type: Conference Paper

References (26)

1. Barber M.D., Powell J.J., Lynch S.F., Gough N.J., Fearon K.C., Ross J.A. Two polymorphisms of the tumour necrosis factor gene do not influence survival in pancreatic cancer. Clin. Exp. Immunol. 117:1999;425-429.
2. Caruso C., Candore G., Colonna Romano G., Lio D., Bonafe M., Valensin S., Franceschi C. HLA, aging, and longevity: a critical reappraisal. Hum. Immunol. 61:2000;942-949.
3. Caruso C., Candore G., Colonna Romano G., Lio D., Bonafe M., Valensin S., Franceschi C. Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data. Mech. Age Dev. 122:2001;445-462.
4. Curran M.D., Williams F., Earle J.A.P., Rima B.K., van Dam M.G., Bunce M., Middleton D. Long-range PCR amplification as an alternative strategy for characterizing novel HLA-B alleles. Eur. J. Immunogenet. 23:1996;297-309.
5. Hajeer A.H., Hutchinson I.V. Influence of TNF-α gene polymorphisms on TNF-α production and disease. Hum. Immunol. 62:2001;1191-1199.
6. Franceschi C., Monti D., Barbieri D., Grassilli E., Troiano L., Salvioli S., Negro P., Capri M., Guido M., Azzi R., Sansoni P., Paganelli R., Fagiolo U., Baggio G., Donazzan S., Mariotti S., D'Addato S., Gaddi A., Ortolani C., Cossarizza A. Immunosenescence in humans: deterioration or remodelling? Int. Rev. Immunol. 12:1995;57-74.
7. Franceschi C., Passeri M., De Benedictis G., Motta L. Immunosenescence. Aging Clin. Exp. Res. 10:(2):1998;153-154.
8. Franceschi C., Bonafe M., Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 18:2000;1717-1720.
9. Guo S., Thompson E. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics. 48:1992;361-372.
10. Izaks, G.J., Remarque, E.J., Schreuder, G.M., Westendorp, R.G., Ligthart, G.J., 2000. The effect of geographic origin on the frequency of HLA antigens and their association with ageing. Eur. J. Immunogenet. 27, 87-92.
11. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Muller-Hermelink H.K., Steinmann G.G. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Age Dev. 28:1984;47-55.
12. Ligthart G.J., Corberand J.X., Goertzen H.G.M., Minders A.E., Knook D.L., Hijmans W. Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech. Age Dev. 55:1990;89-98.
13. Lio D., Candore G., Colonna Romano G., D'Anna C., Gervasi F., Di Lorenzo G., Modica M.A., Potestio M., Caruso C. Modification of cytokine patterns in subjects bearing the HLA-B8,DR3 phenotype: implications for autoimmunity. Cytokines Cell Mol. Ther. 3:1997;217-224.
14. Lio D., Candore G., Colombo A., Colonna Romano G., Gervasi F., Marino V., Scola L., Caruso C. A genetically determined high setting of TNF-α influences immunologic parameters of HLA-B8,DR3 positive subjects: implications for autoimmunity. Hum. Immunol. 62:2001;705-713.
15. Makhatadze N.J. Tumor necrosis factor locus: genetic organisation and biological implications. Hum. Immunol. 59:1998;571-579.
16. Makinodan T. Studies on the influence of age on immune response to understand the biology of immunosenescence. Exp. Gerontol. 33:(1/2):1998;27-38.
17. Malaguarnera L., Ferlito L., Imbesi R.M., Gulizia G.S., Di Mauro S., Maugeri D., Malaguarnera M., Messina A. Immunosenescence: a review. Arch. Gerontol. Geriatr. 32:2001;1-14.
18. Middleton D., Williams F., Cullen C., Mallon E. Modification of an HLA-B PCR-SSOP typing system leading to improved allele determination. Tissue Antigens. 45:1995;232-236.
19. Middleton D., Curran M.D., Williams F. Immunogenetics and lifespan, HLA. Barnett Y.A., Barnett C.R. Methods in Molecular Medicine, Aging Methods and Protocols. 38:2000;Humana Press Inc, Totowa, NJ, USA.
20. Pawelec G., Solana R. Immunosenescence. Immunol. Today. 18:(11):1997;514-516.
21. Pawelec G. Immunosenescence: impact in the young as well as the old? Mech. Age Dev. 108:1999;1-7.
22. Rea I.M., Middleton D. Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity? JAGS. 42:1994;978-983.
23. Rea I.M., McMaster D., Woodside J.V., Young I.S., Archbold G.P., Linton T., Lennox S., McNulty H., Harmon D.L., Whitehead A.S. Community-living nonagenarians in Northern Ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70-89-year-old subjects. Atherosclerosis. 149:2000;207-214.
24. Schneider, S., Roessli, D., Excofier, L. 2000. ARLEQUIN: a software for population genetics data analysis. Version 2.000 Genetics and Biometry Laboratory, Department of Anthropology, University of Geneva.
25. Solana R., Pawelec G. Molecular and cellular basis of immunosenescence. Mech. Age Dev. 102:1998;115-129.
26. Williams F., Meenagh A., Maxwell A.P., Middleton D. Allele resolution of HLA-A using oligonucleotide probes in a two stage typing strategy. Tissue Antigens. 54:1999;59-68.