Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5- tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3802-3809

  Caba, Octavio ^a   Díaz Gavilán, Mónica ^b   Rodríguez Serrano, Fernando ^a   Boulaiz, Houria ^a   Aránega, Antonia ^a   Gallo, Miguel A ^b   Marchal, Juan A ^a   Campos, Joaquín M ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b Facultad de Farmacia   (Spain)

Author keywords

1,2,3,5 Tetrahydro 4,1 benzoxazepines; Acyclic Purine O,N acetals; Anti tumour activity; Apoptosis; cDNA microarray; Invasion; MCF 7; Therapeutic index

Indexed keywords

1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPINE 3 YL] 6 CHLORO 9H PURINE; 7 {2 (N HYDROXYMETHYLPHENYL) 2 NITROBENZENESULFONAMIDO] 1 METHOXYETHYL} 6 CHLORO 7H PURINE; 9 [1 (9H FLUORENYL 9 METHOXYCARBONYL) 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPINE 3 YL] 6 CHLORO 9H PURINE; ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; N ACETALIC 6 CHLORO 7H PURINE; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CELL; CANCER CELL CULTURE; CANCER INVASION; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; CLINICAL ASSESSMENT TOOL; COLON CANCER; CONTROLLED STUDY; DNA MICROARRAY; DRUG POTENCY; DRUG STRUCTURE; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; THERAPEUTIC INDEX;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DNA, COMPLEMENTARY; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION; HUMANS; INHIBITORY CONCENTRATION 50; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PURINES;

EID: 80052946262     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.047     Document Type: Article

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