메뉴 건너뛰기




Volumn 56, Issue 2, 2011, Pages 272-281

Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells

Author keywords

Alternative splicing; Apoptosis; IL 24; Mda 7; SRp55

Indexed keywords

CASPASE 3; CASPASE 7; INTERLEUKIN 24;

EID: 80053311326     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.07.020     Document Type: Article
Times cited : (17)

References (48)
  • 1
    • 0347623371 scopus 로고    scopus 로고
    • Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
    • Johnson J.M., Castle J., Garrett-Engele P., Kan Z., Loerch P.M., Armour C.D., et al. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 2003, 302:2141-2144.
    • (2003) Science , vol.302 , pp. 2141-2144
    • Johnson, J.M.1    Castle, J.2    Garrett-Engele, P.3    Kan, Z.4    Loerch, P.M.5    Armour, C.D.6
  • 2
    • 3042642783 scopus 로고    scopus 로고
    • Splice variants as cancer biomarkers
    • Brinkman B.M. Splice variants as cancer biomarkers. Clin Biochem 2004, 37:584-594.
    • (2004) Clin Biochem , vol.37 , pp. 584-594
    • Brinkman, B.M.1
  • 3
    • 34447106755 scopus 로고    scopus 로고
    • Alternative splicing in cancer: noise, functional, or systematic?
    • Skotheim R.I., Nees M. Alternative splicing in cancer: noise, functional, or systematic?. Int J Biochem Cell Biol 2007, 39:1432-1449.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1432-1449
    • Skotheim, R.I.1    Nees, M.2
  • 4
    • 7444220147 scopus 로고    scopus 로고
    • Aberrant and alternative splicing in cancer
    • Venables J.P. Aberrant and alternative splicing in cancer. Cancer Res 2004, 64:7647-7654.
    • (2004) Cancer Res , vol.64 , pp. 7647-7654
    • Venables, J.P.1
  • 5
    • 0037310045 scopus 로고    scopus 로고
    • Computational analysis and experimental validation of tumor-associated alternative RNA splicing in human cancer
    • Wang Z., Lo H.S., Yang H., Gere S., Hu Y., Buetow K.H., et al. Computational analysis and experimental validation of tumor-associated alternative RNA splicing in human cancer. Cancer Res 2003, 63:655-657.
    • (2003) Cancer Res , vol.63 , pp. 655-657
    • Wang, Z.1    Lo, H.S.2    Yang, H.3    Gere, S.4    Hu, Y.5    Buetow, K.H.6
  • 6
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black D.L. Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 2003, 72:291-336.
    • (2003) Annu Rev Biochem , vol.72 , pp. 291-336
    • Black, D.L.1
  • 7
    • 0033835333 scopus 로고    scopus 로고
    • Sorting out the complexity of SR protein functions
    • Graveley B.R. Sorting out the complexity of SR protein functions. RNA 2000, 6:1197-1211.
    • (2000) RNA , vol.6 , pp. 1197-1211
    • Graveley, B.R.1
  • 8
    • 0033153348 scopus 로고    scopus 로고
    • HnRNP complexes: composition, structure, and function
    • Krecic A.M., Swanson M.S. HnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 1999, 11:363-371.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 363-371
    • Krecic, A.M.1    Swanson, M.S.2
  • 10
    • 0036798006 scopus 로고    scopus 로고
    • Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome
    • Stamm S. Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome. Hum Mol Genet 2002, 11:2409-2416.
    • (2002) Hum Mol Genet , vol.11 , pp. 2409-2416
    • Stamm, S.1
  • 11
    • 0037097637 scopus 로고    scopus 로고
    • The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24
    • Caudell E.G., Mumm J.B., Poindexter N., Ekmekcioglu S., Mhashilkar A.M., Yang X.H., et al. The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24. J Immunol 2002, 168:6041-6046.
    • (2002) J Immunol , vol.168 , pp. 6041-6046
    • Caudell, E.G.1    Mumm, J.B.2    Poindexter, N.3    Ekmekcioglu, S.4    Mhashilkar, A.M.5    Yang, X.H.6
  • 12
    • 0029558740 scopus 로고
    • Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
    • Jiang H., Lin J.J., Su Z.Z., Goldstein N.I., Fisher P.B. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 1995, 11:2477-2486.
    • (1995) Oncogene , vol.11 , pp. 2477-2486
    • Jiang, H.1    Lin, J.J.2    Su, Z.Z.3    Goldstein, N.I.4    Fisher, P.B.5
  • 14
    • 0034502591 scopus 로고    scopus 로고
    • Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro
    • Saeki T., Mhashilkar A., Chada S., Branch C., Roth J.A., Ramesh R. Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther 2000, 7:2051-2057.
    • (2000) Gene Ther , vol.7 , pp. 2051-2057
    • Saeki, T.1    Mhashilkar, A.2    Chada, S.3    Branch, C.4    Roth, J.A.5    Ramesh, R.6
  • 15
    • 0345732497 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24
    • Lebedeva I.V., Sarkar D., Su Z.Z., Kitada S., Dent P., Stein C.A., et al. Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24. Oncogene 2003, 22:8758-8773.
    • (2003) Oncogene , vol.22 , pp. 8758-8773
    • Lebedeva, I.V.1    Sarkar, D.2    Su, Z.Z.3    Kitada, S.4    Dent, P.5    Stein, C.A.6
  • 17
    • 13244268270 scopus 로고    scopus 로고
    • Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis
    • Lebedeva I.V., Su Z.Z., Sarkar D., Gopalkrishnan R.V., Waxman S., Yacoub A., et al. Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis. Oncogene 2005, 24:585-596.
    • (2005) Oncogene , vol.24 , pp. 585-596
    • Lebedeva, I.V.1    Su, Z.Z.2    Sarkar, D.3    Gopalkrishnan, R.V.4    Waxman, S.5    Yacoub, A.6
  • 18
    • 0035317682 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy
    • Mhashilkar A.M., Schrock R.D., Hindi M., Liao J., Sieger K., Kourouma F., et al. Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy. Mol Med 2001, 7:271-282.
    • (2001) Mol Med , vol.7 , pp. 271-282
    • Mhashilkar, A.M.1    Schrock, R.D.2    Hindi, M.3    Liao, J.4    Sieger, K.5    Kourouma, F.6
  • 19
    • 0037468264 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner
    • Su Z.Z., Lebedeva I.V., Sarkar D., Gopalkrishnan R.V., Sauane M., Sigmon C., et al. Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner. Oncogene 2003, 22:1164-1180.
    • (2003) Oncogene , vol.22 , pp. 1164-1180
    • Su, Z.Z.1    Lebedeva, I.V.2    Sarkar, D.3    Gopalkrishnan, R.V.4    Sauane, M.5    Sigmon, C.6
  • 22
    • 85047695547 scopus 로고    scopus 로고
    • The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells
    • Lebedeva I.V., Su Z.Z., Chang Y., Kitada S., Reed J.C., Fisher P.B. The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene 2002, 21:708-718.
    • (2002) Oncogene , vol.21 , pp. 708-718
    • Lebedeva, I.V.1    Su, Z.Z.2    Chang, Y.3    Kitada, S.4    Reed, J.C.5    Fisher, P.B.6
  • 23
    • 0032564357 scopus 로고    scopus 로고
    • The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice
    • Su Z.Z., Madireddi M.T., Lin J.J., Young C.S., Kitada S., Reed J.C., et al. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc Natl Acad Sci USA 1998, 95:14400-14405.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14400-14405
    • Su, Z.Z.1    Madireddi, M.T.2    Lin, J.J.3    Young, C.S.4    Kitada, S.5    Reed, J.C.6
  • 24
    • 1642417725 scopus 로고    scopus 로고
    • MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity
    • Yacoub A., Mitchell C., Brannon J., Rosenberg E., Qiao L., McKinstry R., et al. MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. Mol Cancer Ther 2003, 2:623-632.
    • (2003) Mol Cancer Ther , vol.2 , pp. 623-632
    • Yacoub, A.1    Mitchell, C.2    Brannon, J.3    Rosenberg, E.4    Qiao, L.5    McKinstry, R.6
  • 25
    • 38449096542 scopus 로고    scopus 로고
    • Mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review)
    • Lebedeva I.V., Emdad L., Su Z.Z., Gupta P., Sauane M., Sarkar D., et al. Mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review). Int J Oncol 2007, 31:985-1007.
    • (2007) Int J Oncol , vol.31 , pp. 985-1007
    • Lebedeva, I.V.1    Emdad, L.2    Su, Z.Z.3    Gupta, P.4    Sauane, M.5    Sarkar, D.6
  • 26
    • 27844459421 scopus 로고    scopus 로고
    • Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells
    • Su Z., Emdad L., Sauane M., Lebedeva I.V., Sarkar D., Gupta P., et al. Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene 2005, 24:7552-7566.
    • (2005) Oncogene , vol.24 , pp. 7552-7566
    • Su, Z.1    Emdad, L.2    Sauane, M.3    Lebedeva, I.V.4    Sarkar, D.5    Gupta, P.6
