Blockade of 5-HT 2 receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT 1A receptor antagonism in the median raphe nucleus in mice

Behavioural Brain Research

Volumn 225, Issue 2, 2011, Pages 547-553

  Nunes de Souza, Vanessa ^a,b   Nunes de Souza, Ricardo ^b,c   Rodgers, Robert John ^d   Canto de Souza, Azair ^a,b,c  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

5 HT 2 receptors; Anxiety; Elevated plus maze; Median raphe nucleus; Mice; PAG

Indexed keywords

KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; HIPPOCAMPUS; MALE; MAZE TEST; MEDIAN RAPHE NUCLEUS; NERVE CELL; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; KETANSERIN; MALE; MAZE LEARNING; MICE; MICROINJECTIONS; PERIAQUEDUCTAL GRAY; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; SEROTONIN ANTAGONISTS;

EID: 80052965395     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.07.056     Document Type: Article

References (68)

1. Adell A., Carceller F., Artigas F. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. J Neurochem 1993, 60:1673-1681.
2. Adell A., Celada P., Abellán M.T., Artigas F. Origin and functional role of the extra-cellular serotonin in the midbrain raphe nuclei. Brain Res Rev 2002, 39:154-180.
3. Aghajanian G.K. Chemical-feedback regulation of serotonin-containing neurons in brain. Ann NY Acad Sci 1972, 193:86-94.
4. Aguiar D.C., Moreira F.A., Guimarães F.S. Flight reactions induced by injection of glutamate N-methyl-d-aspartate receptor agonist into the rat dorsolateral periaqueductal gray are not dependent on endogenous nitric oxide. Pharmacol Biochem Behav 2006, 83:296-301.
5. 2C agonists into ventral but not dorsal hippocampus. Behav Pharmacol 2004, 15:37-43.
6. Andrade T.G.C.S., Graeff F.G. Effect of electrolytic and neurotoxic lesion of the median raphe nucleus on anxiety and stress. Pharmacol Biochem Behav 2001, 70:1-14.
7. 1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively. Eur J Pharmacol 1994, 264:259-264.
8. 1A autoreceptors in the median raphe nucleus disrupts the contextual conditioning in rats. Behav Brain Res 2001, 126:175-184.
9. Avanzi V., Silva R.C.B., Macedo C.E., Brandão M.L. 5-HT mechanisms of median raphe nucleus in the conditioned freezing caused by light/foot-shock association. Physiol Behav 2003, 78:471-477.
10. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe. Comp Neurol 1978, 179:641-668.
11. Bandler R., Depaulis A., Vergnes M. Identification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids. Behav Brain Res 1985, 15(2):107-119.
12. Barnes N.M., Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999, 38:1083-1152.
13. Blanchard R.J., Blanchard D.C. Ethoexperimental approaches to the biology of emotion. Annu Rev Psychol 1988, 39:43-68.
14. Bobilier P., Petitjean F., Salvert D., Ligier M., Seguin S. Differential projections of the nucleus raphe dorsalis and nucleus raphe centralis as revealed by autoradiography. Brain Res 1975, 35:205-210.
15. Borelli K.G., Gárgaro A.C., Santos J.M., Brandão M.L. Effects of inactivation of serotonergic neurons of the median raphe nucleus on learning and performance of contextual fear conditioning. Neurosci Lett 2005, 387:105-110.
16. Canto-de-Souza A., Nunes-de-Souza R.L., Rodgers R.J. Anxiolytic-like effect of WAY-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience. Brain Res 2002, 928:50-59.
17. Carli M., Samanin R. Potential anxiolytic properties of 8-hydroxy-2-(Di-N-propylamino)tetralin, a selective serotonin 1A receptor agonist. Psychopharmacol 1988, 94:84-91.
18. Carrive P. The periaqueductal grey and defensive behavior: functional representation and neuronal organization. Behav Brain Res 1993, 58(1-2):24-47.
