Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity

Cancer Epidemiology

Volumn 33, Issue 3-4, 2009, Pages 288-292

  Nomura, Takahiro ^a   Uehara, Yoshimasa ^b   Kawajiri, Hiroo ^a   Ryoyama, Kazuo ^c   Yamori, Takao ^d   Fuke, Yoko ^e  

^a KANAZAWA GAKUIN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c AOMORI UNIVERSITY   (Japan)

^d Japan Medical Association   (Japan)

^e TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

Alkyl isothiocyanates; EGF receptor; Food component; Kinase; Wasabi

Indexed keywords

2 (METHYLSULFINYL)ETHYLISOTHIOCYANATE; 6 (METHYLSULFINYL)HEXYLISOTHIOCYANATE; 8 (METHYLSULFINYL)OCTYLISOTHIOCYANATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ELONGATION FACTOR 2 KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERBSTATIN; ISOTHIOCYANIC ACID DERIVATIVE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; SULFORAPHANE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; WASABI;

ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROQUINONES; ISOTHIOCYANATES; K562 CELLS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 70349734858     PISSN: 18777821     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canep.2009.08.009     Document Type: Article

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