메뉴 건너뛰기




Volumn 187, Issue 6, 2011, Pages 3186-3197

Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; VIRUS VECTOR;

EID: 80053063763     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101649     Document Type: Article
Times cited : (73)

References (58)
  • 3
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- And Th17-cell differentiation
    • Li, M. O., Y. Y. Wan, and R. A. Flavell. 2007. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26: 579-591.
    • (2007) Immunity , vol.26 , pp. 579-591
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 6
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton, A. M., and E. M. Shevach. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 7
    • 36248976097 scopus 로고    scopus 로고
    • CD4+ CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan, P., L. Zheng, S. Ishihara, J. Reed, and M. J. Lenardo. 2007. CD4+ CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat. Immunol. 8: 1353-1362.
    • (2007) Nat. Immunol. , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 8
    • 33746383248 scopus 로고    scopus 로고
    • Regulatory T cells in virus infections
    • Rouse, B. T., P. P. Sarangi, and S. Suvas. 2006. Regulatory T cells in virus infections. Immunol. Rev. 212: 272-286.
    • (2006) Immunol. Rev. , vol.212 , pp. 272-286
    • Rouse, B.T.1    Sarangi, P.P.2    Suvas, S.3
  • 9
    • 77951670712 scopus 로고    scopus 로고
    • Once a killer, always a killer: From cytotoxic T cell to memory cell
    • Lefrançois, L., and J. J. Obar. 2010. Once a killer, always a killer: from cytotoxic T cell to memory cell. Immunol. Rev. 235: 206-218.
    • (2010) Immunol. Rev. , vol.235 , pp. 206-218
    • Lefrançois, L.1    Obar, J.J.2
  • 10
    • 77951681614 scopus 로고    scopus 로고
    • Generating diversity: Transcriptional regulation of effector and memory CD8 T-cell differentiation
    • Rutishauser, R. L., and S. M. Kaech. 2010. Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation. Immunol. Rev. 235: 219-233.
    • (2010) Immunol. Rev. , vol.235 , pp. 219-233
    • Rutishauser, R.L.1    Kaech, S.M.2
  • 11
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: Implications for vaccine design
    • Seder, R. A., P. A. Darrah, and M. Roederer. 2008. T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 8: 247-258.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 12
    • 33745224089 scopus 로고    scopus 로고
    • Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
    • Williams, M. A., A. J. Tyznik, and M. J. Bevan. 2006. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature 441: 890-893.
    • (2006) Nature , vol.441 , pp. 890-893
    • Williams, M.A.1    Tyznik, A.J.2    Bevan, M.J.3
  • 13
    • 74549162832 scopus 로고    scopus 로고
    • Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
    • Kalia, V., S. Sarkar, S. Subramaniam, W. N. Haining, K. A. Smith, and R. Ahmed. 2010. Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity 32: 91-103.
    • (2010) Immunity , vol.32 , pp. 91-103
    • Kalia, V.1    Sarkar, S.2    Subramaniam, S.3    Haining, W.N.4    Smith, K.A.5    Ahmed, R.6
  • 14
    • 74549156399 scopus 로고    scopus 로고
    • CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses
    • Obar, J. J., M. J. Molloy, E. R. Jellison, T. A. Stoklasek, W. Zhang, E. J. Usherwood, and L. Lefrançois. 2010. CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses. Proc. Natl. Acad. Sci. USA 107: 193-198.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 193-198
    • Obar, J.J.1    Molloy, M.J.2    Jellison, E.R.3    Stoklasek, T.A.4    Zhang, W.5    Usherwood, E.J.6    Lefrançois, L.7
  • 15
    • 74549216531 scopus 로고    scopus 로고
    • Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    • Pipkin, M. E., J. A. Sacks, F. Cruz-Guilloty, M. G. Lichtenheld, M. J. Bevan, and A. Rao. 2010. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32: 79-90.
    • (2010) Immunity , vol.32 , pp. 79-90
    • Pipkin, M.E.1    Sacks, J.A.2    Cruz-Guilloty, F.3    Lichtenheld, M.G.4    Bevan, M.J.5    Rao, A.6
  • 16
    • 37549026844 scopus 로고    scopus 로고
    • Replicating and non-replicating viral vectors for vaccine development
    • Robert-Guroff, M. 2007. Replicating and non-replicating viral vectors for vaccine development. Curr. Opin. Biotechnol. 18: 546-556.
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 546-556
    • Robert-Guroff, M.1
  • 17
    • 33746013487 scopus 로고    scopus 로고
    • Inflaming the CD8+ T cell response
    • Haring, J. S., V. P. Badovinac, and J. T. Harty. 2006. Inflaming the CD8+ T cell response. Immunity 25: 19-29.
    • (2006) Immunity , vol.25 , pp. 19-29
    • Haring, J.S.1    Badovinac, V.P.2    Harty, J.T.3
  • 18
    • 9244248089 scopus 로고    scopus 로고
    • Modified vaccinia virus Ankara as antigen delivery system: How can we best use its potential?