  • 27
    • 19944379432 scopus 로고    scopus 로고
    • Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study
    • Cunningham C.C., Chada S., Merritt J.A., Tong A., Senzer N., Zhang Y., et al. Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study. Mol Ther 2005, 11:149-159.
    • (2005) Mol Ther , vol.11 , pp. 149-159
    • Cunningham, C.C.1    Chada, S.2    Merritt, J.A.3    Tong, A.4    Senzer, N.5    Zhang, Y.6
  • 28
    • 19944384118 scopus 로고    scopus 로고
    • Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients
    • Tong A.W., Nemunaitis J., Su D., Zhang Y., Cunningham C., Senzer N., et al. Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients. Mol Ther 2005, 11:160-172.
    • (2005) Mol Ther , vol.11 , pp. 160-172
    • Tong, A.W.1    Nemunaitis, J.2    Su, D.3    Zhang, Y.4    Cunningham, C.5    Senzer, N.6
  • 29
    • 10344230407 scopus 로고    scopus 로고
    • Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism
    • Chada S., Mhashilkar A.M., Ramesh R., Mumm J.B., Sutton R.B., Bocangel D., et al. Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism. Mol Ther 2004, 10:1085-1095.
    • (2004) Mol Ther , vol.10 , pp. 1085-1095
    • Chada, S.1    Mhashilkar, A.M.2    Ramesh, R.3    Mumm, J.B.4    Sutton, R.B.5    Bocangel, D.6
  • 30
    • 2142649182 scopus 로고    scopus 로고
    • Cytokine and tumor cell apoptosis inducing activity of mda-7/IL-24
    • Gopalkrishnan R.V., Sauane M., Fisher P.B. Cytokine and tumor cell apoptosis inducing activity of mda-7/IL-24. Int Immunopharmacol 2004, 4:635-647.
    • (2004) Int Immunopharmacol , vol.4 , pp. 635-647
    • Gopalkrishnan, R.V.1    Sauane, M.2    Fisher, P.B.3
  • 31
    • 7044268950 scopus 로고    scopus 로고
    • Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein
    • Sauane M., Gopalkrishnan R.V., Choo H.T., Gupta P., Lebedeva I.V., Yacoub A., et al. Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein. Oncogene 2004, 23:7679-7690.
    • (2004) Oncogene , vol.23 , pp. 7679-7690
    • Sauane, M.1    Gopalkrishnan, R.V.2    Choo, H.T.3    Gupta, P.4    Lebedeva, I.V.5    Yacoub, A.6
  • 32
    • 0037033092 scopus 로고    scopus 로고
    • Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
    • Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem 2002, 277:47517-47523.
    • (2002) J Biol Chem , vol.277 , pp. 47517-47523
    • Parrish-Novak, J.1    Xu, W.2    Brender, T.3    Yao, L.4    Jones, C.5    West, J.6
  • 33
    • 17644388430 scopus 로고    scopus 로고
    • Mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer
    • Chada S., Bocangel D., Ramesh R., Grimm E.A., Mumm J.B., Mhashilkar A.M., et al. Mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. Mol Ther 2005, 11:724-733.
    • (2005) Mol Ther , vol.11 , pp. 724-733
    • Chada, S.1    Bocangel, D.2    Ramesh, R.3    Grimm, E.A.4    Mumm, J.B.5    Mhashilkar, A.M.6
  • 34
    • 33751505683 scopus 로고    scopus 로고
    • Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10
    • Zheng M., Bocangel D., Doneske B., Mhashilkar A., Ramesh R., Hunt K.K., et al. Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10. Cancer Immunol Immunother 2007, 56:205-215.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 205-215
    • Zheng, M.1    Bocangel, D.2    Doneske, B.3    Mhashilkar, A.4    Ramesh, R.5    Hunt, K.K.6
  • 36
    • 0035950553 scopus 로고    scopus 로고
    • Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties
    • Huang E.Y., Madireddi M.T., Gopalkrishnan R.V., Leszczyniecka M., Su Z., Lebedeva I.V., et al. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. Oncogene 2001, 20:7051-7063.
    • (2001) Oncogene , vol.20 , pp. 7051-7063
    • Huang, E.Y.1    Madireddi, M.T.2    Gopalkrishnan, R.V.3    Leszczyniecka, M.4    Su, Z.5    Lebedeva, I.V.6
  • 37
    • 4143091627 scopus 로고    scopus 로고
    • Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma
    • Allen M., Pratscher B., Roka F., Krepler C., Wacheck V., Schöfer C., et al. Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma. J Invest Dermatol 2004, 123:583-588.
    • (2004) J Invest Dermatol , vol.123 , pp. 583-588