19. Carvalho-Netto E.F., Markham C., Blanchard C.D., Nunes-de-Souza R.L., Blanchard R.J. Physical environment modulates the behavioral responses induced by chemical stimulation of dorsal periaqueductal gray in mice. Pharmacol Biochem Behav 2006, 85:140-147.
20. Castilho V.M., de Macedo C.E., Brandão M.L. Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats. Psychopharmacology 2002, 165:77-85.
21. Cornélio A.M., Nunes-de-Souza R.L. Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze. Behav Brain Res 2007, 178:82-89.
22. Cruz A.P.M., Frei F., Graeff F.G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav 1994, 49:171-176.
23. Cruz A.P.M., Pinheiro G., Alves S.H., Ferreira G., Mendes M., Faria L., Macedo C.E., Motta V., Landeira-Fernandes J. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology 2005, 182:345-354.
24. De Almeida R.M., Giovenardi M., Charchat H., Lucion A.B. 8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats. Neurosci Biobehav Rev 1998, 23:259-264.
25. De Oca B.M., DeCola J.P., Maren S., Fanselow M.S. Distinct regions of the periaqueductal Gray are involved in the acquisition and expression of defensive responses. J Neurosci 1998, 18(9):3426-3432.
26. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms or defence. J Psychopharmacol 1991, 5:305-315.
27. Di Scala G., Schmitt P., Karli P. Flight induced by infusion of bicuculline methiodide into periventricular structures. Brain Res 1984, 309(2):199-208.
28. Dos Santos L., Andrade T.G.C.S., Zangrossi H. Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety. Psychopharmacol 2005, 179:733-741.
29. 1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. Eur Neuropsychopharmacol 2008, 18:286-294.
30. Dudley T.E., Dinardo L.A., Glass J.D. In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. J Neurophysiol 1999, 81:1469-1477.
31. 2B receptor protein in the central nervous system. Neuroscience 1997, 76:323-329.
32. Fornal C.A., Metzler R.A., Gallegos R.A., Veasey S.C., McCreary A.C., Jacobs B.L. WAT100635, a potent and selective 5-hydroxytryptamine 1A antagonist increases serotoninergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. J Pharmacol Exp Ther 1996, 278:752-762.
33. Gomes K.S., Nunes-de-Souza R. Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. Prog Neuro Psychopharmacol Biol Psychiatr 2009, 33:1261-1269.
34. Graeff F.G. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz J Med Biol Res 1994, 27:811-829.
35. Graeff F.G., Guimarães F.S., Andrade T.G.C.S., Deakin J.F.W. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 1996, 54(1):129-141.
36. Graeff F.G., Viana M.B., Mora P.O. Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev 1997, 21(6):791-799.
37. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci Biobehav Rev 2004, 3:239-259.
38. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 1995, 65:319-395.
39. Hall H., Lundkvist C., Halldin C., Farde I., Pike V.W., McCarron J.A. Autoradiografic localization of 5-HT1A receptor in the post-mortem human brain using [3H] WAY-100635 and [11C] WAY100635. Brain Res 1997, 745:96-108.
40. Haddjeri N., Faure C., Lucas G., Mnie-Filali O., Chouvet G., Astier B., Renaud B., Blier P., Debonnel G. In vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic system. Int J Neuropsychopharmacol 2004, 7:391-399.
41. Kalsner S. The question of feedback at the somatodendritic region and antidepressant drug action. Brain Res Bull 2000, 52:467-473.
42. Kia H.K., Miquel M.C., Brisorgueil M.J., Daval G., Riad M., El Mestikawy S., Hamom M., Vergé D. Immunocytochemical localization of serotonin 1A receptors in the rat central nervous system. J Comp Neurol 1996, 365:289-305.
43. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 1987, 92:180-185.
