N-benzoxazol-2-yl-N'-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential

Investigational New Drugs

Volumn 27, Issue 3, 2009, Pages 189-202

  Hofmann, Johann ^a   Easmon, Johnny ^b   Puerstinger, Gerhard ^b   Heinisch, Gottfried ^b   Jenny, Marcel ^a   Shtil, Alexander A ^c   Hermann, Martin ^a   Condorelli, Daniele F ^d   Sciré, Salvatore ^d   Musumarra, Giuseppe ^d  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

Bicyclic hydrazone; Bioinformatics; Drug target; Gene array; Mechanism; Radicals

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; EPH 136; N BENZOXAZOL 2 YL 1 (ISOQUINOLIN 3 YL ETHYLIDENE)HYDRAZINE; NUCLEIC ACID; NUCLEOSIDE; NUCLEOTIDE; SCAVENGER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOINFORMATICS; CARCINOMA CELL; COLON CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATION REDUCTION REACTION; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PROTEIN MODIFICATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BENZOXAZOLES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; FREE RADICALS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDRAZONES; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; RIBONUCLEOTIDE REDUCTASES; RNA;

EID: 64649092051     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9156-x     Document Type: Article

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