Non-steroidal anti-inflammatory drugs affect the methotrexate transport in IEC-6 cells

Life Sciences

Volumn 73, Issue 4, 2003, Pages 437-446

  Sosogi, Aiko ^a   Gao, Feng ^a   Tomimatsu, Takashi ^a   Hirata, Koji ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

ATP; IEC 6 cells; Methotrexate; NSAIDs; Reduced folate carrier

Indexed keywords

ADENOSINE TRIPHOSPHATE; DICLOFENAC; FLUFENAMIC ACID; INDOMETACIN; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL TRANSPORT; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG EFFECT; DRUG INHIBITION; DRUG TRANSPORT; DRUG UPTAKE; INCUBATION TIME; INTESTINE EPITHELIUM CELL; KINETICS; MICHAELIS CONSTANT; NONHUMAN; OXIDATIVE PHOSPHORYLATION; RAT; VELOCITY;

EID: 0038636004     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00316-3     Document Type: Article

References (29)

1. McDougall P., Markham A., Cameron I., Sweetman A.J. The mechanism of inhibition of mitochondrial oxidative phosphorylation by the nonsteroidal anti-inflammatory agent diflunisal. Biochem Pharmacol. 32:1983;2595-2598.
2. Mahmud T., Rafi S.S., Scott D.L., Wrigglesworth J.M., Bjarnason I. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum. 39:1996;1998-2003.
3. Masubuchi Y., Saito H., Horie T. Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther. 287:1998;208-213.
4. Masubuchi Y., Yamada S., Horie T. Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation. Biochem Pharmacol. 58:1999;861-865.
5. Masubuchi Y., Yamada S., Horie T. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 292:2000;982-987.
6. Bannwarth B., Pehourcq F., Schaeverbeke T., Dehais J. Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis. Clin Pharmacokinet. 30:1996;194-210.
7. Camiciottoli G., Trapani S., Castellani W., Ginanni R., Ermini M., Falcini F. Effect on lung function of methotrexate and non-steroid anti-inflammatory drugs in children with juvenile rheumatoid arthritis. Rheumatol Int. 18:1998;11-16.
8. Cron R.Q., Sharma S., Sherry D.D. Current treatment by United States and Canadian pediatric rheumatologists. J Rheumatol. 26:1999;2036-2038.
9. Strum W.B. A pH-dependent, carrier-mediated transport system for the folate analog, amethopterin, in rat jejunum. J Pharmacol Exp Ther. 203:1977;640-645.
10. Strum W.B. Characteristics of the transport of pteroylglutamate and amethopterin in rat jejunum. J Pharmacol Exp Ther. 216:1981;329-333.
11. Schron C.M., Washington C., Blitzer B.L. The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles. J Clin Invest. 76:1985;2030-2033.
12. Dixon K.H., Lanpher B.C., Chiu J., Kelley K., Cowan K.H. A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem. 269:1994;17-20.
13. Williams F.M., Murray R.C., Underhill T.M., Flintoff W.F. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem. 269:1994;5810-5816.
14. Moscow J.A., Gong M., He R., Sgagias M.K., Dixon K.H., Anzick S.L., Meltzer P.S., Cowan K.H. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55:1995;3790-3794.
15. Wong S.C., Proefke S.A., Bhushan A., Matherly L.H. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem. 270:1995;17468-17475.
16. Said H.M., Nguyen T.T., Dyer D.L., Cowan K.H., Rubin S.A. Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA. Biochim Biophys Acta. 1281:1996;164-172.
17. Said H.M., Strum W.B. A pH-dependent, carrier-mediated system for transport of 5-methyltetrahydrofolate in rat jejunum. J Pharmacol Exp Ther. 226:1983;95-99.
18. Said H.M., Ma T.Y., Ortiz A., Tapia A., Valerio C.K. Intracellular regulation of intestinal folate uptake: studies with cultured IEC-6 epithelial cells. Am J Physiol. 272:1997;729-736.
19. Rieger D. Batch analysis of the ATP content of bovine sperm, oocytes, and early embryos using a scintillation counter to measure the chemiluminescence produced by the luciferin-luciferase reaction. Anal Biochem. 246:1997;67-70.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagents. J Biol Chem. 193:1951;265-275.
21. Uwai Y., Okuda M., Takami K., Hashimoto Y., Inui K. Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 438:1998;321-324.
22. Apiwattanakul N., Sekine T., Chairoungdua A., Kanai Y., Nakajima N., Sophasan S., Endou H. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 55:1999;847-854.
23. Masuda S., Saito H., Inui K. Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1. J Pharmacol Exp Ther. 283:1997;1039-1042.
24. + gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. J Pharmacol Exp Ther. 241:1987;594-601.
25. Kajii H., Horie T., Hayashi M., Awazu S. Effects of salicylic acid on the permeability of the plasma membrane of the small intestine of the rat: a fluorescence spectroscopic approach to elucidate the mechanism of promoted drug absorption. J Pharm Sci. 75:1986;475-478.
26. Kajii H., Horie T., Hayashi M., Awazu S. Effects of sodium salicylate and caprylate as an adjuvant of drug absorption on isolated rat small intestinal epithelial cells. Int. J. Pharm. 33:1986;253-255.
27. Kajii H., Horie T., Hayashi M., Awazu S. Fluorescence study on the interaction of salicylate with rat small intestinal epithelial cells: possible mechanism for the promoting effects of salicylate on drug absorption in vivo. Life Sci. 37:1985;523-530.
28. Giraud M.N., Motta C., Romero J.J., Bommelaer G., Lichtenberger L.M. Interaction of indomethacin and naproxen with gastric surface-active phospholipids: a possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs). Biochem Pharmacol. 57:1999;247-254.
29. Lugea A., Antolin M., Mourelle M., Guarner F., Malagelada J.R. Deranged hydrophobic barrier of the rat gastroduodenal mucosa after parenteral nonsteroidal anti-inflammatory drugs. Gastroenterology. 112:1997;1931-1939.