Generation of a variant of human interleukin-4 by alternative splicing

Molecular Immunology

Volumn 33, Issue 4-5, 1996, Pages 361-370

  Alms, William J ^a   Atamas, Sergei P ^a   Yurovsky, Vladimir V ^a   White, Barbara ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

alternative spicing; Interleukin 4

Indexed keywords

CD3 ANTIGEN; COMPLEMENTARY DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; RIBONUCLEASE;

ALTERNATIVE RNA SPLICING; ARTICLE; BASE PAIRING; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; EXON; HUMAN; HUMAN CELL; LEISHMANIASIS; LEPROSY; MOLECULAR CLONING; MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMIASIS; T LYMPHOCYTE;

EID: 0029994459     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(95)00154-9     Document Type: Article

References (52)

1. Abe E., DeWaal Malefyt R., Matsuda I. and Arai K., Arai N. (1992) An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals. Proc. natn. Acad. Sci. U.S.A. 89, 2864-2868.
2. Alms W. J., Braun-Elwert L., James S. P., Yurovsky V. V., and White B. (1995) Simultaneous quantitation of cytokine mRNAs by reverse transcription-polymerase chain reaction using multiple internal standard cRNAs. Diag. molec. Path., in press.
3. Arai N., Nomura D., Villaret D., DeWaal Malefijt R., Seiki M., Yoshida M., Minoshima S., Fukuyama R., Maekawa M., Kudoh J., Shimizu N., Yokata K., Abe E., Yokata T., Takebe Y. and Arai K. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. J. Immun. 142, 274-279.
4. Atamas S. P, Choi J., Yurovsky V. V. and White B. (1996) An alternative splice variant of human interleukin-4, IL-4δ2, inhibits interleukin-4 stimulated T cell proliferation. J. Immun. 156, 435-441.
5. Aversa G., Punnonen J., Cocks B. G., Malefit R. W., Vega F. Jr., Zurawski S. M., Zurawski G. and de Vries J. (1993) An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J. exp. Med. 178, 2213-2218.
6. Boulay J.-L. and Paul W. E. (1992) The interleukin-4-related lymphokines and their binding to hematopoietin receptors. J. biol. Chem. 26, 20525-20528.
7. Brown M. A., Pierce J. H., Watson C. J., Falco J., Ihle J. N. and Paul W. E. (1987) B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell 50, 809-818.
8. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt. Biochem. 162, 156-159.
9. Coffman R. L., Ohara J., Bond M. W., Carty J., Zlotnik A. and Paul W. E. (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immun. 136, 4538-4541.
10. Crawford R. M., Finbloom D. S., Ohara J., Paul W. E. and Meltzer M. S. (1987) B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J. Immun. 139, 135-141.
11. Defrance T., Aubry J. P., Rousset F., Vanbervliet B., Bonnefoy J. Y., Arai N., Takebe Y., Yokata T., Lee F., Arai K., De Vries J. and Banchereau J. (1987) Human recombinant interleukin 4 induces Fce receptors (CD23) on normal human B lymphocytes. J. exp. Med. 165, 1459-1467.
12. Defrance T., Vanbervliet B., Pene J. and Banchereau J. (1988) Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM. J. Immun. 141, 2000-2005.
13. De Vos A. M., Ultsch M. and Kossiakoff A. A. (1992) Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312.
14. Feghali C. A., Bost K. L., Boulware D. W. and Levy L. S. (1992) Human recombinant interleukin-4 induces proliferation and interleukin-6 production by cultured human skin fibroblasts. Clin. Immun. Immunopathol. 63, 182-187.
15. Fernandez-Botran R., Krammer P. H., Diamantstein T., Uhr J. W. and Vitetta E. S. (1986) B cell-stimulatory factor 1 (BSF-1) promotes growth of helper T cell lines. J. exp. Med. 164, 580-593.
16. Heinzel F. P., Sadick M. D., Holaday B. J., Coffman R. L. and Locksley R. M. (1989) Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. J. exp. Med. 169, 59-72.
17. Henkel G., Weiss D. L., McCoy R., Deloughery T., Tara D. and Brown M. A. (1992) A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J. Immun. 149, 3239-3246.
18. Holmes K. and Fowlkes B. J. (1991) Current Protocols in Immunology (Edited by Coligan J. E., Kruisbeek A. M., Margulies D. H., Shevach E. M. and Strober W.), pp. 5.3.1-11. John Wiley and Sons, New York.
19. Howard M., Farrar J., Hilfiker M., Johnson B., Takatsu K., Hamaoka T. and Paul W. E. (1982) Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J. exp. Med. 155, 914-923.
20. Hudak S. A., Gollnick S. O., Conrad D. H. and Kehry M. R. (1987) Murine B-cell stimulatory factor 1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells. Proc. natn. Acad. Sci. U.S.A. 84, 4606-4610.
21. Illera V A., Perandones C. E., Stunz L. L., Mower D. A., Jr. and Ashman R. F. (1993) Apoptosis in splenic B lymphocytes: regulation by protein kinase C and IL-4. J. Immun. 151, 2965-2993.
22. Klein S. C., Golverdingen J. G., Bouwens A. G. M., Tilanus M. G. J. and de Weger R. A. (1995) An alternatively spliced interleukin 4 form in lymphoid cells. Immunogenetics 41, 57.
23. Kruse N., Lehnbecher T. and Sebald W. (1991) Site-directed mutagenesis reveals the importance of disulfide bridges and aromatic residues for structure and proliferative activity of human interleukin-4. FEBS Lett. 286, 58-60.