    • Drexler, I., C. Staib, and G. Sutter. 2004. Modified vaccinia virus Ankara as antigen delivery system: how can we best use its potential? Curr. Opin. Biotechnol. 15: 506-512.
    • (2004) Curr. Opin. Biotechnol. , vol.15 , pp. 506-512
    • Drexler, I.1    Staib, C.2    Sutter, G.3
  • 19
    • 33748642155 scopus 로고    scopus 로고
    • Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus
    • Chahroudi, A., D. A. Garber, P. Reeves, L. Liu, D. Kalman, and M. B. Feinberg. 2006. Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus. J. Virol. 80: 8469-8481.
    • (2006) J. Virol. , vol.80 , pp. 8469-8481
    • Chahroudi, A.1    Garber, D.A.2    Reeves, P.3    Liu, L.4    Kalman, D.5    Feinberg, M.B.6
  • 20
  • 22
    • 33745133006 scopus 로고    scopus 로고
    • Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
    • Qi, H., J. G. Egen, A. Y. Huang, and R. N. Germain. 2006. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312: 672-1676.
    • (2006) Science , vol.312 , pp. 672-1676
    • Qi, H.1    Egen, J.G.2    Huang, A.Y.3    Germain, R.N.4
  • 24
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Webster, K. E., S. Walters, R. E. Kohler, T. Mrkvan, O. Boyman, C. D. Surh, S. T. Grey, and J. Sprent. 2009. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206: 751-760.
    • (2009) J. Exp. Med. , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3    Mrkvan, T.4    Boyman, O.5    Surh, C.D.6    Grey, S.T.7    Sprent, J.8
  • 25
    • 1842681952 scopus 로고    scopus 로고
    • Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    • Huster, K. M., V. Busch, M. Schiemann, K. Linkemann, K. M. Kerksiek, H. Wagner, and D. H. Busch. 2004. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. USA 101: 5610-5615.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5610-5615
    • Huster, K.M.1    Busch, V.2    Schiemann, M.3    Linkemann, K.4    Kerksiek, K.M.5    Wagner, H.6    Busch, D.H.7
  • 26
    • 34548027000 scopus 로고    scopus 로고
    • Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
    • Joshi, N. S., W. Cui, A. Chandele, H. K. Lee, D. R. Urso, J. Hagman, L. Gapin, and S. M. Kaech. 2007. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27: 281-295.
    • (2007) Immunity , vol.27 , pp. 281-295
    • Joshi, N.S.1    Cui, W.2    Chandele, A.3    Lee, H.K.4    Urso, D.R.5    Hagman, J.6    Gapin, L.7    Kaech, S.M.8
  • 27
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J. M., J. P. Rasmussen, and A. Y. Rudensky. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8: 191-197.
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 28
    • 41549114751 scopus 로고    scopus 로고
    • Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    • Biswas, P. S., V. Pedicord, A. Ploss, E. Menet, I. Leiner, and E. G. Pamer. 2007. Pathogen-specific CD8 T cell responses are directly inhibited by IL-10. J. Immunol. 179: 4520-4528.
    • (2007) J. Immunol. , vol.179 , pp. 4520-4528
    • Biswas, P.S.1    Pedicord, V.2    Ploss, A.3    Menet, E.4    Leiner, I.5    Pamer, E.G.6
  • 29
    • 55149111143 scopus 로고    scopus 로고
    • Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation
    • Maynard, C. L., and C. T. Weaver. 2008. Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol. Rev. 226: 219-233.
    • (2008) Immunol. Rev. , vol.226 , pp. 219-233
    • Maynard, C.L.1    Weaver, C.T.2
  • 30
    • 68249141869 scopus 로고    scopus 로고
    • Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells
    • Sanjabi, S., M. M. Mosaheb, and R. A. Flavell. 2009. Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity 31: 131-144.
    • (2009) Immunity , vol.31 , pp. 131-144
    • Sanjabi, S.1    Mosaheb, M.M.2    Flavell, R.A.3
  • 31
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J. D., J. P. Rasmussen, M. A. Gavin, and A. Y. Rudensky. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6: 1142-1151.
    • (2005) Nat. Immunol. , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 32
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • Malek, T. R., and I. Castro. 2010. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 33: 153-165.
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 33
    • 0034897188 scopus 로고    scopus 로고
    • The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: Importance of two widely separated IL-2 response elements
    • Kim, H. P., J. Kelly, and W. J. Leonard. 2001. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity 15: 159-172.
    • (2001) Immunity , vol.15 , pp. 159-172
    • Kim, H.P.1    Kelly, J.2    Leonard, W.J.3
  • 34
    • 77953541634 scopus 로고    scopus 로고
    • Inflammatory cytokines as a third signal for T cell activation
    • Curtsinger, J. M., and M. F. Mescher. 2010. Inflammatory cytokines as a third signal for T cell activation. Curr. Opin. Immunol. 22: 333-340.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 333-340
    • Curtsinger, J.M.1    Mescher, M.F.2
  • 36
    • 33749134189 scopus 로고    scopus 로고
    • Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response
    • Long, M., and A. J. Adler. 2006. Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response. J. Immunol. 177: 4257-4261.
