5-HT2 receptor mechanisms of the dorsal periaqueductal gray in the conditioned and unconditioned fear in rats

Psychopharmacology

Volumn 191, Issue 2, 2007, Pages 253-262

  Oliveira, Luciana Chrystine ^a   Broiz, Ana Carolina ^a   De Macedo, Carlos Eduardo ^a   Landeira Fernandez, J ^b   Brandão, Marcus Lira ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

methyl 5 HT; 5 HT receptors; Contextual fear conditioning; Dorsal periaqueductal gray; Ketanserin; Unconditioned fear

Indexed keywords

ALPHA METHYLSEROTONIN; KETANSERIN; SEROTONIN 2 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; ALPHA-METHYLSEROTONIN; DRUG DERIVATIVE; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; ELECTRIC CURRENT; ESCAPE BEHAVIOR; FEAR; FOOTSHOCK; FREEZING; MALE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; ANIMAL; ANIMAL BEHAVIOR; AVOIDANCE BEHAVIOR; CATALEPSY; CONDITIONED REFLEX; DOSE RESPONSE; ELECTROSTIMULATION; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; WISTAR RAT;

ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CONDITIONING, CLASSICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ESCAPE REACTION; FEAR; FREEZING REACTION, CATALEPTIC; KETANSERIN; MALE; PERIAQUEDUCTAL GRAY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT2; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 33847683864     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0653-3     Document Type: Article

References (45)

