Cutting edge: Trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands

Journal of Immunology

Volumn 163, Issue 1, 1999, Pages 6-10

  Redpath, Stella ^a   Alam, S Munir ^a   Lin, Christina M ^a   O'Rourke, Anne M ^a   Gascoigne, Nicholas R J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; STAPHYLOCOCCUS ENTEROTOXIN A; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; IMMUNOSTIMULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STAPHYLOCOCCUS AUREUS; SURFACE PLASMON RESONANCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, CD; BIOPOLYMERS; COLUMBIDAE; CYTOCHROME C GROUP; DIMERIZATION; ENTEROTOXINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; KINETICS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, IMMUNOLOGIC; SOLUBILITY; SUPERANTIGENS; SURFACE PLASMON RESONANCE;

EID: 0033168149     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Scherer, M. T., L. Ignatowicz, G. M. Winslow, J. W. Kappler, and P. Marrack. 1993. Superantigens: bacterial and viral proteins that manipulate the immune system. Annu. Rev. Cell Biol. 9:101.
2. Gascoigne, N. R. J., S. M. Alam, C. A. Haarstad, and B.-C. Sim. 1995. Structural features of T cell receptor recognition of superantigens. In Bacterial Superantigens: Structure, Function, and Therapeutic Potential. J. Thibodeau and R.-P. Sekaly, eds. R. G. Landes, Austin, TX, p. 97.
3. Fraser, J. D. 1989. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 339:221.
4. Mollick, J. A., R. G. Cook, and R. R. Rich. 1989. Class II MHC molecules are specific receptors for Staphylococcus enterotoxin A. Science 244:817.
5. Fischer, H., M. Dohlsten, M. Lindvall, H.-O. Sjogren, and R. Carlsson. 1989. Binding of Staphylococcal enterotoxin A to HLA-DR on B cell lines. J. Immunol. 142:3151.
6. Jardetzky, T. S., J. H. Brown, J. C. Gorga, L. J. Stern, R. G. Urban, Y. Chi, C. Stauffacher, J. L. Strominger, and D. C. Wiley. 1994. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 368:711.
7. Hudson, K. R., R. E. Tiedeman, R. G. Urban, J. L. Strominger, and J. D. Fraser. 1995. Staphylococcal enterotoxin A has two co-operative binding sites on MHC class II. J. Exp. Med. 182:711.
8. Kozono, H., D. Parker, J. White, P. Marrack, and J. Kappler. 1995. Multiple binding sites for bacterial superantigens on soluble class II MHC molecules. Immunity 3:187.
9. Gascoigne, N. R. J., and K. T. Ames. 1991. Direct binding of secreted T-cell receptor B chain to superantigen associated with class II major histocompatibility complex protein. Proc. Natl. Acad. Sci. USA 88:613.
10. Irwin, M. J., K. R. Hudson, J. D. Fraser, and N. R. J. Gascoigne. 1992. Enterotoxin residues determining T-cell receptor VB binding specificity. Nature 359: 841.
11. Fields, B. A., E. L. Malchiodi, H. M. Li, X. Ysern, C. V. Stauffacher, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. 1996. Crystal structure of a TCR B chain complexed with a superantigen. Nature 384:188.
12. Li, H., A. Llera, D. Tsuchiya, L. Leder, X. Ysern, P. M. Chlievert, K. Karjalainen, and R. A. Mariuzza. 1998. Three-dimensional structure of the complex between a T cell receptor B chain and the superantigen staphylococcal enterotoxin B. Immunity 9:807.
13. Kappler, J. W., A. Herman, J. Clements, and P. Marrack. 1992. Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J. Exp. Med. 175:387.
14. Leder, L., A. Llera, P. M. Lavoie, M. I. Lebedva, H. M. Li, R. P. Sekaly, G. A. Bohach, P. J. Gahn, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. 1998. Mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the TCR B chain and MHC class II. J. Exp. Med. 187:823.
15. Choi, Y., A. Herman, D. DiGiusto, T. Wade, P. Marrack, and J. Kappler. 1990. Residues of the variable region of the T-cell-receptor B-chain that interact with S. aureus toxin superantigens. Nature 346:471.
16. Pontzer, C. H., M. J. Irwin, N. R. J. Gascoigne, and H. J. Johnson. 1992. T-cell antigen receptor binding sites for the microbial superantigen staphylococcal enterotoxin A. Proc. Natl. Acad. Sci. USA 89:7727.
17. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. J. Gascoigne. 1996. T cell receptor affinity and thymocyte positive selection. Nature 381:616.
18. Davis, M. M., J. J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien. 1998. Ligand recognition by αB T cell receptors. Annu. Rev. Immunol. 16:523.
19. Scholl, P. R., A. Diez, and R. S. Geha. 1989. Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules. J. Immunol. 143:2583.
20. Seth, A., L. J. Stern, T. H. M. Ottenhoff, I. Engel, M. J. Owen, J. R. Lamb, R. D. Klausner, and D. C. Wiley. 1994. Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. Nature 369:324.
21. Malchiodi, E. L., E. Eisenstien, B. A. Fields, D. H. Ohlendorf, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. 1995. Superantigen binding to a T cell receptor B chain of known three-dimensional structure. J. Exp. Med. 182:1833.
22. Khandekar, S. S., P. P. Brauer, J. W. Naylor, H.-C. Chang, P. Kern, J. R. Newcomb, K. P. Leclair, H. S. Stump, B. M. Bettencourt, E. Kawasaki, et al. 1997. Affinity and kinetics of the interactions between an αB T-cell receptor and its superantigen and class II-MHC/pcptide ligands. Mol. Immunol. 6:493.
23. Chien, Y., N. R. J. Gascoigne, J. Kavaler, N. E. Lee, and M. M. Davis. 1984. Somatic recombination in a murine T-cell receptor gene. Nature 309:322.
24. Becker, D. M., P. Patten, Y. Chien, T. Yokota, Z. Eshhar, M. Giedlin, N. R. J. Gascoigne, C. Goodnow, R. Wolf, K. Arai, and M. M. Davis. 1985. Variability and repertoire size of T-cell receptor Vα gene segments. Nature 317: 430.
25. Scorer, C. A., R. G. Buckholz, J. J. Clare, and M. A. Romanos. 1993. The intracellular production and secretion of HIV-1 envelope protein in the methyltrophic yeast Pichia postoris. Gene 136:111.
26. Wung, J. L., and N. R. J. Gascoigne. 1996. Antibody screening for secreted proteins expressed in Pichia pastoris. BioTechniques 21:808.
27. + T cells undergo TCR-activated adhesion to extracellular matrix proteins but not to non-antigenic MHC class II proteins. J. Immunol. 151:3839.
28. O'Shanessy, D. J. 1994. Determination of kinetic rate and equilibrium binding constants for macromolecular interactions: a critique of the surface plasmon resonance literature. Curr. Opin. Biotechnol. 5:65.
29. Fraser, J. D., R. G. Urban, J. L. Strominger, and H. Robinson. 1992. Zinc regulates the function of two superantigens. Proc. Natl. Acad. Sci. USA 89:5507.
30. Valitutti, S., and A. Lanzavecchia. 1997. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18:299.
31. Proft, T., S. L. Moffatt, C. J. Berkahn, and J. D. Fraser. 1999. Identification and characterization of novel superantigens from Streptococcus pyogenes. J. Exp. Med. 189:89.