24. Le Gros G., Ben-Sasson S. Z., Seder R., Finkelman F. D. and Paul W. E. (1990) Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. exp. Med. 172, 921-929.
25. Li-Weber M., Elder A., Krafft-Czepa H. and Krammer P. H. (1992) T cell-specific negative regulation of the transcription of the human cytokine interleukin 4. J. Immun. 148, 1913-1918.
26. Li-Weber M., Krafft H. and Krammer P. H. (1993) A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer. J. Immun. 151, 1371-1382.
27. Lundgren M., Persson U., Larsson P., Magnusson C., Smith C. I. E., Hammarstrom L. and Severinson E. (1989) Interleukin-4 induces synthesis of IgE and IgG4 in human B cells. Eur. J. Immun. 13, 1311-1317.
28. McKenzie A. N. J., Li X., Largaespada D. A., Sato A., Kaneda A., Zurawski A. M., Doyle E. L., Milatovich A., Francke U., Copeland N. G., Jenkins N. A. and Zurawski G. (1993) Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J. Immun. 150, 5436-5444.
29. Mitchell L. C., Davis L. S. and Lipsky P. E. (1989) Promotion of human T lymphocyte proliferation by IL-4. J. Immun. 142, 1548-1557.
30. Mosmann T. R., Bond M. W., Coffman R. L., O'Hara J. and Paul W. E. (1986) T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc. natn. Acad. Sci. U.S.A. 83, 5654-5658.
31. Peschel C., Paul W. E., O'Hara J. and Green I. (1987) Effects of B-cell stimulatory factor/interleukin-4 on hematopoietic progenitor cells. Blood 70, 254-263.
32. Postlethwaite A., Holness M. A., Katai H. and Raghow R. (1992) Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J. clin. Invest. 90, 1479-1485.
33. Postlethwaite A. E. and Seyer J. M. (1991) Fibroblast chemotaxis induced by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122. J. clin. Invest. 87, 2147-2152.
34. Piela-Smith T. H., Broketa G., Hand A. and Korn J. H. (1992) Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4. J. Immun. 148, 1375-1381.
35. Powers R., Garrett D. S., March C. J., Frieden E. A., Gronenborn A. M. and Clore G. M. (1992) Three-dimensional solution structure of human interleukin-4 by multi-dimensional heteronuclear magnetic resonance spectroscopy. Science 256, 1673-1677.
36. Renz H., Domenico J. and Gelfand E. W. (1991) IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cells. J. Immun. 146, 3049-3055.
37. Roehm N. W., Leibson H. J., Zlotnik A., Kappler J., Marrack P. and Cambier J. C. (1984) Interleukin-induced increase in Ia expression by normal mouse B cells. J. exp. Med. 160, 679-694.
38. Rousset F., Billaud M., Blanchard D., Figdor C., Lenoir G. M., Spits H. and De Vries J. E. (1989) IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines: requirement of additional activation by phorbal myristate acetate for induction of homotypic cell adhesions. J. Immun. 143, 1490-1498.
39. Rousset F., de Waal Malefijt R., Slierendregt B., Aubry J.-P., Bonnefoy J.-Y., Defrance T., Banchereau J. and de Vries J. E. (1988) Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-γ. J. Immun. 140, 2625-2632.
40. Sanger F., Nicklen S. and Coulson A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. natn. Acad. Sci. U.S.A. 74, 5463-5467.
41. Sambrook J., Fritsch E. F. and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, New York.
42. Scott P., Natovitz P., Coffman R. L., Pearce E. and Sher A. (1988) Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. exp. Med. 168, 1675-1684.
43. Seder R. A., Paul W. E., Dvorak A. M., Sharkis S. J., Kagey-Sobotka A., Niv Y., Finkelman F. D., Barbieri S. A., Galli S. J. and Plaut M. (1991) Mouse splenic and bone marrow cell populations that express high-affinity Fc∈ receptors and produce interleukin 4 are highly enriched in basophils. Proc. natn. Acad. Sci. U.S.A. 88, 2835-2839.
44. Shields J. G., Armitage R. J., Jamieson B. N., Beverly P. C. and Calliard R. E. (1989) Increased expression of surface IgM but not IgD or IgG on human B cells in response to interleukin 4. Immunology 66, 224-227.
45. Smith C. W. J., Patton J. G. and Nadal-Ginard J. (1989) Alternative splicing in the control of gene expression. A. Rev. Genet. 23, 527-557.
46. Sorg R. V., Enczmann J., Sorg U. R., Schneider E. M. and Wernet P. (1993) Identification of an alternatively spliced transcript of human interleukin-4 lacking the sequence encoded by exon 2. Exp. Hematol. 21, 560-563.
47. c. Molec. cell. Biol. 13, 4793-4805.
48. Vitetta E. S., Ohara J., Myers C. D., Layton J. E., Krammer P. H. and Paul W. E. (1985) Serological, biochemical, and functional identify of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J. exp. Med. 162, 1726-1731.
49. + T lymphocytes in atopic patients. J. Immun. 144, 4651-4656.
50. Yamamura M., Uyemura K., Deans R. J., Weinberg K., Rea T. H., Bloom B. R. and Modlin R. L. (1991) Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254, 277-279.
51. Zurawski S. M., Vega F. Jr., Huyghe B. and Zurawski G. (1993) Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12, 2663-2670.
52. Zwingenberger K., Hohmann A., Cardoso de Brito M. and Ritter M. (1991) Impaired balance of interleukin-4 and interferon-γ production in infections with Schistosoma mansoni and intestinal nematodes. Scand. J. Immun. 34, 243-252.