1. APA (1994) American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC
2. Baxter G, Kennett G, Blaney F, Blackburn T (1995) 5-HT2 receptor subtypes: a family re-united? Trends Pharmacol Sci 16:105-110
3. Beitz AJ, Clements JR, Mullet M, Ecklund L (1986) Differential origin of brainstem serotonergic projections to the midbrain periaqueductal gray and superior colliculus of the rat. J Comp Neurol 250:498-509
4. Blanchard DC, Blanchard RJ, Rodgers RJ (1990) Pharmacological and neural control of antipredator defense in the rat. Aggress Behav 16:165-175
5. Borelli KG, Nobre MJ, Brandão ML (2004) Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal gray matter. Pharmacol Biochem Behav 77:557-566
6. Borelli KG, Ferreira-Netto C, Coimbra NC, Brandão ML (2005) Fos-like immunoreactivity in the brain associated with freezing or escape induced by inhibition of either glutamic acid decarboxylase or GABAA receptors in the dorsal periaqueductal gray. Brain Res 105:100-111
7. Brandão ML, Aguiar JC, Graeff FG (1982) GABA mediation of the anti-aversive action of minor tranquilizers. Pharmacol Biochem Behav 16:397-402
8. Brandão ML, DiScala G, Bouchet MK, Schmitt P (1986) Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus. Pharmacol Biochem Behav 24:497-502
9. 1A receptors on neurones of the rat midbrain tectum. Bran Res 556:259-266
10. Brandão ML, Troncoso AC, Silva MAS, Huston JP (2003) The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations. Eur J Pharmacol 463:225-233
11. Brandão ML, Borelli KG, Nobre MJ, Santos JM, Albrechet-Souza L, Oliveira AR, Martinez RC (2005) Gabaergic regulation of the neural organization of fear in the midbrain tectum. Neurosci Biobehav Rev 29:1299-1311
12. Castilho VM, Brandão ML (2001) Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats. Psychopharmacology 155:154-162
13. Castilho VM, Macedo CE, Brandão ML (2002) Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats. Psychopharmacology 165:77-85
14. Coimbra NC, Brandão ML (1993) GABAergic nigro-collicular pathways modulate the defensive behavior elicited by midbrain tectum stimulation. Behav Brain Res 59:131-139
15. 2 receptors blockade on fear-induced analgesia elicited by electrical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray. Behav Brain Res 87:97-103
16. Davis M, Astrachan DI (1978) Conditioned fear and startle magnitude: effects of different footshock and backshock intensities used in training. J Exp Psychol Anim Behav Process 4:95-103
17. De Oca BN, DeCola JP, Maren S, Fanselow MS (1998) Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses. J Neurosci 18:3426-3432
18. Ferreira-Netto C, Borelli KG, Brandão ML ( 2005) Neural segregation of Fos-protein distribution in the brain following freezing and escape behaviors induced by injections of either glutamate or NMDA into the dorsal periaqueductal gray of rats. Brain Res 1031:151-163
19. Graeff FG (1990) Brain defense systems and anxiety. In: Roth M, Burrow GD, Noyes R (eds) Handbook of anxiety, vol 3. Elsevier, New York, pp 307-354
20. Graeff FG (2004) Serotonin, the periaqueductal gray and panic. Neurosci Biobehav Rev 28:239-259
21. Graeff FG, Brandão ML, Audi EA, Schultz MTB (1986) Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behav Brain Res 21:65-72
22. Jenck F, Broekkamp CLE, Van Delft ML (1989) Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5-HT1, 5HT2 and 5HT3 receptors. Psychopharmacology 97:489-495
23. Johnson PL, Shekhar A (2006) Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors. J Neurosci 28:1015-1022
24. Leysen JE, Awonters F, Kennis L, Laduron PH, Vandenberk J, Jansem PAJ (1981) Receptor binding profile of R41468, a novel antagonist of 5-HT2 receptors. Life Sci 28:1015-1022
25. Lovick TA (1993) Serotonergic influence from raphe nucleus obscurus on neurons in the periaqueductal grey matter in the rat. Brain Res 606:92-98
26. Magierek V, Ramos PL, Silveira-Filho NG, Nogueira RL, Landeira-Fernandez J (2004) Context fear conditioning inhibits panic-like behavior elicited by electrical stimulation of dorsal periaqueductal gray. NeuroReport 14:1641-1644
27. Maisonnette SS, Morato S, Brandão ML (1993) Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus maze test. Physiol Behav 54:753-758
28. Maisonnette SS, Kawasaki MC, Coimbra NC, Brandão ML (1996) Effects of lesions of amygdaloid nuclei and substantia nigra on aversive responses induced by electrical stimulation of the inferior colliculus. Brain Res Bull 40:93-98
29. Maritjena ID, Calvo N, Volosin M, Molina VA (1997) Prior exposure to a brief restraint session facilitates the occurrence of fear in response to a conflict situation: behavioral and neurochemical correlates. Brain Res 752:136-142
30. Nashold BS, Wilson WP, Slaughter DG (1969) Sensation evoked by stimulation in the midbrain of man. J Neurosurg 30:14-24
31. Nobre MJ, Sandner G, Brandão ML (2003) Enhancement of acoustic evoked potentials and impairment of startle reflex induced by reduction of GABAergic control of the neural substrates of aversion in the inferior colliculus. Hear Res 184:82-90
32. Nogueira RL, Graeff FG (1995) Role of 5-HT receptor subtypes in the modulation of aversion generated in the dorsal periaqueductal gray. Pharmacol Biochem Behav 52:1-6
33. Oliveira LC, Nobre MJ, Brandão ML, Landeira-Fernandez J (2004) Role of amygdala in conditioned and unconditioned fear generated in the periaqueductal gray. NeuroReport 15:2281-2285
34. Papaioannou VE, Fox JG (1993) The efficacy of tribromoethanol anesthesia in mice. Lab Anim Sci 43:189-192
35. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates. Academic, San Diego, CA
36. Reiman EM, Raichle ME, Robins E (1989) Neuroanatomical correlates of a lactate-induced anxiety attack. Arch Gen Psychiatry 46:493-500
37. Ruiz-Martinez RC, Oliveira AR, Brandão ML (2006) Conditioned and unconditioned fear organized in the periaqueductal gray are differentially sensitive to injections of muscimol into amygdaloid nuclei. Neurobiol Learn Mem 85:58-65
38. Santos JM, Gárgaro AC, Oliveira AR, Masson S, Brandão ML (2005) Pharmacological dissociation of moderate and high contextual fear as assessed by freezing behavior and fear-potentiated startle. Eur Neuropsychopharmacol 15:239-246
39. Santos JM, Martinez RC, Brandão ML (2006) Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioning. Eur J Pharmacol 542:121-128
40. Schenberg LC, Bittencourt AS, Sudre EC, Vargas LC (2001) Modeling panic attacks. Neurosci Biobehav Rev 25:647-659
41. Schenberg LC, Póvoa RMF, Costa ALP, Caldellas AV, Tufik S, Bittencourt AS (2005) Functional specializations within the tectum defense systems of the rat. Neurosci Biobehav Rev 29:1279-1298
42. Silva RCB, Gárgaro AC, Brandão ML (2004) Differential regulation of the expression of contextual freezing and fear-potentiated startle by 5-HT mechanisms of the median raphe nucleus. Behav Brain Res 151: 93-101
43. Vianna DML, Landeira-Fernandez J, Graeff FG, Brandão ML (2001a) Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal. periaqueductal gray. Learn Mem 8:164-169
44. Vianna DML, Landeira-Fernandez J, Brandão ML (2001b) Dorsolateral and ventral regions of the periaqueductal gray matter are involved in distinct types of fear. Neurosci Biobehav Rev 25:711-719
45. Walker DL, Cassella JV, Lee Y, De Lima TCM, Davis M (1997) Opposing roles of the amygdala and dorsolateral periaqueductal gray in fear-potentiated startle. Neurosci Biobehav Rev 21:743-753