    • Allen, M.1    Pratscher, B.2    Roka, F.3    Krepler, C.4    Wacheck, V.5    Schöfer, C.6
  • 39
    • 57649155853 scopus 로고    scopus 로고
    • A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis
    • Sahoo A., Jung Y.M., Kwon H.K., Yi H.J., Lee S., Chang S., et al. A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis. J Biol Chem 2008, 283:28860-28872.
    • (2008) J Biol Chem , vol.283 , pp. 28860-28872
    • Sahoo, A.1    Jung, Y.M.2    Kwon, H.K.3    Yi, H.J.4    Lee, S.5    Chang, S.6
  • 40
    • 0029994459 scopus 로고    scopus 로고
    • Generation of a variant of human interleukin-4 by alternative splicing
    • Alms W.J., Atamas S.P., Yurovsky V.V., White B. Generation of a variant of human interleukin-4 by alternative splicing. Mol Immunol 1996, 33:361-370.
    • (1996) Mol Immunol , vol.33 , pp. 361-370
    • Alms, W.J.1    Atamas, S.P.2    Yurovsky, V.V.3    White, B.4
  • 42
    • 2442732585 scopus 로고    scopus 로고
    • Extensive alternative splicing of interleukin-7 in malignant hematopoietic cells: implication of distinct isoforms in modulating IL-7 activity
    • Korte A., Möricke A., Beyermann B., Köchling J., Taube T., Kebelmann-Betzing C., et al. Extensive alternative splicing of interleukin-7 in malignant hematopoietic cells: implication of distinct isoforms in modulating IL-7 activity. J Interferon Cytokine Res 1999, 19:495-503.
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 495-503
    • Korte, A.1    Möricke, A.2    Beyermann, B.3    Köchling, J.4    Taube, T.5    Kebelmann-Betzing, C.6
  • 43
    • 34547668626 scopus 로고    scopus 로고
    • Cloning and characterization of an isoform of interleukin-21
    • Rahman M., Nara H., Onoda T., Araki A., Li J., Hoshino T., et al. Cloning and characterization of an isoform of interleukin-21. FEBS Lett 2007, 581:4001-4009.
    • (2007) FEBS Lett , vol.581 , pp. 4001-4009
    • Rahman, M.1    Nara, H.2    Onoda, T.3    Araki, A.4    Li, J.5    Hoshino, T.6
  • 44
    • 0029817355 scopus 로고    scopus 로고
    • Identification and characterization of two alternative splice variants of human interleukin-2
    • Tsytsikov V.N., Yurovsky V.V., Atamas S.P., Alms W.J., White B. Identification and characterization of two alternative splice variants of human interleukin-2. J Biol Chem 1996, 271:23055-23060.
    • (1996) J Biol Chem , vol.271 , pp. 23055-23060
    • Tsytsikov, V.N.1    Yurovsky, V.V.2    Atamas, S.P.3    Alms, W.J.4    White, B.5
  • 45
    • 19444386673 scopus 로고    scopus 로고
    • Expression of interleukin-10 splicing variants is a positive prognostic feature in relapsed childhood acute lymphoblastic leukemia
    • Wu S., Gessner R., Taube T., von Stackelberg A., Henze G., Seeger K. Expression of interleukin-10 splicing variants is a positive prognostic feature in relapsed childhood acute lymphoblastic leukemia. J Clin Oncol 2005, 23:3038-3042.
    • (2005) J Clin Oncol , vol.23 , pp. 3038-3042
    • Wu, S.1    Gessner, R.2    Taube, T.3    von Stackelberg, A.4    Henze, G.5    Seeger, K.6
  • 46
    • 46149105398 scopus 로고    scopus 로고
    • Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes
    • Filippov V., Schmidt E.L., Filippova M., Duerksen-Hughes P.J. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes. Gene 2008, 420:34-41.
    • (2008) Gene , vol.420 , pp. 34-41
    • Filippov, V.1    Schmidt, E.L.2    Filippova, M.3    Duerksen-Hughes, P.J.4
  • 47
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282:1497-1501.
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3    Waldman, T.4    Zhou, S.5    Brown, J.P.6
  • 48
    • 0037439799 scopus 로고    scopus 로고
    • Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability
    • Piboonniyom S.O., Duensing S., Swilling N.W., Hasskarl J., Hinds P.W., Münger K. Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability. Cancer Res 2003, 63:476-483.
    • (2003) Cancer Res , vol.63 , pp. 476-483
    • Piboonniyom, S.O.1    Duensing, S.2    Swilling, N.W.3    Hasskarl, J.4    Hinds, P.W.5    Münger, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.