Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data

Mechanisms of Ageing and Development

Volumn 122, Issue 5, 2001, Pages 445-462

  Caruso, Calogero ^a   Candore, Giuseppina ^a   Romano, Giuseppina Colonna ^a   Lio, Domenico ^a   Bonafè, Massimiliano ^b   Valensin, Silvana ^b   Franceschi, Claudio ^b,c  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c INRCA   (Italy)

Author keywords

Centenarians; HLA; HLA B8,DR3; Longevity

Indexed keywords

HLA ANTIGEN; HLA B8 ANTIGEN; HLA DR3 ANTIGEN;

ALLELE; DISEASE PREDISPOSITION; DISEASE RESISTANCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HAPLOTYPE; HISTOCOMPATIBILITY COMPLEX; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOGENETICS; INFECTION; LIFESPAN; LONGEVITY; LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AGING; ANIMALS; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; IMMUNOGENETICS; LONGEVITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; POLYMORPHISM, GENETIC;

EID: 0035972077     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00255-4     Document Type: Review

References (94)

1. Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity
2. Genetic control of the CD4/CD8 T-cell ratio in humans
3. Hemopoiesis in healthy old people and centenarians: Well maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network
4. HLA and T-lymphocyte function in old age
5. C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians
6. Absolute peripheral blood lymphocyte count and subsequent mortality of elderly men. The Baltimore Longitudinal Study of Aging
7. No indication of postnatal selection at the HL-A loci
8. Cytokine gene polymorphism in human disease: On-line databases
9. Lack of association between HLA and age in an aging population
10. CD28 expression in T cell aging and human longevity
11. Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians
12. Biological basis of the HLA-B8,DR3 associated progression of acquired immune deficiency virus syndrome
13. HLA-DR-linked genes are involved in the control of T lymphocyte blood levels
14. Major histocompatibility complex regulation of cytokine production
15. Interleukin-10 (IL-10) genotypes in Italian centenarians
16. Increased HLA-B heterozygosity with age
17. Genomics of the major histocompatibility complex: Haplotypes, duplication, retroviruses and disease
18. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)
19. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
20. Selective pressure on HLA polymorphism
21. Genetic and environmental influences on serum level of immunoglobulins and complement components in monozygotic and dizygotic twins
22. A biological role for the major histocompatibility antigens
23. Homozigous MHC genotypes and longevity
24. Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
25. Genetics of aging
26. Genomic instability and aging. Studies in centenarians (successful aging) and in Down's syndrome patients (accelerated aging)
27. The immunology of exceptional individuals: The lesson of centenarians
28. Successful immunosenescence and the remodelling of immune responses with ageing
29. Biomarkers of immunosenescence within an evolutionary perspective: The challenge of hetrogeneity and the role of antigenic load
30. Inflamm-aging. An evolutionary perspective on immunosenescence
31. Evolution, mutations, and human longevity: European royal and noble families
32. HL-A heterozygosity as a genetic marker of long term survival
33. Histocompatibility determinants, immune responsiveness and ageing in man
34. Evolving views of the major histocompatibility complex
35. Autoimmune diseases and HLA
36. An examination of HLA frequencies in three age groups
37. Familial versus sporadic longevity and MHC markers
38. The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870-1900
39. Molecular analysis of the association of HLA-B53 and resistance to severe malaria
40. The immunogenetics of human infectious diseases
41. HLA distribution in aged normals
42. HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity
43. Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity?
44. The association between human leucocyte antigens (HLA) and mortality in community residents aged 85 and older
45. The effect of geographic origin on the frequency of HLA antigens and their association with ageing
46. The HLA system
47. Longevity and heredity in humans. Association with the human leucocyte antigen phenotype
48. Changes in lymphocyte subsets and immune competence in very advanced age
49. Modification of cytokine patterns in subjects bearing the HLA-B8, DR3 phenotype: Implications for autoimmunity
50. The effect of genetic factors for longevity: A comparison of identical and fraternal twins in the Swedish Twin Registry
51. HL-A antigens in aged persons
52. Tumor necrosis factor locus: Genetic organisation and biological implications
53. Thyroid and other organ-specific autoantibodies in healthy centenarians
54. Thyroid autoimmunity and aging
55. Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands
56. Sex influences on the penetrance of HLA shared epitope genotypes for rheumatoid arthritis
57. Age-sensitive T cell phenotypes covary in genetically heterogeneous mice and predict early death from lymphoma
58. The HLA-B8,DR3 haplotype and immune response in healthy subjects
59. HLA and disease susceptibility
60. HLA antigens and aging
61. Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly
62. The effect of variations in human immune response genes
63. Anti-inflammatory cytokines
64. HLA antigens in different age groups
65. HLA phenotypes in healthy aged subjects
66. Virtual reality in the MHC
67. T cells and aging
68. Studies on human longevity. IV. The inheritance of longevity. Preliminary report
69. Siblings of centenarians live longer
70. An analysis of genetic factors regulating life span in congenic mice
71. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases
72. HLA and longevity
73. Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity?
74. Association between longevity and allelic forms of human leukocyte antigens (HLA): Population study of aged Italian human subjects
75. Ageing, immune response and mortality
76. The oldest human
77. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
78. T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians
79. Genetic determination of telomere size in humans: A twin study of three age groups
80. Influence of the main histocompatibility complex on ageing in mice
81. Immunology of centenarians
82. HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus
83. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians
84. The immune status of healthy centenarians
85. HLA associated diseases
86. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
87. Autoimmunity and atherosclerosis
88. Selective binding of self peptides to disease-association major histocompatibility complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases
89. The distribution, age effects and disease associations of HLA antigens and other blood group markers in a random sample of an elderly population
90. HLA heterozygosity in children and old people
91. HLA and longevity or aging among Shangai Chinese
92. Genetics of Life Span in Mice