Mornings with art, lessons learned: Feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses

Journal of Cellular Physiology

Volumn 209, Issue 3, 2006, Pages 604-610

  Bey, Erik A ^a   Wuerzberger Davis, Shelly M ^a   Pink, John J ^a   Yang, Chin Rang ^a   Araki, Shinako ^a   Reinicke, Kathryn E ^a   Bentle, Melissa S ^a   Dong, Ying ^a   Cataldo, Eva ^a   Criswell, Tracy L ^a   Wagner, Mark W ^a   Li, Longshan ^a   Gao, Jinming ^a   Boothman, David A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BETA LAPACHONE; CAMPTOTHECIN; CELL PROTEIN; CLUSTERIN; DIMETHYL SULFOXIDE; DNA; PROTEIN XIP3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANALYTICAL RESEARCH; ANIMAL CELL; CARCINOGENESIS; CELL CYCLE G2 PHASE; CONTROLLED STUDY; CYTOLOGY; DNA REPAIR; FEEDBACK SYSTEM; IONIZING RADIATION; MAMMAL; MISMATCH REPAIR; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REDUNDANCY ANALYSIS; REGULATORY MECHANISM; RESTRICTION THRESHOLD; SHORT SURVEY; STRESS;

APOPTOSIS; CELL CYCLE; CELL DEATH; CELL PHYSIOLOGY; CLUSTERIN; DNA MISMATCH REPAIR; FEEDBACK, BIOCHEMICAL; HUMANS; NAPHTHOQUINONES; NEOPLASMS; RADIATION-SENSITIZING AGENTS;

MAMMALIA;

EID: 33750525510     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20783     Document Type: Short Survey

References (47)