    • (2006) J. Immunol. , vol.177 , pp. 4257-4261
    • Long, M.1    Adler, A.J.2
  • 38
    • 77649242104 scopus 로고    scopus 로고
    • Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments
    • Busse, D., M. De la Rosa, K. Hobiger, K. Thurley, M. Flossdorf, A. Scheffold, and T. Höfer. 2010. Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc. Natl. Acad. Sci. USA 107: 3058-3063.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3058-3063
    • Busse, D.1    De La Rosa, M.2    Hobiger, K.3    Thurley, K.4    Flossdorf, M.5    Scheffold, A.6    Höfer, T.7
  • 40
    • 23844469143 scopus 로고    scopus 로고
    • Depletion of CD25+CD4+T cells (Tregs) enhances the HBV-specific CD8+ T cell response primed by DNA immunization
    • Furuichi, Y., H. Tokuyama, S. Ueha, M. Kurachi, F. Moriyasu, and K. Kakimi. 2005. Depletion of CD25+CD4+T cells (Tregs) enhances the HBV-specific CD8+ T cell response primed by DNA immunization. World J. Gastroenterol. 11: 3772-3777.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 3772-3777
    • Furuichi, Y.1    Tokuyama, H.2    Ueha, S.3    Kurachi, M.4    Moriyasu, F.5    Kakimi, K.6
  • 41
    • 0141449974 scopus 로고    scopus 로고
    • CD4+ CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    • Suvas, S., U. Kumaraguru, C. D. Pack, S. Lee, and B. T. Rouse. 2003. CD4+ CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J. Exp. Med. 198: 889-901.
    • (2003) J. Exp. Med. , vol.198 , pp. 889-901
    • Suvas, S.1    Kumaraguru, U.2    Pack, C.D.3    Lee, S.4    Rouse, B.T.5
  • 42
    • 8644290853 scopus 로고    scopus 로고
    • CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1
    • Toka, F. N., S. Suvas, and B. T. Rouse. 2004. CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J. Virol. 78: 13082-13089.
    • (2004) J. Virol. , vol.78 , pp. 13082-13089
    • Toka, F.N.1    Suvas, S.2    Rouse, B.T.3
  • 44
    • 33947640163 scopus 로고    scopus 로고
    • Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice
    • Couper, K. N., D. G. Blount, J. B. De Souza, I. Suffia, Y. Belkaid, and E. M. Riley. 2007. Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. J. Immunol. 178: 4136-4146.
    • (2007) J. Immunol. , vol.178 , pp. 4136-4146
    • Couper, K.N.1    Blount, D.G.2    De Souza, J.B.3    Suffia, I.4    Belkaid, Y.5    Riley, E.M.6
  • 45
    • 79956296631 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis
    • McNally, A., G. R. Hill, T. Sparwasser, R. Thomas, and R. J. Steptoe. 2011. CD4+ CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc. Natl. Acad. Sci. USA 108: 7529-7534.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 7529-7534
    • McNally, A.1    Hill, G.R.2    Sparwasser, T.3    Thomas, R.4    Steptoe, R.J.5
  • 48
    • 79952769679 scopus 로고    scopus 로고
    • CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model
    • Pandiyan, P., H. R. Conti, L. Zheng, A. C. Peterson, D. R. Mathern, N. Hernández-Santos, M. Edgerton, S. L. Gaffen, and M. J. Lenardo. 2011. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity 34: 422-434.
    • (2011) Immunity , vol.34 , pp. 422-434
    • Pandiyan, P.1    Conti, H.R.2    Zheng, L.3    Peterson, A.C.4    Mathern, D.R.5    Hernández-Santos, N.6    Edgerton, M.7    Gaffen, S.L.8    Lenardo, M.J.9
  • 49
    • 48249103057 scopus 로고    scopus 로고
    • Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • Onishi, Y., Z. Fehervari, T. Yamaguchi, and S. Sakaguchi. 2008. Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA 105: 10113-10118.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehervari, Z.2    Yamaguchi, T.3    Sakaguchi, S.4
  • 54
    • 17144407983 scopus 로고    scopus 로고
    • Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection
    • Whitmire, J. K., J. T. Tan, and J. L. Whitton. 2005. Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection. J. Exp. Med. 201: 1053-1059.
    • (2005) J. Exp. Med. , vol.201 , pp. 1053-1059
    • Whitmire, J.K.1    Tan, J.T.2    Whitton, J.L.3
  • 55
    • 70349249977 scopus 로고    scopus 로고
    • Dynamics of peripheral tolerance and immune regulation mediated by Treg
    • Sakaguchi, S., K. Wing, and T. Yamaguchi. 2009. Dynamics of peripheral tolerance and immune regulation mediated by Treg. Eur. J. Immunol. 39: 2331-2336.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2331-2336
    • Sakaguchi, S.1    Wing, K.2    Yamaguchi, T.3
  • 58
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng, M. W., S. F. Ngiow, B. Von Scheidt, N. McLaughlin, T. Sparwasser, and M. J. Smyth. 2010. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res. 70: 7800-7809.
    • (2010) Cancer Res. , vol.70 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    Von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5    Smyth, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.