A synthetic naringenin derivative, 5-hydroxy-7,4′- diacetyloxyflavanone- N -phenyl hydrazone (N101-43), induces apoptosis through up-regulation of fas/FasL expression and inhibition of PI3K/Akt signaling pathways in non-small-cell lung cancer cells

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 18, 2011, Pages 10286-10297

  Bak, Yesol ^a   Kim, Heejong ^a   Kang, Jeong Woo ^a   Lee, Dong Hun ^a   Kim, Man Sub ^a   Park, Yun Sun ^a   Kim, Jung Hee ^a   Jung, Kang Yeoun ^b   Lim, Yoongho ^a   Hong, Jintae ^c   Yoon, Do Young ^a  

^a Konkuk University   (South Korea)

^b Gangneung Wonju National University   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

apoptosis; flavonoid; lung cancer; naringenin derivative

Indexed keywords

A549 CELLS; ADP-RIBOSE; ANTI-CANCER AGENTS; ANTICANCER EFFECTS; BINDING PARTNERS; CASPASE-3; CASPASES; CDK INHIBITORS; CELL CYCLE; CELL LINES; CELL SURVIVAL; CELL-CYCLE ARREST; CYCLINS; DEATH-RECEPTOR; EXPRESSION LEVELS; FAS/FASL; FLAVONOID; HUMAN CANCER CELLS; HYDRAZONES; INHIBITORY EFFECT; LUNG CANCER; LUNG CANCER CELLS; NATURALLY OCCURRING; NON SMALL CELL LUNG CANCER; PRO-APOPTOTIC FACTORS; REGULATORY FACTORS; SIGNALING PATHWAYS; SMALL-MOLECULE INHIBITORS; THERAPEUTIC APPLICATION; TUMOR GROWTH; UP-REGULATION;

BIOLOGICAL ORGANS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; DRUG PRODUCTS; ORGANIC COMPOUNDS;

DISEASES;

5 HYDROXY 7,4' DIACETYLOXYFLAVANONE N PHENYL HYDRAZONE; 5-HYDROXY-7,4'-DIACETYLOXYFLAVANONE-N-PHENYL HYDRAZONE; FAS ANTIGEN; FAS LIGAND; FLAVANONE DERIVATIVE; HYDRAZONE DERIVATIVE; NARINGENIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

ANTIGENS, CD95; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; FAS LIGAND PROTEIN; FLAVANONES; HUMANS; HYDRAZONES; LUNG NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 80053108325     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf2017594     Document Type: Article

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