1. Araki S, Israel S, Leskov KS, Criswell TL, Beman M, Klokov DY, Sampalth L, Reinicke KE, Cataldo E, Mayo LD, Boothman DA. 2005. Clusterin proteins: stress-inducible polypeptides with proposed functions in multiple organ dysfunction. BJR 27:106-113.
2. Blagosklonny MV, Pardee AB. 2002. The restriction point of the cell cycle. Cell Cycle 1(2):103-110.
3. Boorstein RJ, Pardee AB. 1984. Beta-lapachone greatly enhances MMS lethality to human fibroblasts. Biochem Biophys Res Commun 118(3):828-834.
4. Boothman DA, Greer S, Pardee AB. 1987. Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor. Cancer Res 47(20):5361-5366.
5. Boothman DA, Bouvard I, Hughes EN. 1989a. Identification and characterization of X-ray-induced proteins in human cells. Cancer Res 49(11):2871-2878.
6. Boothman DA, Trask DK, Pardee AB. 1989b. Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I. Cancer Res 49(3):605-612.
7. Boothman DA, Meyers M, Fukunaga N, Lee SW. 1993. Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells. Proc Natl Acad Sci U S A 90(15):7200-7204.
8. Bradley DW, Dou QP, Fridovich-Keil JL, Pardee AB. 1990. Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter. Proc Natl Acad Sci U S A 87(23):9310-9314.
9. Campisi J, Medrano EE, Morreo G, Pardee AB. 1982. Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells. Proc Natl Acad Sci U S A 79(2):436-440.
10. Coppock DL, Pardee AB. 1985. Regulation of thymidine kinase activity in the cell cycle by a labile protein. J Cell Physiol 124(2):269-274.
11. Criswell T, Klokov D, Beman M, Lavik JP, Boothman DA. 2003. Repression of IR-inducible clusterin expression by the p53 tumor suppressor protein. Cancer Biol Ther 2(4):372-380.
12. Criswell T, Beman M, Araki S, Leskov K, Cataldo E, Mayo LD, Boothman DA. 2005. Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor. J Biol Chem 280(14):14212-14221.
13. Das SK, Lau CC, Pardee AB. 1982. Abolition by cycloheximide of caffeine-enhanced lethality of alkylating agents in hamster cells. Cancer Res 42(11):4499-4504.
14. Dou QP, Pardee AB. 1996. Transcriptional activation of thymidine kinase, a marker for cell cycle control. Prog Nucleic Acid Res Mol Biol 53:197-217.
15. Dou QP, Markell PJ, Pardee AB. 1992. Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase. Proc Natl Acad Sci U S A 89(8):3256-3260.
16. Fingert HJ, Chang JD, Pardee AB. 1986. Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer Res 46(5):2463-2467.
17. Frydman B, Marton LJ, Sun JS, Neder K, Witiak DT, Liu AA, Wang HM, Mao Y, Wu HY, Sanders MM, Liu LF. 1997. Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res 57(4):620-627.
18. Gudas JM, Fridovich-Keil JL, Datta MW, Bryan J, Pardee AB. 1992. Characterization of the murine thymidine kinase-encoding gene and analysis of transcription start point heterogeneity. Gene 118(2):205-216.
19. Gudas JM, Fridovich-Keil JL, Pardee AB. 1993. Posttranscriptional control of thymidine kinase messenger RNA accumulation in cells released from G0-G1 phase blocks. Cell Growth Differ 4(5):421-430.
20. Lau CC, Pardee AB. 1982. Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci U S A 79(9):2942-2946.
21. Leskov KS, Criswell T, Antonio S, Li J, Yang CR, Kinsella TJ, Boothman DA. 2001. When X-ray-inducible proteins meet DNA double strand break repair. Semin Radiat Oncol 11(4):352-372.
22. Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA. 2003. Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 278(13):11590-11600.
23. Li CJ, Averboukh L, Pardee AB. 1993. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem 268(30):22463-22468.
24. Li Y, Sun X, LaMont JT, Pardee AB, Li CJ. 2003. Selective killing of cancer cells by beta-lapachone: direct checkpoint activation as a strategy against cancer. Proc Natl Acad Sci U S A 100(5):2674-2678.
25. Manna SK, Gad YP, Mukhopadhyay A, Aggarwal BB. 1999. Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone. Biochem Pharmacol 57(7):763-774.
26. Meyers M, Hwang A, Wagner MW, Boothman DA. 2004. Role of DNA mismatch repair in apoptotic responses to therapeutic agents. Environ Mol Mutagen 44(4):249-264.
27. Meyers M, Wagner MW, Mazurek A, Schmutte C, Fishel R, Boothman DA. 2005. DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. J Biol Chem 280(7):5516-5526.
28. Neder K, Marton LJ, Liu LF, Frydman B. 1998. Reaction of beta-lapachone and related naphthoquinones with 2-mercaptoethanol: a biomimetic model of topoisomerase II poisoning by quinones. Cell Mol Biol (Noisy-le-grand) 44(3):465-474.
29. Ough M, Lewis A, Bey EA, Gao J, Ritchie JM, Bornmann W, Boothman DA, Oberley LW, Cullen JJ. 2005. Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biol Ther 4(1):95-102.
30. Pardee AB. 2002. PaJaMas in Paris. Trends Genet 18(11):585-587.
31. Pardee AB, Jacob F, Monod J. 1958. The role of the inducible alleles and the constitutive alleles in the synthesis of beta-galactosidase in zygotes of [Escherichia coli]. C R Hebd Seances Acad Sci 246(21):3125-3128.
32. Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim EJ, Griffin R, Bey EA, Bornmann WG, Gao J, Park HJ, Boothman DA, Song CW. 2005a. Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation. Int J Radiat Oncol Biol Phys 61(1):212-219.
33. Park HJ, Choi EK, Choi J, Ahn KJ, Kim EJ, Ji IM, Kook YH, Ahn SD, Williams B, Griffin R, Boothman DA, Lee CK, Song CW. 2005b. Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone. Clin Cancer Res 11(24 Pt 1):8866-8871.
34. Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. 2000a. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem 275(8):5416-5424.
35. Pink JJ, Wuerzberger-Davis S, Tagliarino C, Planchon SM, Yang X, Froelich CJ, Boothman DA. 2000b. Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res 255(2):144-155.
36. Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA. 2001. beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3. Exp Cell Res 267(1):95-106.
37. Prem veer Reddy G, Pardee AB. 1980. Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci U S A 77(6):3312-3316.
38. Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA. 2005. Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clin Cancer Res 11(8):3055-3064.
39. Schlegel R, Pardee AB. 1986. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science 232(4755):1264-1266.
40. Schlegel R, Croy RG, Pardee AB. 1987. Exposure to caffeine and suppression of DNA replication combine to stabilize the proteins and RNA required for premature mitotic events. J Cell Physiol 131(1):85-91.
41. Sutton D, Kim S, Shuai X, Leskou K, Marques J, Williams BRG, Boothman DA, Gao J. 2006. Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro. Int J Nanomed. In press.
42. Tagliarino C, Pink JJ, Dubyak GR, Nieminen AL, Boothman DA. 2001. Calcium is a key signaling molecule in beta-lapachone-mediated cell death. J Biol Chem 276(22):19150-19159.
43. Tagliarino C, Pink JJ, Reinicke KE, Simmers SM, Wuerzberger-Davis SM, Boothman DA. 2003. Mu-calpain activation in beta-lapachone-mediated apoptosis. Cancer Biol Ther 2(2):141-152.
44. Wang F, Blanco E, Ai H, Boothman DA, Gao J. 2006. Modulating complexation. J Pharm Sci. In press.
45. Wuerzberger SM, Pink JJ, Planchon SM, Byers KL, Bornmann WG, Boothman DA. 1998. Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone. Cancer Res 58(9):1876-1885.
46. Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ, Boothman DA. 1999. Isolation of Ku70-binding proteins (KUBs). Nucleic Acids Res 27(10):2165-2174.
47. Yang CR, Leskov K, Hosley-Eberlein K, Criswell T, Pink JJ, Kinsella TJ, Boothman DA. 2000. Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death. Proc Natl Acad Sci U S A 97(11):5907-5912.