Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity

Biochemistry

Volumn 37, Issue 20, 1998, Pages 7194-7202

  Earhart, Cathleen A ^a   Mitchell, David T ^a   Murray, Debra L ^a   Pinheiro, Denise M ^b   Matsumura, Masazumi ^b,c   Schlievert, Patrick M ^a   Ohlendorf, Douglas H ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b GILEAD SCIENCES   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAPHYLOCOCCUS TOXIN;

ANTIGENICITY; ARTICLE; DRUG DESIGN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXIC SHOCK SYNDROME;

ALANINE; ANIMALS; BACTERIAL TOXINS; CRYSTALLOGRAPHY, X-RAY; ENTEROTOXINS; GLUTAMINE; HISTIDINE; HUMANS; LYSINE; MICE; MODELS, MOLECULAR; MUTATION; RABBITS; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; THREONINE;

BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS; POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0032546586     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9721896     Document Type: Article

References (52)

1. Bergdoll, M. S., and Schlievert, P. M. (1984) Lancet ii, 691.
2. Cone, L. A., Woodard, D. R., Byrd, R. G., Schulz, K., Kopp, S. M., and Schlievert, P. M. (1992) J. Infect. Dis. 165, 638-643.
3. Newbould, M. J., Malam, J., McIllmurray, J. M., Morris, J. A., Telford, D. R., and Barson, A. J. (1989) J. Clin. Pathol. 42, 935-939.
4. Leung, D. Y. M., Meissner, H. C., Fulton, D. R., Murray, D. L., Kotzin, B. L., and Schlievert, P. M. (1993) Lancet 342, 1385-1388.
5. Burns, J. C., and Newburger, J. W. (1992) in Infectious Diseases (Gorbach, S. L., Bartlett, J. G., and Blacklow, N. R., Eds.) pp 1370-1374, W. B. Saunders Co., Philadelphia PA.
6. Bohach, G. A., Fast, D. J., Nelson, R. D., and Schlievert, P. M. (1990) Crit. Rev. Microbiol. 17, 251-272.
7. Schlievert, P. M., Bohach, G. A., Ohlendorf, D. H., Stauffacher, C. V., Leung, D. Y. M., Murray, D. L., Prasad, G. S., Earhart, C. A., Jablonski, L. M., Hoffmann, M. L., and Chi, Y.-I. (1995) J. Clin, Immunol. 15, 4S-10S.
8. Schad, E. M., Zaitseva, I., Zaitsev, V. N., Dohlsten, M., Kalland, T., Schlievert, P. M., Ohlendorf, D. H., and Svensson, L. A. (1995) EMBO J. 14, 3292-3301.
9. Swaminathan, S., Furey, W., Pletcher, J., and Sax, M. (1992) Nature 359, 801-806.
10. Swaminathan, S., Furey, W., Pletcher, J., and Sax, M. (1995) Nat. Struct. Biol. 2, 680-686.
11. Papageorgiou, A. C., Acharya, K. R., Shapiro, R., Passalacqua, R., Brehm, R. D., and Tranter, H. S. (1995) Structure 3, 769-779.
12. Bohach, G. A., Stauffacher, C. V., Ohlendorf, D. H., Chi, Y.-I., Vath, G. M., and Schlievert, P. M. (1996) Adv. Exp. Med. Biol. 391, 131-154.
13. Roussel, A., Anderson, B. F., Baker, H. M., Fraser, J. D., and Baker, E. N. (1997) Nat. Struct. Biol. 4, 635-643.
14. Prasad, G. S., Earhart, C. A., Murray, D. L., Novick, R. P., Schlievert, P. M., and Ohlendorf, D. H. (1993) Biochemistry 32, 13761-13766.
15. Acharya, K. R., Passalacqua, E. F., Jones, E. Y., Harlos, K., Stuart, D. I., Brehm, R. D., and Tranter, H. S. (1994) Nature 367, 94-97.
16. Jardetsky, T. S., Brown, J. H., Gorga, J. C., Stern, L. J., Urban, R. G., Chi, Y.-I., Stauffacher, C. V., Strominger, J. L., and Wiley, D. C. (1994) Nature 368, 711-718.
17. Kim, J., Urban, R. G., Strominger, J. L., and Wiley, D. C. (1994) Science 266, 1870-1874.
18. Fields, B. A., Malchiodi, E. L., Li, H., Ysern, X., Stauffacher, C. V., Schlievert, P. M., Karjalainen, K., and Mariuzza, R. A. (1996) Nature 384, 188-192.
