Identification of a novel IL-6 isoform binding to the endogenous IL-6 receptor

American Journal of Respiratory Cell and Molecular Biology

Volumn 27, Issue 1, 2002, Pages 48-56

  Bihl, Michel P ^a   Heinimann, Karl ^a   Rüdiger, Jochen J ^a   Eickelberg, Oliver ^a   Perruchoud, André P ^a   Tamm, Michael ^a   Roth, Michael ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; ISOPROTEIN; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DIMERIZATION; EXON; FIBROBLAST; GENETICS; HUMAN; LUNG; METABOLISM; PROTEIN SYNTHESIS;

ALTERNATIVE SPLICING; BINDING SITES; CELLS, CULTURED; DIMERIZATION; EXONS; FIBROBLASTS; HUMANS; INTERLEUKIN-6; LUNG; MODELS, MOLECULAR; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; RECEPTORS, INTERLEUKIN-6; RNA, MESSENGER;

EID: 0035983251     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.27.1.4637     Document Type: Article

References (34)

1. Interleukin-6 in biology and medicine
2. Major role of the soluble interleukin-6/interleukin-6 receptor complex for the proliferation of interleukin-6-dependent human myeloma cell lines
3. Recruitment of primitive peripheral blood cells: Synergism of interleukin 12 with interleukin 6 and stem cell factor
4. Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes
5. Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma
6. Interferon-gamma and interleukin-6 inhibit proliferation in human melanoma cells by different signalling pathways
7. Proliferation of human non-small cell lung cancer cell lines: Role of interleukin-6
8. Intracellular interleukin 6 mediates platelet-derived growth factor- induced proliferation of nontransformed cells
9. Interleukin 6 and its relationship to clinical parameters in patients with malignant pleural mesothelioma
10. Interleukin-6-mediated autocrine growth promotion in human glioblastoma multiforme cell line U87MG
11. IL-6, M-CSF and IAP cytokines in ovarian cancer: Simultaneous assessment of serum levels
12. Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma
13. Differential shedding of the two subunits of the interleukin-6 receptor
14. The soluble interleukin-6 receptor is generated by shedding
15. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
16. Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6
17. Interleukin-6 signal transducer gp130 mediates oncostatin M signaling
18. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130
19. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of L1F and IL-6 signal transduction
20. Cell-mediated suppression of human interleukin-2 gene expression at splicing of mRNA
21. Molecular models of two competitive inhibitors, IL-2delta2 and IL-2delta3, generated by alternative splicing of human interleukin-2
22. Molecular model of an alternative splice variant of human IL-4, IL-4 delta 2, a naturally occurring inhibitor of IL-4-stimulated T cell proliferation
23. An alternative splice variant of human IL-4, IL-4 delta 2, inhibits IL-4-stimulated T cell proliferation
24. Cell cultures from cryopreserved human lung tissue
25. Solution structure of recombinant human interleukin-6
26. 1.9 A crystal structure of interleukin 6: Implications for a novel mode of receptor dimerization and signaling
27. Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling
28. Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor
29. Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells
30. The interleukin-4 family of lymphokines
31. Antagonistic effects of an alternative splice variant of human IL-4, IL-4delta2, on IL-4 activities in human monocytes and B cells
32. Identification and characterization of two alternative splice variants of human interleukin-2
33. Interleukin-4 and its alternatively spliced variant (IL-4delta2) in patients with atopic asthma
34. Rational design of a receptor super-antagonist of human interleukin-6