Effects of inactivation of serotonergic neurons of the median raphe nucleus on learning and performance of contextual fear conditioning

Neuroscience Letters

Volumn 387, Issue 2, 2005, Pages 105-110

  Borelli, Karina Genaro ^a   Gárgaro, Ana Carolina ^a   Dos Santos, Júlia Maria ^a   Brandão, Marcus Lira ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Fear conditioning; Freezing; Median raphe nucleus; Startle reflex

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; AUTORECEPTOR; N METHYL DEXTRO ASPARTIC ACID; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AVERSION; CONDITIONED REFLEX; CONTROLLED STUDY; FEAR; FREEZING; HIPPOCAMPUS; LEARNING; MALE; MEDIAN RAPHE NUCLEUS; MEMORY; NERVE CELL INHIBITION; NEUROCHEMISTRY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; SEROTONINERGIC NERVE CELL; SHOCK;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANXIETY DISORDERS; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); DENERVATION; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGONISTS; FEAR; LEARNING; MALE; N-METHYLASPARTATE; NEURAL PATHWAYS; NEURONS; NEUROTOXINS; PONS; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SEROTONIN AGONISTS; STARTLE REACTION;

EID: 23644455304     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.07.031     Document Type: Article

References (16)

1. T.G.C.S. Andrade, C.E.A. Macedo, H. Zangrossi, and F.G. Graeff Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze Behav. Brain Res. 153 2004 55 60
2. 1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively Eur. J. Pharmacol. 264 1994 259 264
3. 1A autoreceptors in the raphe nucleus disrupts the contextual conditioning in rats Behav. Brain Res. 126 2001 175 184
4. V. Avanzi, V.M. Castilho, T.G.C. Andrade, and M.L. Brandão Regulation of contextual conditioning by the median raphe nucleus Brain Res. 790 1998 178 184
5. V. Avanzi, R.C.B. Silva, C.E. Macedo, and M.L. Brandrão 5-HT mechanisms of median raphe nucleus in the conditioned freezing caused by light/foot-shock association Physiol. Behav. 78 2003 471 477
6. E.C. Azmitia, and M. Segal An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe Comp. Neurol. 179 1978 641 668
7. P. Bobilier, F. Petitjean, D. Salvert, M. Ligier, and S. Seguin Differential projections of the nucleus raphe dorsalis and nucleus raphe centralis as revealed by autoradiography Brain Res. 35 1975 205 210
8. M.S. Fanselow Contextual fear, gestalt memories, and the hippocampus Behav. Brain Res. 110 2000 73 81
9. F.G. Graeff, and G. Silveira Filho Behavioral inhibition induced by electrical stimulation of the median raphe nucleus of the rat Physiol. Behav. 71 1978 477 484
10. J.A. Gray, and N. McNaughton Fundamentals of the septo-hippocampal system J.A. Gray N. McNaughton The Neuropsychology of Anxiety: An Enquiry Into the Functions of Septo-Hippocampal System second ed. 2000 Oxford University Press Oxford 204 232
11. V. Hillegaart Effects of application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on motor activity in the rat Physiol. Behav. 48 1990 143 148
12. J.J. Kim, and M.S. Fanselow Modality-specific retrograde amnesia of fear Science 256 1992 675 677
13. K.A. McNish, J.C. Gewirtz, and M. Davis Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-potentiated startle J. Neurosci. 17 1997 9253 9360
14. G. Paxinos, and P. Watson The Rat Nervous Coordinates, The New Coronal Set fifth ed. 2004 Elsevier Academic Press New York
15. J.M. Santos, A.C. Gargaro, A.R. Oliveira, S. Masson, and M.L. Brandão Pharmacological dissociation of moderate and high contextual fear as assessed by freezing behavior and fear-potentiated startle Eur. Neuropsychopharmacol. 15 2005 239 246
16. R.C. Silva, A.C. Gargaro, and M.L. Brandão Differential regulation of the expression of contextual freezing and fear-potentiated startle by 5-HT mechanisms of the median raphe nucleus Behav. Brain Res. 151 1-2 2004 93 101