19. Parsonnet, J., and Gillis, Z. A. (1988) J. Infect. Dis. 158, 1026-1033.
20. Poindexter, N. J., and Schlievert, P. M. (1985) J. Infect. Dis. 151, 65-72.
21. Fast, D. J., Schlievert, P. M., and Nelson, R. D. (1988) J. Immunol. 140, 949-953.
22. Schlievert, P. M., and Watson, D. W. (1978) Infect. Immun. 21, 753-763.
23. Fast, D. J., Schlievert, P. M., and Nelson, R. D. (1989) Infect. Immun. 57, 291-294.
24. Lee, P. K., Vercellotti, G. M., Deringer, J. R., and Schlievert, P. M. (1991) J. Infect. Dis. 164, 711-719.
25. Kim, Y. B., and Watson, D. W. (1970) J. Exp. Med. 131, 611-628.
26. Schlievert, P. M., Bettin, K. M., and Watson, D. W. (1980) Infect. Immun. 27, 542-548.
27. Schlievert, P. M. (1983) J. Infect. Dis. 147, 391-398.
28. Murray, D. L., Earhart, C. A., Mitchell, D. T., Ohlendorf, D. H., Novick, R. P., and Schlievert, P. M. (1996) Infect. Immun. 64, 371-374.
29. Murray, D. L., Prasad, G. S., Earhart, C. A., Leonard, B. A. B., Kreiswirth, B. N., Novick, R. P., Ohlendorf, D. H., and Schlievert, P. M. (1994) J. Immunol. 152, 87-95.
30. Blanco, L., Choi, E. M., Connolly, K., Thompson, M. R., and Bonventre, P. F. (1990) Infect. Immun. 58, 3020-3028.
31. Bonventre, P. F., Heeg, H., Cullen, C., and Lian, C.-J. (1993) Infect. Immun. 61, 793-799.
32. Hurley, J. M., Shimonkevitz, R., Hanagan, A., Enney, K., Boen, E., Kotzin, B. L., and Matsumura, M. (1995) J. Exp. Med. 181, 2229-2235.
33. Prasad, G. S., Radhakrishnan, R., Mitchell, D. T., Earhart, C. A., Dinges, M. M., Cook, W. J., Schlievert, P. M., and Ohlendorf, D. H. (1997) Protein Sci. 6, 1220-1227.
34. Blomster-Hautamaa, D. A., and Schlievert, P. M. (1988) Methods Enzymol. 165, 37-43.
35. Wlodawer, A., and Hodgson, K. O. (1975) Proc. Natl. Acad. Sci. U.S.A. 72, 398-399.
36. McPherson, A. (1982) The Preparation and Analysis of Protein Crystals, John Wiley, New York.
37. Earhart, C. A., Prasad, G. S., Murray, D. L., Novick, R. P., Schlievert, P. M., and Ohlendorf, D. H. (1993) Proteins 17, 329-334.
38. Howard, A. J., Gilliland, G. L., Finzel, B. C., Poulos, T. L., Ohlendorf, D. H., and Salemme, F. R. (1987) J. Appl. Crystallogr. 20, 383-387.
39. Brünger, A. T., Kuriyan, J., and Karplus, M. (1987) Science 235, 458-460.
40. Jones, T. A. (1978) J. Appl. Crystallogr. 11, 268-272.
41. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
42. Mitchell, D. T., Schlievert, P. M., Ohlendorf, D. H., Kim, J., Wiley, D. C., Urban, R. G., and Strominger, J. L. (1996) in Superantigens: Structure, Biology and Relevance to Human Disease (Leung, D. Y. M., Huber, B. T., and Schlievert, P. M., Eds.) pp 149-166, Marcel Dekker, New York.
43. Chothia, C., and Lesk, A. M. (1986) EMBO J. 5, 823-826.
44. Ohlendorf, D. H. (1994) Acta Crystallogr. D50, 808-812.
45. Zhang, X. J., Wozniak, J. A., and Matthews, B. W. (1995) J. Mol. Biol. 250, 527-552.
46. Papageorgiou, A. C., Brehm, R. D., Leonidas, D. D., Tranter, H. S., and Acharya, K. R. (1996) J. Mol. Biol. 260, 553-569.
47. Brünger, A. T. (1992) Acta Crystallogr. D49, 24-46.
48. Bonventre, P. F., Heeg, H., Edwards, C. K., III, and Cullen, C. M. (1995) Infect. Immun. 63, 509-515.
49. Deresiewicz, R. L., Woo, J. H., Chan, M., Finberg, R. W., and Kasper, D. L. (1994) Biochemistry 33, 12844-12851.
50. Efimov, A. V. (1986) Mol. Biol. (Moscow) 20, 2250-2260.
51. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
52. Evans, S. V. (1993) J. Mol. Graphics 11, 134-138.