44. Lovick T.A. Influence of the dorsal and median raphe nuclei on neurons in the periaqueductal gray matter: role of 5-hydroxytryptamine. Neuroscience 1994, 59:993-1000.
45. McQuade R., Sharp T. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J Neurochem 1997, 69:791-796.
46. Menard J., Treit D. Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neurosci Biobehav Rev 1999, 23:591-613.
47. Miguel T.T., Nunes-de-Souza R.L. Defensive-like behaviors and antinociception induced by NMDA injection into the periaqueductal gray of mice depend on nitric oxide synthesis. Brain Res 2006, 1076:42-48.
48. Millan M.J. The neurobiology and control of anxious states. Prog Neurobiol 2003, 70:83-244.
49. Mokler D.J., Dugal J.R., Hoffman J.M., Morgane P.J. Functional interrelations between nucleus raphé dorsalis and nucleus raphé medianus: a dual probe microdialysis study of glutamate-stimulated serotonin release. Brain Res Bull 2009, 78:132-138.
50. Mundey M.K., Fletcher A., Marsden C.A. Effects of 8-OH-DPAT and 5-HT1A antagonists WAY100135 and WAY100635 on guinea-pig behavior and dorsal raphe 5-HT neurone firing. Br J Pharmacol 1996, 117:750-756.
51. Netto S.M., Silveira R., Coimbra N.C., Joca S.R.I., Guimarães F.S. Anxiogenic effect of median raphe nucleus lesion in stressed rats. Progr Neuro-Psychopharmacol Bio Psychiatry 2002, 26:1135-1141.
52. Nunes-de-Souza R.L., Canto-de-Souza A., Da-Costa M., Fornari R.V., Pelá I.R., Graeff F.G. Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam. Psychopharmacology 2000, 150:300-310.
53. Nunes-de-Souza R.L., Canto-de-Souza A., Rodgers R.J. Effects of intra-hippocampal infusion of WAY 100635 on plus-maze behavior in mice. Influence of site of injection and prior test experience. Brain Res 2002, 9:87-96.
54. 2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice. Behav Brain Res 2008, 187:72-79.
55. 2 receptor mechanisms of the dorsal periaqueductal gray in the conditioned and unconditioned fear in rats. Psychopharmacology 2007, 191:253-262.
56. Paxinos G., Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates 2001, Elsevier Science, California.
57. Rodgers R.J., Johnson N.J.T. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol Biochem Behav 1995, 52:297-303.
58. Silva R.C.B., Gárgaro A.C., Brandão M.L. Differential regulation of the expression of contextual freezing and fear-potentiated startle by 5-HT mechanisms of the median raphe nucleus. Behav Brain Res 2004, 151:93-101.
59. Soares V.P., Zangrossi Jr H Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain Res Bull 2004, 64:181-188.
60. Soares V.P., Zangrossi H. Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic, but not panicolytic-like effect in rats. Behav Brain Res 2009, 197:178-185.
61. 1A autoreceptors on serotoninergic neurons in the median raphe nuclei. Eur J neurosci 1990, 2:1144-1154.
62. Takase L.F., Nogueira M.L. Patterns of fos activation in rat raphe nuclei during feeding behavior. Brain Res 2008, 1200:10-18.
63. Thomas H., Fink H., Sohr R., Voits M. Lesiono of the median raphe nucleus: a combined behavioural and microdialysis study in rats. Pharmacol Biochem Behav 2000, 65:15-21.
64. Treit D., Menard J., Royan C. Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 1993, 44:463-469.
65. Vertes R.P., Fortin W.J., Crane A.M. Projections of the median raphe nucleus in the rat. J Comp Neurol 1999, 407:555-582.
66. Walther D.J., Bader M. A unique central tryptophan hydroxiylase isoform. Biochem Pharmacol 2003, 66:1673-1680.
67. Whitton P., Curzon G. Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus. Psychopharmacology 1990, 100:138-140.
68. Yamashita P.S., de Bortoli V.C., Zangrossi H. 5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray. Neuropharmacology 2011, 60:216-222.